Pub Date : 2025-01-01DOI: 10.1016/j.genhosppsych.2024.09.006
Christina M. van der Feltz-Cornelis , Fidan Turk , Jennifer Sweetman , Kamlesh Khunti , Mark Gabbay , Jessie Shepherd , Hugh Montgomery , W. David Strain , Gregory Y.H. Lip , Dan Wootton , Caroline Leigh Watkins , Daniel J. Cuthbertson , Nefyn Williams , Amitava Banerjee
{"title":"Corrigendum to “Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis” [General Hospital Psychiatry volume 88 (2024)10–22 10.1016/j.genhosppsych.2024.02.009]","authors":"Christina M. van der Feltz-Cornelis , Fidan Turk , Jennifer Sweetman , Kamlesh Khunti , Mark Gabbay , Jessie Shepherd , Hugh Montgomery , W. David Strain , Gregory Y.H. Lip , Dan Wootton , Caroline Leigh Watkins , Daniel J. Cuthbertson , Nefyn Williams , Amitava Banerjee","doi":"10.1016/j.genhosppsych.2024.09.006","DOIUrl":"10.1016/j.genhosppsych.2024.09.006","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Page 112"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess the cumulative incidence of severe neutropenia and agranulocytosis (SNA) and mild and moderate neutropenia (MMN) in patients with Parkinson's disease psychosis (PDP) who receive clozapine treatment.
Methods
We searched multiple databases to identify clozapine studies in PDP patients. Incidence rates were assessed during short-term (within 1 month), medium-term (within 6 months), and long-term (> 6 months) monitoring periods. A proportional meta-analysis was performed using random-effects and generalized linear mixed models (GLMMs).
Results
We included 691 PDP patients from 19 studies. During the short-term monitoring period, none of the 573 participants in 16 studies developed SNA. The pooled incidence of SNA was 0.001 (95 % confidence interval [CI]: 0.000–0.253, 525 participants, 15 studies) during the medium-term period and 0.002 (95 % CI: 0.000–0.015, 475 participants, 12 studies) during the long-term period. The pooled incidence of MMN was 0.004 (95 % CI: 0.000–0.281, 164 participants, 7 studies) for short- and medium-term periods and 0.013 (95 % CI: 0.002–0.094, 193 participants, 7 studies) in the long-term period. Funnel plot asymmetry indicated potential bias in the medium-term dataset of SNA (p = 0.035).
Conclusion
Clozapine treatment in PDP patients may carry a very low risk of SNA and a low risk of MMN.
{"title":"Risk of agranulocytosis and neutropenia in patients with Parkinson's disease psychosis receiving clozapine treatment: A systematic review and meta-analysis","authors":"Nahathai Limveeraprajak , Worawut Makkapavee , Surinporn Likhitsathian , Manit Srisurapanont","doi":"10.1016/j.genhosppsych.2024.12.003","DOIUrl":"10.1016/j.genhosppsych.2024.12.003","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the cumulative incidence of severe neutropenia and agranulocytosis (SNA) and mild and moderate neutropenia (MMN) in patients with Parkinson's disease psychosis (PDP) who receive clozapine treatment.</div></div><div><h3>Methods</h3><div>We searched multiple databases to identify clozapine studies in PDP patients. Incidence rates were assessed during short-term (within 1 month), medium-term (within 6 months), and long-term (> 6 months) monitoring periods. A proportional meta-analysis was performed using random-effects and generalized linear mixed models (GLMMs).</div></div><div><h3>Results</h3><div>We included 691 PDP patients from 19 studies. During the short-term monitoring period, none of the 573 participants in 16 studies developed SNA. The pooled incidence of SNA was 0.001 (95 % confidence interval [CI]: 0.000–0.253, 525 participants, 15 studies) during the medium-term period and 0.002 (95 % CI: 0.000–0.015, 475 participants, 12 studies) during the long-term period. The pooled incidence of MMN was 0.004 (95 % CI: 0.000–0.281, 164 participants, 7 studies) for short- and medium-term periods and 0.013 (95 % CI: 0.002–0.094, 193 participants, 7 studies) in the long-term period. Funnel plot asymmetry indicated potential bias in the medium-term dataset of SNA (<em>p</em> = 0.035).</div></div><div><h3>Conclusion</h3><div>Clozapine treatment in PDP patients may carry a very low risk of SNA and a low risk of MMN.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 4-11"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Home-Based Transcranial Direct Current Stimulation for Major Depressive Disorder: A Meta-Analysis of Randomized Controlled Trials","authors":"Omar Kassar , Moaz Elsayed Abouelmagd , Ahmed Elshahat , Sheikh Shoib","doi":"10.1016/j.genhosppsych.2024.12.015","DOIUrl":"10.1016/j.genhosppsych.2024.12.015","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 48-49"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of reversible visual impairments and their association with the psychiatric illness severity among inpatients with psychotic disorders","authors":"Mathieu Fradet , Fannie Nadeau , Alexandre Suey , Mazen Choulakian , Sylvain Grignon","doi":"10.1016/j.genhosppsych.2024.11.005","DOIUrl":"10.1016/j.genhosppsych.2024.11.005","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 135-136"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.genhosppsych.2024.11.014
Sharon Taub , Noa Menkes-Caspi , Tom Fruchtman-Steinbok , Shiri Kamhi-Nesher , Amir Krivoy
Background
Morbidity and mortality rates are notably higher among individuals with severe mental illnesses (SMI). People with SMI often have lower access to healthcare services, and the medical care they receive is known to be suboptimal. Consequently, treatment in an acute care setting rather than a community setting is more common. We aim to explore medical care in the emergency department (ED) for people with SMI compared to a control population.
Methods
In this matched cohort study, data on all adult Clalit Health Services (CHS) members who were referred to the general ED during the years 2018–2021 were extracted. Patients with SMI (ICD-10 codes for schizophrenia, schizoaffective disorder, and bipolar disorder) were matched with a control group of ED patients without SMI in a 1:3 ratio. The two groups were compared regarding ED admission reasons, management, and outcomes.
Results
The total sample (n = 92,848) included ED patients with SMI (n = 23,212) and without (n = 69,636). The most common ED admission reasons in both groups were pain, traumatic injury, and cardiac symptoms. Patients in the SMI group had higher rates of diagnosed diabetes mellitus and obstructive pulmonary disease.
ED assessment, measured by resource allocation, was less comprehensive for patients with SMI who presented with subjective complaints such as pain and weakness, while it was comparable between patients with and without SMI for other main presenting complaints. Workup for patients with SMI lasted longer and necessitated hospitalization at higher rates for most admission reasons. Mortality during the study period was almost twice as high among the SMI group (5 % vs. 2.3 %, p < 0.001).
Discussion
Our findings indicate higher rates of morbidity and treatment complexity among patients with SMI. As expected, the mortality rate was higher in this group. An alarming gap in resource allocation for ED assessment was observed when patients presented with subjective complaints. Enhanced awareness and integrated resources in primary care are required to improve the management and physical healthcare of patients with SMI.
背景：严重精神疾病（SMI）患者的发病率和死亡率明显较高。重度精神障碍患者通常很少获得医疗保健服务，而且他们得到的医疗保健是不理想的。因此，在急症护理机构而不是社区机构进行治疗更为常见。我们的目的是探索医疗护理在急诊科（ED）的人与重度精神障碍的对照人群。方法：在这项匹配的队列研究中，提取了2018-2021年间转介到普通急诊科的所有成年Clalit Health Services （CHS）成员的数据。重度精神障碍患者（精神分裂症、分裂情感性障碍和双相情感障碍的ICD-10编码）与对照组无重度精神障碍患者按1:3的比例配对。比较两组患者入院的原因、治疗和结果。结果：总样本（n = 92,848）包括伴有SMI的ED患者（n = 23,212）和不伴有SMI的ED患者（n = 69,636）。两组中最常见的急诊科入院原因是疼痛、创伤性损伤和心脏症状。重度精神分裂症组的患者诊断为糖尿病和阻塞性肺病的比例更高。ED评估，通过资源分配来衡量，对于表现为主观主诉（如疼痛和虚弱）的重度精神障碍患者来说，ED评估不太全面，而对于其他主要主诉，重度精神障碍患者和非重度精神障碍患者之间的ED评估具有可比性。重度精神障碍患者的随访时间更长，住院率更高。研究期间，重度精神障碍组的死亡率几乎是前者的两倍（5% vs. 2.3%）。讨论：我们的研究结果表明，重度精神障碍患者的发病率和治疗复杂性更高。不出所料，这一组的死亡率更高。当患者出现主观抱怨时，ED评估的资源分配存在惊人的差距。需要在初级保健方面提高认识并整合资源，以改善重度精神障碍患者的管理和身体保健。
{"title":"Patients with severe mental illness in the general emergency department: Clinical characteristics, quality of care and challenges","authors":"Sharon Taub , Noa Menkes-Caspi , Tom Fruchtman-Steinbok , Shiri Kamhi-Nesher , Amir Krivoy","doi":"10.1016/j.genhosppsych.2024.11.014","DOIUrl":"10.1016/j.genhosppsych.2024.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Morbidity and mortality rates are notably higher among individuals with severe mental illnesses (SMI). People with SMI often have lower access to healthcare services, and the medical care they receive is known to be suboptimal. Consequently, treatment in an acute care setting rather than a community setting is more common. We aim to explore medical care in the emergency department (ED) for people with SMI compared to a control population.</div></div><div><h3>Methods</h3><div>In this matched cohort study, data on all adult Clalit Health Services (CHS) members who were referred to the general ED during the years 2018–2021 were extracted. Patients with SMI (ICD-10 codes for schizophrenia, schizoaffective disorder, and bipolar disorder) were matched with a control group of ED patients without SMI in a 1:3 ratio. The two groups were compared regarding ED admission reasons, management, and outcomes.</div></div><div><h3>Results</h3><div>The total sample (<em>n</em> = 92,848) included ED patients with SMI (<em>n</em> = 23,212) and without (<em>n</em> = 69,636). The most common ED admission reasons in both groups were pain, traumatic injury, and cardiac symptoms. Patients in the SMI group had higher rates of diagnosed diabetes mellitus and obstructive pulmonary disease.</div><div>ED assessment, measured by resource allocation, was less comprehensive for patients with SMI who presented with subjective complaints such as pain and weakness, while it was comparable between patients with and without SMI for other main presenting complaints. Workup for patients with SMI lasted longer and necessitated hospitalization at higher rates for most admission reasons. Mortality during the study period was almost twice as high among the SMI group (5 % vs. 2.3 %, <em>p</em> < 0.001).</div></div><div><h3>Discussion</h3><div>Our findings indicate higher rates of morbidity and treatment complexity among patients with SMI. As expected, the mortality rate was higher in this group. An alarming gap in resource allocation for ED assessment was observed when patients presented with subjective complaints. Enhanced awareness and integrated resources in primary care are required to improve the management and physical healthcare of patients with SMI.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 100-105"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.genhosppsych.2024.11.001
Jingjing Hu, Shuangqin Chen
{"title":"Comment on: “Global prevalence of poor sleep quality in cancer patients: A systematic review and meta-analysis”","authors":"Jingjing Hu, Shuangqin Chen","doi":"10.1016/j.genhosppsych.2024.11.001","DOIUrl":"10.1016/j.genhosppsych.2024.11.001","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 131-132"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.genhosppsych.2024.10.004
Yiyuchen Zhu
{"title":"The impact of physiological marker variations during kidney transplantation on emotional and cognitive outcomes","authors":"Yiyuchen Zhu","doi":"10.1016/j.genhosppsych.2024.10.004","DOIUrl":"10.1016/j.genhosppsych.2024.10.004","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"Pages 115-116"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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