Rajasekhar Sreerama, Somu Ashok Kumar, Audi Narayana Nelavala
To protect the public's health, the pharmaceutical business must first ensure the efficacy and safety of its products. In this comparative study, the regulatory frameworks for fake and inferior-quality medicines in India and the United States are analysed and contrasted. The study uses a mixed-approaches methodology, combining qualitative and quantitative research methods. Interviews with important figures from pharmaceutical corporations, healthcare organisations, and regulatory authorities are used to collect primary data. These interviews are combined with a thorough analysis of the literature, laws, and case studies that have already been published. We evaluate the efficacy of corrective measures implemented by regulatory bodies to reduce the dangers associated with fake and subpar medications. The comparative research identifies the regulatory frameworks of each nation's strong and weak points, revealing possible areas for development. Suggestions are made for improving inter-agency communication, streamlining inspection processes, and implementing cutting-edge technologies for improved surveillance.In the end, this study contributes to the global conversation on drug regulation and public health by illuminating the obstacles and opportunities that India and the USA must overcome in their fight against fake and subpar medications. Policy makers, regulatory bodies, and stakeholders in both nations are likely to benefit from the research's findings, which will help create a more effective and flexible regulatory framework for pharmaceuticals.
{"title":"A Comparative Study on the Review and Evaluation of the Regulatory Process of Spurious and not Standard Quality Drugs in Different Countries","authors":"Rajasekhar Sreerama, Somu Ashok Kumar, Audi Narayana Nelavala","doi":"10.26452/fjphs.v3i4.513","DOIUrl":"https://doi.org/10.26452/fjphs.v3i4.513","url":null,"abstract":"To protect the public's health, the pharmaceutical business must first ensure the efficacy and safety of its products. In this comparative study, the regulatory frameworks for fake and inferior-quality medicines in India and the United States are analysed and contrasted. The study uses a mixed-approaches methodology, combining qualitative and quantitative research methods. Interviews with important figures from pharmaceutical corporations, healthcare organisations, and regulatory authorities are used to collect primary data. These interviews are combined with a thorough analysis of the literature, laws, and case studies that have already been published. We evaluate the efficacy of corrective measures implemented by regulatory bodies to reduce the dangers associated with fake and subpar medications. The comparative research identifies the regulatory frameworks of each nation's strong and weak points, revealing possible areas for development. Suggestions are made for improving inter-agency communication, streamlining inspection processes, and implementing cutting-edge technologies for improved surveillance.In the end, this study contributes to the global conversation on drug regulation and public health by illuminating the obstacles and opportunities that India and the USA must overcome in their fight against fake and subpar medications. Policy makers, regulatory bodies, and stakeholders in both nations are likely to benefit from the research's findings, which will help create a more effective and flexible regulatory framework for pharmaceuticals.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"66 16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alström disease is a condition of autosomal recessive trait disorders that are characterized. At the same time, cone-rod spinal muscular atrophy, hearing impairment, adolescent upper abdominal overweight, insulin sensitivity but also insulin production, insulin-dependent, hypercholesterolemia, present approximately through sexual maturity, myocardial infarction, but also accelerated respiratory, hepatic, but also renal failure to thrive. A multitude of interesting alternative strand management functionality. alms1 protein is present through the centromere, metabolic rate organization, and intracellular space of any connective tissue infected with the disease. Identifying alms1 as little more than a pupillary transcription factor helps explain its variety like witnessed phenotypic expression and their resemblance from those of someone else ciliopathies, including such burden-field disorder. Experiments conducted by mouse models and cell membrane model types like alström disorder have made available an understanding of the staphylococcus aureus mechanisms that underlie obesity in children, hyperglycemia, and many other diagnostic and therapeutic significant issues. Inevitably, data analysis into pathophysiology like alström disorder could perhaps translate to more vital organization and coverings for people and also have crucially substantial potential consequences for these other relatively uncommon ciliopathies, along with more frequent symptoms like obesity and heart disease, as well as other circumstances prevalent inside the overall population.
{"title":"A Review of Alstrom Syndrome","authors":"Borra Sandhya","doi":"10.26452/fjphs.v3i4.512","DOIUrl":"https://doi.org/10.26452/fjphs.v3i4.512","url":null,"abstract":"Alström disease is a condition of autosomal recessive trait disorders that are characterized. At the same time, cone-rod spinal muscular atrophy, hearing impairment, adolescent upper abdominal overweight, insulin sensitivity but also insulin production, insulin-dependent, hypercholesterolemia, present approximately through sexual maturity, myocardial infarction, but also accelerated respiratory, hepatic, but also renal failure to thrive. A multitude of interesting alternative strand management functionality. alms1 protein is present through the centromere, metabolic rate organization, and intracellular space of any connective tissue infected with the disease. Identifying alms1 as little more than a pupillary transcription factor helps explain its variety like witnessed phenotypic expression and their resemblance from those of someone else ciliopathies, including such burden-field disorder. Experiments conducted by mouse models and cell membrane model types like alström disorder have made available an understanding of the staphylococcus aureus mechanisms that underlie obesity in children, hyperglycemia, and many other diagnostic and therapeutic significant issues. Inevitably, data analysis into pathophysiology like alström disorder could perhaps translate to more vital organization and coverings for people and also have crucially substantial potential consequences for these other relatively uncommon ciliopathies, along with more frequent symptoms like obesity and heart disease, as well as other circumstances prevalent inside the overall population.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135884631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gautham Chakra R, Naveen T G, Abdul Rahem Sk, Harshitha A, Aravind Goud K
One of the most frequent diseases is Parkinson's disease (PD). Recent years have seen notable improvements in the understanding of the disease's in terms of prevalence and incidence. Additionally, there has been a growing understanding that, in addition to the more well acknowledged difficulties, the disorder may also be linked to important causes and disturbances. Despite accumulating suggestive evidence, it has not yet been determined which of the Parkinson's disease treatments possess a effect. There are numerous therapy options available, but there is no known cure for Parkinson's disease. As the illness worsens, additional treatments are available, but managing the symptoms of PD is still difficult and will benefit from more clinical study.
{"title":"A Review of Parkinson’s Disease: Diagnosis and Treatment","authors":"Gautham Chakra R, Naveen T G, Abdul Rahem Sk, Harshitha A, Aravind Goud K","doi":"10.26452/fjphs.v3i4.510","DOIUrl":"https://doi.org/10.26452/fjphs.v3i4.510","url":null,"abstract":"One of the most frequent diseases is Parkinson's disease (PD). Recent years have seen notable improvements in the understanding of the disease's in terms of prevalence and incidence. Additionally, there has been a growing understanding that, in addition to the more well acknowledged difficulties, the disorder may also be linked to important causes and disturbances. Despite accumulating suggestive evidence, it has not yet been determined which of the Parkinson's disease treatments possess a effect. There are numerous therapy options available, but there is no known cure for Parkinson's disease. As the illness worsens, additional treatments are available, but managing the symptoms of PD is still difficult and will benefit from more clinical study.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136252686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chandana B, Thanushree D R, Kumaraswamy M, Robin George
The second most prevalent type of cancer after lung cancer, breast cancer affects women more frequently than any other type.BSE is a screening method that women can use at home to find breast cancer early on. Whether female college students are sufficiently informed about breast cancer. They can aid in reducing the prevalence of breast cancer in their neighbourhood and assist in cancer prevention for themselves. As the nation's future mothers, they ought to be at least somewhat knowledgeable about breast cancer. The secondary objective was to perform its reliability and validity. Apart from referring to previous existing scales, were also considered while developing the scale. The scale was administered to a total of 1006 participants, from pharmacy, medical, nursing, and BSC &MSC with ages ranging from 18-33 years. The participants did not report any difficulty in understanding the questions. The final scale consists of (21-items development and validation of breast cancer and breast self-examination scale) with a content validity index (CVI=1), Pearson's 'r' value (0.96), Cronbach's Alpha (0.923). Hence (21-items development and validation of breast cancer and breast self-examination scale) turned out to be a reliable and valid tool in assessing knowledge, attitude about breast cancer and breast self-examination among female college students. The (21-items development and validation of breast cancer and breast self-examination scale) is expected to aid in the clinical evaluation and research the field.
{"title":"Development and Validation of Breast cancer and Breast self-examination scale to assess the Knowledge and attitude towards Breast cancer and Breast self-examination","authors":"Chandana B, Thanushree D R, Kumaraswamy M, Robin George","doi":"10.26452/fjphs.v3i4.509","DOIUrl":"https://doi.org/10.26452/fjphs.v3i4.509","url":null,"abstract":"The second most prevalent type of cancer after lung cancer, breast cancer affects women more frequently than any other type.BSE is a screening method that women can use at home to find breast cancer early on. Whether female college students are sufficiently informed about breast cancer. They can aid in reducing the prevalence of breast cancer in their neighbourhood and assist in cancer prevention for themselves. As the nation's future mothers, they ought to be at least somewhat knowledgeable about breast cancer. The secondary objective was to perform its reliability and validity. Apart from referring to previous existing scales, were also considered while developing the scale. The scale was administered to a total of 1006 participants, from pharmacy, medical, nursing, and BSC &MSC with ages ranging from 18-33 years. The participants did not report any difficulty in understanding the questions. The final scale consists of (21-items development and validation of breast cancer and breast self-examination scale) with a content validity index (CVI=1), Pearson's 'r' value (0.96), Cronbach's Alpha (0.923). Hence (21-items development and validation of breast cancer and breast self-examination scale) turned out to be a reliable and valid tool in assessing knowledge, attitude about breast cancer and breast self-examination among female college students. The (21-items development and validation of breast cancer and breast self-examination scale) is expected to aid in the clinical evaluation and research the field.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136252518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alcohol dependence is a pattern of substance use, leading to clinically significant impairment or distress; chronic alcohol abuse has been known to disrupt the normal sleep cycle and lead to sleep disorders, including sleep terror disorder. A male patient of age 42 years was a known alcoholic for 24 years, and the patient does not have any previous psychiatric history. Then, he stopped drinking for four days and developed insomnia. The patient gave an account of emotional outbreaks from 2 days; vital signs included blood pressure 14090 , pulse rate 81 bpm, respiratory rate 20 , and oxygen saturation 97%@RA and the patient's GRBS level was 210 mg, and the patient was immediately given with medication in. 4mg (IV), . (2 amp in 100 ml NS, BD), . Panto 40mg (IV), the same drug, was continued for three days, and there was no complaint of visual hallucinations. The patient felt symptomatically better and was discharged on the 4th day with no fresh complaints. The patient was advised to continue Tab. 2mg for three days. The preliminary case investigation evaluated the link between insomnia and alcohol dependence syndrome (ADS).
{"title":"A Case Report on Alcohol Dependence Syndrome with Relation to Insomnia","authors":"Fiza S H, Prajnesh J Shetty, Robin George","doi":"10.26452/fjphs.v3i4.508","DOIUrl":"https://doi.org/10.26452/fjphs.v3i4.508","url":null,"abstract":"Alcohol dependence is a pattern of substance use, leading to clinically significant impairment or distress; chronic alcohol abuse has been known to disrupt the normal sleep cycle and lead to sleep disorders, including sleep terror disorder. A male patient of age 42 years was a known alcoholic for 24 years, and the patient does not have any previous psychiatric history. Then, he stopped drinking for four days and developed insomnia. The patient gave an account of emotional outbreaks from 2 days; vital signs included blood pressure 14090 , pulse rate 81 bpm, respiratory rate 20 , and oxygen saturation 97%@RA and the patient's GRBS level was 210 mg, and the patient was immediately given with medication in. 4mg (IV), . (2 amp in 100 ml NS, BD), . Panto 40mg (IV), the same drug, was continued for three days, and there was no complaint of visual hallucinations. The patient felt symptomatically better and was discharged on the 4th day with no fresh complaints. The patient was advised to continue Tab. 2mg for three days. The preliminary case investigation evaluated the link between insomnia and alcohol dependence syndrome (ADS).","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135350436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salma Shaik, K. Baba, Katakam Pavana Narasimha, Mohammed Arshiya Rehamath, P. Dharani, Polisetty Harshavardhan, Poori Kusuma Kumari
The current study is to prepare hydroalcoholic extraction of ipomea pes caprae leaf extract of antifungal activity against candida albicans. Ipomoea pes caprae leaves are extracted using a hydroalcoholic solvent in a 1:9 ratio, which consists of 1 part water as well as 9 parts of the alcohol. These plant extracts are used to treat antifungal diseases. The antifungal activity of ipomoea pes-caprae leaf extract and their respective zone of inhibitions were evaluated. From the results, it was confirmed that the hydroalcoholic extract obtained from the leaves of the ipomoea pes caprae demonstrated exceptional activity as compared to that of a typical medication.
{"title":"Hydroalcoholic Extraction of Ipomoea pes caprae Leaf Extract of Antifungal Activity Against Candida albicans","authors":"Salma Shaik, K. Baba, Katakam Pavana Narasimha, Mohammed Arshiya Rehamath, P. Dharani, Polisetty Harshavardhan, Poori Kusuma Kumari","doi":"10.26452/fjphs.v3i3.505","DOIUrl":"https://doi.org/10.26452/fjphs.v3i3.505","url":null,"abstract":"The current study is to prepare hydroalcoholic extraction of ipomea pes caprae leaf extract of antifungal activity against candida albicans. Ipomoea pes caprae leaves are extracted using a hydroalcoholic solvent in a 1:9 ratio, which consists of 1 part water as well as 9 parts of the alcohol. These plant extracts are used to treat antifungal diseases. The antifungal activity of ipomoea pes-caprae leaf extract and their respective zone of inhibitions were evaluated. From the results, it was confirmed that the hydroalcoholic extract obtained from the leaves of the ipomoea pes caprae demonstrated exceptional activity as compared to that of a typical medication.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86124657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug stability is a significant problem that affects drug quality. Freeze drying is one of the techniques that can be used to develop stable drugs. This paper presents a new technique for developing regular drugs by a freeze-drying process with the potential for various applications in and the pharmaceutical industry. This review aims to improve the current systems from unstable to stable by freeze drying technique. systems are dangerous, which leads to the degradation of the drug. The freeze-drying process can be used for sound systems. Characteristics of proteins and peptides are the primary concern of the pharmaceutical industry. Freeze drying provides a new, safe, and effective way to preserve these substances without refrigeration or freezing. In the pharmaceutical industry, many efforts have been made to improve current protein formulations for injection. A new technique called freeze drying is emerging as a potential solution. This paper will explore the characteristics of freeze-drying and its possibilities for developing stable drugs in more detail. Especially complex protein-based drugs present significant challenges to manufacturers because their stability is low, and they often have harsh conditions that need to be stored such as being kept frozen or cooled on ice at all times.
{"title":"Development of Stable Injectable Formulation by Freeze Drying Technique","authors":"Rajni K, Naresh Kalra, Hunny Dabas","doi":"10.26452/fjphs.v3i3.500","DOIUrl":"https://doi.org/10.26452/fjphs.v3i3.500","url":null,"abstract":"Drug stability is a significant problem that affects drug quality. Freeze drying is one of the techniques that can be used to develop stable drugs. This paper presents a new technique for developing regular drugs by a freeze-drying process with the potential for various applications in and the pharmaceutical industry. This review aims to improve the current systems from unstable to stable by freeze drying technique. systems are dangerous, which leads to the degradation of the drug. The freeze-drying process can be used for sound systems. Characteristics of proteins and peptides are the primary concern of the pharmaceutical industry. Freeze drying provides a new, safe, and effective way to preserve these substances without refrigeration or freezing. In the pharmaceutical industry, many efforts have been made to improve current protein formulations for injection. A new technique called freeze drying is emerging as a potential solution. This paper will explore the characteristics of freeze-drying and its possibilities for developing stable drugs in more detail. Especially complex protein-based drugs present significant challenges to manufacturers because their stability is low, and they often have harsh conditions that need to be stored such as being kept frozen or cooled on ice at all times.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76413540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suchitra M, Harinadha Baba K, Yamini R, S. P, Surekha G, P. T, Sakshi Jain
Herbal medicines are used for their safety, efficacy, cultural acceptability and lesser side effects. The chemical constituents present in plants are a part of the physiological functions of living system and hence they are believed to have better compatibility with the human body. These drugs are made from renewable resources of raw materials by eco-friendly processes and will bring economic prosperity. An herb is a plant or plant part used for its scent, flavor, or therapeutic properties. They are sold as tablets, capsules, powders, teas, extracts, and fresh or dried plants. People use herbal medicines to try to maintain or improve their health. Products made from botanicals, or plants, that are used to treat diseases or to maintain health are called herbal products, botanical products, or phytomedicines. A product made from plants and used solely for internal use is called an herbal supplement.
{"title":"To develop and evaluate the in-vitro anti oxidant and anti-inflammatory activity of polyherbal Gel","authors":"Suchitra M, Harinadha Baba K, Yamini R, S. P, Surekha G, P. T, Sakshi Jain","doi":"10.26452/fjphs.v3i3.496","DOIUrl":"https://doi.org/10.26452/fjphs.v3i3.496","url":null,"abstract":"Herbal medicines are used for their safety, efficacy, cultural acceptability and lesser side effects. The chemical constituents present in plants are a part of the physiological functions of living system and hence they are believed to have better compatibility with the human body. These drugs are made from renewable resources of raw materials by eco-friendly processes and will bring economic prosperity. An herb is a plant or plant part used for its scent, flavor, or therapeutic properties. They are sold as tablets, capsules, powders, teas, extracts, and fresh or dried plants. People use herbal medicines to try to maintain or improve their health. Products made from botanicals, or plants, that are used to treat diseases or to maintain health are called herbal products, botanical products, or phytomedicines. A product made from plants and used solely for internal use is called an herbal supplement.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"29 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84242558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leukaemia, one of the most lethal illnesses of the twentieth century, is becoming one of the most common illnesses of the twenty-first. The most common carcinoma among those under the mandatory age of 20 is oral also tumor cancer. Siddha herbal mineral formulation's perspective this study aims to assess the anti-microbiological, anti-oral cancer, and anti-tumor activities of Kaalamega Narayana Chendhooram in vitro experiments. As well as to measure anti-tumor activity against KB cell lines as well as anti-cancer activity (MTT assay) and validate the therapeutic effects of KMNC in order to evaluate the therapeutic effects of KMNC. In the modern medical setting, oral cancer must be effectively treated. The percentage of KB cell viability in the MTT experiment was 69.46%, 55.06%, 51.67%, 40.33%, and 35.34% at concentrations of 62.5 µg/mL, 12.5 µg/mL, 25 µg/mL, 50 µg/mL, and 100 µg/mL, respectively. The results of the present study support the anti-cancer activity of the formulation KMNC. The results of the present study support the anti-cancer activity of the formulation KMNC. KMNC is demonstrating its effectiveness as a tumor and oral carcinoma cancer prevention. Numerous pharmacological actions, including as antibacterial and anticancer properties, are present. This cancer treatment is inexpensive and doesn't have any negative side effects. The anticancer properties of KMNC have been documented in scientific journals. In this paper, the anticancer activity of KMNC is discussed in the context of several in-vitro researches.
{"title":"The perspective of herbal mineral formulation Kaalamega Narayana Chendhooram (KMNC) as an anti-microbiological, anti-oral carcinoma, anti-tumor evaluations (A Siddha medicine for oral cancer, lung cancer) in in-vitro studies","authors":"S. C, B. S, K. D, A. R","doi":"10.26452/fjphs.v3i3.494","DOIUrl":"https://doi.org/10.26452/fjphs.v3i3.494","url":null,"abstract":"Leukaemia, one of the most lethal illnesses of the twentieth century, is becoming one of the most common illnesses of the twenty-first. The most common carcinoma among those under the mandatory age of 20 is oral also tumor cancer. Siddha herbal mineral formulation's perspective this study aims to assess the anti-microbiological, anti-oral cancer, and anti-tumor activities of Kaalamega Narayana Chendhooram in vitro experiments. As well as to measure anti-tumor activity against KB cell lines as well as anti-cancer activity (MTT assay) and validate the therapeutic effects of KMNC in order to evaluate the therapeutic effects of KMNC. In the modern medical setting, oral cancer must be effectively treated. The percentage of KB cell viability in the MTT experiment was 69.46%, 55.06%, 51.67%, 40.33%, and 35.34% at concentrations of 62.5 µg/mL, 12.5 µg/mL, 25 µg/mL, 50 µg/mL, and 100 µg/mL, respectively. The results of the present study support the anti-cancer activity of the formulation KMNC. The results of the present study support the anti-cancer activity of the formulation KMNC. KMNC is demonstrating its effectiveness as a tumor and oral carcinoma cancer prevention. Numerous pharmacological actions, including as antibacterial and anticancer properties, are present. This cancer treatment is inexpensive and doesn't have any negative side effects. The anticancer properties of KMNC have been documented in scientific journals. In this paper, the anticancer activity of KMNC is discussed in the context of several in-vitro researches.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"412 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76471778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present research work was to formulate Transdermal patches of Clotrimazole and to enhance effectiveness and to avoid side effects of the drug. Transdermal patch of clotrimazole was prepared with EC and HPMC in different ratios in order to improve the drug diffusion. Clotrimazole has formulated Transdermal patches were prepared by solvent evaporation technique. Drug and polymers has been characterized by FT-IR. The FTIR spectra of formulation shows that no interaction between drug and excipient. The evaluation of Transdermal patches of Clotrimazole were performed mainly for their Physical parameters such as Weight variation, Thickness, Folding endurance test And also for their Drug content and In-vitro Drug diffusion studies. The patch prepared by solvent evaporation technique passes the prepared patch were found to be non irritant, weight variation was found in the range of 39±5.81 to 48±2.90mg, thickness in the range of 0.08±0.09 to 0.04±0.08 mm, Folding endurance of patches was found to be in the range of 98 ±0.57 to 128±0.59, The tensile strength of the patches was ranging from 1.95±1.2to 3.98±1.9, The percentage elongation ranges from 10.6 to 18.6, drug content uniformity was in between 78.25 to 89.76 %. The in-vitro drug diffusion profiles of the formulations in pH 7.4 show differences depending on their composition. A Tran’s dermal patches of all the preparations were observed by the diffusion test. It was also observed that F6 showed highest drug release.
{"title":"Formulation and Evaluation of Transdermal Patches of Clotrimazole","authors":"Yelamanda Jagadeesh, Hari Kiran, Reddy Naveena B, Chandra Prakash D, Bhagya Lakshmi G, Vaishnavi P, Varshini S, Vadamala Prudhvi Raj","doi":"10.26452/fjphs.v3i3.492","DOIUrl":"https://doi.org/10.26452/fjphs.v3i3.492","url":null,"abstract":"The aim of the present research work was to formulate Transdermal patches of Clotrimazole and to enhance effectiveness and to avoid side effects of the drug. Transdermal patch of clotrimazole was prepared with EC and HPMC in different ratios in order to improve the drug diffusion. Clotrimazole has formulated Transdermal patches were prepared by solvent evaporation technique. Drug and polymers has been characterized by FT-IR. The FTIR spectra of formulation shows that no interaction between drug and excipient. The evaluation of Transdermal patches of Clotrimazole were performed mainly for their Physical parameters such as Weight variation, Thickness, Folding endurance test And also for their Drug content and In-vitro Drug diffusion studies. The patch prepared by solvent evaporation technique passes the prepared patch were found to be non irritant, weight variation was found in the range of 39±5.81 to 48±2.90mg, thickness in the range of 0.08±0.09 to 0.04±0.08 mm, Folding endurance of patches was found to be in the range of 98 ±0.57 to 128±0.59, The tensile strength of the patches was ranging from 1.95±1.2to 3.98±1.9, The percentage elongation ranges from 10.6 to 18.6, drug content uniformity was in between 78.25 to 89.76 %. The in-vitro drug diffusion profiles of the formulations in pH 7.4 show differences depending on their composition. A Tran’s dermal patches of all the preparations were observed by the diffusion test. It was also observed that F6 showed highest drug release.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135208719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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