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Genetic testing and molecular biomarkers最新文献

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The Application of Artificial Intelligence in the Diagnosis of Cancer and Rare Genetic Diseases. 人工智能在癌症和罕见遗传病诊断中的应用。
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-07-01 DOI: 10.1089/gtmb.2023.29074.persp
Danielle Donadio, Sharon F Terry
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引用次数: 1
Role of Genetic Polymorphism and Expression of Angiopoietin-2 in Patients with Primary Liver Cancer Among the Southeastern Chinese Hans Population. 血管生成素-2基因多态性和表达在中国东南汉族原发性肝癌患者中的作用
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-06-01 DOI: 10.1089/gtmb.2022.0198
Bin Wang, Yunxiao Lv, Shenjian Ye, Jin Zhao, Xinling Pan

Background: Angiopoietin-2 (Ang2)-mediated angiogenesis plays a crucial role in the pathogenesis of vascular-rich cancers. However, the genetic polymorphism and expression level of Ang2 in patients with primary liver cancer remain unknown. Methods: This study included 234 primary liver cancer patients and 199 healthy controls. The expression levels of Ang2 in liver cancer tissues and plasma were determined. Peripheral blood samples were collected to test five ANGPT2 single nucleotide polymorphisms (rs2442598, rs734701, rs1823375, rs11137037, and rs12674822). Results: Plasma Ang2 levels in patients with liver cancer were upregulated compared with that in healthy controls. The upregulation of plasma Ang2 levels was significantly associated with vascular invasion, metastasis, and clinical stage. Notably, the transcription level of ANGPT2 was elevated in tumor tissues compared with para-carcinoma tissues. Individuals with the TT genotype at rs2442598 and genotype AC and AC+CC at rs11137037 had higher liver cancer risk compared with healthy controls. Conclusions: Upregulated Ang2 levels in blood plasma and cancer tissues of liver cancer patients confirm that Ang2 plays a vital role in the pathogenesis of liver cancer. ANGPT2 rs2442588 and rs11137037 are associated with liver cancer risk, thereby highlighting their role in screening individuals susceptible to liver cancer.

背景:血管生成素-2 (Ang2)介导的血管生成在血管丰富的癌症的发病机制中起着至关重要的作用。然而,原发性肝癌患者中Ang2的基因多态性和表达水平尚不清楚。方法:本研究纳入234例原发性肝癌患者和199例健康对照。测定肝癌组织和血浆中Ang2的表达水平。采集外周血样本检测5个ANGPT2单核苷酸多态性(rs2442598、rs734701、rs1823375、rs11137037和rs12674822)。结果:肝癌患者血浆Ang2水平明显高于正常对照组。血浆Ang2水平上调与血管侵袭、转移及临床分期有显著相关性。值得注意的是,与癌旁组织相比,肿瘤组织中ANGPT2的转录水平升高。与健康对照相比,TT基因型rs2442598和基因型AC和AC+CC rs11137037的个体患肝癌的风险更高。结论:肝癌患者血浆及癌组织中Ang2水平上调,证实了Ang2在肝癌发病过程中起着至关重要的作用。ANGPT2 rs2442588和rs11137037与肝癌风险相关,从而突出了其在筛查肝癌易感个体中的作用。
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引用次数: 0
Impact of PIWIL1 Single Nucleotide Polymorphisms on Gastric Cancer Risk in a Chinese Population. PIWIL1单核苷酸多态性对中国人群胃癌风险的影响
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-06-01 DOI: 10.1089/gtmb.2022.0061
Dan Hu, Laicheng Wang, Xin Chen, Yunchai Lin, Shunpeng Zhang, Zongcheng Fan, Feng Peng

Background: PIWI-like proteins contribute to the onset and progression of carcinogenesis. Whether single nucleotide polymorphisms (SNPs) in the PIWI-like 1 (PIWIL1) gene affect the morbidity and mortality of gastric cancer (GC) remains unclear. To investigate the efficacy of PIWIL1 SNPs genotype on the morbidity and mortality of GC and its interaction within PIWIL1 gene SNPs variation and between elevated plasma glucose. Materials and Methods: We conducted a case-control study that contained 216 GC patients and 204 cancer-free controls to compare differential expression of PIWIL1 SNPs. Results: PIWIL1 gene rs1106042 AA and AG genotypes were associated with significantly reduced GC risk (odds ratio [OR]: 0.15 and 0.26, p < 0.001 and p = 0.016), and rs10773771 CT+CC type significantly increased cancer risk (OR: 1.54 p = 0.037). We observed strong associations between rs10773771 and pathological type (p = 0.012), rs11703684, and invasion depth (p = 0.012). We noticed significant gene-gene interaction between rs1106042 and rs10773771 (p = 0.0107). Interaction between the copresence of rs1106042 GG plus hyperglycemia was also significant (relative excess risk due to interaction: 28.78, attributable proportion due to interaction: 68.2%, synergy index: 3.32). Patients with rs1892723 TT and rs1892722 GG+GA type had better survival (p = 0.030 and p = 0.048). Conclusion: rs10773771 CT+CC was associated with GC risk increase, rs1106042 AA and AG function as a protective factor. rs1892723 CT+TT and rs1892722 AA type may portend a poor prognosis. Elevated fasting plasma glucose will significantly increase the risk of PIWIL gene rs1106042 GG carcinogenesis by multiplicative interaction.

背景:piwi样蛋白参与癌变的发生和进展。PIWI-like 1 (PIWIL1)基因的单核苷酸多态性(snp)是否影响胃癌(GC)的发病率和死亡率尚不清楚。目的探讨PIWIL1 snp基因型对胃癌发病率和死亡率的影响及其与PIWIL1基因内snp变异和血糖升高之间的相互作用。材料和方法:我们进行了一项病例对照研究,包括216例胃癌患者和204例无癌对照,比较PIWIL1 snp的差异表达。结果:PIWIL1基因rs1106042 AA和AG基因型与胃癌风险显著降低相关(比值比[OR]: 0.15和0.26,p p = 0.016), rs10773771 CT+CC基因型与胃癌风险显著升高相关(OR: 1.54 p = 0.037)。我们观察到rs10773771与病理类型(p = 0.012)、rs11703684与侵袭深度(p = 0.012)有很强的相关性。我们发现rs1106042和rs10773771之间存在显著的基因-基因互作(p = 0.0107)。rs1106042 GG的存在与高血糖之间的相互作用也很显著(相互作用的相对超额风险:28.78,相互作用的归因比例:68.2%,协同指数:3.32)。rs1892723 TT和rs1892722 GG+GA型患者生存率更高(p = 0.030和p = 0.048)。结论:rs10773771 CT+CC与胃癌风险增加相关,rs1106042 AA和AG为保护因素。rs1892723 CT+TT和rs1892722 AA型可能预示预后不良。空腹血糖升高会通过增殖相互作用显著增加PIWIL基因rs1106042 GG致癌的风险。
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引用次数: 0
Creating a Path for Gene and Cell Therapies to Be Accessible to Patients. 为患者提供基因和细胞治疗的途径。
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-06-01 DOI: 10.1089/gtmb.2023.29073.hal
Helen Albert
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引用次数: 0
The Applicability of Polygenic Risk Scores in Under-Represented Populations. 多基因风险评分在代表性不足人群中的适用性。
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-06-01 DOI: 10.1089/gtmb.2023.29072.persp
Katie Riefski, Sharon F Terry
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引用次数: 0
Correction to: Identifying Mitochondrial Transcription Factor A As a Potential Biomarker for the Carcinogenesis and Prognosis of Prostate Cancer, by Yaqiong Tian, et al. Genet Test Mol Biomarkers 2023; (vol. 27, no. 1; 5-11); doi: 10.1089/gtmb.2022.0141. 田雅琼等对“鉴定线粒体转录因子A作为前列腺癌发生和预后的潜在生物标志物”的更正。Genet Test Mol Biomarkers 2023;(第27卷,第27号)1;5-11);doi: 10.1089 / gtmb.2022.0141。
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-06-01 DOI: 10.1089/gtmb.2022.0141.correx
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引用次数: 0
Identification of Variants Underlying Phenylalanine Hydroxylase Deficiency in Saudi Arabia. 沙特阿拉伯苯丙氨酸羟化酶缺乏症的变异鉴定。
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-05-01 DOI: 10.1089/gtmb.2022.0218
Ameera Balobaid, Faiqa Imtiaz, Khushnooda Ramzan, Sibtain Afzal, Moeenaldeen AlSayed

Background: Deleterious mutations in the human gene phenylalanine hydroxylase (PAH) encoding the phenylalanine hydroxylase enzyme give rise to classic phenylketonuria and hyperphenylalaninemia. Our study was designed to characterize the spectrum of variants in the PAH gene in Saudi patients. Materials and Methods: We screened a cohort of 72 Saudi patients with clinical and biochemical diagnoses of hyperphenylalaninemia at the largest tertiary care center in Saudi Arabia; the King Faisal Specialist Hospital and Research Center (KFSH&RC), Riyadh. All patient's charts were reviewed under an approved study by Institutional Review Board. Results: Twenty-one different PAH variants were identified among the 144 PAH alleles assessed by targeted gene sequencing. Within the studied cohort, 60 of 72 patients had homozygous mutations with the the remaining 12 being compound heterozygotes. The most prevalent of the disease alleles identified in this study was the p.(Arg252Trp) mutation, which accounted for 38 of 144 alleles (26.4%). With the high incidence of genetic disorders in the population, religiously permissible preventive reproductive measures are a priority in our practice. Prenatal diagnoses carried out on four fetuses revealed two that were homozygous for PAH pathogenic variants. In addition, pre-implantation genetic diagnoses were initiated for 19 families. Eight of these families completed more than one full cycle of treatment, from which one healthy newborn was delivered. Conclusions: This study describes the spectrum of PAH variants in the Saudi population and highlights the molecular heterogeneity underlying phenylketonuria and hyperphenylalaninemia. These results add to the existing knowledge about PAH variants in Middle Eastern Countries. These results can be further translated to provide: informed counseling; cascade carrier testing in extended family members; and pre-marital screening.

背景:编码苯丙氨酸羟化酶的人类基因苯丙氨酸羟化酶(PAH)的有害突变可引起典型的苯丙酮尿和高苯丙氨酸血症。我们的研究旨在描述沙特患者的多环芳烃基因变异谱。材料和方法:我们在沙特阿拉伯最大的三级保健中心筛选了72名临床和生化诊断为高苯丙氨酸血症的沙特患者;利雅得费萨尔国王专科医院和研究中心(KFSH&RC)。所有患者的病历都在机构审查委员会批准的研究下进行了审查。结果:通过靶向基因测序,在144个PAH等位基因中鉴定出21个不同的PAH变异。在研究队列中,72例患者中有60例为纯合子突变,其余12例为复合杂合子突变。本研究中发现的最普遍的疾病等位基因是p.(Arg252Trp)突变,占144个等位基因中的38个(26.4%)。由于人口中遗传疾病的发病率很高,宗教允许的预防性生殖措施是我们实践中的一个优先事项。对四个胎儿进行的产前诊断显示,两个胎儿的多环芳烃致病变异为纯合子。此外,对19个家庭进行了胚胎植入前遗传学诊断。其中8个家庭完成了一个以上完整周期的治疗,并由此诞生了一个健康的新生儿。结论:本研究描述了沙特人群中多环芳烃变异谱,并强调了苯丙酮尿和高苯丙氨酸血症的分子异质性。这些结果增加了对中东国家多环芳烃变异的现有知识。这些结果可以进一步转化为:知情咨询;在大家庭成员中进行级联携带者检测;还有婚前检查。
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引用次数: 0
Who Are the Experts? 谁是专家?
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-05-01 DOI: 10.1089/gtmb.2023.29071.persp
Sharon F Terry
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引用次数: 0
Association of BRCA2 Gene Functional Polymorphisms with Nonsyndromic Cleft Lip With or Without Cleft Palate in a Chinese Population. 中国人群BRCA2基因功能多态性与伴或不伴腭裂的非综合征性唇裂的关系
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-05-01 DOI: 10.1089/gtmb.2022.0223
Siyuan Guo, Zuo Zhou, Tingting Guo, Yi Xu, Xintao Yang, Yupei Wang, Renji Chen

Background: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex congenital disease affected by genetic and environmental factors however, the specific pathogenic alleles and regulatory mechanisms remain unclear in many cases. Here, we aimed to study the association between eight potentially functional single nucleotide polymorphisms (SNPs) of the BRCA2 and MGMT genes and NSCL/P in a Chinese population through a case-control study. Materials and Methods: To investigate the relationship between potentially functional SNPs of the BRCA2 and MGMT genes and NSCL/P, we selected 200 affected patients and 200 unrelated normal controls in a Chinese population. The BRCA2 gene SNPs (rs11571836, rs144848, rs7334543, rs15869, rs766173 and rs206118) and MGMT gene SNPs (rs12917 and rs7896488) were genotyped using the SNaPshot technique and the resulting data were subjected to statistical and bioinformatic analyses. Results: Our study identified for the first time that alleles of the BRCA2 are associated with NSCL/P in a Chinese population and that the s11571836 G allele was protective against NSCL/P. Under four genetic models, rs11571836 had a significant correlation with NSCL/P. Preliminary bioinformatic analyses revealed four potential miRNA matching sites (miR-1244, miR-1323, miR-562, and miR-633) associated with the rs11571836 which is located in the 3' untranslated region of BRCA2. Conclusions: These results support the role of polymorphisms of BRCA2 gene in affecting susceptibility to NSCL/P and its progression, but further research is necessary to elucidate the mechanism by which the BRCA2 gene polymorphisms affect the penetrance of NSCL/P.

背景:非综合征性唇裂伴或不伴腭裂(NSCL/P)是一种受遗传和环境因素影响的复杂先天性疾病,但在许多病例中,具体的致病等位基因和调控机制尚不清楚。在这里,我们旨在通过病例对照研究,研究中国人群中BRCA2和MGMT基因的8个潜在功能单核苷酸多态性(snp)与NSCL/P之间的关系。材料和方法:为了研究BRCA2和MGMT基因的潜在功能snp与nsl /P之间的关系,我们在中国人群中选择了200名受影响的患者和200名无关的正常对照。采用SNaPshot技术对BRCA2基因snp (rs11571836、rs144848、rs7334543、rs15869、rs766173和rs206118)和MGMT基因snp (rs12917和rs7896488)进行基因分型,并对所得数据进行统计学和生物信息学分析。结果:我们的研究首次在中国人群中发现BRCA2等位基因与NSCL/P相关,并且s11571836 G等位基因对NSCL/P具有保护作用。在4种遗传模型下,rs11571836与NSCL/P有显著相关。初步的生物信息学分析揭示了四个潜在的miRNA匹配位点(miR-1244, miR-1323, miR-562和miR-633)与位于BRCA2 3'非翻译区的rs11571836相关。结论:这些结果支持BRCA2基因多态性在影响NSCL/P易感性及其进展中的作用,但BRCA2基因多态性影响NSCL/P外显率的机制尚需进一步研究。
{"title":"Association of <i>BRCA2</i> Gene Functional Polymorphisms with Nonsyndromic Cleft Lip With or Without Cleft Palate in a Chinese Population.","authors":"Siyuan Guo,&nbsp;Zuo Zhou,&nbsp;Tingting Guo,&nbsp;Yi Xu,&nbsp;Xintao Yang,&nbsp;Yupei Wang,&nbsp;Renji Chen","doi":"10.1089/gtmb.2022.0223","DOIUrl":"https://doi.org/10.1089/gtmb.2022.0223","url":null,"abstract":"<p><p><b><i>Background:</i></b> Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex congenital disease affected by genetic and environmental factors however, the specific pathogenic alleles and regulatory mechanisms remain unclear in many cases. Here, we aimed to study the association between eight potentially functional single nucleotide polymorphisms (SNPs) of the <i>BRCA2</i> and <i>MGMT</i> genes and NSCL/P in a Chinese population through a case-control study. <b><i>Materials and Methods:</i></b> To investigate the relationship between potentially functional SNPs of the <i>BRCA2</i> and <i>MGMT</i> genes and NSCL/P, we selected 200 affected patients and 200 unrelated normal controls in a Chinese population. The <i>BRCA2</i> gene SNPs (rs11571836, rs144848, rs7334543, rs15869, rs766173 and rs206118) and <i>MGMT</i> gene SNPs (rs12917 and rs7896488) were genotyped using the SNaPshot technique and the resulting data were subjected to statistical and bioinformatic analyses. <b><i>Results:</i></b> Our study identified for the first time that alleles of the <i>BRCA2</i> are associated with NSCL/P in a Chinese population and that the s11571836 G allele was protective against NSCL/P. Under four genetic models, rs11571836 had a significant correlation with NSCL/P. Preliminary bioinformatic analyses revealed four potential miRNA matching sites (miR-1244, miR-1323, miR-562, and miR-633) associated with the rs11571836 which is located in the 3' untranslated region of <i>BRCA2</i>. <b><i>Conclusions:</i></b> These results support the role of polymorphisms of <i>BRCA2</i> gene in affecting susceptibility to NSCL/P and its progression, but further research is necessary to elucidate the mechanism by which the <i>BRCA2</i> gene polymorphisms affect the penetrance of NSCL/P.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"27 5","pages":"157-164"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between the SLC2A2 Gene rs1499821 Polymorphism and Caries Susceptibility. SLC2A2基因rs1499821多态性与龋易感性的关系
IF 1.4 4区 生物学 Q4 GENETICS & HEREDITY Pub Date : 2023-05-01 DOI: 10.1089/gtmb.2022.0201
Li Liu, Fei Ma, Qiulin Liu, Xueting Yu, Xiaojuan Zeng

Objectives: This study was designed to analyze the association between the SLC2A2 rs1499821 polymorphism and caries susceptibility in the Chinese Han, Zhuang, and Baikuyao populations. Materials and Methods: The present case-control study included 1067 12-year-old children: 481 with caries (142 Han, 166 Zhuang and 173 Baikuyao) and 586 who were caries-free (135 Han, 178 Zhuang and 273 Baikuyao). Questionnaires about diet and oral habits were obtained from all subjects. All of the children received dental examinations and DNA collection. The SLC2A2 rs1499821 SNP was genotyped using the SNPscan technique. Results: The rs1499821 T polymorphism was significantly associated with caries susceptibility in both the Han population and the combined populations of the three ethnic subgroups. SLC2A2 rs1499821 was associated with caries susceptibility in the dominant model in the Han (p = 0.045) population and the combined (p = 0.038) group. The CT+TT genotypes at rs1499821 were associated with a higher risk of caries in the Han (OR = 1.69, adjusted 95% CI: 1.01-2.81) and combined (OR = 1.33, adjusted 95% CI: 1.02-1.74) populations. In both Han (p = 0.009) and the combined populations (p = 0.004), there were statistically significant associations between the frequency of sweet food intake and dental caries. However, the rs1499821 polymorphisms did not associate with the frequency of sweet food intake in these ethnic subgroups. Conclusion: In the Han population, the SLC2A2 rs1499821 T allele and the frequency of sweet food intake may be regarded as risk factors for caries susceptibility. The SLC2A2 rs1499821 T allele had no association with the frequency of sweet food intake in any of the three ethnic groups.

目的:本研究旨在分析中国汉族、壮族和白库瑶族人群SLC2A2 rs1499821多态性与龋齿易感性的关系。材料与方法:本研究纳入1067例12岁儿童,其中龋病患儿481例(汉族142例、壮族166例、白库窑173例),无龋患儿586例(汉族135例、壮族178例、白库窑273例)。对所有受试者的饮食和口腔习惯进行问卷调查。所有儿童都接受了牙齿检查和DNA采集。利用SNP扫描技术对SLC2A2 rs1499821 SNP进行基因分型。结果:rs1499821 T多态性与汉族人群及3个民族亚群组合人群的龋易感性均有显著相关。SLC2A2 rs1499821与显性模型汉族群体(p = 0.045)和组合组(p = 0.038)龋齿易感性相关。rs1499821的CT+TT基因型与汉族人群(OR = 1.69,校正95% CI: 1.01-2.81)和综合人群(OR = 1.33,校正95% CI: 1.02-1.74)中较高的龋齿风险相关。在汉族(p = 0.009)和其他人群(p = 0.004)中,甜食摄入频率与龋齿之间存在统计学意义上的显著关联。然而,rs1499821多态性与这些种族亚群中甜食摄入的频率无关。结论:在汉族人群中,SLC2A2 rs1499821 T等位基因和甜食摄入频率可能是龋易感性的危险因素。SLC2A2 rs1499821 T等位基因与三个族群中任何一个族群的甜食摄入频率都没有关联。
{"title":"Association Between the <i>SLC2A2</i> Gene rs1499821 Polymorphism and Caries Susceptibility.","authors":"Li Liu,&nbsp;Fei Ma,&nbsp;Qiulin Liu,&nbsp;Xueting Yu,&nbsp;Xiaojuan Zeng","doi":"10.1089/gtmb.2022.0201","DOIUrl":"https://doi.org/10.1089/gtmb.2022.0201","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> This study was designed to analyze the association between the <i>SLC2A2</i> rs1499821 polymorphism and caries susceptibility in the Chinese Han, Zhuang, and Baikuyao populations. <b><i>Materials and Methods:</i></b> The present case-control study included 1067 12-year-old children: 481 with caries (142 Han, 166 Zhuang and 173 Baikuyao) and 586 who were caries-free (135 Han, 178 Zhuang and 273 Baikuyao). Questionnaires about diet and oral habits were obtained from all subjects. All of the children received dental examinations and DNA collection. The <i>SLC2A2</i> rs1499821 SNP was genotyped using the SNPscan technique. <b><i>Results:</i></b> The rs1499821 T polymorphism was significantly associated with caries susceptibility in both the Han population and the combined populations of the three ethnic subgroups. <i>SLC2A2</i> rs1499821 was associated with caries susceptibility in the dominant model in the Han (<i>p</i> = 0.045) population and the combined (<i>p</i> = 0.038) group. The CT+TT genotypes at rs1499821 were associated with a higher risk of caries in the Han (OR = 1.69, adjusted 95% CI: 1.01-2.81) and combined (OR = 1.33, adjusted 95% CI: 1.02-1.74) populations. In both Han (<i>p</i> = 0.009) and the combined populations (<i>p</i> = 0.004), there were statistically significant associations between the frequency of sweet food intake and dental caries. However, the rs1499821 polymorphisms did not associate with the frequency of sweet food intake in these ethnic subgroups. <b><i>Conclusion:</i></b> In the Han population, the <i>SLC2A2</i> rs1499821 T allele and the frequency of sweet food intake may be regarded as risk factors for caries susceptibility. The <i>SLC2A2</i> rs1499821 T allele had no association with the frequency of sweet food intake in any of the three ethnic groups.</p>","PeriodicalId":12603,"journal":{"name":"Genetic testing and molecular biomarkers","volume":"27 5","pages":"149-156"},"PeriodicalIF":1.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Genetic testing and molecular biomarkers
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