Pharmaceutical Industry is striving hard to improve the dissolution of drugs with limited water solubility. One of the approaches to improve the dissolution rate of poorly soluble drugs is solid dispersion. Hence in the present research, an attempt was made to improve the bioavailability of Rosuvastatin by formulating it as a solid dispersion. The release of Rosuvastatin calcium solid dispersion was prolonged using HPMC. Eudragit L-100 and PEG-6000 were used as carriers. Nine formulations of prolonged-release Rosuvastatin calcium (RS-SD 1 to RS-SD 9) were prepared and evaluated for pre and post formulation studies. Among all the formulations RS SD-3 showed an optimum release profile with 97.5±3.89 % indicating it to be the best formulation in the present research.
{"title":"Formulation and Evaluation of Prolonged-Release Tablets Containing Solid Dispersions of Rosuvastatin Calcium","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.180","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.180","url":null,"abstract":"Pharmaceutical Industry is striving hard to improve the dissolution of drugs with limited water solubility. One of the approaches to improve the dissolution rate of poorly soluble drugs is solid dispersion. Hence in the present research, an attempt was made to improve the bioavailability of Rosuvastatin by formulating it as a solid dispersion. The release of Rosuvastatin calcium solid dispersion was prolonged using HPMC. Eudragit L-100 and PEG-6000 were used as carriers. Nine formulations of prolonged-release Rosuvastatin calcium (RS-SD 1 to RS-SD 9) were prepared and evaluated for pre and post formulation studies. Among all the formulations RS SD-3 showed an optimum release profile with 97.5±3.89 % indicating it to be the best formulation in the present research.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79487863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The inappropriate use of antibiotics contributes to the development of resistant bacteria and has a significant influence on the treatment failure. The increasing rapid development and spread of ABR (Antibiotic Resistance) has become a big issue through worldwide during the past few decades. The main objective is to identify most prescribing antibiotics in clinical practice. To evaluate the prescribing pattern of antibiotics for different microbial infection. It is a prospective observational study of antibiotic prescribing patterns conducted over 6 months in outpatient and inpatient departments of Narayana General Hospital, Nellore. Collected data was analysed based on demographics like age, gender, monotherapy, dual therapy, triple therapy and quadrupole therapy. In 614 antibiotic prescribed patients, utilization of antibiotic is more in 45+years. The mono, dual, triple & quadruple therapy of antibiotics was observed as 79.8%, 17.2%, 2.6% & 0.3% respectively. The most commonly prescribed antibiotics are Cefuroxime and Metronidazole (5%), Ceftriaxone and Doxycycline (6%), Ciprofloxacin (7%), Cefixime (11%), Ceftriaxone (13%), Cefpodoxime (14%), Amoxicillin (24%). Utilization of antibiotics is more in general medicine, followed by surgery departments. Most of the infections are due to Escherichia coli (54%) and Klebsiella species (34%) and were mostly isolated from urine and blood specimens. Antibiotics which are highly prescribing in clinics were Amoxicillin, Ciprofloxacin, Ceftriaxone and Cefuroxime. Most of the isolated bacterial species in the community had developed resistance to above antibiotics. Re-evaluation and advancement in antibiotic therapy is strongly recommended to overcome antibiotic resistance.
{"title":"Utilization of Antibiotics and Identification of Antibiotic Resistance in Different Microbes","authors":"G. Prakash","doi":"10.26452/fjphs.v1i4.186","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.186","url":null,"abstract":"The inappropriate use of antibiotics contributes to the development of resistant bacteria and has a significant influence on the treatment failure. The increasing rapid development and spread of ABR (Antibiotic Resistance) has become a big issue through worldwide during the past few decades. The main objective is to identify most prescribing antibiotics in clinical practice. To evaluate the prescribing pattern of antibiotics for different microbial infection. It is a prospective observational study of antibiotic prescribing patterns conducted over 6 months in outpatient and inpatient departments of Narayana General Hospital, Nellore. Collected data was analysed based on demographics like age, gender, monotherapy, dual therapy, triple therapy and quadrupole therapy. In 614 antibiotic prescribed patients, utilization of antibiotic is more in 45+years. The mono, dual, triple & quadruple therapy of antibiotics was observed as 79.8%, 17.2%, 2.6% & 0.3% respectively. The most commonly prescribed antibiotics are Cefuroxime and Metronidazole (5%), Ceftriaxone and Doxycycline (6%), Ciprofloxacin (7%), Cefixime (11%), Ceftriaxone (13%), Cefpodoxime (14%), Amoxicillin (24%). Utilization of antibiotics is more in general medicine, followed by surgery departments. Most of the infections are due to Escherichia coli (54%) and Klebsiella species (34%) and were mostly isolated from urine and blood specimens. Antibiotics which are highly prescribing in clinics were Amoxicillin, Ciprofloxacin, Ceftriaxone and Cefuroxime. Most of the isolated bacterial species in the community had developed resistance to above antibiotics. Re-evaluation and advancement in antibiotic therapy is strongly recommended to overcome antibiotic resistance.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83727371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herbal Products have huge demand from few decades as they yield good results without any side effects and provide a soothing effect for longer period of time. Using natural ingredients in a cosmetic formulation thus provides healthy and glowing skin. Currently, due to increase in pollution rate, skin allergic conditions, microbes and external effects human skin have become sensitive and prone to faster aging. Here we have made an attempt to formulate a pack ideal for all skin types. Thus, in the current work, the face packs that can be easily made with the available ingredients showed all the benefits and further optimization studies are necessary on various parameters to identify benefits on humans. The flow properties of natural herbal face pack show accurate results. All the ingredients were mixed homogenously and were evaluated for parameters like organoleptic properties (Appearance, color, odor, texture & smoothness) particle size ranges from 23.5±2.15 ?m to 24.4±5.14 ?m, Ash content ranges from 86 ± 0.951 % to 94 ± 0.34 %, pH was ranges from 6.51 ± 0.12 to 6.65± 0.16. Loss on drying ranges from 3.18 % to 4.12 %. Irritancy tests, rheological features and stability. The obtained results showed that the prepared formulation was stable on all parameters. Irritancy test revealed negative. Stability tests showed the inertness of the formulation.
{"title":"Preparation and Characterization of Natural Face Pack","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.223","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.223","url":null,"abstract":"Herbal Products have huge demand from few decades as they yield good results without any side effects and provide a soothing effect for longer period of time. Using natural ingredients in a cosmetic formulation thus provides healthy and glowing skin. Currently, due to increase in pollution rate, skin allergic conditions, microbes and external effects human skin have become sensitive and prone to faster aging. Here we have made an attempt to formulate a pack ideal for all skin types. Thus, in the current work, the face packs that can be easily made with the available ingredients showed all the benefits and further optimization studies are necessary on various parameters to identify benefits on humans. The flow properties of natural herbal face pack show accurate results. All the ingredients were mixed homogenously and were evaluated for parameters like organoleptic properties (Appearance, color, odor, texture & smoothness) particle size ranges from 23.5±2.15 ?m to 24.4±5.14 ?m, Ash content ranges from 86 ± 0.951 % to 94 ± 0.34 %, pH was ranges from 6.51 ± 0.12 to 6.65± 0.16. Loss on drying ranges from 3.18 % to 4.12 %. Irritancy tests, rheological features and stability. The obtained results showed that the prepared formulation was stable on all parameters. Irritancy test revealed negative. Stability tests showed the inertness of the formulation.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80306850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, ketoprofen emulgels were prepared using Sodium CMC, Sodium alginate and Hibiscus as gelling agents in order to overcome gastric side effects and to achieve pharmacological response. Pre formulation parameters were performed to know the compatibility of pure drug ketoprofen with polymers CMC, Na alginate, hibiscus prior to the preparation of Emulgel. It indicates that no change was observed in the peak values of the drug in the physical mixture thus providing that both the drug and polymer were said to be compatible with each other. Emulgel of ketoprofen 2.5% w/w was prepared in 3 steps i.e., Preparation of gel, emulsion phases separately and incorporate both phases in homogenizer for a period of 45 min and stabilized it for 2 hrs. The prepared emulgels were evaluated for physical characteristics, drug content, pH, spreadability and in-vitro permeation studies. The physical appearance of all the formulations was creamy white, consistent, homogenous and stable. The pH of the prepared emulgels was found well within the range of 6-7. Release rate kinetics of the drug was studied with in vitro drug permeation data for all the formulations F1 to F9 and results were stated the best fit model for selected formulation F6 were found to be Zero order model with non-fickian diffusion. The formulations were compared with the reference product. The in-vitro dissolution of F6 was nearest to the reference product F10 (f2 = 85.17).
{"title":"Formulation and Evaluation of Ketoprofen Emulgels by Model Independent Approach","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.224","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.224","url":null,"abstract":"In the current study, ketoprofen emulgels were prepared using Sodium CMC, Sodium alginate and Hibiscus as gelling agents in order to overcome gastric side effects and to achieve pharmacological response. Pre formulation parameters were performed to know the compatibility of pure drug ketoprofen with polymers CMC, Na alginate, hibiscus prior to the preparation of Emulgel. It indicates that no change was observed in the peak values of the drug in the physical mixture thus providing that both the drug and polymer were said to be compatible with each other. Emulgel of ketoprofen 2.5% w/w was prepared in 3 steps i.e., Preparation of gel, emulsion phases separately and incorporate both phases in homogenizer for a period of 45 min and stabilized it for 2 hrs. The prepared emulgels were evaluated for physical characteristics, drug content, pH, spreadability and in-vitro permeation studies. The physical appearance of all the formulations was creamy white, consistent, homogenous and stable. The pH of the prepared emulgels was found well within the range of 6-7. Release rate kinetics of the drug was studied with in vitro drug permeation data for all the formulations F1 to F9 and results were stated the best fit model for selected formulation F6 were found to be Zero order model with non-fickian diffusion. The formulations were compared with the reference product. The in-vitro dissolution of F6 was nearest to the reference product F10 (f2 = 85.17).","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78883631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present work is to evaluate the critical process parameters and techniques and improve the quality and reduce cast and scaling up time. The pharmaceutical industry R & D refers to the process of successful progress from drug discovery to product development. The need to the target market are identified alternative product concept are generated and evaluate and single concept of selected for future development. The concept is a description of the from function and features a product and a usefully. The Scale up is the process as define to increasing the batch size or increasing different physical parameter the output of volume. The old process scale up techniques doesn’t involve studying the critical process parameters (Raw Process). The scale up batches industry to improve quality of the product in moving from Scale up batches/Exhibit Batches and validation batches. To improve the batches quality scale up of a process Transformation of small scale lab batches into commercial scale depended on experience and probability and involving the more technique. Due to this probability of success is less understanding of critical process parameters and process enables control of critical step process parameter during manufacturing and successful transformation from lab scale to Exhibit batches and commercial batches.
{"title":"Comparison of Process Parameter of Lab Batches, Scale-Up Batches Exhibit Batches Commercial Batches","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.220","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.220","url":null,"abstract":"The aim of the present work is to evaluate the critical process parameters and techniques and improve the quality and reduce cast and scaling up time. The pharmaceutical industry R & D refers to the process of successful progress from drug discovery to product development. The need to the target market are identified alternative product concept are generated and evaluate and single concept of selected for future development. The concept is a description of the from function and features a product and a usefully. The Scale up is the process as define to increasing the batch size or increasing different physical parameter the output of volume. The old process scale up techniques doesn’t involve studying the critical process parameters (Raw Process). The scale up batches industry to improve quality of the product in moving from Scale up batches/Exhibit Batches and validation batches. To improve the batches quality scale up of a process Transformation of small scale lab batches into commercial scale depended on experience and probability and involving the more technique. Due to this probability of success is less understanding of critical process parameters and process enables control of critical step process parameter during manufacturing and successful transformation from lab scale to Exhibit batches and commercial batches.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85154799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charantin, a steroidal saponin found in the plant Momordica charantia and functions like insulin. It is combined with natural insulin, increasing insulin release and inhibiting gluconeogenesis. Charantin improves blood glucose levels by enhancing glucose absorption and glycogen synthesis in the liver, muscles, and fat cells, according to a large body of research. The great majority of the time, it is taken in the form of a capsule. Because of the increased availability of these newly released formulations, a new way of calculating the amount of medications included in the formulations is now required. The current work's RP-HPLC technique is aimed to estimate Charantin as well as confirm that Charantin is being calculated. The proposed RP-HPLC technology for assessing Charantin in capsule dosage form was found to be precise, specific, accurate, quick, and cost-effective. Label Claims (also known as labelling claims) are representations of the actual product attributes as stated on the product label. The sample recoveries from all formulations were consistent with their respective Label Claims, and this method is suitable for routine analysis. It is suitable for normal laboratory analysis and may be used to control the quality of raw materials, formulations, dissolution tests, and bioequivalence studies for the same formulation.
{"title":"RP-HPLC Method Designed for Determining Charantin in its Capsule Dosage Form","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.219","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.219","url":null,"abstract":"Charantin, a steroidal saponin found in the plant Momordica charantia and functions like insulin. It is combined with natural insulin, increasing insulin release and inhibiting gluconeogenesis. Charantin improves blood glucose levels by enhancing glucose absorption and glycogen synthesis in the liver, muscles, and fat cells, according to a large body of research. The great majority of the time, it is taken in the form of a capsule. Because of the increased availability of these newly released formulations, a new way of calculating the amount of medications included in the formulations is now required. The current work's RP-HPLC technique is aimed to estimate Charantin as well as confirm that Charantin is being calculated. The proposed RP-HPLC technology for assessing Charantin in capsule dosage form was found to be precise, specific, accurate, quick, and cost-effective. Label Claims (also known as labelling claims) are representations of the actual product attributes as stated on the product label. The sample recoveries from all formulations were consistent with their respective Label Claims, and this method is suitable for routine analysis. It is suitable for normal laboratory analysis and may be used to control the quality of raw materials, formulations, dissolution tests, and bioequivalence studies for the same formulation.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86628934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The compound chalcone is very common which can available by synthetic means and naturally occurring from plant sources. These compounds have predominant value for their abundant properties with less adverse impacts on biological systems. The naturally occurring chalcone belongs to the flavonoid family. Chalcones are structural with two aromatic rings connected with three carbon ? & ? unsaturated carbonyl systems. They possess many pharmacological activities like anti-inflammatory, antimalarial, antifungal, antileishmanial activities based on the substituents substituted on them. Benzene rings containing conjugated double bonds and completely delocalized ? electron system, molecules possessing this system have low redox potential and greater electron transfer reactions. This review article covers the chemistry, synthesis, biological activities, Isolation of natural or synthesized derivatives of chalcone. The main entity of this article is to summarize the expansion of this molecule related to the structural entities and pharmacological actions.
{"title":"A Glimpse of the Molecule Chalcone","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.206","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.206","url":null,"abstract":"The compound chalcone is very common which can available by synthetic means and naturally occurring from plant sources. These compounds have predominant value for their abundant properties with less adverse impacts on biological systems. The naturally occurring chalcone belongs to the flavonoid family. Chalcones are structural with two aromatic rings connected with three carbon ? & ? unsaturated carbonyl systems. They possess many pharmacological activities like anti-inflammatory, antimalarial, antifungal, antileishmanial activities based on the substituents substituted on them. Benzene rings containing conjugated double bonds and completely delocalized ? electron system, molecules possessing this system have low redox potential and greater electron transfer reactions. This review article covers the chemistry, synthesis, biological activities, Isolation of natural or synthesized derivatives of chalcone. The main entity of this article is to summarize the expansion of this molecule related to the structural entities and pharmacological actions.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91378677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The most sensitive and complex organ in the human body is the eye, so special attention should be needed for the administration of pharmaceutical substances into the eye. It is one of the most difficult for researchers in the preparation of drug delivery to the eye. The anatomical characteristics and physiological properties of the eye should be considered in drug delivery. The properties of pharmaceutical dosage forms depend upon the anatomy and physiology of the eye. Drug delivery on to the outer part as well as in the inner part of the ocular structure for the therapy is a unique and challenging one. Physiochemical, microbiological, and pharmaceutical properties lead to absorption and elimination of active therapeutic agents into and out of the eye. Loss of precorneal more and fastly occurs due to drainage in the region of extraocular are some of the drawbacks in ocular drug delivery of conventional dosage forms. To overcome these problems, advancements in conventional dosage forms take place.
{"title":"Conventional Opthalamic Drug Delivery System: An Outlook","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.207","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.207","url":null,"abstract":"The most sensitive and complex organ in the human body is the eye, so special attention should be needed for the administration of pharmaceutical substances into the eye. It is one of the most difficult for researchers in the preparation of drug delivery to the eye. The anatomical characteristics and physiological properties of the eye should be considered in drug delivery. The properties of pharmaceutical dosage forms depend upon the anatomy and physiology of the eye. Drug delivery on to the outer part as well as in the inner part of the ocular structure for the therapy is a unique and challenging one. Physiochemical, microbiological, and pharmaceutical properties lead to absorption and elimination of active therapeutic agents into and out of the eye. Loss of precorneal more and fastly occurs due to drainage in the region of extraocular are some of the drawbacks in ocular drug delivery of conventional dosage forms. To overcome these problems, advancements in conventional dosage forms take place.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"422 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76326737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"1","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.214","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.214","url":null,"abstract":"<jats:p>a</jats:p>","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84741495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present study one such species, Wedelia trilobata, has be chosen to review the In vitro antibacterial activity of the root extract by using solvent ethanol for the selected plant Wedelia triolobata. The deduction of nanoparticles used to be unalterable by UV-Visible spectroscopy, FTIR, particle size, and zeta potential. The anti-bacterial activity of Wedelia trilobata mediated synthesis silver nanoparticles was tested by disc diffusion assay against standard organisms like Escherichia coli and staphylococcus aureus bacteria. The formation of silver nanoparticles by Wedelia trilobata was initially demonstrated by color changes confirmed by UV-Visible root exhibited a specific absorbance peak around 450 nm and leaf exhibited a specific absorbance peak around 418nm respectively. The Zeta potential of silver nanoparticles was found to be root 0.1 and leaf 0.4, so it indicates the dispersion and stability. The antibacterial activity against Gram-positive Staphylococcus aureus was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (9.5Mm), standard (12.3Mm), control (11.3Mm), extraction for AgNPs Wedelia trilobata (13.8). 5Mm for normal (7.3Mm), standard (19.4Mm), control (10.5Mm), extraction for AgNPs Wedelia trilobata (19.8). The antibacterial activity against Gram-negative E.coli was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (7.8Mm), standard (8.5Mm), control (10.2Mm), extraction for AgNPs Wedelia trilobata (14.3). 5Mm for normal (13Mm), standard (19.6Mm), control (15.3Mm) extraction for AgNPs Wedelia trilobata (19.8). The present investigation revealed that the ethanolic Root and aqueous leaf extracts the chosen plant have potential to suppress the expansion of infective bacterial strains.
{"title":"Formulation and Characterization of Anti-Bacterial Activity of Silver Nanoparticles Using Root and Leaf of Wedelia trilobata","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i3.211","DOIUrl":"https://doi.org/10.26452/fjphs.v1i3.211","url":null,"abstract":"In the present study one such species, Wedelia trilobata, has be chosen to review the In vitro antibacterial activity of the root extract by using solvent ethanol for the selected plant Wedelia triolobata. The deduction of nanoparticles used to be unalterable by UV-Visible spectroscopy, FTIR, particle size, and zeta potential. The anti-bacterial activity of Wedelia trilobata mediated synthesis silver nanoparticles was tested by disc diffusion assay against standard organisms like Escherichia coli and staphylococcus aureus bacteria. The formation of silver nanoparticles by Wedelia trilobata was initially demonstrated by color changes confirmed by UV-Visible root exhibited a specific absorbance peak around 450 nm and leaf exhibited a specific absorbance peak around 418nm respectively. The Zeta potential of silver nanoparticles was found to be root 0.1 and leaf 0.4, so it indicates the dispersion and stability. The antibacterial activity against Gram-positive Staphylococcus aureus was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (9.5Mm), standard (12.3Mm), control (11.3Mm), extraction for AgNPs Wedelia trilobata (13.8). 5Mm for normal (7.3Mm), standard (19.4Mm), control (10.5Mm), extraction for AgNPs Wedelia trilobata (19.8). The antibacterial activity against Gram-negative E.coli was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (7.8Mm), standard (8.5Mm), control (10.2Mm), extraction for AgNPs Wedelia trilobata (14.3). 5Mm for normal (13Mm), standard (19.6Mm), control (15.3Mm) extraction for AgNPs Wedelia trilobata (19.8). The present investigation revealed that the ethanolic Root and aqueous leaf extracts the chosen plant have potential to suppress the expansion of infective bacterial strains.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"159 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77473606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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