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2018 IEEE International Work Conference on Bioinspired Intelligence (IWOBI)最新文献

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Parallelization of a Denoising Algorithm for Tonal Bioacoustic Signals Using OpenACC Directives 利用OpenACC指令并行化音调生物声信号去噪算法
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464129
J. Castro, E. Meneses
Automatic segmentation and classification methods for bioacoustic signals enable real-time monitoring, population estimation, as well as other important tasks for the conservation, management, and study of wildlife. These methods normally require a filter or a denoising strategy to enhance relevant information in the input signal and avoid false positive detections. This denoising stage is usually the performance bottleneck of such methods. In this paper, we parallelize a denoising algorithm for tonal bioacoustic signals using mainly OpenACC directives. The implemented program was executed in both multicore and GPU architectures. The proposed parallelized algorithm achieves a higher speedup on GPU than CPU, leading to a 10.67 speedup compared to the original sequential algorithm in C++.
生物声信号的自动分割和分类方法为野生动物的保护、管理和研究提供了实时监测、种群估计和其他重要任务。这些方法通常需要一个滤波器或去噪策略来增强输入信号中的相关信息,避免误报检测。这一去噪阶段通常是这类方法的性能瓶颈。在本文中,我们主要使用OpenACC指令并行化音调生物声学信号的去噪算法。所实现的程序在多核和GPU架构下均可执行。本文提出的并行化算法在GPU上比在CPU上实现了更高的加速,与原来的顺序算法相比,在c++中实现了10.67的加速。
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引用次数: 4
A Systems Biology Approach to Investigate Control Targets of Intracellular Calcium Transients Induced by Clostridium Perfringens Phospholipase C 用系统生物学方法研究产气荚膜梭菌磷脂酶C诱导细胞内钙瞬变的控制靶点
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464200
L. Brenes-Guillén, Man-Sai Acón-Chan, R. Mora-Rodríguez, Laura Monturiol-Gross
Clostridium perfringens phospholipase C (CpPLC) plays a key role in the pathogenesis of gas gangrene, an acute and life-threatening infection in humans. CpPLC leads to the unregulated production of second messengers, such as calcium, and activates important signaling pathways like PKC, MEK, and NFkB, inducing ROS production, that leads towards cellular damage. We propose a systems biology approach to identify potential microRNAs which could be used as tools to explore the role of calcium channels in the mechanism of action of CpPLC, and eventually as therapeutic agents that render cells less sensitive to this toxin. Results show that miR19B1 and miR449B are interesting candidate targets which perturbations may affect the expression of genes involved in calcium transport. This approach may be useful to elucidate calcium molecular interactions involved in the CpPLC mechanism of action.
产气荚膜梭菌磷脂酶C (CpPLC)在气性坏疽的发病机制中起关键作用,气性坏疽是一种危及生命的急性感染。CpPLC导致第二信使(如钙)不受调节的产生,并激活PKC、MEK和NFkB等重要信号通路,诱导ROS的产生,从而导致细胞损伤。我们提出了一种系统生物学方法来鉴定潜在的microrna,这些microrna可以作为工具来探索钙通道在CpPLC作用机制中的作用,并最终作为治疗药物,使细胞对这种毒素不那么敏感。结果表明,miR19B1和miR449B是可能影响钙转运相关基因表达的有趣的候选靶点。这种方法可能有助于阐明钙分子相互作用参与CpPLC的作用机制。
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引用次数: 1
Comparative Analysis of de Bruijn Graph Parallel Genome Assemblers de Bruijn图平行基因组组装器的比较分析
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464194
Carlos Gamboa-Venegas, Esteban Meneses
Finding the genome of new species remains as one of the most crucial tasks in molecular biology. To achieve that end, de novo sequence assembly feeds from the vast amount of data provided by Next-Generation Sequencing technology. Therefore, genome assemblers demand a high amount of computational resources, and parallel implementations of those assemblers are readily available. This paper presents a comparison of three well-known de novo genome assemblers: Velvet, ABySS and SOAPdenovo, all of them using de Bruijn graphs and having a parallel implementation. We based our analysis on parallel execution time, scalability, quality of assembly, and sensitivity to the choice of a critical parameter (k- mer size). We found one of the tools clearly stands out for providing faster execution time and better quality in the output. Also, all assemblers are mildly sensitive to the choice of k-mer size and they all show limited scalability. We expect the findings of this paper provide a guide to the development of new algorithms and tools for scalable parallel genome sequence assemblers.
寻找新物种的基因组仍然是分子生物学中最重要的任务之一。为了实现这一目标,从头序列组装从下一代测序技术提供的大量数据中获取信息。因此,基因组组装器需要大量的计算资源,而这些组装器的并行实现很容易获得。本文比较了三个著名的从头基因组组装器:Velvet, ABySS和SOAPdenovo,它们都使用de Bruijn图并具有并行实现。我们的分析基于并行执行时间、可扩展性、装配质量和对关键参数(k- mer尺寸)选择的敏感性。我们发现其中一个工具在提供更快的执行时间和更好的输出质量方面非常突出。此外,所有汇编程序对k-mer大小的选择都比较敏感,它们都显示出有限的可扩展性。我们期望本文的发现为可扩展的并行基因组序列组装器的新算法和工具的开发提供指导。
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引用次数: 4
A Multilingual System Based on Semantic Knowledge for Complex Environments 复杂环境下基于语义知识的多语言系统
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464207
K. L. D. Ipiña, N. Barroso, P. Calvo, A. Ezeiza, Carmen Hernández
This paper presents a system for the management of audio information based on semantic knowledge in complex environments. These environments are defined by: the limited resources (audio corpora); the poor quality of the signal (internet radio); the trilingual context (Basque, French and Spanish); the cross-lingual elements between the languages; and the critical under-resourced situation of the Basque minority language. Evolutionary methods have been applied to fulfill the specifications based on: folksonomies, automatic configuration selection, and collaborative networks. The resulting system includes a multilingual ASR engine that is able to tackle under-resourced languages with a very small audio corpus.
提出了一种基于语义知识的复杂环境下音频信息管理系统。这些环境的定义是:有限的资源(音频语料库);信号质量差(网络无线电);三语语境(巴斯克语、法语和西班牙语);两种语言之间的跨语言因素;以及巴斯克少数民族语言资源严重不足的情况。已经应用了进化方法来实现基于:大众分类法、自动配置选择和协作网络的规范。由此产生的系统包括一个多语言ASR引擎,能够用非常小的音频语料库处理资源不足的语言。
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引用次数: 1
Localization of Facial Landmarks in Depth Images Using Gated Multiple Ridge Descent 基于门控多重脊下降的深度图像人脸特征定位
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464215
J. Krizaj, Ž. Emeršič, S. Dobrišek, P. Peer, Vitomir Štruc
A novel method for automatic facial landmark localization is presented. The method builds on the supervised descent framework, which was shown to successfully localize landmarks in the presence of large expression variations and mild occlusions, but struggles when localizing landmarks on faces with large pose variations. We propose an extension of the supervised descent framework that trains multiple descent maps and results in increased robustness to pose variations. The performance of the proposed method is demonstrated on the Bosphorus, the FRGC and the UND data sets for the problem of facial landmark localization from 3D data. Our experimental results show that the proposed method exhibits increased robustness to pose variations, while retaining high performance in the case of expression and occlusion variations.
提出了一种新的人脸标记自动定位方法。该方法建立在监督下降框架的基础上,该框架在存在大的表情变化和轻微遮挡的情况下成功地定位了地标,但在具有大姿态变化的面部上定位地标时却遇到了困难。我们提出了一种监督下降框架的扩展,该框架可以训练多个下降图,从而提高对姿态变化的鲁棒性。在Bosphorus、FRGC和UND数据集上验证了该方法在三维人脸地标定位问题上的性能。实验结果表明,该方法对姿态变化的鲁棒性增强,同时在表达和遮挡变化的情况下保持高性能。
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引用次数: 8
Towards Accessories-Aware Ear Recognition 面向配件感知耳朵识别
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464138
Ž. Emeršič, Nil Oleart Playà, Vitomir Štruc, P. Peer
Automatic ear recognition is gaining popularity within the research community due to numerous desirable properties, such as high recognition performance, the possibility of capturing ear images at a distance and in a covert manner, etc. Despite this popularity and the corresponding research effort that is being directed towards ear recognition technology, open problems still remain. One of the most important issues stopping ear recognition systems from being widely available are ear occlusions and accessories. Ear accessories not only mask biometric features and by this reduce the overall recognition performance, but also introduce new non-biometric features that can be exploited for spoofing purposes. Ignoring ear accessories during recognition can, therefore, present a security threat to ear recognition and also adversely affect performance. Despite the importance of this topic there has been, to the best of our knowledge, no ear recognition studies that would address these problems. In this work we try to close this gap and study the impact of ear accessories on the recognition performance of several state-of-the-art ear recognition techniques. We consider ear accessories as a tool for spoofing attacks and show that CNN-based recognition approaches are more susceptible to spoofing attacks than traditional descriptor-based approaches. Furthermore, we demonstrate that using inpainting techniques or average coloring can mitigate the problems caused by ear accessories and slightly outperforms (standard) black color to mask ear accessories.
由于具有许多理想的特性,例如高识别性能、远距离和隐蔽方式捕获耳朵图像的可能性等,自动耳朵识别在研究界越来越受欢迎。尽管耳朵识别技术很受欢迎,相关的研究工作也在进行中,但仍然存在一些问题。阻止耳朵识别系统广泛使用的最重要的问题之一是耳朵堵塞和附件。耳饰不仅掩盖了生物特征,从而降低了整体识别性能,而且还引入了新的非生物特征,可以用于欺骗目的。因此,在识别过程中忽略耳附件会对耳朵识别带来安全威胁,也会对性能产生不利影响。尽管这个话题很重要,但据我们所知,还没有耳朵识别研究能解决这些问题。在这项工作中,我们试图缩小这一差距,并研究耳附件对几种最先进的耳朵识别技术的识别性能的影响。我们将耳附件视为欺骗攻击的工具,并表明基于cnn的识别方法比传统的基于描述符的方法更容易受到欺骗攻击。此外,我们证明了使用涂漆技术或平均着色可以减轻耳饰引起的问题,并且略优于(标准)黑色来掩盖耳饰。
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引用次数: 8
Simple Graph Comparison Inspired on Metabolic Pathway Correlation 基于代谢途径相关性的简单图比较
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464212
Esteban Arias-Méndez, Alonso Montero-Marín, Danny Chaves-Chaves, F. Torres-Rojas
Comparing two graphs is a computationally difficult task [9], [8]. After a work by E. Arias-Mendez and F. Torres-Rojas [7] about the correlation of metabolic pathways with two new proposed approaches to simplify the comparison of its associated graph representation, we extended this work to general graph structures as a simple way to compare them. The approach presented here is an extension of those algorithms to general graphs. The first algorithm proposed looks to transform the comparing graphs into linear sequences, to be analyzed using sequence-alignment tools from bioinformatics and get a numeric score as its value of similitude. The second proposed algorithm consists of the search of equal connected nodes between 2 graphs to eliminate then on both structures, only leaving the differences, as heuristic for comparison. These algorithms were developed as a low-cost process to correlate metabolic pathways showing good results; the suggestion is to use this information as a previous analysis to a deeper, more expensive, comparing tools use. Here we review the extension of this work as an application to a more general graph data structure. These methods have shown to be an effective way to treat the problem as listed in the results section.
比较两个图是一个计算困难的任务[9],[8]。在E. Arias-Mendez和F. Torres-Rojas b[7]关于代谢途径与两种新提出的简化其相关图表示比较的方法的相关性的工作之后,我们将这项工作扩展到一般图结构,作为比较它们的简单方法。这里提出的方法是将这些算法扩展到一般图。提出的第一种算法将比较图转换为线性序列,使用生物信息学的序列比对工具进行分析,并获得数字分数作为其相似性值。第二种算法包括搜索两个图之间的相等连接节点,以消除两个结构上的节点,只留下差异,作为比较的启发式。这些算法被开发为一种低成本的过程,以关联代谢途径,显示出良好的结果;建议将此信息用作更深入、更昂贵的工具使用比较的前一个分析。在这里,我们回顾一下将这项工作扩展到更一般的图数据结构中的应用。这些方法已被证明是处理结果部分列出的问题的有效方法。
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引用次数: 2
Modeling Gene Dosage Compensation Mediated by Sensor Loops in Large-Scale Mathematical Models of Microrna-Transcription Factor Networks 微rna-转录因子网络大尺度数学模型中传感器回路介导的基因剂量补偿建模
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464210
Man-Sai Acón-Chan, Francisco Siles Canales, R. Mora-Rodríguez
In a previous work we developed a biocomputational platform to automatically construct mathematical models of microRNA-transcription factor (TF) regulatory network to study gene dosage compensation. We hypothesized that gene dosage compensation maintains the viability of tumoral cells with high levels of chromosomal alterations by down regulating the expression of a core group of compensated genes. Here we report that those compensated candidates form clusters according to their chromosomal locations and they share the connections of a large-scale network of putative interactions with miRNAs and TFs. Although initial models of feed-forward loops do not show gene dosage compensation, we simplified the model by including only sensor loops of experimentally validated interactions. A sensor loop allows a gene to sense and react to fluctuations of its own expression. The resulting model shows gene dosage compensation for MYC and STAT3 but the genetic regulation of these two genes can be extended to co-regulate the expression of other compensated genes. These results contribute to the identification of a network of gene dosage compensation, which manipulation of specific nodes has the potential to become a novel approach to specifically target aneuploid cancer cells.
在之前的工作中,我们开发了一个生物计算平台,用于自动构建microrna -转录因子(TF)调控网络的数学模型,以研究基因剂量补偿。我们假设基因剂量补偿通过下调一组核心补偿基因的表达来维持具有高水平染色体改变的肿瘤细胞的活力。在这里,我们报告了这些补偿候选者根据其染色体位置形成簇,并且它们共享与mirna和tf相互作用的大规模网络的连接。虽然前馈回路的初始模型不显示基因剂量补偿,但我们通过只包括实验验证的相互作用的传感器回路来简化模型。传感器回路允许基因感知并对其自身表达的波动做出反应。该模型显示基因剂量补偿MYC和STAT3,但这两个基因的遗传调控可以扩展到共同调节其他补偿基因的表达。这些结果有助于确定基因剂量补偿网络,对特定节点的操作有可能成为特异性靶向非整倍体癌细胞的新方法。
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引用次数: 0
A Dreaming Approach to Perceptual Class Delimitation Within the DREAM Architecture 梦境结构中感知类划分的做梦方法
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464201
J. Becerra, R. Duro, J. Monroy, F. Bellas
Perceptual classes allow cognitive systems to organize the continuous perceptual space they are usually faced with into discrete categories so that planning and long-term prospection can take place. However, for the correct operation of the system it is quite important that the perceptual classes are precisely delimited in order to prevent classification errors that would lead to planning and prediction errors. In this paper we propose a simple but effective mechanism that makes use of the prospective capabilities of a cognitive architecture during a dreaming phase in order to allow it to generate hypotheses on the delimitation of perceptual classes. These hypotheses are later tested as the system interacts with the world when in an awake state.
感知类允许认知系统将它们通常面临的连续感知空间组织成离散的类别,以便进行规划和长期展望。然而,为了系统的正确运行,精确划分感知类是非常重要的,以防止分类错误导致规划和预测错误。在本文中,我们提出了一种简单而有效的机制,利用认知结构在做梦阶段的预期能力,以允许它产生关于感知类别划分的假设。当系统在清醒状态下与外界互动时,这些假设随后会得到验证。
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引用次数: 1
Using Deep Convolutional Networks for Species Identification of Xylotheque Samples 基于深度卷积网络的木质素样本物种识别
Pub Date : 2018-07-01 DOI: 10.1109/IWOBI.2018.8464216
Geovanni Figueroa-Mata, Erick Mata-Montero, Juan Carlos Valverde-Otarola, Dagoberto Arias-Aguilar
Forest species identification is critical to scientifically support many environmental, commercial, forensic, archaeological, and paleontological actividades. Therefore, it is very important to develop fast and accurate identification systems. We present a deep CNN for automated forest species identification based on macroscopic images of wood cuts. We first implement and study a modified version of the LeNet convolutional network, which is trained from scratch with a database of macroscopic images of 41 forest species of the Brazilian flora. With this network we achieve a top-1 accuracy of 93.6%. Additionally, we fine-tune the Resnet50 model with pre-trained weights on Imagenet to reach a top-1 accuracy of 98.03%, which improves previous published results of research on the same image database.
森林物种鉴定对于科学支持许多环境、商业、法医、考古和古生物学活动至关重要。因此,开发快速、准确的识别系统显得尤为重要。提出了一种基于宏观木刻图像的深度CNN森林物种自动识别方法。我们首先实现并研究了LeNet卷积网络的改进版本,该网络是用巴西41种森林植物的宏观图像数据库从头开始训练的。通过这个网络,我们实现了93.6%的前一名准确率。此外,我们在Imagenet上使用预训练的权值对Resnet50模型进行了微调,达到了98.03%的top-1准确率,提高了之前在同一图像数据库上发表的研究结果。
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引用次数: 10
期刊
2018 IEEE International Work Conference on Bioinspired Intelligence (IWOBI)
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