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Pre-Heating of Low-Shrinkage Composite Resins: Effects on Color Stability and Surface Roughness. 低收缩复合树脂的预热:对颜色稳定性和表面粗糙度的影响。
Q3 Dentistry Pub Date : 2022-08-10 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i26.10597
Parnian Alizadeh Oskoee, Siavash Savadi Oskoee, Fatemeh Pournaghi-Azar, Sana Dibazar, Mehdi Esmaeili

Objectives: The present study aimed to investigate the effect of preheating on the color stability and surface roughness of a silorane-based composite resin. Materials and Methods: A total of 44 Filtek P90 composite resin disks, (10mm×1mm), were fabricated using plastic molds and were divided into two groups. In group 2, the composite resin syringes were placed in a thermostatically controlled water bath at 55‒60°C before preparing the disks. After polishing the samples with silicon carbide papers, they were stored in distilled water for 48 hours. Roughness and color parameters were then measured in two stages: immediately after retrieval from distilled water and after 40 days of storage in tea solution. Finally, the differences in roughness and color parameters were recorded. Independent sample t-test and regression analysis were used at a significance level of P<0.05. Results: Based on the findings of the present study, there was no significant difference among the mean ∆E values (P=0.4); however, a significant difference in mean surface roughness (P=0.01) was found between the two groups. Regression analysis showed a significant relationship between the study groups in terms of surface roughness and ΔE values​ (preheated: r2 = 0.73; non-preheated: r2= 0.76). Conclusion: Filtek P90 silorane-base composite showed ΔE>3.3 and surface roughness above 0.2µ under preheated and non-preheated conditions and discoloration increased following preheating.

目的:研究预热对硅烷基复合树脂颜色稳定性和表面粗糙度的影响。材料与方法:采用塑料模具制作44个Filtek P90复合树脂圆盘(10mm×1mm),分为两组。第2组,在制备圆盘之前,将复合树脂注射器置于55-60℃的恒温水浴中。样品用碳化硅纸抛光后,置于蒸馏水中保存48小时。然后在两个阶段测量粗糙度和颜色参数:从蒸馏水中提取后立即测量和在茶溶液中储存40天后测量。最后,记录粗糙度和颜色参数的差异。结果采用独立样本t检验和回归分析,在显著性水平上:根据本研究结果,平均∆E值之间无显著差异(P=0.4);然而,两组之间的平均表面粗糙度有显著差异(P=0.01)。回归分析显示,各研究组表面粗糙度与ΔE值之间存在显著相关(预热:r2 = 0.73;未预热:r2= 0.76)。结论:Filtek P90硅基复合材料在预热和非预热条件下,其表面粗糙度均大于0.2µ,ΔE>3.3,变色程度随预热而增加。
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引用次数: 0
Relevance of Teledentistry: Brief Report and Future Perspectives. 电视诊断学的相关性:简要报告和未来展望。
Q3 Dentistry Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i25.10596
Carlo Fornaini, Jean-Paul Rocca

Teledentistry is a type of telemedicine and telehealth that aims to make all major specialties of the discipline easier through a remote approach to prevention and treatment of oral and dental issues. This new method enables distant access to individuals instead of direct, face-to-face, doctor-patient contact and has been made possible thanks to developments in information technology. Teledentistry was described in 1997 as "… the practice of using video-conferencing technologies to diagnose and provide advice about treatment over a distance", and today it represents a modern way to practice dentistry by integrating digital imaging, electronics, health records, and telecommunications technology via an internet connection. This approach facilitates patients' access to care in remote settings and also enables specialists at distant locations to arrive at a correct diagnosis as well as to propose proper therapy or refer patients, where warranted. The current brief report aims to describe the present and future of this modern approach in dentistry and its advantages in patient management from prevention to diagnosis to treatment.

远程牙科是一种远程医疗和远程保健,旨在通过远程方法预防和治疗口腔和牙科问题,使该学科的所有主要专业更容易。这种新方法可以远程访问个人,而不是直接面对面的医患接触,这要归功于信息技术的发展。远程牙科在1997年被描述为“…使用视频会议技术进行远程诊断和提供治疗建议的实践”,而今天,它代表了一种通过互联网连接集成数字成像、电子、健康记录和电信技术的现代牙科实践方式。这种方法便于患者在远程环境中获得护理,也使远程专家能够得出正确的诊断,并在必要时提出适当的治疗建议或转诊患者。当前的简短报告旨在描述现在和未来的这种现代方法在牙科和它的优势,在病人管理从预防到诊断到治疗。
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引用次数: 2
Diagnosis and Treatment of an Incomplete Crown-Root Fracture with Intentional Replantation: A Case Report. 不完全性冠根骨折的诊断与治疗:一例报告。
Q3 Dentistry Pub Date : 2022-08-05 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i24.10595
Soheil Niavarzi, Faranak Noori, Mohammad Saeid Sheikhrezaei, Sholeh Ghabraei

Acute traumatic injuries to the maxillary incisors may lead to a crown-root fracture. If the fracture is left untreated, the fracture line will propagate and extend apically, resulting in microbial contamination of the attachment apparatus and subsequent bone loss. In cases with extensive periodontal involvement, extraction has been suggested. However, bonding and sealing the fracture line with a biocompatible material seems to be an effective alternative treatment option. In this case report, management of a central incisor with an incomplete crown-root fracture that showed signs and symptoms of vertical root fracture is discussed. As the extension of the fracture line was not clear, intentional replantation and sealing the fracture line with a glass ionomer was performed. The tooth showed no signs and symptoms at six-month follow up, and the radiographic examination exhibited substantial bone repair.

上颌门牙的急性创伤性损伤可导致冠根骨折。如果骨折不及时治疗,骨折线将向根尖扩展,导致附着体的微生物污染和随后的骨质流失。如果牙周严重受累,建议拔牙。然而,用生物相容性材料粘合和密封骨折线似乎是一种有效的替代治疗选择。在这个病例报告中,处理中切牙不完全冠根骨折,显示垂直根骨折的迹象和症状进行了讨论。由于骨折线延伸不清楚,我们进行了有意的再植和玻璃离聚体封闭骨折线。在6个月的随访中,牙齿没有任何体征和症状,x线检查显示骨修复良好。
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引用次数: 2
Surgery-First Approach; from Claims to Evidence: A Comprehensive Review. Surgery-First方法;从主张到证据:全面回顾。
Q3 Dentistry Pub Date : 2022-08-03 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i23.10594
Amir Hosein Mirhashemi, Hannaneh Ghadirian, Seyed Morteza Samimi

The main goals of treatment of dentofacial deformities are to achieve optimal esthetics and ideal functional occlusion. The conventional orthognathic surgical approach includes a long presurgical orthodontic phase, which takes about 18 months. During this phase, the patients' appearance is deteriorated and their motivation to continue treatment significantly decreases. In the surgery first approach (SFA), orthognathic surgery is performed prior to orthodontic treatment, and orthodontic treatment is performed postoperatively to improve dental occlusion and for final settling. The SFA has two main advantages namely shortening of treatment period, and early improvement of the appearance of patient. The SFA has significant advantages especially for class III patients. This study aimed to review the available articles on this topic published from 2012 to 2019 to achieve a comprehensive understanding of different aspects of the SFA. The databases were searched by two researchers and a total of 11 eligible articles were selected for study inclusion. The results were categorized into two categories of stability of the results of the SFA, and duration of treatment, in comparison with the conventional approach. Although different aspects of the SFA have been previously evaluated by dental clinicians, a considerable gap of information still exists regarding the details of this approach, which calls for further research in this respect.

牙面畸形治疗的主要目标是达到最佳的美观性和理想的功能性咬合。传统的正颌外科方法包括一个很长的术前正畸阶段,大约需要18个月。在这个阶段,患者的外观恶化,他们继续治疗的动机明显下降。在手术先入路(SFA)中,在正畸治疗之前进行正颌手术,并在术后进行正畸治疗以改善牙合并最终固定。SFA具有缩短治疗周期和早期改善患者外观两大优点。SFA具有显著的优势,特别是对于III级患者。本研究旨在回顾2012年至2019年发表的关于该主题的现有文章,以全面了解SFA的不同方面。两名研究人员检索了数据库,共选择了11篇符合条件的文章纳入研究。与常规方法相比,结果分为SFA结果的稳定性和治疗持续时间两类。尽管牙科临床医生已经对SFA的不同方面进行了评估,但关于该方法的细节信息仍然存在相当大的差距,这需要在这方面进行进一步的研究。
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引用次数: 1
Evaluation of Abrasion and Whitening Effect of Toothpastes Containing Charcoal on Primary Teeth. 含炭牙膏对乳牙的磨耗增白效果评价。
Q3 Dentistry Pub Date : 2022-07-03 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i22.9969
Masoud Fallahinejad Ghajari, Maryam Shamsaei, Maedeh Sadeghpour Galouyak, Kimia Basandeh

Objectives: Parents are aware of the importance of anterior tooth esthetics in their children. Children also pay attention to their appearance more than ever. Today, charcoal has been added to toothpastes. Charcoal can help whiten teeth through abrasion. This study aimed to investigate the degree of bleaching and abrasion of charcoal toothpaste on primary teeth. Materials and Method: This in-vitro study was performed on 30 extracted primary teeth. Initially, the samples were polished, cut, and mounted in blocks of putty. The samples were placed in a coffee solution and then the tooth color was measured by a spectrophotometer and the initial surface profile was measured by a profilometer. The samples were brushed back and forth by the brushing machine with 20 gr Bancer, Beverly, and Colgate toothpastes (mixed with 40 ml of distilled water) for 2000 times (equivalent to 3 times a day for 1.5 months). A color determination was performed again and a second surface profile was measured. The data were analyzed by one-way ANOVA, ANCOVA and paired t-test. Results: The results of this study showed that all three Beverly, Bencer and Colgate whitening toothpastes increased the surface profile and made significant statistical changes in the roughness of dental specimens (P=0.01, P=0.005, P=0.001). The statistical study of the data did not show a significant difference between the groups in terms of abrasion and whitening properties (P=0.78, P= 0.99). Conclusion: Three whitening toothpastes whiten primary teeth and increase their surface roughness. These three toothpastes are not statistically different in terms of abrasion and whitening properties.

目的:家长意识到孩子前牙美学的重要性。孩子们也比以往任何时候都更注重自己的外表。今天,木炭被添加到牙膏中。木炭可以通过磨损来美白牙齿。本研究旨在探讨木炭牙膏对乳牙的漂白和磨损程度。材料与方法:采用30颗拔除的乳牙进行体外实验。最初,样品被抛光,切割,并安装在油灰块。将样品置于咖啡溶液中,然后用分光光度计测量牙齿颜色,用轮廓仪测量初始表面轮廓。用20克Bancer、Beverly和高露洁牙膏(与40毫升蒸馏水混合)在牙刷机上来回刷牙2000次(相当于每天3次,持续1.5个月)。再次进行颜色测定,并测量第二次表面轮廓。数据分析采用单因素方差分析、方差分析和配对t检验。结果:本研究结果显示,贝弗利、贝赛、高露洁三种美白牙膏均能提高牙体表面轮廓,对牙体表面粗糙度有显著的统计学意义(P=0.01, P=0.005, P=0.001)。对数据进行统计研究,两组间的磨耗和美白性能差异无统计学意义(P=0.78, P= 0.99)。结论:三种美白牙膏可以美白乳牙,增加乳牙表面粗糙度。这三种牙膏在磨损和美白性能方面没有统计学上的差异。
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引用次数: 1
Management of Dental and Orthodontic Practice in the COVID-19 Scenario. COVID-19情况下牙科和正畸治疗的管理。
Q3 Dentistry Pub Date : 2022-07-02 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i20.9966
Syed Wajahat Mohammad Rizvi, Chanjyot Singh Walia

The coronavirus disease-2019 (COVID-19) pandemic due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has casted a deep impact on every aspect of the human life all over the world. The healthcare professionals dealing with the patients have been at the greatest risk of exposure. Dental practitioners fall among the highest risk practitioners because of their field of operation being around the oropharyngeal region of patients, as well as due to the risk of generation of aerosols during various dental procedures. There is a continuous urgent need of modifying the dental practice in accordance with the guidelines issued by the health authorities time to time. Meticulously planned approaches, and adequate precautions and modifications need to be introduced into dental practice. The field of orthodontics also demands a high level of practice modification in order to ensure proper infection control for patients, practitioners, and dental staff.

由严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2)引起的冠状病毒病-2019 (COVID-19)大流行,深刻影响了全世界人类生活的方方面面。与患者打交道的医疗保健专业人员面临的暴露风险最大。牙科医生属于风险最高的从业人员,因为他们的手术领域在病人的口咽区附近,以及在各种牙科手术期间产生气溶胶的风险。一直迫切需要根据卫生当局不时发布的指导方针修改牙科做法。精心计划的方法,适当的预防措施和修改需要引入牙科实践。正畸领域也需要高水平的实践修改,以确保适当的感染控制患者,从业者和牙科工作人员。
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引用次数: 0
Effects of Two Fluoride Mouthwashes on Surface Topography and Frictional Resistance of Orthodontic Wires. 两种含氟漱口水对正畸丝表面形貌和摩擦阻力的影响。
Q3 Dentistry Pub Date : 2022-07-02 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i21.9968
Eilnaz Ehrami, Alireza Omrani, Masood Feizbakhsh

Objectives: This study compared the effects of fluoride mouthwashes on surface topography of orthodontic wires, and static and kinetic frictional forces between the stainless steel (SS) orthodontic brackets and SS and nickel-titanium (NiTi) archwires. Materials and Methods: This in vitro, study evaluated 240 standard SS maxillary central incisor brackets and 0.018, and 0.025×0.019 inch NiTi and SS archwires. The wire-bracket sets (different combinations of wire diameters and types) were exposed to artificial saliva (control), 0.05% sodium fluoride (NaF) for 1 minute daily, or 0.2% NaF for 1 minute, weekly (37°C) for 3 months. The wires were pulled in bracket slots by 5 mm in a universal testing machine (10 mm/minute). The static and kinetic forces were measured. The surface topography of wires was inspected under a scanning electron microscope (SEM; x500). Data were analyzed by SPSS 25. Results: The mean static and kinetic frictional forces of 0.025×0.019 inch NiTi wire in 0.05% NaF group were significantly greater than SS wire (P=0.000). The mean kinetic frictional force in 0.05% NaF was significantly greater than 0.2% NaF and artificial saliva for all wires (P=0.001). The mean static and kinetic forces in 0.2% NaF were significantly greater than in artificial saliva (P=0.025). In all groups, larger wires showed higher mean frictional forces (P=0.000). SEM results revealed higher wire surface roughness in 0.05% NaF followed by 0.2% NaF group. Conclusion: Weekly use of 0.2% NaF mouthwash is recommended during sliding mechanics to minimize frictional forces between the SS and NiTi wires and SS brackets.

目的:比较含氟漱口水对正畸金属丝表面形貌的影响,以及不锈钢(SS)正畸托槽与不锈钢(SS)和镍钛(NiTi)弓丝之间静摩擦和动摩擦的影响。材料和方法:本研究评估了240个标准SS上颌中切牙托槽和0.018,0.025×0.019英寸NiTi和SS弓丝。将金属丝托架组(金属丝直径和类型的不同组合)暴露于人工唾液(对照组)、0.05%氟化钠(NaF)每天1分钟或0.2%氟化钠(NaF)每周1分钟(37°C),持续3个月。钢丝在万能试验机上以10mm /分钟的速度在支架槽中拉入5mm。测量了静力和动能。用扫描电子显微镜(SEM)观察了金属丝的表面形貌;x500)。数据采用SPSS 25进行分析。结果:0.05% NaF组0.025×0.019英寸NiTi丝的平均静摩擦力和动摩擦力显著大于SS丝(P=0.000)。0.05% NaF条件下钢丝的平均动摩擦力显著大于0.2% NaF和人工唾液条件下钢丝的平均动摩擦力(P=0.001)。0.2% NaF的平均静力和动能显著大于人工唾液(P=0.025)。在所有组中,较大的导线显示更高的平均摩擦力(P=0.000)。扫描电镜结果显示,0.05% NaF组线材表面粗糙度较高,其次是0.2% NaF组。结论:建议在滑动力学期间每周使用0.2% NaF漱口水,以减少SS和NiTi丝及SS托槽之间的摩擦力。
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引用次数: 0
Relationship of Maxillary Sinus Mucosal Thickening and Residual Alveolar Ridge Height: A CBCT Analysis. 上颌窦黏膜增厚与残余牙槽嵴高度的CBCT分析。
Q3 Dentistry Pub Date : 2022-06-29 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i19.9965
Solmaz Akbari, Mina Taheri, Hoori Aslroosta, Alireza Ordoukhani, Mojgan Paknejad, Flora Hashemi, Zeinab Farimani

Objectives: Maxillary sinus pathological conditions, like thickening of the Schneiderian membrane, can influence the outcomes of augmentation procedures and implant treatment. The present study aimed to evaluate the relationship between the residual ridge height and maxillary sinus membrane thickening. Materials and Methods: A total of 240 cone-beam computed tomography (CBCT) images of the maxillary sinus of 141 patients (62.1% males and 37.9% females, bilateral in 99 patients and unilateral in 42 patients) who were candidates for implant placement were evaluated. The CBCT scans were subsequently assessed for the following variables: residual ridge height, sinus membrane thickening at future implant(s) site(s), the ostium patency, and presence of periapical lesion adjacent to the edentulous area. Results: The total prevalence of sinus membrane thickening (66.2%) was sub-classified as follows: flat in 53.7%, polypoid in 12.1%, and complete opacification in 0.4%. The prevalence of sinus membrane thickening was higher in male participants. It was revealed that age had no significant relationship with presence of a periapical lesion or sinus membrane thickening (P>0.05). Membrane thickening was detected in all sinuses with obstructed ostium. Reduced residual ridge height was significantly associated with higher sinus membrane thickening at the second premolar and first molar sites (P<0.05). Conclusion: Maxillary sinus membrane thickening (mostly with flat appearance) is frequently observed on CBCT scans taken prior to augmentation and implant placement. This, in return, may trigger a reduction in ridge height.

目的:上颌窦的病理状况,如施耐德膜增厚,会影响隆鼻手术和种植治疗的结果。本研究旨在探讨残脊高度与上颌窦膜增厚的关系。材料与方法:对141例(男性62.1%,女性37.9%,双侧99例,单侧42例)候选种植体上颌窦的240张CBCT图像进行评价。随后评估CBCT扫描的以下变量:残余嵴高度,未来种植体位置的窦膜增厚,口通畅,无牙区附近根尖周病变的存在。结果:窦膜增厚的总发生率(66.2%)分为:扁平(53.7%)、息肉样(12.1%)和完全混浊(0.4%)。窦膜增厚的患病率在男性参与者中较高。结果显示,年龄与根尖周围病变及窦膜增厚无显著关系(P>0.05)。所有阻塞的鼻窦均可见膜增厚。残留脊高的降低与第二前磨牙和第一磨牙部位的窦膜增厚显著相关(结论:上颌窦膜增厚(大部分呈扁平状)在隆胸和种植体放置前的CBCT扫描中经常观察到。反过来,这可能会导致脊高降低。
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引用次数: 1
Concerns and Problems of Orthodontic Patients during the COVID-19 Pandemic. 新冠肺炎大流行期间正畸患者的关注与问题
Q3 Dentistry Pub Date : 2022-06-29 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i18.9964
Atefe Saffar Shahroudi, Ahmad Sodagar, Ahmad Reza Shamshiri, Samar Rahimpour, Seyed Morteza Samimi

Objectives: We aimed to find the main concerns of patients undergoing active orthodontic treatments and their orthodontic treatment-related (OTR) problems during the coronavirus disease-2019 (COVID-19) pandemic.

Materials and methods: A researcher-made questionnaire addressing several aspects of the effects of COVID-19 pandemic on treatment was distributed among 181 orthodontic patients receiving active treatment. Anxiety, concern, problems, and willingness to attend orthodontic appointments and to undergo other dental procedures was questioned. The correlation of gender, age, COVID-19-related anxiety and OTR anxiety was statistically analyzed. Patient satisfaction level with different aspects of dental-clinic performance was also evaluated.

Results: The participants included 117 females and 64 males, of which 94% adhered to the pandemic restrictions. The mean COVID-19-related- and OTR-anxiety were 51.7% and 52.7%, respectively. Higher COVID-19-related anxiety was significantly correlated with higher OTR anxiety (P<0.001). There was an inverse correlation between general COVID-19-related anxiety and OTR anxiety and willingness to attend orthodontic appointments (P<0.05). A positive insignificant (P=0.07) correlation existed between age and willingness to attend appointments. The main concern was prolongation of treatment and the most common problem was irritation of oral soft tissues by appliances. The majority (65.3%) were willing to attend their orthodontic appointments. Orthognathic surgery (62%) had the highest while, dental restorations and radiography had the lowest refusal rates (9.9%).

Conclusion: COVID-19 pandemic significantly affected orthodontic treatment. The level of COVID-19-related anxiety was moderately high and patients were concerned about the impact of lockdown on their orthodontic treatment outcome. Young adults demonstrated higher levels of stress than other age-groups.

目的:了解2019冠状病毒病(COVID-19)大流行期间接受积极正畸治疗的患者主要关注的问题及其正畸治疗相关(OTR)问题。材料与方法:对181例接受积极治疗的正畸患者进行问卷调查,调查新冠肺炎疫情对治疗的影响。焦虑、担忧、问题和参加正畸预约和接受其他牙科手术的意愿被质疑。统计分析性别、年龄、新冠肺炎相关焦虑与OTR焦虑的相关性。患者对牙科门诊各方面表现的满意度也进行了评估。结果:参与者包括117名女性和64名男性,其中94%遵守了大流行限制。与covid -19相关的焦虑和otr焦虑的平均值分别为51.7%和52.7%。结论:新冠肺炎大流行对正畸治疗有显著影响。与covid -19相关的焦虑水平中等,患者担心封锁对其正畸治疗结果的影响。年轻人表现出比其他年龄组更高的压力水平。
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引用次数: 2
Streptococcus M utans-Specific Antimicrobial Peptide C16G2-Mediated Caries Prevention: A Review. 变形链球菌特异性抗菌肽c16g2介导的龋齿预防研究进展
Q3 Dentistry Pub Date : 2022-06-28 eCollection Date: 2022-01-01 DOI: 10.18502/fid.v19i17.9963
Janaki Ramya Namburu, Arvind Babu Rajendra Sanosh, Chandra Shekar Poosarla, Suvarna Manthapuri, Mythri Pinnaka, Venkat Ramana Reddy Baddam

Oral biofilms are a group of healthy synergistic organisms, that on interplay with the immune system undergo transition and colonize the pathogenic bacteria, leading to various diseases like dental caries, gingivitis, periodontitis and a few systemic conditions. Dental caries being the most common disease of the oral cavity, comprise a heterogeneous group of bacteria that can cause imbalance in the biofilm. Caries prevention has been in research for decades, where antibiotics, chemical biocides and fluoride-antimicrobial approaches have not been adequate for this multifactorial disease. In recent years, the major focus of caries prevention has been shifted to plaque-biofilm modification as an ecological approach that would prevent bacterial colonization. Saliva produces various natural antimicrobial peptides that can regulate biofilm modification. Synthetic production of antimicrobial peptides concentrates on selective elimination and a targeted approach towards cariogenic pathogens, precisely Streptococcus mutans (S. mutans). A search in Medline/PubMed, EBSCO and ScienceDirect databases on C16G2, antimicrobial peptides (AMPs) and S. mutans, using MeSH (Medical Subject Heading) terms was performed and papers published until 2020 were included for further evaluation. A total of eight articles written in English with available full texts were selected based on the search strategy. They included four publications on AMPs against S. mutans and another four articles on AMPs in caries prevention. This review focuses on C16G2 antimicrobial peptide and its potential to modify biofilm and inhibit the targeted bacteria causing dental caries.

口腔生物膜是一群健康的协同生物,与免疫系统相互作用,发生转化并定植致病菌,导致龋齿、牙龈炎、牙周炎等各种疾病和一些全身性疾病。龋齿是口腔中最常见的疾病,由一组异质性细菌组成,可导致生物膜失衡。预防龋齿的研究已经进行了几十年,抗生素、化学杀菌剂和氟化物抗微生物方法还不足以治疗这种多因素疾病。近年来,龋齿预防的主要焦点已经转移到牙菌斑生物膜修饰上,作为一种防止细菌定植的生态方法。唾液产生多种天然抗菌肽,可以调节生物膜修饰。抗菌肽的合成生产集中于选择性消除和针对致龋病原体的靶向方法,特别是变形链球菌(S. mutans)。在Medline/PubMed、EBSCO和ScienceDirect数据库中使用MeSH(医学主题标题)检索C16G2、抗菌肽(AMPs)和S. mutans,并纳入2020年之前发表的论文进行进一步评估。根据搜索策略,总共选择了8篇英文文章,并提供全文。其中包括四篇关于抗变形链球菌抗菌肽的文章和另外四篇关于抗菌肽预防龋齿的文章。本文就C16G2抗菌肽及其在修饰生物膜和抑制龋齿目标细菌方面的研究进展进行综述。
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引用次数: 2
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Frontiers in Dentistry
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