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Standard Systemic Analgesic Agents 标准全身止痛剂
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0010
Michele L Matthews, Benjamin S Kematick
Chapter 9 addresses drugs used for pain management. These drugs are categorized as standard systemic analgesic agents, including nonopioid and opioid analgesics, and other, neuromodulating, agents that are addressed in subsequent chapters. There is significant variability in individual response to standard systemic analgesics, and choice of therapy should foremost include patient-specific considerations balancing efficacy with tolerability. Acetaminophen is widely recommended for various acute and chronic pain syndromes and is generally considered safe when taken within therapeutic doses. Nonsteroidal anti-inflammatory drugs (NSAIDs) are versatile analgesics and are commonly utilized for general mild to moderate pain. NSAIDs are the most widely used analgesics today. Opioids are effective for severe pain, such as pain from acute trauma, postsurgical pain, and cancer pain, but require intense monitoring for side effects. All opioids cause sedation, constipation, nausea, and somnolence and can cause respiratory depression, physical dependence, and death. Opioids are available in both short-acting and extended-release or long-acting formulations. Like NSAIDs, opioids should be used at the lowest dose for the shortest duration of time when possible.
第9章讨论用于疼痛管理的药物。这些药物被归类为标准的全身性镇痛药,包括非阿片类镇痛药和阿片类镇痛药,以及其他神经调节剂,这些将在后面的章节中讨论。个体对标准全身性镇痛药的反应存在显著差异,治疗的选择应首先考虑患者的具体情况,平衡疗效和耐受性。对乙酰氨基酚被广泛推荐用于各种急性和慢性疼痛综合征,通常认为在治疗剂量内服用是安全的。非甾体抗炎药(NSAIDs)是一种通用的镇痛药,通常用于一般轻度至中度疼痛。非甾体抗炎药是当今应用最广泛的镇痛药。阿片类药物对严重疼痛有效,如急性创伤疼痛、术后疼痛和癌症疼痛,但需要密切监测副作用。所有阿片类药物均可引起镇静、便秘、恶心和嗜睡,并可导致呼吸抑制、身体依赖和死亡。阿片类药物可用于短效和缓释或长效制剂。与非甾体抗炎药一样,阿片类药物应尽可能在最短时间内以最低剂量使用。
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引用次数: 0
Extremes of Pain 极度痛苦
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0018
B. Hogans
Chapter 17 covers the range of extreme and unusual pain-associated conditions by highlighted selected conditions that illustrate the extent of severe pain and informative aberrations in pain signaling, including congenital insensitivity. Multiple forms of severe intractable pain are addressed, including trigeminal neuralgia, postherpetic neuralgia, phantom limb pain, complex regional pain syndrome, peripheral nerve vasculitis, fibromyalgia, Ehlers-Danlos syndrome, stiff-person syndrome, endometriosis, and erythromelalgia. The preponderance of these conditions are neuropathic in nature, and all require coordinated pharmacologic and nonpharmacologic treatment. Pharmacologic therapies may include neuromodulating agents, and nonpharmacologic approaches may include clinical psychology, psychologically informed physical therapy, daily moderate exercise, stress management, sleep optimization, and mind–body approaches. These extreme pain conditions range from fairly prevalent but poorly understood (e.g., fibromyalgia) to rare but associated with specific molecular processes, as in erythromelalgia.
第17章涵盖了极端和不寻常的疼痛相关疾病的范围,重点介绍了严重疼痛的程度和疼痛信号的信息畸变,包括先天性不敏感。治疗多种形式的严重难治性疼痛,包括三叉神经痛、带状疱疹后神经痛、幻肢痛、复杂区域疼痛综合征、周围神经血管炎、纤维肌痛、Ehlers-Danlos综合征、僵硬人综合征、子宫内膜异位症和红斑性肢痛症。这些情况的优势是神经性的,并且都需要协调的药物和非药物治疗。药物治疗可能包括神经调节剂,而非药物治疗可能包括临床心理学、心理知情物理治疗、日常适度运动、压力管理、睡眠优化和身心方法。这些极端疼痛的范围从相当普遍但知之甚少的(如纤维肌痛)到罕见但与特定分子过程相关的(如红斑性肢痛症)。
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引用次数: 0
Common Chronic Pain Problems 常见的慢性疼痛问题
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0017
B. Hogans
Chapter 16 addresses several common chronic pain-associated conditions. Utilizing the comprehensive, multimodal, evidence-based approach to assisting patients in planning for pain self-management, the chapter describes common chronic pain-associated conditions, including those of the head, such as chronic tension headache, temporomandibular joint disorder, and chronic migraine; the spine, such as chronic neck and low back pain; the appendicular musculoskeletal system, such as hip, knee, and shoulder pain; common neuropathic pain conditions, such as diabetic peripheral neuropathy; and common compressive neuropathies, such as carpal tunnel syndrome and ulnar neuropathy. The conditions are presented in terms of common characteristics, pathophysiologic features, and the basic approach to treatment.
第16章讨论了几种常见的慢性疼痛相关疾病。利用全面的、多模式的、基于证据的方法来帮助患者规划疼痛自我管理,本章描述了常见的慢性疼痛相关疾病,包括头部疾病,如慢性紧张性头痛、颞下颌关节紊乱和慢性偏头痛;脊柱,如慢性颈、腰痛;附肢肌肉骨骼系统,如髋关节、膝关节和肩部疼痛;常见的神经性疼痛状况,如糖尿病周围神经病变;以及常见的压缩性神经病变,如腕管综合征和尺神经病变。该条件提出了共同的特点,病理生理特征和基本的方法来治疗。
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引用次数: 0
Impact of Pain on the Individual and Others 疼痛对个人和他人的影响
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0004
P. Arnstein, M. Keating
Chapter 3 describes how pain is a powerful stressor that aids in surviving an injury and how the resultant physiologic stressors put vulnerable patients at risk for pulmonary, renal, gastrointestinal, metabolic, and psychosocial complications. The timeliness and efficacy of pain control contribute to health outcomes. Of the estimated 30% of adults who develop chronic pain, these individuals face increased risk for an impoverished, premature death. Pain is a biopsychosocial experience that undermines health, activities, and enjoyment of life. Unless assessed and treated properly, pain devalues important things in the life of the sufferer, often leading down a path to disability and despair. Pain is always a combined physical, mental, and social experience that often partially responds to properly targeted therapy. Disparities are common in the way pain is managed and may relate to factors at the patient, provider, organizational, or payer levels. Thus, healthcare professionals who interact with people experiencing pain have a duty to dampen the biopsychosocial impact of pain to help them think, feel, and do better. Given potential harm related to analgesics or invasive treatments, ethical practices involve advocating for delivering personalized treatments, with vigilant monitoring to avoid potential harm.
第3章描述了疼痛如何成为一种强大的压力源,有助于在受伤后存活,以及由此产生的生理压力源如何使脆弱的患者面临肺部、肾脏、胃肠道、代谢和社会心理并发症的风险。疼痛控制的及时性和有效性有助于健康结果。估计有30%的成年人患有慢性疼痛,这些人面临贫困和过早死亡的风险增加。疼痛是一种破坏健康、活动和生活乐趣的生物-心理-社会体验。除非评估和治疗得当,否则疼痛会贬低患者生命中重要的东西,往往导致残疾和绝望。疼痛总是一种生理、心理和社会经验的结合,通常对适当的靶向治疗有部分反应。疼痛管理方式的差异很常见,可能与患者、提供者、组织或付款人层面的因素有关。因此,与经历疼痛的人互动的医疗保健专业人员有责任抑制疼痛的生物心理社会影响,以帮助他们思考,感觉和做得更好。考虑到与止痛剂或侵入性治疗相关的潜在危害,伦理实践包括倡导提供个性化治疗,并进行警惕监测以避免潜在危害。
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引用次数: 0
Nociceptive Processing 疼痛的处理
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0003
C. Renn, S. Dorsey
Chapter 2 describes the molecular events associated with pain signaling. The mechanisms associated with chemical, thermal, and mechanical pain signaling in the peripheral nerve endings are detailed. Molecular signaling mechanisms occurring in the spinal dorsal horn, including the primary afferent nociceptor, the inhibitory interneurons, and the descending on-cells and off-cells projecting from the nucleus raphe magnocellularis are described. Persistent increases in pain signaling resulting from inflammatory mediators are explained with reference to specific molecules. Signaling events at supraspinal levels, such as the thalamus, cortex, periaqueductal gray, and nucleus raphe magnus, including cannabinoids, opioids, and noradrenergic and serotonergic neurotransmitter events, are described as critical to pain pathways with relevance to potential pain therapies.
第2章描述了与疼痛信号相关的分子事件。周围神经末梢中与化学、热和机械疼痛信号相关的机制详细介绍。本文描述了脊髓背角发生的分子信号机制,包括初级传入伤害感受器、抑制性中间神经元以及中缝大细胞核投射的下行细胞上和细胞外信号。由炎症介质引起的疼痛信号的持续增加与特定分子有关。棘上水平的信号事件,如丘脑、皮层、导水管周围灰质和中缝大核,包括大麻素、阿片类物质、去甲肾上腺素能和血清素能神经递质事件,被描述为与潜在疼痛治疗相关的疼痛通路的关键。
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引用次数: 1
Diagnostic Reasoning in the Pain-Focused Encounter 聚焦于疼痛的诊断推理
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0008
B. Hogans
Chapter 7 addresses the processes and pitfalls of evaluating, reasoning about, and attending to the needs of patients with pain. This chapter builds on Chapter 6, which addressed clinical assessment, explaining in detail the process of extracting and abstracting information from the pain narrative (clinical history or interview) to lay the foundation for a problem list and differential diagnosis. The problem list and differential diagnosis are described and contrasted so that clinicians will be comfortable with both. A clinical model explains the need for patient-centered approaches to be omnipresent but balanced with an appropriate disease-centered knowledge base that is likewise informed by understanding the patient’s healthcare-related values and motivations. A balanced approach is emphasized. The process of planning for diagnostic testing, including imaging, laboratory testing, provocative maneuvers, and targeted referrals, is described. The last section of the chapter addresses the impact and nature of cognitive and affective biases that can mitigate the effectiveness of diagnostic reasoning. A coordinated strategy to limit the negative impact of diagnostic reasoning biases is presented in a memorable way. Finally, the ethics of errors and error disclosure are discussed as well as the process of error disclosure.
第7章解决的过程和陷阱评估,推理,并出席病人的需要与疼痛。本章建立在第6章的基础上,第6章讨论了临床评估,详细解释了从疼痛叙述(临床病史或访谈)中提取和抽象信息的过程,为问题清单和鉴别诊断奠定了基础。问题清单和鉴别诊断是描述和对比,以便临床医生将舒适的两者。临床模型解释了以患者为中心的方法无处不在的必要性,但与适当的以疾病为中心的知识库相平衡,该知识库同样通过了解患者的医疗保健相关价值观和动机来获得信息。强调采取平衡的办法。计划诊断测试的过程,包括成像,实验室测试,挑衅演习,和有针对性的转诊,被描述。本章的最后一部分讨论了认知和情感偏见的影响和本质,这些偏见会降低诊断推理的有效性。以一种令人难忘的方式提出了一种限制诊断推理偏差负面影响的协调策略。最后,讨论了错误和错误披露的伦理问题以及错误披露的过程。
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引用次数: 0
Opioid Misuse and Addiction Among Patients With Chronic Pain 慢性疼痛患者的阿片类药物滥用和成瘾
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0021
M. Martel, R. Jamison
Chapter 20 provides an introduction to understanding the prevalence and risk factors as well as screening tools for assessing opioid misuse and addiction in patients with chronic pain. In the era of the opioid epidemic in North America and beyond, the use of prescription opioid medications to help improve function in chronic noncancer pain is frequently debated. Out of fear of iatrogenic addiction, litigation, and/or potential medication misuse, some clinicians are refusing to prescribe opioids for chronic pain. Evidence indicates that rates of opioid misuse and addiction are fairly high among chronic pain patients prescribed long-term opioid therapy, but there is consensus that opioids can be safe and effective for carefully selected and monitored patients.
第20章介绍了慢性疼痛患者阿片类药物滥用和成瘾的患病率和危险因素,以及评估阿片类药物滥用和成瘾的筛选工具。在北美及其他地区阿片类药物流行的时代,使用处方阿片类药物来帮助改善慢性非癌性疼痛的功能经常引起争论。出于对医源性成瘾、诉讼和/或潜在药物滥用的恐惧,一些临床医生拒绝开阿片类药物治疗慢性疼痛。有证据表明,在长期服用阿片类药物治疗的慢性疼痛患者中,阿片类药物滥用和成瘾的比例相当高,但人们一致认为,对于精心选择和监测的患者,阿片类药物是安全有效的。
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引用次数: 0
Pain in Older Patients 老年患者的疼痛
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0020
Staja Q. Booker, K. Herr
Chapter 19 discusses the complexities of pain assessment and treatment in older adults and provides best practice recommendations for comprehensive pain management. Pain in older patients is a common, yet significant quality-of-life issue necessitating accurate assessment and safe multimodal treatment. The assessment and treatment of older adults in pain pose distinct challenges and unique opportunities to provide proactive and patient-centered care for a high-risk population with complex health needs. Thus, it is important that providers are prepared to identify these challenges and implement an effective and safe pain management plan.
第19章讨论了老年人疼痛评估和治疗的复杂性,并提供了全面疼痛管理的最佳实践建议。老年患者的疼痛是一个常见的,但重要的生活质量问题,需要准确的评估和安全的多模式治疗。老年人疼痛的评估和治疗带来了独特的挑战和独特的机会,为具有复杂健康需求的高风险人群提供积极和以患者为中心的护理。因此,重要的是,提供者准备识别这些挑战,并实施有效和安全的疼痛管理计划。
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引用次数: 1
Acute Pain 剧烈的疼痛
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0015
N. Zinboonyahgoon, K. Schreiber
Chapter 14 covers the essentials of acute pain care in the hospital and procedural setting. The chapter begins with an overview of the negative physiologic impacts of uncontrolled acute pain. Based on a foundational understanding of pain pathways and nociceptive signaling, it is possible to construct an acute pain management plan incorporating nonpharmacologic, systemic, and focal pharmacologic elements for an effective multimodal treatment plan. Acute opioid management, including analgesic equivalence, is discussed in detail. Benefits, precautions, side effects, and toxicities of opioids are addressed. Naloxone administration is described in detail. Obstetric, regional, nerve blockade, and multimodal analgesia are described. Adjustments to therapy for patients with substance use disorder are addressed in detail.
第14章涵盖了医院急性疼痛护理和程序设置的要点。本章首先概述了不受控制的急性疼痛的负面生理影响。基于对疼痛通路和伤害性信号的基本理解,可以构建一个包括非药物、全身和局部药物因素的急性疼痛管理计划,以实现有效的多模式治疗计划。急性阿片类药物管理,包括镇痛等效,详细讨论。阿片类药物的益处、预防措施、副作用和毒性被讨论。详细描述了纳洛酮的给药。描述了产科,区域,神经阻滞和多模式镇痛。调整治疗的病人物质使用障碍是详细解决。
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引用次数: 0
Pain Emergencies and Complications of Pain Treatments 疼痛紧急情况和疼痛治疗并发症
Pub Date : 2019-11-01 DOI: 10.1093/med/9780199768912.003.0014
I. Tong, R. J. Yong, B. Hogans
Chapter 13 reviews some common pain-associated emergencies and also discusses some complications of pain treatments that require immediate attention. Pain is a common occurrence in emergent illness, and some complications of pain treatments require emergent management. Chest pain is an excellent example of clinical decision-making following a process of organized, rapid pain assessment and then diagnostic and treatment reasoning based on the findings and observations of the clinical assessment. Providers assessing patients for acute chest pain elicit basic pain characteristics of region, quality, severity, and timing as well as usually associated factors and then pursue testing and treatment for elements in the differential diagnosis accordingly. The chapter illustrates this same process applied to conditions of acute abdominal, limb, headache, and spine emergencies. In the second part of the chapter, emergencies arising in the context of pain treatments are discussed, including overdose and withdrawal from opioids, benzodiazepines, and other pain-active medications as well as pump and device complications.
第13章回顾了一些常见的与疼痛相关的紧急情况,并讨论了一些需要立即注意的疼痛治疗并发症。疼痛是紧急疾病的常见现象,一些疼痛治疗的并发症需要紧急处理。胸痛是临床决策的一个很好的例子,它遵循一个有组织的、快速的疼痛评估过程,然后根据临床评估的结果和观察进行诊断和治疗推理。对急性胸痛患者进行评估时,医生会提出基本的疼痛特征,包括疼痛的区域、质量、严重程度和时间,以及通常的相关因素,然后根据这些特征进行鉴别诊断中的检测和治疗。本章说明了同样的过程适用于急性腹部,肢体,头痛和脊柱紧急情况的条件。在本章的第二部分,讨论了在疼痛治疗的背景下出现的紧急情况,包括阿片类药物过量和戒断,苯二氮卓类药物和其他止痛药以及泵和设备并发症。
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引用次数: 0
期刊
Pain Care Essentials
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