S. Gvidiani, Lasha Gulbani, L. Svanadze, K. Tsomaia, I. Bebiashvili, D. Kordzaia
In this paper, the features of ductular reaction (DR) and remodeling of the biliary tract in experimental models are discussed in total and selective biliary occlusion. It has been shown that the intensity of DR, as well as the shape, number, and topography of ductular profiles following common bile duct occlusion (CBDO) are closely related to the duration of the biliary obstruction. In addition, the formation of new ductular profiles can occur by the widening of existing bile ducts/ductules as a result of cholangiocyte proliferation, hepatocyte transdifferentiation, and/or activation and differentiation of stem/progenitor cells. It has been concluded that DR induced by CBDO consists of the components of all types of DRs, including I, II (A and B), and III, thus increasing the interest in further studies of this model. In the DR following CBDO, the consequent “preproliferative” and “proliferative” phases developed in parallel with cells differentiation and transdifferentiation (the “para-proliferative” phase) should be distinguished. The dynamics of these phases are important to consider for further detailed classification of DRs. During selective biliary obstruction, the full range of DR characteristics for CBDO has not been determined (mainly the events of biliary proliferation and fibrosis are noted). However, the great compensatory potential of the biliary bed has been confirmed, as reflected by the formation of new collaterals between congested and noncongested bile ducts.
{"title":"Ductular Reaction in Total and Partial Biliary Obstruction in Experimental Settings","authors":"S. Gvidiani, Lasha Gulbani, L. Svanadze, K. Tsomaia, I. Bebiashvili, D. Kordzaia","doi":"10.14218/ge.2023.00002s","DOIUrl":"https://doi.org/10.14218/ge.2023.00002s","url":null,"abstract":"In this paper, the features of ductular reaction (DR) and remodeling of the biliary tract in experimental models are discussed in total and selective biliary occlusion. It has been shown that the intensity of DR, as well as the shape, number, and topography of ductular profiles following common bile duct occlusion (CBDO) are closely related to the duration of the biliary obstruction. In addition, the formation of new ductular profiles can occur by the widening of existing bile ducts/ductules as a result of cholangiocyte proliferation, hepatocyte transdifferentiation, and/or activation and differentiation of stem/progenitor cells. It has been concluded that DR induced by CBDO consists of the components of all types of DRs, including I, II (A and B), and III, thus increasing the interest in further studies of this model. In the DR following CBDO, the consequent “preproliferative” and “proliferative” phases developed in parallel with cells differentiation and transdifferentiation (the “para-proliferative” phase) should be distinguished. The dynamics of these phases are important to consider for further detailed classification of DRs. During selective biliary obstruction, the full range of DR characteristics for CBDO has not been determined (mainly the events of biliary proliferation and fibrosis are noted). However, the great compensatory potential of the biliary bed has been confirmed, as reflected by the formation of new collaterals between congested and noncongested bile ducts.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48576474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alla Turshudzhyan, Lucas da Cunha Godoy, C. Kuo, George Y Wu
{"title":"Alpha Feto-protein Expression Trends for Screening Early Hepatocellular Carcinoma","authors":"Alla Turshudzhyan, Lucas da Cunha Godoy, C. Kuo, George Y Wu","doi":"10.14218/ge.2023.00001","DOIUrl":"https://doi.org/10.14218/ge.2023.00001","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44962009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Metformin on Prevention and Treatment of Biliary Tract Cancer: A Meta-analysis of Observational Studies","authors":"Suangson Supabphol, Luxzup Wattanasukchai, Seksan Nasomjit, Wunchana Seubwai, S. Wongkham, Charupong Saengboonmee","doi":"10.14218/ge.2022.00006s","DOIUrl":"https://doi.org/10.14218/ge.2022.00006s","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43871153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution of Non-alcoholic Fatty Liver Disease to Liver Cancer: Insights from Genome-wide Association Studies","authors":"S. K. Mungamuri, Y. Gupta, P. Rao, B. Ravishankar","doi":"10.14218/ge.2022.00014","DOIUrl":"https://doi.org/10.14218/ge.2022.00014","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44714848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Perreira Barreto, Raissa Yolanda de Oliveira Silva, B. B. de Almeida, P. Ovídio, A. A. Jordão
{"title":"Metabolic Effects of Coconut Oil on Fatty Liver and Oxidative Stress Induced by a High-fat Diet in Rats","authors":"Laura Perreira Barreto, Raissa Yolanda de Oliveira Silva, B. B. de Almeida, P. Ovídio, A. A. Jordão","doi":"10.14218/ge.2022.00006","DOIUrl":"https://doi.org/10.14218/ge.2022.00006","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48695428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brady Jin-Smith, Natacha Jn-Simon, S. Basha, Chunbao Sun, Shang Wu, J. M. Barkin, Liya Pi
{"title":"Acetaldehyde Dehydrogenases in Liver Zonation and Liver Cancer","authors":"Brady Jin-Smith, Natacha Jn-Simon, S. Basha, Chunbao Sun, Shang Wu, J. M. Barkin, Liya Pi","doi":"10.14218/ge.2022.00022","DOIUrl":"https://doi.org/10.14218/ge.2022.00022","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45561288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Varsha D. Shiragannavar, Shreyas H. Karunakara, Lakshana D. Puttahanumantharayappa, Nirmala G. Sannappa Gowda, Prasanna K. Santhekadur
{"title":"Unraveling Key Signaling Pathways Altered in Hepatocellular Carcinoma","authors":"Varsha D. Shiragannavar, Shreyas H. Karunakara, Lakshana D. Puttahanumantharayappa, Nirmala G. Sannappa Gowda, Prasanna K. Santhekadur","doi":"10.14218/ge.2022.00009s","DOIUrl":"https://doi.org/10.14218/ge.2022.00009s","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46893014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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