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Sex-specific associations between depressive symptoms and cardiovascular risk among middle-aged and older adults without standard modifiable risk factors: Evaluating the ‘SMuRF-less but depressed’ 无标准可改变危险因素的中老年人抑郁症状与心血管风险之间的性别特异性关联:评估“少smurf但抑郁”
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-12 DOI: 10.1016/j.genhosppsych.2026.01.005
Lu Zhai , Jue-Ling Wei , Rong-Rui Huo , Xue-Mei You

Background

The emergence of the ‘SMuRF-less’ (absence of Standard Modifiable Risk Factors) phenotype challenges traditional cardiovascular disease (CVD) prediction models. While depression is an established CVD risk factor, its pathogenic role in the absence of hypertension, diabetes, hypercholesterolemia, and smoking remains unclear, especially regarding potential sex differences.

Methods

This prospective analysis included 2484 middle-aged and older adults (≥45 years) free of baseline CVD and all SMuRFs (hypertension, diabetes, hypercholesterolemia, smoking) from the China Health and Retirement Longitudinal Study. Cox proportional hazard models were used to calculate the hazard ratio (HR) and 95% confidence interval (95% CI) for the association between depressive symptoms and CVD events after adjusting for potential confounders. Dose-response associations were examined using restricted cubic splines, and all analyses were stratified by sex.

Results

Over a median follow-up of 10.3 years, 523 CVD events occurred. Elevated depressive symptoms were associated with increased risks of CVD (adjusted HR = 1.47, 95% CI: 1.22–1.77), stroke (HR = 1.61, 95% CI: 1.13–2.28), and heart disease (HR = 1.42, 95% CI: 1.16–1.74) in the overall population. However, stratified analysis revealed this association was entirely driven by women, with significant risks for CVD (HR = 1.50, 95% CI: 1.22–1.86) and stroke (HR = 2.08, 95% CI: 1.35–3.21). No significant association was observed in men. A linear negative association was evident in women but not in men.

Conclusions

In this SMuRF-less cohort, depressive symptoms independently predicted incident CVD, with the association being particularly strong in women. Our findings identify a “SMuRF-less but depressed” women phenotype that warrants targeted attention in primary prevention.
“SMuRF-less”(缺乏标准可修改风险因素)表型的出现挑战了传统的心血管疾病(CVD)预测模型。虽然抑郁症是一种确定的心血管疾病危险因素,但在没有高血压、糖尿病、高胆固醇血症和吸烟的情况下,其致病作用尚不清楚,特别是在潜在的性别差异方面。方法前瞻性分析纳入2484名来自中国健康与退休纵向研究的无基线CVD和所有smurf(高血压、糖尿病、高胆固醇血症、吸烟)的中老年人(≥45岁)。在调整潜在混杂因素后,使用Cox比例风险模型计算抑郁症状与CVD事件之间关联的风险比(HR)和95%置信区间(95% CI)。使用受限三次样条检验剂量-反应关联,所有分析均按性别分层。结果在10.3年的中位随访中,发生了523例CVD事件。在总体人群中,抑郁症状升高与心血管疾病(调整后HR = 1.47, 95% CI: 1.22-1.77)、中风(HR = 1.61, 95% CI: 1.13-2.28)和心脏病(HR = 1.42, 95% CI: 1.16-1.74)的风险增加相关。然而,分层分析显示,这种关联完全由女性驱动,女性患心血管疾病(HR = 1.50, 95% CI: 1.22-1.86)和中风(HR = 2.08, 95% CI: 1.35-3.21)的风险显著。在男性中没有观察到明显的关联。线性负相关在女性中很明显,但在男性中不明显。结论:在这个smurf较少的队列中,抑郁症状独立预测CVD的发生,在女性中相关性尤其强。我们的研究结果确定了一种“smurf较少但抑郁”的女性表型,值得在初级预防中给予有针对性的关注。
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引用次数: 0
General Hospital Psychiatry: Serving the cause of reuniting the brain, mind and body 综合医院精神病学:服务于脑、心、身的统一事业
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-07 DOI: 10.1016/j.genhosppsych.2026.01.004
Dimitry S. Davydow
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引用次数: 0
Evaluating impact of population health outreach and an interdepartmental approach to perinatal depression 评估人口健康外展和跨部门方法对围产期抑郁症的影响
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-06 DOI: 10.1016/j.genhosppsych.2026.01.003
Lara S. Lemon , Jennifer Chaney , Melissa Young , William Garrard , Beth Quinn , Kelly O'Toole , Priya Gopalan , Hyagriv N. Simhan

Objective

Evaluate the impact of connecting obstetrics with psychiatry in addressing prenatal depression. We compared patient engagement with behavioral health, prescriptions and follow-up over time after implementation of a population health central team outreach to depressed pregnant persons in 2019. Behavioral health joined the EHR facilitating collaboration in 2020.

Methods

In a cohort of deliveries across 8 hospitals from 1/1/2021–12/31/2024, we studied patients who screened positive for depression prenatally.

Outcomes

1. Documentation of behavioral health visit while pregnant or within 1 year postpartum, 2. Antidepressant prescription while pregnant or within 1 year postpartum, and 3. Compliance with Pennsylvania's Medicaid obstetric reimbursement bundle quality metric for depression follow-up within 30 days of positive screen. Secondary analyses explored collaboration by limiting to targeted behavioral health departments and explored impact of telemedicine.

Results

Of 54,483 deliveries, 48,238 (89 %) were administered the PHQ-2/9, 5139 screened positive and 3732 had 1-year postpartum follow-up. As collaboration efforts increased and the population health team expanded, we observed a linear increase in engagement with behavioral health and adherence with depression follow-up. Depressed pregnant persons delivering in 2023 were 50 % more likely to have a behavioral health visit (adjOR 1.54; 95 % CI: 1.25, 1.91) and 40 % more likely to have follow-up (adjOR 1.41, 95 % CI: 1.21, 1.65) compared with persons delivering in 2021. These trends were stronger when limiting to collaborative behavioral health departments.

Conclusion

A cross-disciplinary care model facilitated by centralized population health team is an impactful approach to connect depressed pregnant persons with appropriate care.
2890/4000; /4 tables or figures.

Precis

A cross-discipline approach facilitated by a population health team increased behavioral health engagement for patients with perinatal depression.
目的评价产科与精神病学结合治疗产前抑郁的效果。在2019年对抑郁孕妇实施人口健康中心团队外展后,我们比较了患者参与行为健康、处方和随访的时间。行为卫生部门于2020年加入电子病历,促进了合作。方法对8家医院在2021年1月1日至2024年12月31日期间分娩的患者进行队列研究,研究产前抑郁筛查阳性的患者。1 .怀孕期间或产后1年内的行为健康检查记录;怀孕期间或产后1年内服用抗抑郁药;依从宾夕法尼亚州的医疗补助产科报销束质量指标抑郁症随访30天内阳性筛选。二级分析通过限制目标行为卫生部门探索合作,并探索远程医疗的影响。结果在54,483例分娩中,48,238例(89%)接受了phq -2/ 9,5139例筛查阳性,3732例进行了1年的产后随访。随着合作努力的增加和人口健康团队的扩大,我们观察到行为健康的参与和抑郁症随访的依从性呈线性增加。与2021年分娩的孕妇相比,2023年分娩的抑郁孕妇接受行为健康检查的可能性高出50% (adjOR 1.54; 95% CI: 1.25, 1.91),接受随访的可能性高出40% (adjOR 1.41, 95% CI: 1.21, 1.65)。当仅限于合作行为健康部门时,这些趋势更为明显。结论集中人口卫生队推动的跨学科护理模式是连接抑郁孕妇与适当护理的有效途径。/4个表格或数字。由人口健康小组促进的PrecisA跨学科方法增加了围产期抑郁症患者的行为健康参与。
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引用次数: 0
Challenges of enrolling participants with alcohol and opioid use disorders in the emergency department for clinical trials of ketamine: The experience from two randomized controlled trials 在急诊科招募酒精和阿片类药物使用障碍患者进行氯胺酮临床试验的挑战:来自两项随机对照试验的经验
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-01 DOI: 10.1016/j.genhosppsych.2025.12.019
P.R. Chai , E. Lee , M.A. Hasdianda , M. Bianchi , D. Campbell , C. Goldfine , J. Suzuki

Purpose of research

Application of psychedelics including ketamine may be important adjuncts in the treatment of alcohol and opioid use disorders. Most patients with alcohol or opioid use disorder (AUD/OUD) may present to the emergency department (ED) seeking care both for substance use and associated complaints. Understanding safety and preliminary efficacy of ketamine and other psychedelics to improve the care and potentially facilitate linkage to long term care for AUD/OUD in the ED is of high importance. Here, we describe our experience conducting rigorous double blind placebo controlled trials to evaluate safety of ketamine in the ED for AUD/OUD and the challenges in conducting this research among this important population.

Principal results

We conducted two studies to evaluate the safety of a single dose ketamine infusion for individuals seeking detox with AUD and those seeking psychiatric care who had OUD. Studies were conducted at an urban community and academic ED with variable pharmacy capabilities. Over the study period study 1 (AUD) screened N = 180 individuals for the study of which N = 3 were preliminarily eligible. None were able to pass full eligibility criteria resulting in no enrollments. Study 2 (OUD) screened N = 234 ED visits were screen of which N = 8 were eligible and N = 4 consented. All four participants were successfully randomized and treated with ketamine or placebo. We were unable to conduct follow up in any of the participants.

Major conclusions

Enrollment of ED patients with AUD/OUD for ketamine trials in the ED is difficult and fraught with multiple challenges. Even with enrollment in the ED, follow up can be a significant challenge. This reinforces the need to consider innovative strategies to conduct ketamine and other psychedelic related trials among ED patients with AUD/OUD.
研究目的:氯胺酮等致幻剂的应用可能是治疗酒精和阿片类药物使用障碍的重要辅助手段。大多数酒精或阿片类药物使用障碍(AUD/OUD)患者可能会到急诊科(ED)寻求药物使用和相关投诉的护理。了解氯胺酮和其他迷幻药的安全性和初步疗效,以改善ED中AUD/OUD的护理,并可能促进与长期护理的联系,是非常重要的。在这里,我们描述了我们进行严格的双盲安慰剂对照试验的经验,以评估氯胺酮在AUD/OUD急症治疗中的安全性,以及在这一重要人群中进行这项研究的挑战。主要结果:我们进行了两项研究,以评估单剂量氯胺酮输注对患有AUD的患者寻求排毒和患有OUD的患者寻求精神治疗的安全性。研究在城市社区和具有不同药房能力的学术ED进行。在研究期间,研究1 (AUD)筛选了N = 180人,其中N = 3人初步符合研究条件。没有一个能够通过全部资格标准,导致没有登记。研究2 (OUD)筛选了N = 234个ED就诊,其中N = 8个符合条件,N = 4个同意。所有四名参与者都成功地随机化并接受氯胺酮或安慰剂治疗。我们无法对任何参与者进行随访。主要结论:在ED中纳入AUD/OUD患者进行氯胺酮试验是困难的,并且充满了多重挑战。即使在急诊科注册,跟进也可能是一个重大挑战。这加强了考虑创新策略在AUD/OUD ED患者中进行氯胺酮和其他致幻剂相关试验的必要性。
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引用次数: 0
Internet-based problem solving therapy improves depressive and dialysis related physical symptoms in hemodialysis patients under 65 years of age: A post-hoc secondary subgroup analysis of a cluster randomized controlled trial 基于互联网的问题解决疗法改善65岁以下血液透析患者的抑郁和透析相关身体症状:一项聚类随机对照试验的事后次级亚组分析
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-01 DOI: 10.1016/j.genhosppsych.2025.12.022
Debbie Zittema , Robbert W. Schouten , Els Nadort , Rosa E. Boeschoten , Yves Smets , Prataap Chandie Shaw , Louis Jean Vleming , Marijke J.E. Dekker , Michiel Westerman , Ellen K. Hoogeveen , Willem J.W. Bos , Marcel Schouten , Karima Farhat , Patricia van Oppen , Friedo W. Dekker , Carl E.H. Siegert , Birit F.P. Broekman

Background and hypothesis

Patients on hemodialysis therapy often experience a high burden of mental and physical health symptoms. We developed a guided internet-based self-help problem-solving therapy (IPST) targeted on practical daily life issues. While we did not find an effect for all patients, we hypothesized that an internet intervention might be effective in younger patients below 65 years of age. In this post-hoc secondary subgroup analysis we divided our study population based on age to study the effect of our intervention on depressive- and dialysis-related symptoms.

Methods

Chronic hemodialysis patients with a depression score on the Beck Depression Inventory (BDI-II) of ≥10, were randomized into a five modules guided IPST or a care-as-usual control group. The study population was stratified by age (< 65 and ≥ 65 years). The primary outcome was depressive symptoms (BDI-II). Secondary outcomes were anxiety (BAI), health-related quality of life (HRQoL) and dialysis related symptoms (DSI). Analyses were performed using linear mixed models.

Results

122 out of 190 randomized patients completed post-intervention measurements. In 25 younger patients (age < 65), a significant effect was found in reduction of BDI-II (−30 %, p = 0.04) and DSI (presence of symptoms: −27 %, p = 0.001; level of distress: −25 %, p = 0.03). No effect was seen on BAI or HRQoL. In the older population (n = 29), no effect of the intervention was found on any outcomes.

Conclusion

An easy to implement guided IPST showed a clinically relevant decrease in depressive symptoms and dialysis related physical symptoms in hemodialysis patients aged below 65 years although results should be interpreted cautiously given the post-hoc design.

Trial registration

Dutch Trial Register: Trial NL6648 (NTR6834) (prospectively registered 13th November 2017).
背景与假设:接受血液透析治疗的患者往往会经历精神和身体健康症状的沉重负担。我们开发了一种基于互联网的自助解决问题疗法(IPST),针对日常生活中的实际问题。虽然我们没有发现对所有患者都有效,但我们假设网络干预可能对65岁以下的年轻患者有效。在这个事后次要亚组分析中,我们根据年龄对研究人群进行了划分,以研究我们的干预对抑郁和透析相关症状的影响。方法将贝克抑郁量表(BDI-II)抑郁评分≥10分的慢性血液透析患者随机分为5个模块引导的IPST组和照旧对照组。研究人群按年龄(65岁和≥65岁)分层。主要结局是抑郁症状(BDI-II)。次要结局是焦虑(BAI)、健康相关生活质量(HRQoL)和透析相关症状(DSI)。采用线性混合模型进行分析。结果190名随机患者中有122名完成了干预后的测量。在25名年轻患者(65岁)中,发现BDI-II (- 30%, p = 0.04)和DSI(出现症状:- 27%,p = 0.001;痛苦程度:- 25%,p = 0.03)的降低有显著效果。对BAI和HRQoL均无影响。在年龄较大的人群中(n = 29),没有发现干预对任何结果的影响。结论易于实施的引导IPST在65岁以下血液透析患者的抑郁症状和透析相关的身体症状中具有临床相关的减少作用,但考虑到术后设计,结果应谨慎解释。试验注册荷兰试验注册:试验NL6648 (NTR6834)(预期于2017年11月13日注册)。
{"title":"Internet-based problem solving therapy improves depressive and dialysis related physical symptoms in hemodialysis patients under 65 years of age: A post-hoc secondary subgroup analysis of a cluster randomized controlled trial","authors":"Debbie Zittema ,&nbsp;Robbert W. Schouten ,&nbsp;Els Nadort ,&nbsp;Rosa E. Boeschoten ,&nbsp;Yves Smets ,&nbsp;Prataap Chandie Shaw ,&nbsp;Louis Jean Vleming ,&nbsp;Marijke J.E. Dekker ,&nbsp;Michiel Westerman ,&nbsp;Ellen K. Hoogeveen ,&nbsp;Willem J.W. Bos ,&nbsp;Marcel Schouten ,&nbsp;Karima Farhat ,&nbsp;Patricia van Oppen ,&nbsp;Friedo W. Dekker ,&nbsp;Carl E.H. Siegert ,&nbsp;Birit F.P. Broekman","doi":"10.1016/j.genhosppsych.2025.12.022","DOIUrl":"10.1016/j.genhosppsych.2025.12.022","url":null,"abstract":"<div><h3>Background and hypothesis</h3><div>Patients on hemodialysis therapy often experience a high burden of mental and physical health symptoms. We developed a guided internet-based self-help problem-solving therapy (IPST) targeted on practical daily life issues. While we did not find an effect for all patients, we hypothesized that an internet intervention might be effective in younger patients below 65 years of age. In this post-hoc secondary subgroup analysis we divided our study population based on age to study the effect of our intervention on depressive- and dialysis-related symptoms.</div></div><div><h3>Methods</h3><div>Chronic hemodialysis patients with a depression score on the Beck Depression Inventory (BDI-II) of ≥10, were randomized into a five modules guided IPST or a care-as-usual control group. The study population was stratified by age (&lt; 65 and ≥ 65 years). The primary outcome was depressive symptoms (BDI-II). Secondary outcomes were anxiety (BAI), health-related quality of life (HRQoL) and dialysis related symptoms (DSI). Analyses were performed using linear mixed models.</div></div><div><h3>Results</h3><div>122 out of 190 randomized patients completed post-intervention measurements. In 25 younger patients (age &lt; 65), a significant effect was found in reduction of BDI-II (−30 %, <em>p</em> = 0.04) and DSI (presence of symptoms: −27 %, <em>p</em> = 0.001; level of distress: −25 %, <em>p</em> = 0.03). No effect was seen on BAI or HRQoL. In the older population (<em>n</em> = 29), no effect of the intervention was found on any outcomes.</div></div><div><h3>Conclusion</h3><div>An easy to implement guided IPST showed a clinically relevant decrease in depressive symptoms and dialysis related physical symptoms in hemodialysis patients aged below 65 years although results should be interpreted cautiously given the post-hoc design.</div></div><div><h3>Trial registration</h3><div>Dutch Trial Register: Trial NL6648 (NTR6834) (prospectively registered 13th November 2017).</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"98 ","pages":"Pages 165-171"},"PeriodicalIF":3.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145880469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing DSM-5 criteria of somatic symptom disorder in medically hospitalized inpatients: A cross-sectional analysis 评估医学住院患者躯体症状障碍的DSM-5标准:一项横断面分析
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-01 DOI: 10.1016/j.genhosppsych.2025.12.023
Sebastian Dietsche , Franziska Weeren , Gunther Meinlschmidt , Anne Toussaint , Iris Baenteli , Sanaa Bahmane , Alex Frick , Christina Karpf , Anja Studer , Kaspar Wyss , Matthias Schwenkglenks , Günther Fink , Sibil Tschudin , Sarah Trost , Marco Bachmann , Andreas Dörner , David Buechel , Lukas Ebner , Rainer Schaefert , the SomPsyNet Consortium

Introduction

In the revised DSM-5, Somatic Symptom Disorder (SSD) no longer requires medically unexplained symptoms and instead focuses on psychobehavioral positive criteria, applicable regardless of the underlying cause. Evidence on the frequency and characteristics of SSD among medically hospitalized inpatients remains scarce. We therefore investigated SSD frequency and age- and gender-associated characteristics in this population.

Methods

This cross-sectional analysis used baseline data from SomPsyNet, an intervention targeting SOMatic hospital inpatients to prevent PSYchosocial distress through a care NETwork. SSD was assessed using the Somatic Symptom Scale-8 (SSS-8) and the Somatic Symptom Disorder-B Criteria Scale (SSD-12), applying DSM-5-aligned and established cut-offs. Criteria were operationalized as A) somatic symptom burden (SSS-8 sum score ≥ 9 or per item≥3), B) symptom-related distress (SSD-12 ≥ 23), and C) proxies for symptom persistence. Associations with age were examined using robust regression.

Results

Among 3109 inpatients enrolled between June 2020 and December 2022, 20.6 % (SSS-8 sum score ≥ 9) to 21.9 % (SSS-8 per item≥3) met all three SSD criteria. Among the 25.5 % of patients positive for Criterion B (SSD-12 ≥ 23), Criteria A and C were frequently also met. No female predominance in symptom-related distress was observed. Younger patients reported higher somatic symptom burden and symptom-related distress (SSS-8: B = -0.04, t = −7.51; SSD-12: B = -0.05, t = −5.11).

Conclusion

Symptoms consistent with DSM-5 SSD criteria were common among medically hospitalized inpatients. These findings underscore the frequency of SSD-related distress in this setting, highlight age- and gender-related differences in symptom presentation, and emphasize the need for further research to clarify its clinical implications.
在修订后的DSM-5中,躯体症状障碍(SSD)不再需要医学上无法解释的症状,而是关注心理行为阳性标准,无论潜在原因如何都适用。关于住院患者发生SSD的频率和特征的证据仍然很少。因此,我们调查了该人群的SSD频率和年龄、性别相关特征。方法横断面分析使用来自SomPsyNet的基线数据,这是一项针对躯体医院住院患者的干预措施,通过护理网络预防心理社会困扰。采用躯体症状量表-8 (ssss -8)和躯体症状障碍- b标准量表(sssd -12)对SSD进行评估,采用与dsm -5一致的既定截止值。标准分为:A)躯体症状负担(ssss -8总评分≥9或每项评分≥3),B)症状相关困扰(ssss -12≥23),C)症状持续性代理。使用稳健回归检验与年龄的关系。结果在2020年6月至2022年12月期间纳入的3109例住院患者中,20.6% (SSS-8总评分≥9)至21.9% (SSS-8单项评分≥3)符合所有SSD标准。在标准B (SSD-12≥23)阳性的25.5%的患者中,标准A和C也经常满足。没有观察到女性在症状相关的窘迫中占优势。年轻患者报告更高的躯体症状负担和症状相关窘迫(ssss -8: B = -0.04, t = - 7.51; ssss -12: B = -0.05, t = - 5.11)。结论符合DSM-5 SSD标准的症状在内科住院患者中较为常见。这些发现强调了在这种情况下与ssd相关的痛苦的频率,强调了症状表现的年龄和性别相关差异,并强调需要进一步研究以阐明其临床意义。
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引用次数: 0
Patient-reported outcomes and acceptability of suggestion and hypnosis-based therapy for functional neurological disorder within an NHS service 患者报告的结果和可接受性的建议和催眠为基础的治疗功能神经障碍在NHS服务
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-31 DOI: 10.1016/j.genhosppsych.2025.12.024
Anjana Lukose , Abhijit Das
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引用次数: 0
Assessing capacity at an academic medical center: Epidemiology, predictors of outcomes, and the role of surrogate decision makers 评估学术医疗中心的能力:流行病学、结果预测因素和替代决策者的作用
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-31 DOI: 10.1016/j.genhosppsych.2025.12.025
Alyssa M. Nelson , Sushmitha Divakar , Daniel J. Daunis , Jonathan D. Smith , Timothy Adegoke , Devin Greene , Jo Ellen Wilson
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引用次数: 0
Associations of cognitive function and depression with future cancer risk in middle-aged and older adults: Findings from a National China Survey 中老年人认知功能和抑郁与未来癌症风险的关系:来自中国全国调查的结果
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-30 DOI: 10.1016/j.genhosppsych.2025.12.020
Zi-Mu Chen , He-Li Sun , Yue-Ying Wang , Yuan Feng , Qinge Zhang , Zhaohui Su , Teris Cheung , Gabor S. Ungvari , Hua-Qing Xing , Qian-Hua Huang , Todd Jackson , Gang Wang , Yu-Tao Xiang

Background

While links between depression and cancer risk are well documented, specific depressive symptoms involved remain unclear, as does the presence of associations between cognitive function and cancer risk. To address these gaps, we assessed associations of cognitive function levels and depressive symptoms with cancer occurrence among middle-aged and older Chinese adults.

Methods

This prospective cohort study utilized 2011 to 2020 data from the CHARLS, a population-based nationwide survey from China. Adults aged 45 years or older with cognitive function and depressive symptom data and no baseline cancer diagnosis were included for analysis. Global cognitive function scores were calculated for executive function and episodic memory performance using an adapted version of the Telephone Interview for Cognitive Status. Depressive symptoms were assessed using the CESD-10. Risk of events was reported based on adjusted HRs and 95 % CIs for cancer incidence, using a Cox proportional hazards regression model.

Results

Of 16,518 cancer-free adults (mean [SD] age: 56.5 [8.9] years) assessed at baseline, 244 new cancer cases were diagnosed (mean [SD] age: 57.6 [8.9] years) during a median follow-up period of 9 years (IQR, 7–9 years). A lower level of executive function (adjusted HR [95 %CI], 0.69 [0.52–0.92]) and higher somatic retardation levels (adjusted HR [95 %CI], 1.34 [1.00–1.79]) were associated with higher subsequent risk of cancer incidence, after controlling for the impact of demographic characteristics, health-related lifestyle factors and medical conditions.

Conclusion

In this longitudinal cohort study, lower initial levels of executive function and higher somatic retardation depressive symptom levels predicted higher subsequent cancer incidence.
背景:虽然抑郁症和癌症风险之间的联系有充分的文献记载,但具体的抑郁症状仍不清楚,认知功能和癌症风险之间的联系也不清楚。为了解决这些差距,我们评估了中国中老年成年人认知功能水平和抑郁症状与癌症发生的关系。方法:这项前瞻性队列研究利用了2011年至2020年CHARLS的数据,CHARLS是一项基于中国人口的全国性调查。年龄在45岁或以上、有认知功能和抑郁症状资料且无基线癌症诊断的成年人纳入分析。使用认知状态电话访谈的改编版本计算执行功能和情景记忆表现的整体认知功能评分。使用cced -10评估抑郁症状。使用Cox比例风险回归模型,根据调整后的hr和95% ci的癌症发病率报告事件风险。结果:在基线评估的16,518名无癌成人(平均[SD]年龄:56.5[8.9]岁)中,在中位随访9年(IQR, 7-9年)期间,诊断出244例新发癌症病例(平均[SD]年龄:57.6[8.9]岁)。在控制了人口统计学特征、健康相关生活方式因素和医疗条件的影响后,较低的执行功能水平(调整后的HR [95% CI], 0.69[0.52-0.92])和较高的躯体发育迟缓水平(调整后的HR [95% CI], 1.34[1.00-1.79])与较高的后续癌症发病率相关。结论:在这项纵向队列研究中,较低的初始执行功能水平和较高的躯体发育迟缓抑郁症状水平预示着较高的后续癌症发病率。
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引用次数: 0
Psychological support can be distinguished from psychotherapy: Clarifications for future empirical work 心理支持可以区别于心理治疗:对未来实证工作的澄清
IF 3.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-29 DOI: 10.1016/j.genhosppsych.2025.12.021
Jonathan R. Schettino , Katherine Cheung , Sandeep M. Nayak , Brandon M. Weiss , David B. Yaden
Classic psychedelic studies involve interpersonal interactions with participants before, during, and after the acute effects of psychedelics. In the field of psychedelic research, there is currently a debate about whether this interpersonal interaction is most accurately considered “psychological support,” “psychotherapy,” or something else. Proponents of the psychological support label describe the interpersonal interaction in most classic psychedelic studies as aimed at safety, while proponents of the psychotherapy label argue that the interpersonal interaction involves intervening on psychotherapeutic processes that not only support safety, but also contribute to treatment efficacy. However, we believe that the debate has so far been largely unproductive due to a lack of shared definitions or criteria for the relevant interpersonal interactions. Here, we propose definitions and criteria for two viable forms of interpersonal interaction in psychedelic administration: one directed solely towards safety (psychological support) and one directed towards both safety and efficacy (psychotherapy). We then trial our proposed criteria on a sample of 11 published classic psychedelic clinical trials. Our procedure categorized 10 out of 11 studies as being more or less consistent with psychological support or psychotherapy, but achieved clear distinctions in only 4 out of 11 studies. Given these findings, we argue that higher quality data on the interpersonal interaction is needed to clearly distinguish between psychological support and psychotherapy. We conclude by suggesting ways that our criteria can be used in the future to empirically test the relative safety and efficacy of psychological support vs. psychotherapy in psychedelic medicine.
经典的迷幻药研究包括在迷幻药产生急性效应之前、期间和之后与参与者的人际互动。在迷幻药研究领域,目前存在一种争论,即这种人际互动是否更准确地被认为是“心理支持”、“心理治疗”或其他什么。心理支持标签的支持者将大多数经典迷幻研究中的人际互动描述为旨在安全,而心理治疗标签的支持者则认为,人际互动涉及对心理治疗过程的干预,这不仅支持安全,而且有助于治疗效果。然而,我们认为,由于缺乏有关人际交往的共同定义或标准,迄今为止的辩论在很大程度上是无效的。在这里,我们提出了迷幻药管理中两种可行的人际互动形式的定义和标准:一种只针对安全性(心理支持),另一种针对安全性和有效性(心理治疗)。然后,我们在11个已发表的经典迷幻药临床试验样本上试用我们提出的标准。我们的程序将11项研究中的10项分类为或多或少与心理支持或心理治疗一致,但在11项研究中只有4项获得了明确的区别。鉴于这些发现,我们认为需要更高质量的人际互动数据来明确区分心理支持和心理治疗。最后,我们提出了一些方法,我们的标准可以在未来用于对迷幻药物中心理支持与心理治疗的相对安全性和有效性进行实证测试。
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General hospital psychiatry
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