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Long-Term Results of a Hybrid Revascularization Procedure for Peripheral Arterial Disease. 外周动脉疾病混合型血运重建术的长期疗效。
Pub Date : 2015-09-01 DOI: 10.15017/1544197
Jun Okadome, Takuya Matsumoto, Y. Aoyagi, Daisuke Matsuda, Shinichi Tanaka, Eisuke Kawakubo, R. Kyuragi, K. Morisaki, Kenichi Homma, K. Iwasa, T. Ohmine, A. Guntani, Ryota Fukunaga, Y. Maehara
OBJECTIVETo evaluate the efficacy of hybrid procedure for peripheral arterial disease (PAD), we compared the cases treated using the hybrid procedure with those treated using open revascularization (bypass alone) in our facilities.MATERIALS AND METHODSWe retrospectively reviewed 204 patients who underwent revascularization for PAD between 2007 and 2013. We divided the patients into two groups based on the type of procedure. Group 1 included patients who underwent the hybrid procedure, that is, doing endovascular therapy (EVT) either femoral or iliac resion and added the bypass procedure (infragenicular vein bypass) to the below knee artery, and group 2 included patients who underwent only bypass procedure (used autovein), that is, central anastomotic region was femoral artery region and peripheral anastomotic region was below knee artery. We evaluated various factors between the two groups, including the primary patency rate, secondary patency rate, amputation-free survival rate, and determined the efficacy of the hybrid procedure for PAD.RESULTSIn the patient's characteristics, there was significant difference between the two groups in the cases with cerebrovascular disease, only (p = 0.03). There were no significant differences in the primary or secondary patency rates, and the amputation-free survival rate.CONCLUSIONSPrimary patency rate, secondary patency rate, and amputation-free survival rate of the hybrid procedure were comparable to those of bypass (alone) procedure. The hybrid procedure is therefore an acceptable strategy for patients with PAD.
目的评价混合手术治疗外周动脉疾病(PAD)的疗效,比较我院采用混合手术治疗外周动脉疾病(PAD)的病例与采用开放血运重建术(单独旁路)治疗的病例。材料与方法我们回顾性分析了2007年至2013年间接受PAD血运重建术的204例患者。我们根据手术方式将患者分为两组。组1为混合型手术,即行股动脉或髂血管内治疗(EVT),并在膝下动脉上加搭桥手术(细静脉搭桥);组2为仅行搭桥手术(自体静脉),即中央吻合区为股动脉区域,外周吻合区为膝下动脉。我们评估了两组间的各种因素,包括原发性通畅率、继发性通畅率、无截肢生存率,并确定混合手术治疗PAD的疗效。结果两组在脑血管疾病患者的特征上差异有统计学意义(p = 0.03)。原发性和继发性通畅率及无截肢生存率无显著差异。结论混合手术的一次通畅率、二次通畅率和无截肢生存率与单纯旁路手术相当。因此,混合手术是PAD患者可接受的策略。
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引用次数: 5
Novel Surgical Skill Evaluation with Reference to Two-handed Coordination. 参考双手协调的新手术技能评价。
Munenori Uemura, Kazuhito Sakata, Morimasa Tomikawa, Yoshihiro Nagao, Kenoki Ohuchida, Satoshi Ieiri, Tomohiko Akahoshi, Makoto Hashizume

Introduction: We evaluated the differences in instrument manipulation skills between expert laparoscopic surgeons and novices.

Methods: Six expert surgeons who had performed more than 500 laparoscopic surgeries and one skilled instructor at Kyushu University Training Center for Minimally Invasive Surgery, and 20 medical students who had experienced no laparoscopic surgery were enrolled. A new skill assessment task was designed using zippers on an unstable, mobile platform in a box trainer. The examinees were asked to close the zippers, while trying to avoid moving the platform. The path lengths of the tips of the instruments and of the platform were measured, and the performance time was also recorded. Surgical skill score was calculated from the correlation between the path lengths of the instruments and that of the platform, in addition to the performance time.

Results: The path lengths of the tips of both instruments and of the platform were significantly shorter in the experts than in the novices (all p < 0.05). The performance time was also significantly shorter for experts than novices (p < 0.05). The surgical skill score was significantly higher for experts than novices (p < 0.01).

Conclusion: The differences in the instrument manipulation skills between expert laparoscopic surgeons and novices could therefore be evaluated using our surgical skill scoring system.

简介:我们评估了专家腹腔镜外科医生和新手在器械操作技巧上的差异。方法:选取九州大学微创外科培训中心完成500例以上腹腔镜手术的6名专家外科医生和1名熟练的指导医生,以及20名没有腹腔镜手术经验的医学生。设计了一种新的技能评估任务,在一个不稳定的移动平台上使用拉链。考生被要求拉上拉链,同时尽量避免移动平台。测量了仪器尖端和平台尖端的路径长度,并记录了运行时间。手术技能评分根据器械路径长度和平台路径长度的相关性以及手术时间计算。结果:专家组器械尖端路径长度和平台路径长度均明显短于新手组(p < 0.05)。专家的表演时间也显著短于新手(p < 0.05)。专科医师的手术技能评分明显高于新手(p < 0.01)。结论:使用我们的手术技巧评分系统可以评估专家腹腔镜外科医生和新手在器械操作技巧上的差异。
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引用次数: 0
Survival with Collateral Circulation after Gastrointestinal Ischemia Caused by Aortic Dissection: A Case Report. 主动脉夹层引起胃肠缺血后伴侧支循环存活1例。
Eiji Kusumoto, Kazuya Endo, Mitsuhiko Ota, Norifumi Tsutsumi, Kenkichi Hashimoto, Akinori Egashira, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Koji Ikejiri

We report a case of a 43-year-old man who presented with gradually intensifying abdominal pain of acute onset and was shown by contrast-enhanced computed tomography (CT) examination to have acute aortic dissection (Stanford type B). A diagnosis of gastrointestinal necrosis was made and he underwent emergency surgery. At laparoscopy, he was found to have no superior mesenteric arterial pulse and intestinal necrosis from the upper jejunum to the right transverse colon. Resection of the superior mesenteric artery (SMA) perfusion area was performed. Postoperatively, ischemia in the perfusion area of the celiac artery was also diagnosed, manifesting as gallbladder necrosis, portal vein gas accompanying gastric wall necrosis, perforation of the remaining upper jejunum, and hepatic and splenic infarction. However, development of a collateral circulation originating in the left colic branch of the inferior mesenteric artery (IMA) enabled retrograde provision of blood to the celiac artery through the SMA pancreaticoduodenal arcade. Thus, in this case, spontaneous development of a natural bypass created a new route for arterial perfusion, contributing to the patient's survival. When ischemia of the celiac artery and SMA perfusion areas occur, collateral circulation can develop from the IMA.

我们报告一例43岁男性患者,急性发作腹痛逐渐加重,CT增强检查显示为急性主动脉夹层(Stanford B型),诊断为胃肠坏死,并接受紧急手术。腹腔镜检查发现患者肠系膜上动脉无脉搏,从空肠上部至右横结肠均有肠坏死。切除肠系膜上动脉(SMA)灌注区。术后还诊断腹腔动脉灌注区缺血,表现为胆囊坏死、门静脉气体伴胃壁坏死、剩余上空肠穿孔、肝脾梗死。然而,起源于肠系膜下动脉(IMA)左结肠分支的侧支循环的发展使得血液通过SMA胰十二指肠拱桥向腹腔动脉逆行供应。因此,在本例中,自然旁路的自发发展为动脉灌注创造了新的途径,有助于患者的生存。当腹腔动脉和SMA灌注区发生缺血时,IMA可形成侧支循环。
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引用次数: 0
Avulsion Fracture of the Tibial Tuberosity Requiring Meniscal Repair: A Case Report. 胫骨粗隆撕脱骨折需半月板修复一例报告。
Naohide Takeuchi, Kousuke Sasaki, Takao Mae, Yukihide Iwamoto

Avulsion fractures of the tibial tuberosity are uncommon injuries. A 16-year-old male sustained injuries to his right knee joint after jumping from stairs and landed on his feet with his right knee forced into flexion. X-ray photographs showed a type III avulsion fracture of the tibial tuberosity. On the next day of the injury, open reduction and internal fixation, followed by arthroscopy was performed. The fracture fragment was fixed with three 5.0mm cannulated cancellous screws. The torn anterior portion of medial meniscus was repaired with 3-0 Polydioxanone (PDS) using outside-in sutures and the torn midportion of medial meniscus was repaired using the FasT-Fix meniscal repair system. Eight months after the injury, removal of the screws and arthroscopy were undertaken. The medial meniscus was completely healed. The range of motion was full at the knee joint. Meniscal suture should be strongly considered for type III avulsion fractures of the tibial tuberosity in adolescents.

胫骨粗隆撕脱骨折是一种罕见的损伤。一名16岁的男性从楼梯上跳下来,右膝盖被迫弯曲,右膝关节受伤。x线照片显示胫骨结节撕脱性骨折III型。在受伤的第二天进行切开复位和内固定,然后进行关节镜检查。骨折碎片用3枚5.0mm空心松质螺钉固定。采用3-0聚二恶酮(PDS)外置缝合修复内侧半月板前部撕裂,采用FasT-Fix半月板修复系统修复内侧半月板中部撕裂。伤后8个月,取下螺钉并进行关节镜检查。内侧半月板完全愈合。膝关节的活动范围很广。对于青少年III型胫骨结节撕脱性骨折,应强烈考虑半月板缝合。
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引用次数: 0
[The Epidemiology of Gastric Cancer: The Hisayama Study]. 胃癌的流行病学:Hisayama研究。
Fumie Ikeda, Yutaka Kiyohasa
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引用次数: 0
Avulsion Fracture of the Tibial Tuberosity Requiring Meniscal Repair: A Case Report. 胫骨粗隆撕脱骨折需半月板修复一例报告。
Pub Date : 2015-06-01 DOI: 10.15017/1518484
N. Takeuchi, K. Sasaki, T. Mae, Y. Iwamoto
Avulsion fractures of the tibial tuberosity are uncommon injuries. A 16-year-old male sustained injuries to his right knee joint after jumping from stairs and landed on his feet with his right knee forced into flexion. X-ray photographs showed a type III avulsion fracture of the tibial tuberosity. On the next day of the injury, open reduction and internal fixation, followed by arthroscopy was performed. The fracture fragment was fixed with three 5.0mm cannulated cancellous screws. The torn anterior portion of medial meniscus was repaired with 3-0 Polydioxanone (PDS) using outside-in sutures and the torn midportion of medial meniscus was repaired using the FasT-Fix meniscal repair system. Eight months after the injury, removal of the screws and arthroscopy were undertaken. The medial meniscus was completely healed. The range of motion was full at the knee joint. Meniscal suture should be strongly considered for type III avulsion fractures of the tibial tuberosity in adolescents.
胫骨粗隆撕脱骨折是一种罕见的损伤。一名16岁的男性从楼梯上跳下来,右膝盖被迫弯曲,右膝关节受伤。x线照片显示胫骨结节撕脱性骨折III型。在受伤的第二天进行切开复位和内固定,然后进行关节镜检查。骨折碎片用3枚5.0mm空心松质螺钉固定。采用3-0聚二恶酮(PDS)外置缝合修复内侧半月板前部撕裂,采用FasT-Fix半月板修复系统修复内侧半月板中部撕裂。伤后8个月,取下螺钉并进行关节镜检查。内侧半月板完全愈合。膝关节的活动范围很广。对于青少年III型胫骨结节撕脱性骨折,应强烈考虑半月板缝合。
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引用次数: 2
[An Autopsy Case of Abnormal Behaviour Induced by Zolpidem]. 唑吡坦致异常行为尸检一例
Yosuke Usumoto, Keiko Kudo, Naomi Sameshima, Kazuo Sato, Akiko Tsuji, Noriaki Ikeda

Zolpidem is a widely used ultrashort-acting non-benzodiazepine in clinical practice; compared with benzodiazepines, it does not have side effects such as daytime hangover, rebound insomnia, and development of tolerance. We report an autopsy case of abnormal behaviour induced by zolpidem. A man in his 60's had suffered from postherpetic neuralgia about 2 months ago and had been prescribed zolpidem for insomnia. According to his family, he had no memory of his actions such as striking a wall, taking his futon outside, and eating 5 times a day after he took zolpidem. Because his postherpetic neuralgia did not improve, he was hospitalized and treated with an epidural block. During hospitalization, he took off his clothes, removed the epidural block catheter by himself, and slept on others' beds. He disappeared from the hospital one day; the next day, he was found dead in a narrow water storage tank 10 km away from the hospital. He was thought to have driven a car by himself to reach the place. Forensic autopsy revealed that the cause of death was drowning. Zolpidem and several other drugs were detected by toxicological analysis of his blood; the concentrations of these drugs were within therapeutic range. There are several reports about somnambulism induced by zolpidem such as sleepwalking, sleep driving, and eating. Considering the strange episodes following zolpidem administration, his behaviour on the day of his death was considered abnormal behaviour induced by zolpidem.

唑吡坦是临床广泛使用的超短效非苯二氮卓类药物;与苯二氮卓类药物相比,它没有白天宿醉、反弹性失眠等副作用,也没有耐受性的发展。我们报告了一例由唑吡坦引起的异常行为的尸检病例。一名60多岁的男子在大约2个月前患了带状疱疹后神经痛,医生给他开了唑吡坦治疗失眠。据他的家人说,在服用唑吡坦后,他对自己的行为没有记忆,比如撞墙、把床垫搬到外面、每天吃5次饭。由于他的带状疱疹后神经痛没有改善,他住院并接受硬膜外阻滞治疗。住院期间,他脱下衣服,自己取下硬膜外阻滞导尿管,睡在别人的床上。有一天他从医院消失了;第二天,他被发现死在离医院10公里远的一个狭窄的水箱里。人们认为他是自己开车去的。法医尸检显示死因是溺水。血液毒理学分析检出唑吡坦等药物;这些药物的浓度在治疗范围内。有一些关于唑吡坦诱发的梦游症的报道,如梦游、睡眠驾驶和睡眠进食。考虑到服用唑吡坦后出现的奇怪事件,其死亡当天的行为可考虑为唑吡坦所致异常行为。
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引用次数: 0
Metabolomics of Salivary Biomarkers in Yusho Patients. 玉树患者唾液生物标志物代谢组学研究
Pub Date : 2015-05-25 DOI: 10.15017/1518359
G. Kawasaki, Yoko Ichikawa, I. Yoshitomi, M. Umeda
Yusho patients had many symptoms, and mouth dryness was one of the important oral symptoms. Presently, some Yusho patients complain of mouth dryness. In the present study, we measured mouth dryness by using an oral moisture checking device and examined metabolites of saliva by using metabolome analysis. We found no difference between Yusho patients and controls in terms of mouth dryness. Concerning metabolomes of saliva, there were some metabolites in Yusho patients that were not in controls.
玉松患者有多种症状,口干是重要的口腔症状之一。目前,一些玉树病人抱怨口干舌燥。在本研究中,我们使用口腔水分检测装置测量口腔干燥度,并使用代谢组学分析检测唾液的代谢物。我们发现玉树病人和对照组在口腔干燥方面没有区别。在唾液代谢组中,有一些代谢产物在玉树患者中没有出现。
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引用次数: 5
[Anti- SSA/Ro and Anti-SSB/ La Antibodies in Patients with Yusho]. [抗SSA/Ro和抗ssb / La抗体在玉露患者中的应用]。
Pub Date : 2015-05-01 DOI: 10.1007/978-3-211-79280-3_69
H. Tsuji
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引用次数: 0
[Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients]. [二恶英半衰期与鱼穗患者AhR中snp的关系]。
Shinya Matsumoto, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Kiyomi Tsukimori, Norio Wake, Chikage Mitoma, Hiroshi Uchi, Masutaka Furue, Tomoaki Imamura

Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF. We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n = 11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

玉树患者血中2,3,4,7,8-五氯二苯并呋喃(PeCDF)半衰期各不相同。目的是评估93名玉树患者PeCDF水平半衰期与芳烃受体(AHR)基因rs10249788 SNP类型之间的关系。我们根据身体症状、年龄、性别、体质指数等因素,建立合适的计算公式,拟合实际PeCDF水平和PeCDF变化率。我们发现C/T SNP患者的半衰期比C/C和T/T SNP患者的半衰期更长。已知T/T SNP患者表达更高数量的AHR mrna。然而,由于T/T组患者数量有限(n = 11),无法进行详细的分析。需要进一步的研究来确定C/T患者半衰期较长的原因。
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引用次数: 0
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Fukuoka igaku zasshi = Hukuoka acta medica
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