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Evaluating robotic assistance on the learning curve and efficiency of mandibular angle ostectomy: an animal model study. 评估机器人辅助下颌角切除术的学习曲线和效率:一项动物模型研究。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1453135
Wenqing Han, Yingjie Yan, Mengzhe Sun, Ziwei Zhang, Li Lin, Yan Zhang, Gang Chai

Introduction: This study evaluated the efficacy and learning curve of a maxillofacial surgical robotic system (MSRS) guided by electromagnetic navigation for mandibular angle ostectomy (MAO), compared to traditional surgical methods.

Methods: The study utilized a controlled experiment involving thirty rabbits, paired divided into experimental and control groups. The experimental group underwent MAO using the MSRS, while the control group was treated with conventional surgical techniques. The surgeons performing the procedures were inexperienced in robotic surgery and MAO to assess the learning curve and the impact of robotic assistance. Key parameters measured included the accuracy of ostectomy, setup time, and ostectomy efficiency, with data analyzed through a paired-t test to compare the performance between the two groups.

Results: The study indicated a significant reduction in ostectomy time for the experimental group, with improved accuracy and efficiency in ostectomy. The study found that robotic assistance could decrease the risk of complications and enhance surgical outcomes. It also highlighted the presence of an initial learning curve when adopting new robotic technologies, which could be mitigated through adequate training and simulation practices.

Discussion: Using MSRS for MAO could lead to faster early learning curves and increased ostectomy efficiency compared to traditional surgical methods. It demonstrated the potential benefits of integrating robotic systems into craniofacial surgery, suggesting a promising direction for future surgical practices.

导言:本研究评估了电磁导航引导下颌角切除术(MAO)的颌面外科机器人系统(MSRS)与传统手术方法相比的疗效和学习曲线:研究采用对照实验,将 30 只兔子配对分为实验组和对照组。实验组使用 MSRS 进行 MAO 手术,而对照组则使用传统手术技术。执行手术的外科医生没有机器人手术和 MAO 的经验,以评估学习曲线和机器人辅助的影响。测量的主要参数包括输卵管切除术的准确性、设置时间和输卵管切除术的效率,通过配对t检验分析数据,比较两组的表现:结果:研究表明,实验组的切除术时间明显缩短,切除术的准确性和效率也有所提高。研究发现,机器人辅助可降低并发症风险,提高手术效果。研究还强调,在采用新的机器人技术时,初期学习曲线是存在的,但可以通过适当的培训和模拟练习来缓解这一问题:讨论:与传统手术方法相比,使用MSRS进行MAO手术可加快早期学习曲线,并提高切除术的效率。它证明了将机器人系统整合到颅颌面手术中的潜在好处,为未来的手术实践指明了方向。
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引用次数: 0
Extreme hypernatremia after a laparoscopic hysterectomy and bilateral salpingo-oophorectomy: a case report and literature review. 腹腔镜子宫切除术和双侧输卵管切除术后极度高钠血症:病例报告和文献综述。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1462525
Fei Ding, Xin Nie, Yuemei Chen, Minjin Wang, Yong He

Congenital nephrogenic diabetes insipidus (NDI) primarily arises from an X-linked recessive inheritance caused by mutations in the AVPR2 gene, which is responsible for approximately 90% of cases. This condition has an incidence rate of 4-8 per million male live births, with females being much less frequently affected. Symptoms typically manifest shortly after birth, predominantly in males. The key clinical features of NDI include excessive urination (polyuria), compensatory excessive thirst (polydipsia), cognitive impairment, consistently low urine specific gravity, dehydration, and imbalances in electrolyte levels. This case study highlights an unusual occurrence of NDI in a 50-year-old Chinese woman attributed to a mutation in the AVPR2 gene. For more than a year, she had been suffering from excessive urination and severe thirst. The patient, who had undergone surgery for cervical cancer, developed polyuria and hypernatremia postoperatively. Initial laboratory analyses revealed normal blood sodium and chloride levels but reduced urine osmolality and specific gravity. Imaging assessments revealed no irregularities. To validate the diagnosis of NDI, she participated in a water deprivation and vasopressin test. Subsequent genetic tests revealed a thymine (T) to adenine (A) mutation, leading to a missense mutation in the AVPR2 gene. As part of her treatment, she was placed on a low-sodium diet and prescribed oral hydrochlorothiazide and indomethacin for 1 month, resulting in a marked improvement in her symptoms. To the best of our knowledge, this is the first documented case of NDI diagnosed postoperatively in an older female patient with AVPR2 heterozygosity. This case highlights an unusual instance of an X-linked recessive clinical presentation of NDI in an elderly female patient. This study also underscores the importance of conducting water deprivation, vasopressin tests, and genetic testing in establishing the underlying cause for individuals diagnosed with NDI.

先天性肾源性糖尿病(NDI)主要是由 AVPR2 基因突变导致的 X 连锁隐性遗传引起的,约 90% 的病例都是由 AVPR2 基因突变引起的。这种疾病的发病率为每百万活产男性中有 4-8 例,而女性的发病率要低得多。症状通常在出生后不久出现,主要发生在男性身上。NDI 的主要临床特征包括多尿、代偿性多渴、认知障碍、尿比重持续偏低、脱水和电解质水平失衡。本病例研究强调了一名 50 岁中国妇女因 AVPR2 基因突变而导致的 NDI 异常发生。一年多来,她一直受到多尿和严重口渴的困扰。患者曾接受宫颈癌手术,术后出现多尿和高钠血症。初步实验室分析显示血钠和血氯水平正常,但尿渗透压和尿比重降低。影像学评估未发现异常。为了验证 NDI 诊断,她参加了缺水和血管加压素试验。随后的基因检测发现胸腺嘧啶(T)变为腺嘌呤(A),导致 AVPR2 基因发生错义突变。作为治疗的一部分,她接受了低钠饮食,并口服氢氯噻嗪和吲哚美辛 1 个月,症状得到明显改善。据我们所知,这是第一例有记录的术后诊断为 NDI 的 AVPR2 杂合子老年女性患者。本病例凸显了 X 连锁隐性临床表现的 NDI 在老年女性患者中的不寻常病例。这项研究还强调了进行水剥夺、血管加压素测试和基因测试以确定被诊断为 NDI 患者的潜在病因的重要性。
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引用次数: 0
Bleeding complications related to external ventricular drainage placement in patients with ruptured intracranial aneurysms: a single-center study. 颅内动脉瘤破裂患者脑室外引流置管引起的出血并发症:一项单中心研究。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1403668
Yue Tang, Xiangping Zhong, Tingting Lin, Fujun Zuo, Min Fu, Li Wang, Xiaodu Yu, Dong Liu, Jincan Zhang

Objective: Acute aneurysmal rupture can be treated with endovascular therapy or surgical clipping. For patients with concurrent acute hydrocephalus, the placement of an external ventricular drainage (EVD) is required. This study aims to investigate the impact of pre-treatment EVD placement on rebleeding in ruptured aneurysms and to examine the influence of dual antiplatelet therapy and the sequencing of dual antiplatelet therapy with EVD placement on EVD-related hematomas.

Methods: We reviewed the clinical data of 83 patients with ruptured aneurysms who underwent EVD placement from a total of 606 aneurysm patients consecutively admitted between January 2018 and January 2023. The analysis focused on the impact of pre-treatment EVD placement on aneurysmal rebleeding and the effect of dual antiplatelet therapy and its sequencing with EVD placement on EVD-related hematomas.

Results: Among the 503 patients with ruptured aneurysms, 83 required EVD placement. EVD was placed before aneurysm treatment in 63 patients and after treatment in 20 patients. The number of aneurysmal rebleeding cases in the pre-treatment EVD group and non-EVD group was 1 (1.6%) and 20 (4.8%), respectively (p = 0.406). 31 patients (37.3%) underwent stent-assisted embolization or flow diversion requiring dual antiplatelet therapy, while 52 patients (62.7%) underwent simple embolization or surgical clipping without antiplatelet therapy. EVD-related hematomas occurred in 14 patients (16.9%), with 10 cases (32.3%) in those receiving dual antiplatelet therapy and 4 cases (7.7%) in those not receiving antiplatelet therapy (p = 0.01). Among 16 patients who had EVD placed before dual antiplatelet therapy, 4 (25%) developed EVD-related hematomas. Of the 15 patients who had EVD placed after dual antiplatelet therapy, 6 (40%) developed EVD-related hematomas (p = 0.458).

Conclusion: In patients with aneurysmal subarachnoid hemorrhage (aSAH) and acute hydrocephalus, the placement of EVD before aneurysm treatment does not increase the risk of rebleeding. However, dual antiplatelet therapy increases the risk of EVD-related hematoma, and the sequence of EVD placement relative to dual antiplatelet therapy does not appear to significantly affect the outcome of EVD-related hematoma.

目的:急性动脉瘤破裂可通过血管内治疗或手术剪切治疗。对于并发急性脑积水的患者,需要放置脑室外引流管(EVD)。本研究旨在探讨治疗前放置 EVD 对动脉瘤破裂再出血的影响,并研究双联抗血小板疗法和双联抗血小板疗法与 EVD 放置的先后顺序对 EVD 相关血肿的影响:我们回顾了2018年1月至2023年1月期间连续收治的总共606名动脉瘤患者中83名接受EVD置管的动脉瘤破裂患者的临床数据。分析的重点是治疗前 EVD 置入对动脉瘤再出血的影响,以及双联抗血小板疗法及其与 EVD 置入的排序对 EVD 相关血肿的影响:在503例动脉瘤破裂患者中,83例需要放置EVD。63名患者在动脉瘤治疗前置入EVD,20名患者在治疗后置入。治疗前 EVD 组和非 EVD 组的动脉瘤再出血病例数分别为 1 例(1.6%)和 20 例(4.8%)(P = 0.406)。31名患者(37.3%)接受了需要双重抗血小板治疗的支架辅助栓塞或血流分流术,52名患者(62.7%)接受了无需抗血小板治疗的单纯栓塞或手术剪切术。14例患者(16.9%)发生了与EVD相关的血肿,其中10例(32.3%)接受了双重抗血小板治疗,4例(7.7%)未接受抗血小板治疗(P = 0.01)。在双联抗血小板治疗前植入 EVD 的 16 例患者中,有 4 例(25%)出现了与 EVD 相关的血肿。在双联抗血小板疗法后置入EVD的15名患者中,有6名(40%)出现了EVD相关血肿(p = 0.458):结论:对于动脉瘤性蛛网膜下腔出血(aSAH)和急性脑积水患者,在动脉瘤治疗前置入 EVD 不会增加再出血的风险。但是,双联抗血小板疗法会增加 EVD 相关血肿的风险,相对于双联抗血小板疗法,放置 EVD 的顺序似乎不会对 EVD 相关血肿的结果产生重大影响。
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引用次数: 0
Complications of tunneled and non-tunneled peripherally inserted central catheter placement in chemotherapy-treated cancer patients: a meta-analysis. 化疗癌症患者置入隧道式和非隧道式外周置入中心导管的并发症:一项荟萃分析。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1469847
Jiana Hong, Xiaodan Mao

Background: Tunneled peripherally inserted central catheters (PICC) have potential to reduce complications compared to non-tunneled PICC in previous studies. Which is better is debatable. Thus, the aim to compare the effect of tunneled and non-tunneled PICC for cancer patients undergoing chemotherapy.

Methods: Embase, PubMed, Cochrane Library database, and CNKI were searched from inception to March 15, 2024. Odds ratios (ORs) with 95% confidence intervals (95% CIs) was calculated to assess the complications of tunneled and non-tunneled PICC for cancer patients undergoing chemotherapy using random- or fixed-effects models.

Results: A total of 12 articles were retrieved. Meta-analysis showed that tunneled PICC significantly decreased the risk of wound oozing (OR: 0.29, 95% CI: 0.20-0.41), infection risk (OR: 0.41, 95% CI: 0.20-0.85), thrombosis risk (OR: 0.26, 95% CI: 0.15-0.44), phlebitis risk (OR: 0.23, 95% CI: 0.13-0.40), and catheter dislodgement risk (OR: 0.33, 95% CI: 0.22-0.50) compared to non-tunneled PICC.

Conclusions: The subcutaneous tunneling technology has advantages over normal technique in decreasing PICC-related complications for cancer patients undergoing chemotherapy.

Systematic review registration: PROSPERO (CRD42024522862).

背景:在以往的研究中,隧道式外周置入中心导管(PICC)与非隧道式 PICC 相比,有可能减少并发症。孰优孰劣尚存争议。因此,本文旨在比较隧道式和非隧道式 PICC 对接受化疗的癌症患者的影响:方法:检索了从开始到 2024 年 3 月 15 日的 Embase、PubMed、Cochrane Library 数据库和 CNKI。采用随机或固定效应模型计算出患病率比(ORs)及95%置信区间(95% CIs),以评估接受化疗的癌症患者使用隧道式和非隧道式PICC的并发症:结果:共检索到 12 篇文章。Meta 分析显示,隧道式 PICC 可显著降低伤口渗液风险(OR:0.29,95% CI:0.20-0.41)、感染风险(OR:0.41,95% CI:0.20-0.85)、血栓风险(OR:0.26,95% CI:0.15-0.44)、静脉炎风险(OR:0.23,95% CI:0.13-0.40)、导管脱落风险(OR:0.33,95% CI:0.22-0.50):与普通技术相比,皮下隧道技术在减少接受化疗的癌症患者的 PICC 相关并发症方面具有优势:系统综述注册:PROCROPERO (CRD42024522862)。
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引用次数: 0
Radiological evaluation of fusion patterns after Lateral Lumbar Interbody fusion with 3D-printed porous titanium cages vs. conventional titanium cages. 使用 3D 打印多孔钛笼与传统钛笼进行侧腰椎椎间融合术后融合模式的放射学评估。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1446792
Calogero Velluto, Gregory Mundis, Laura Scaramuzzo, Andrea Perna, Giacomo Capece, Andrea Cruciani, Michele Inverso, Maria Ilaria Borruto, Luca Proietti

Introduction: The assessment of segmental fusion after Lateral Lumbar Interbody fusion (LLIF) using 3D-printed porous titanium cage is still not well studied. Various criteria, such as the presence of bone bridges (BB) between adjacent vertebrae, serve as indicators for anterior fusion. However, limited radiological studies have investigated zygapophyseal joints (ZJ) status following LLIF with porous titanium cages vs. conventional titanium threaded cages. The porous design of the latest titanium intervertebral cages is thought to enhance the bone-to-implant fusion rate. This radiological study aimed to compare the fusion patterns post-LLIF using 3D-printed porous titanium cages against those using threaded titanium cages. This radiological study aimed to compare the fusion patterns after LLIF using 3D-printed porous titanium cages against those using threaded titanium cages.

Material and methods: This retrospective, single-center radiological study involved 135 patients who underwent LLIF and posterior percutaneous screw fixation for degenerative spondylolisthesis. The study included 51 patients (Group A) with the novel porous titanium cages and 84 patients (Group B) with conventional threaded titanium cages. Inclusion criteria mandated complete radiological data and a minimum follow-up period of 24 months. The study evaluated intervertebral bone bridges (BB) for anterior fusion and zygapophyseal joints (ZJ) ankylotic degeneration, based on Pathria et al., as evidence of posterior fusion and segmental immobilization.

Results: Two years after surgery, intervertebral BB were identified in 83 segments (94.31%) in Group A and in 87 segments (88.77%) in Group B. ZJ Pathria grade I was observed in 2 segments (2.27%) of Group A and in 4 segments (4.08%) of Group B. Grade II was seen in 5 segments (5.68%) of Group A and in 6 segments (6.12%) of Group B. Posterior fusion, classified as grade III, was found in 81 segments (92.04%) of Group A and 88 segments (89.79%) of Group B. Subsidence incidence was 5.88% (3 segments) for the novel cage and 9.88% (8 segments) for the conventional cage.

Conclusions: The architecture of porous titanium cages offers a promising solution for increasing bone ingrowth and bridging space, supporting successful spinal fusion while minimizing the risk of subsidence.

导言:使用三维打印多孔钛笼进行侧腰椎椎体间融合术(LLIF)后节段融合的评估仍未得到充分研究。相邻椎体之间是否存在骨桥(BB)等各种标准可作为前路融合的指标。然而,对使用多孔钛笼与传统钛螺纹笼进行 LLIF 后颧骨关节(ZJ)状态的放射学研究还很有限。最新钛椎间笼的多孔设计被认为可提高骨与植入物的融合率。这项放射学研究旨在比较使用三维打印多孔钛笼与使用螺纹钛笼的 LLIF 术后融合模式。这项放射学研究旨在比较使用三维打印多孔钛笼与使用螺纹钛笼的 LLIF 术后融合模式:这项回顾性、单中心放射学研究涉及 135 名接受 LLIF 和后路经皮螺钉固定治疗的退行性脊柱滑脱症患者。其中 51 名患者(A 组)使用新型多孔钛笼,84 名患者(B 组)使用传统螺纹钛笼。纳入标准为完整的放射学数据和至少 24 个月的随访期。研究根据 Pathria 等人的研究结果,评估了用于前路融合的椎间骨桥(BB)和作为后路融合和节段固定证据的颧骨关节(ZJ)强直性变性:术后两年,A 组 83 个节段(94.31%)和 B 组 87 个节段(88.77%)发现椎间 BB。A组81个节段(92.04%)和B组88个节段(89.79%)发现后方融合,被归类为III级。新型保持架的下沉发生率为5.88%(3个节段),传统保持架为9.88%(8个节段):结论:多孔钛笼的结构为增加骨的生长和桥接空间提供了一种很有前景的解决方案,在支持脊柱融合成功的同时最大限度地降低了下沉的风险。
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引用次数: 0
Editorial: Application of rehabilomics in surgical conditions. 社论:康复医学在外科手术中的应用。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1493770
Huaide Qiu, Raquel Alarcon Rodriguez, Yuxuan Song
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引用次数: 0
Dural tears with cauda equina herniation following percutaneous endoscopic lumbar discectomy: a case report and literature review. 经皮内窥镜腰椎间盘切除术后硬脊膜撕裂伴马尾神经疝:病例报告和文献综述。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1487567
Shiwei Xie, Mingwei Luo, Heng Xiao

Lumbar disc herniation (LDH) is a prevalent condition that severely impacts patients' quality of life and work capacity. Traditional surgical treatments like laminectomy, while effective, involve significant invasiveness and potential complications, including long-term spinal instability and recurrent symptoms. With the advancement of minimally invasive techniques, percutaneous endoscopic lumbar discectomy (PELD) has become a popular option due to its reduced trauma and faster recovery. However, PELD, while beneficial, carries risks, including complications that may not be immediately evident. This report presents the case of a 60-year-old female patient who underwent PELD for L4/5 disc herniation but experienced significant postoperative complications, including increased pain and neurological symptoms. Initial conservative management failed, and further investigations suggested possible postoperative infection, though this was later ruled out through surgical exploration and bacterial cultures. The patient subsequently underwent open surgical exploration, which revealed extensive tissue damage and required additional interventions, including a minimally invasive lateral anterior approach for stabilization and fusion (MIS-OLIF). Postoperative recovery was successful, with complete symptom resolution and stable spine alignment at a six-month follow-up. This case highlights the complexity of managing PELD-related complications and underscores the importance of thorough diagnostic evaluation and the potential need for additional surgical interventions to ensure long-term patient outcomes.

腰椎间盘突出症(LDH)是一种严重影响患者生活质量和工作能力的常见疾病。椎板切除术等传统手术治疗方法虽然有效,但创伤大,且存在潜在并发症,包括长期脊柱不稳和症状复发。随着微创技术的发展,经皮内窥镜腰椎间盘切除术(PELD)因其创伤小、恢复快而成为一种流行的选择。然而,经皮内窥镜腰椎间盘切除术虽然有益,但也存在风险,包括可能不会立即显现的并发症。本报告介绍了一名 60 岁女性患者的病例,她因 L4/5 椎间盘突出症接受了 PELD 手术,但术后出现了严重的并发症,包括疼痛和神经症状加重。最初的保守治疗无效,进一步检查显示可能存在术后感染,但后来通过手术探查和细菌培养排除了感染可能。患者随后接受了开放性手术探查,结果显示组织广泛受损,需要进行更多干预,包括微创侧前路稳定和融合术(MIS-OLIF)。术后恢复顺利,随访六个月时症状完全消失,脊柱排列稳定。该病例凸显了处理 PELD 相关并发症的复杂性,强调了彻底诊断评估的重要性,以及为确保患者的长期预后而采取额外手术干预措施的潜在必要性。
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引用次数: 0
Predicting acetabular version in native hip joints through plain x-ray radiographs: a comparative analysis of convolutional neural network model and the current gold standard, with insights and implications for hip arthroplasty. 通过 X 光平片预测原生髋关节的髋臼形态:卷积神经网络模型与当前黄金标准的比较分析,以及对髋关节置换术的启示和影响。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1329085
Ata Jodeiri, Hadi Seyedarabi, Parmida Shahbazi, Fatemeh Shahbazi, Seyed Mohammad Mahdi Hashemi, Seyed Mohammad Javad Mortazavi, Seyyed Hossein Shafiei

Introduction: This study presents the development and validation of a Deep Learning Convolutional Neural Network (CNN) model for estimating acetabular version (AV) from native hip plain radiographs.

Methods: Utilizing a dataset comprising 300 participants with unrelated pelvic complaints, the CNN model was trained and evaluated against CT-Scans, considered the gold standard, using a 5-fold cross-validation.

Results: Notably, the CNN model exhibited a robust performance, demonstrating a strong Pearson correlation with CT-Scans (right hip: r = 0.70, p < 0.001; left hip: r = 0.71, p < 0.001) and achieving a mean absolute error of 2.95°. Remarkably, over 83% of predictions yielded errors ≤5°, highlighting the model's high precision in AV estimation.

Discussion: The model holds promise in preoperative planning for hip arthroplasty, potentially reducing complications like recurrent dislocation and component wear. Future directions include further refinement of the CNN model, with ongoing investigations aimed at enhancing preoperative planning potential and ensuring comprehensive assessment across diverse patient populations, particularly in diseased cases. Additionally, future research could explore the model's potential value in scenarios necessitating minimized ionizing radiation exposure, such as post-operative evaluations.

简介:本研究介绍了一种深度学习卷积神经网络(CNN)模型的开发和验证情况,该模型可用于从原生髋关节平片估算髋臼版本(AV):本研究介绍了深度学习卷积神经网络(CNN)模型的开发和验证情况,该模型用于根据髋关节原位平片估算髋臼版本(AV):方法:利用一个由 300 名骨盆无相关症状的参与者组成的数据集,采用 5 倍交叉验证的方法训练 CNN 模型,并对照被视为黄金标准的 CT 扫描进行评估:值得注意的是,CNN 模型表现出强劲的性能,与 CT 扫描显示出很强的皮尔逊相关性(右髋:r = 0.70,p < 0.001;左髋:r = 0.71,p < 0.001),平均绝对误差为 2.95°。值得注意的是,超过 83% 的预测结果误差小于 5°,这凸显了该模型在动静脉估计方面的高精度:讨论:该模型有望用于髋关节置换术的术前规划,减少复发性脱位和组件磨损等并发症。未来的发展方向包括进一步完善 CNN 模型,目前正在进行的研究旨在提高术前规划的潜力,确保对不同患者群体进行全面评估,尤其是在患病病例中。此外,未来的研究还可以探索该模型在需要尽量减少电离辐射暴露的情况下(如术后评估)的潜在价值。
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引用次数: 0
Microbiology of periprosthetic infections following implant-based breast reconstruction surgery: a multicentric retrospective study. 假体乳房再造手术后假体周围感染的微生物学:一项多中心回顾性研究。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1477023
Andrea Vittorio Emanuele Lisa, Flavia Zeneli, Martina Mazzucco, Benedetta Barbieri, Mario Rietjens, Germana Lissidini, Valeriano Vinci, Michele Bartoletti, Alessandra Belati, Davide Bavaro

Introduction: Implant-based breast reconstruction (IBR) is the predominant breast reconstruction technique post-mastectomy, with bacterial infections being a significant complication affecting patient recovery and quality of life. The following study aimed to determine the microbiological features of the causative agents responsible for breast implant infections, with more attention paid to the comparative analysis of Gram-positive and Gram-negative bacteria and their presentation.

Methods: We conducted a retrospective analysis of 214 patients who presented with periprosthetic infection and underwent implant removal following implant-based breast reconstruction at Humanitas Research Hospital and Istituto Europeo di Oncologia between January 2018 and March 2024.

Results: The study revealed that Gram-positive bacteria were more prevalent, with Staphylococcus species, particularly Staphylococcus aureus, being the most isolated pathogen in both institutions (∼39.96%). In contrast, Gram-negative bacteria were less frequent, with a higher proportion of these pathogens being multi-resistant strains. A significant difference was observed (p = 0.007), indicating that individuals with normal BMI have a higher prevalence of Gram-positive infections (88.46%), whereas obese and overweight patients had higher proportions of Gram-negative infections (23.53% and 28.89%, respectively). In addition, smoking status was also significantly associated with pathogen distribution (p = 0.032), with active and past smokers being related to higher percentages of polymicrobial infections. Furthermore, positive prophylactic MSSA/MRSA swabs were significantly more associated with Staphylococcus aureus infections compared to those with negative results (p = <0.001).

Conclusions: Gram-positive bacteria, especially Staphylococcus species, dominate the microbiological landscape of implant-based breast reconstruction (IBR) infections. Our findings provide insights into this critical issue, facilitating a more precise choice of empiric antibiotic treatment and prevention strategies. This analysis underscores the necessity for prophylactic protocols and therapeutic approaches tailored to the predominant bacterial groups. Further research is needed to explore long-term trends and resistance mechanisms to improve patient management.

导言:植入物乳房再造(IBR)是乳房切除术后最主要的乳房再造技术,细菌感染是影响患者康复和生活质量的重要并发症。以下研究旨在确定乳房假体感染致病菌的微生物学特征,并更加关注革兰氏阳性菌和革兰氏阴性菌的比较分析及其表现形式:我们对2018年1月至2024年3月期间在Humanitas研究医院和Istituto Europeo di Oncologia进行假体乳房重建后出现假体周围感染并接受假体移除手术的214名患者进行了回顾性分析:研究显示,革兰氏阳性菌在两家医院中较为普遍,其中葡萄球菌,尤其是金黄色葡萄球菌,是分离出最多的病原体(∼39.96%)。相比之下,革兰氏阴性菌的发病率较低,而且这些病原体中多重耐药菌株的比例较高。观察结果显示,体重指数正常者的革兰氏阳性菌感染率较高(88.46%),而肥胖和超重患者的革兰氏阴性菌感染率较高(分别为 23.53% 和 28.89%),两者之间存在明显差异(p = 0.007)。此外,吸烟状况与病原体分布也有显著相关性(p = 0.032),正在吸烟和既往吸烟者的多微生物感染比例较高。此外,与阴性结果相比,预防性 MSSA/MRSA 拭子阳性结果与金黄色葡萄球菌感染的相关性明显更高(p = 0.032):革兰氏阳性菌,尤其是葡萄球菌,在植入式乳房再造 (IBR) 感染的微生物中占主导地位。我们的研究结果让我们对这一关键问题有了更深入的了解,有助于更准确地选择经验性抗生素治疗和预防策略。这项分析强调了针对主要细菌群制定预防方案和治疗方法的必要性。还需要进一步研究探索长期趋势和耐药机制,以改善患者管理。
{"title":"Microbiology of periprosthetic infections following implant-based breast reconstruction surgery: a multicentric retrospective study.","authors":"Andrea Vittorio Emanuele Lisa, Flavia Zeneli, Martina Mazzucco, Benedetta Barbieri, Mario Rietjens, Germana Lissidini, Valeriano Vinci, Michele Bartoletti, Alessandra Belati, Davide Bavaro","doi":"10.3389/fsurg.2024.1477023","DOIUrl":"10.3389/fsurg.2024.1477023","url":null,"abstract":"<p><strong>Introduction: </strong>Implant-based breast reconstruction (IBR) is the predominant breast reconstruction technique post-mastectomy, with bacterial infections being a significant complication affecting patient recovery and quality of life. The following study aimed to determine the microbiological features of the causative agents responsible for breast implant infections, with more attention paid to the comparative analysis of Gram-positive and Gram-negative bacteria and their presentation.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 214 patients who presented with periprosthetic infection and underwent implant removal following implant-based breast reconstruction at Humanitas Research Hospital and Istituto Europeo di Oncologia between January 2018 and March 2024.</p><p><strong>Results: </strong>The study revealed that Gram-positive bacteria were more prevalent, with <i>Staphylococcus</i> species, particularly <i>Staphylococcus aureus</i>, being the most isolated pathogen in both institutions (∼39.96%). In contrast, Gram-negative bacteria were less frequent, with a higher proportion of these pathogens being multi-resistant strains. A significant difference was observed (<i>p</i> = 0.007), indicating that individuals with normal BMI have a higher prevalence of Gram-positive infections (88.46%), whereas obese and overweight patients had higher proportions of Gram-negative infections (23.53% and 28.89%, respectively). In addition, smoking status was also significantly associated with pathogen distribution (<i>p</i> = 0.032), with active and past smokers being related to higher percentages of polymicrobial infections. Furthermore, positive prophylactic MSSA/MRSA swabs were significantly more associated with <i>Staphylococcus aureus</i> infections compared to those with negative results (<i>p</i> = <0.001).</p><p><strong>Conclusions: </strong>Gram-positive bacteria, especially <i>Staphylococcus</i> species, dominate the microbiological landscape of implant-based breast reconstruction (IBR) infections. Our findings provide insights into this critical issue, facilitating a more precise choice of empiric antibiotic treatment and prevention strategies. This analysis underscores the necessity for prophylactic protocols and therapeutic approaches tailored to the predominant bacterial groups. Further research is needed to explore long-term trends and resistance mechanisms to improve patient management.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Newest challenges and advances in the treatment of colorectal disorders; from predictive biomarkers to minimally invasive techniques. 社论:治疗结直肠疾病的最新挑战和进展;从预测性生物标记物到微创技术。
IF 1.6 4区 医学 Q2 SURGERY Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.3389/fsurg.2024.1487878
M P Dimopoulos, G I Verras, F Mulita
{"title":"Editorial: Newest challenges and advances in the treatment of colorectal disorders; from predictive biomarkers to minimally invasive techniques.","authors":"M P Dimopoulos, G I Verras, F Mulita","doi":"10.3389/fsurg.2024.1487878","DOIUrl":"10.3389/fsurg.2024.1487878","url":null,"abstract":"","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Frontiers in Surgery
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