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Oral communication abstracts 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13012
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引用次数: 0
Master 2 award 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13013
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引用次数: 0
Drug news and therapeutic news 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13011
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引用次数: 0
Discussed Poster Abstracts – PM2 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13016
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引用次数: 0
Theme and main topic index 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13018
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引用次数: 0
Thesis awards 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13014
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引用次数: 0
Discussed Poster Abstracts – PM1 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13015
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引用次数: 0
Poster abstracts 法国药理学和治疗学学会年会摘要 2024 年 6 月 11-13 日，法国图尔。
IF 2.9 4区 医学 Q2 Medicine
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-08 DOI: 10.1111/fcp.13017
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引用次数: 0
Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function 癌症中 METTL3 蛋白表达失调的预后作用以及抑制 METTL3 功能的潜在抗癌价值。
IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Fundamental & Clinical Pharmacology
Pub Date : 2024-06-07 DOI: 10.1111/fcp.13020
Rong Zhao, Jiaping Chen, Yangwei Wang, Han Xiao, Peiyuan Mei, Wei Lin, Mingxin Diao, Shiwen He, Yongde Liao, Wangyang Meng

Background

Many studies have demonstrated the relationship between METTL3 protein expression and clinical outcomes in various cancers and elucidated the mechanism by which METTL3 disrupts the behavior of cancer cells. Here, we attempted to define the prognostic value of METTL3 protein in patients with cancer via systematic analysis and explored the potential effect of inhibiting METTL3 using its specific inhibitor.

Methods

We searched PubMed, Embase, and the Web of Science databases for studies that elucidated the prognostic value of METTL3 protein expression in all cancer types and then calculated the pooled hazard ratios with 95% confidence intervals for the overall survival (OS) of all cancer types and subgroups. Data from The Cancer Genome Atlas dataset were used to study METTL3 mRNA expression in cancers. Further, the effects of a METTL3-specific inhibitor were studied in cancer cells via the colony formation assay, the cell proliferation assay, and apoptosis detection.

Results

Meta-analysis of the 33 cohorts in 32 studies (3666 patients in total) revealed that higher METTL3 protein expression indicated poor OS in the majority of cancers. Bioinformatics analysis of METTL3 mRNA expression and cancer prognosis did not show the extremely prominent prognostic value of METTL3 mRNA. Nevertheless, the METTL3-specific inhibitor attenuated cell proliferation and cell cloning formation and promoted apoptosis.

Conclusions

METTL3 protein expression is associated with poor prognosis in most cancer types and could be a biomarker for OS. Further, METTL3 inhibition might be a potential treatment strategy for cancers.

背景：许多研究已经证明了METTL3蛋白的表达与各种癌症的临床预后之间的关系，并阐明了METTL3扰乱癌细胞行为的机制。在此，我们试图通过系统分析来确定METTL3蛋白在癌症患者中的预后价值，并探索使用特异性抑制剂抑制METTL3的潜在效果：我们在PubMed、Embase和Web of Science数据库中检索了阐明METTL3蛋白表达在所有癌症类型中预后价值的研究，然后计算了所有癌症类型和亚组总生存期（OS）的汇总危险比及95%置信区间。癌症基因组图谱数据集的数据被用于研究癌症中METTL3 mRNA的表达。此外，还通过集落形成试验、细胞增殖试验和细胞凋亡检测，研究了METTL3特异性抑制剂对癌细胞的影响：对32项研究中的33个队列（共3666名患者）进行的元分析表明，METTL3蛋白表达较高表明大多数癌症的OS较差。对METTL3 mRNA表达和癌症预后的生物信息学分析并未显示出METTL3 mRNA极其突出的预后价值。然而，METTL3特异性抑制剂可减轻细胞增殖和细胞克隆形成，促进细胞凋亡：结论：METTL3蛋白表达与大多数癌症类型的不良预后有关，可作为OS的生物标志物。此外，抑制 METTL3 可能是一种潜在的癌症治疗策略。
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引用次数: 0
Experimental approaches for induction of diabetes mellitus and assessment of antidiabetic activity: An in vitro and in vivo methodological review 诱发糖尿病和评估抗糖尿病活性的实验方法：体外和体内方法综述。
IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Fundamental & Clinical Pharmacology
Pub Date : 2024-05-15 DOI: 10.1111/fcp.13009
Shahin Gavanji, Azizollah Bakhtari, Rania Abdel-latif, Elena Bencurova, Eman M. Othman

Background

Diabetes mellitus poses a global health challenge, driving the need for innovative therapeutic solutions. Experimental methods play a crucial role in evaluating the efficacy of potential antidiabetic drugs, both in vitro and in vivo. Yet concerns about reproducibility persist, necessitating comprehensive reviews.

Objectives

This review aims to outline experimental approaches for inducing diabetes and evaluating antidiabetic activity, synthesizing data from authoritative sources and academic literature.

Methods

We conducted a systematic search of prominent databases, including PubMed, ScienceDirect, and Scopus, to identify relevant articles spanning from 1943 to the present. A total of 132 articles were selected for inclusion in this review, focusing on in vitro and in vivo experimental validations of antidiabetic treatments.

Results

Our review highlights the diverse array of experimental methods employed for inducing diabetes mellitus and evaluating antidiabetic interventions. From cell culture assays to animal models, researchers have employed various techniques to study the effectiveness of novel therapeutic agents.

Conclusion

This review provides a comprehensive guide to experimental approaches for assessing antidiabetic activity. By synthesizing data from a range of sources, we offer valuable insights into the current methodologies used in diabetes research. Standardizing protocols and enhancing reproducibility are critical for advancing effective antidiabetic treatments.

背景：糖尿病对全球健康构成挑战，因此需要创新的治疗方案。实验方法在评估潜在抗糖尿病药物的体外和体内疗效方面发挥着至关重要的作用。然而，对可重复性的担忧依然存在，因此有必要进行全面综述：本综述旨在概述诱导糖尿病和评估抗糖尿病活性的实验方法，综合权威来源和学术文献中的数据：我们对包括 PubMed、ScienceDirect 和 Scopus 在内的著名数据库进行了系统检索，以确定从 1943 年至今的相关文章。本综述共选取了 132 篇文章，重点关注抗糖尿病治疗的体外和体内实验验证：结果：我们的综述强调了诱发糖尿病和评估抗糖尿病干预措施所采用的各种实验方法。从细胞培养实验到动物模型，研究人员采用了各种技术来研究新型治疗药物的有效性：本综述为评估抗糖尿病活性的实验方法提供了全面指导。通过综合各种来源的数据，我们对当前糖尿病研究中使用的方法提出了宝贵的见解。标准化方案和提高可重复性对于推进有效的抗糖尿病治疗至关重要。
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引用次数: 0
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