首页 > 最新文献

Graefe's Archive for Clinical and Experimental Ophthalmology最新文献

英文 中文
MicroRNA expression profiling in tears and blood as predictive biomarkers for anti-VEGF treatment response in wet age-related macular degeneration 泪液和血液中的微RNA表达谱分析是湿性老年性黄斑变性患者抗血管内皮生长因子治疗反应的预测性生物标志物
Pub Date : 2024-04-06 DOI: 10.1007/s00417-024-06478-x

Abstract

Purpose

This study aimed to investigate the potential of microRNAs (miRNAs) in tears, blood, and aqueous humor as biomarkers for predicting treatment response in wet age-related macular degeneration (AMD) patients undergoing anti-vascular endothelial growth factor (anti-VEGF) therapy.

Methods

In a single-center prospective cohort study, treatment-naïve wet AMD patients and age-matched controls were enrolled. Clinical data and miRNA levels (miR-199a-3p, miR-365-3p, miR-200b-3p, miR-195-5p, miR-335-5p, and miR-185-5p) in tears, blood, and aqueous humor were collected. Treatment response was categorized into responders and non-responders based on visual acuity and central subfield thickness. MiRNA levels were quantified using reverse-transcription PCR. Statistical analyses were performed, including ROC analysis, to evaluate predictive accuracy.

Results

Dysregulated miRNA profiles were observed in wet AMD tears and blood compared to controls. Specifically, miR-199a-3p, miR-195-5p, and miR-185-5p were upregulated, while miR-200b-3p was downregulated in tears. All six miRNAs were elevated in wet AMD blood samples. Notably, responders showed higher tear expression of miR-195-5p and miR-185-5p. Combining these miRNAs yielded the highest predictive power (AUC = 0.878, p = 0.006) for anti-VEGF responders.

Conclusions

Dysregulated miRNA profiles in tears and blood suggest their potential as biomarkers for wet AMD. MiR-195-5p and miR-185-5p in tears demonstrate predictive value for anti-VEGF treatment responders. This study underscores the non-invasive prediction potential of miRNA tear analysis in wet AMD treatment responses.

摘要 目的 本研究旨在探讨泪液、血液和房水中的微RNA(miRNA)作为生物标志物的潜力,以预测接受抗血管内皮生长因子(anti-VEGF)治疗的湿性年龄相关性黄斑变性(AMD)患者的治疗反应。 方法 在一项单中心前瞻性队列研究中,招募了治疗无效的湿性 AMD 患者和年龄匹配的对照组。研究人员收集了临床数据以及泪液、血液和房水中的 miRNA 水平(miR-199a-3p、miR-365-3p、miR-200b-3p、miR-195-5p、miR-335-5p 和 miR-185-5p)。根据视力和中央子场厚度将治疗反应分为有反应者和无反应者。使用反转录 PCR 对 MiRNA 水平进行量化。进行统计分析,包括 ROC 分析,以评估预测的准确性。 结果 与对照组相比,在湿性 AMD 泪液和血液中观察到了失调的 miRNA 图谱。具体来说,泪液中的 miR-199a-3p、miR-195-5p 和 miR-185-5p 上调,而 miR-200b-3p 下调。所有六种 miRNA 在湿性 AMD 血液样本中都升高了。值得注意的是,应答者的泪液中 miR-195-5p 和 miR-185-5p 表达较高。将这些 miRNA 结合起来,对抗 VEGF 反应者的预测能力最高(AUC = 0.878,p = 0.006)。 结论 泪液和血液中失调的 miRNA 图谱表明它们有可能成为湿性 AMD 的生物标记物。泪液中的 miR-195-5p 和 miR-185-5p 对抗 VEGF 治疗应答者具有预测价值。这项研究强调了泪液中 miRNA 分析在湿性 AMD 治疗反应中的非侵入性预测潜力。
{"title":"MicroRNA expression profiling in tears and blood as predictive biomarkers for anti-VEGF treatment response in wet age-related macular degeneration","authors":"","doi":"10.1007/s00417-024-06478-x","DOIUrl":"https://doi.org/10.1007/s00417-024-06478-x","url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Purpose</h3> <p>This study aimed to investigate the potential of microRNAs (miRNAs) in tears, blood, and aqueous humor as biomarkers for predicting treatment response in wet age-related macular degeneration (AMD) patients undergoing anti-vascular endothelial growth factor (anti-VEGF) therapy.</p> </span> <span> <h3>Methods</h3> <p>In a single-center prospective cohort study, treatment-naïve wet AMD patients and age-matched controls were enrolled. Clinical data and miRNA levels (miR-199a-3p, miR-365-3p, miR-200b-3p, miR-195-5p, miR-335-5p, and miR-185-5p) in tears, blood, and aqueous humor were collected. Treatment response was categorized into responders and non-responders based on visual acuity and central subfield thickness. MiRNA levels were quantified using reverse-transcription PCR. Statistical analyses were performed, including ROC analysis, to evaluate predictive accuracy.</p> </span> <span> <h3>Results</h3> <p>Dysregulated miRNA profiles were observed in wet AMD tears and blood compared to controls. Specifically, miR-199a-3p, miR-195-5p, and miR-185-5p were upregulated, while miR-200b-3p was downregulated in tears. All six miRNAs were elevated in wet AMD blood samples. Notably, responders showed higher tear expression of miR-195-5p and miR-185-5p. Combining these miRNAs yielded the highest predictive power (AUC = 0.878, <em>p</em> = 0.006) for anti-VEGF responders.</p> </span> <span> <h3>Conclusions</h3> <p>Dysregulated miRNA profiles in tears and blood suggest their potential as biomarkers for wet AMD. MiR-195-5p and miR-185-5p in tears demonstrate predictive value for anti-VEGF treatment responders. This study underscores the non-invasive prediction potential of miRNA tear analysis in wet AMD treatment responses.</p> </span>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with early hydroxychloroquine-induced retinal toxicity in patients with systemic lupus erythematosus 系统性红斑狼疮患者早期羟氯喹诱发视网膜毒性的相关因素
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06461-6
Olga Araújo, Halbert Hernández-Negrín, Ricardo P. Casaroli-Marano, José Hernández-Rodríguez, Alfredo Adán, Gerard Espinosa, Laura Pelegrín, Ricard Cervera

Purpose

Hydroxychloroquine is currently recommended for the treatment of systemic lupus erythematosus (SLE), but it can cause irreversible retinal toxicity. This study aimed to identify factors associated with early hydroxychloroquine-induced retinal toxicity in patients with SLE from a single centre for 20 years.

Methods

SLE patients diagnosed between 1998 and 2017 and followed up for at least 1 year were included. Demographic, clinical, laboratory and therapeutic data were collected from the electronic medical records and retrospectively analysed. Early hydroxychloroquine-induced retinal toxicity was defined as the development of macular toxicity within the first 5 years of hydroxychloroquine treatment.

Results

A total of 345 patients followed for a median of 15 years were analysed; 337 (97.7%) patients received hydroxychloroquine, 38 (11.3%) of them presented with retinal toxicity, and 10 (3%) developed early retinal toxicity. These patients had a mean treatment duration of 3.3 years with a mean cumulative dose of 241 g. Patients were diagnosed by visual field (VF) and fundoscopy, and two were also assessed using spectral domain optical coherence tomography (SD-OCT). The median (IQR) age of patients with early toxicity was 56 (51–66) years, and 80% were female. Factors independently associated with early hydroxychloroquine-induced retinal toxicity were lupus anticoagulant positivity (OR 4.2; 95% CI 1.2–15.5) and hypercholesterolaemia (OR 5.6; 95% CI 1.5–21.5).

Conclusion

Our results suggest that lupus anticoagulant positivity and hypercholesterolaemia among SLE patients may be risk factors for early hydroxychloroquine-induced retinal toxicity, regardless of the dose or duration of treatment.

目的羟氯喹是目前推荐用于治疗系统性红斑狼疮(SLE)的药物,但它可能导致不可逆的视网膜毒性。本研究旨在确定一个单一中心20年来系统性红斑狼疮患者早期羟氯喹诱发视网膜毒性的相关因素。方法纳入1998年至2017年间确诊并随访至少1年的系统性红斑狼疮患者。从电子病历中收集人口统计学、临床、实验室和治疗数据,并进行回顾性分析。结果 共分析了345名随访时间中位数为15年的患者,其中337人(97.7%)接受了羟氯喹治疗,38人(11.3%)出现视网膜毒性,10人(3%)出现早期视网膜毒性。这些患者的平均治疗时间为 3.3 年,平均累积剂量为 241 克。患者通过视野(VF)和眼底镜检查进行诊断,其中两名患者还通过光谱域光学相干断层扫描(SD-OCT)进行了评估。早期毒性患者的中位(IQR)年龄为 56(51-66)岁,80% 为女性。结论我们的研究结果表明,系统性红斑狼疮患者中的狼疮抗凝物阳性和高胆固醇血症可能是羟氯喹诱发早期视网膜毒性的危险因素,与治疗剂量或疗程无关。
{"title":"Factors associated with early hydroxychloroquine-induced retinal toxicity in patients with systemic lupus erythematosus","authors":"Olga Araújo, Halbert Hernández-Negrín, Ricardo P. Casaroli-Marano, José Hernández-Rodríguez, Alfredo Adán, Gerard Espinosa, Laura Pelegrín, Ricard Cervera","doi":"10.1007/s00417-024-06461-6","DOIUrl":"https://doi.org/10.1007/s00417-024-06461-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Hydroxychloroquine is currently recommended for the treatment of systemic lupus erythematosus (SLE), but it can cause irreversible retinal toxicity. This study aimed to identify factors associated with early hydroxychloroquine-induced retinal toxicity in patients with SLE from a single centre for 20 years.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>SLE patients diagnosed between 1998 and 2017 and followed up for at least 1 year were included. Demographic, clinical, laboratory and therapeutic data were collected from the electronic medical records and retrospectively analysed. Early hydroxychloroquine-induced retinal toxicity was defined as the development of macular toxicity within the first 5 years of hydroxychloroquine treatment.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 345 patients followed for a median of 15 years were analysed; 337 (97.7%) patients received hydroxychloroquine, 38 (11.3%) of them presented with retinal toxicity, and 10 (3%) developed early retinal toxicity. These patients had a mean treatment duration of 3.3 years with a mean cumulative dose of 241 g. Patients were diagnosed by visual field (VF) and fundoscopy, and two were also assessed using spectral domain optical coherence tomography (SD-OCT). The median (IQR) age of patients with early toxicity was 56 (51–66) years, and 80% were female. Factors independently associated with early hydroxychloroquine-induced retinal toxicity were lupus anticoagulant positivity (OR 4.2; 95% CI 1.2–15.5) and hypercholesterolaemia (OR 5.6; 95% CI 1.5–21.5).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Our results suggest that lupus anticoagulant positivity and hypercholesterolaemia among SLE patients may be risk factors for early hydroxychloroquine-induced retinal toxicity, regardless of the dose or duration of treatment.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Following prevalence of myopia in a large Swiss military cohort over the last decade: where is the European “myopia boom”? 过去十年间,瑞士军队中近视眼的流行情况:欧洲的 "近视热潮 "在哪里?
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06467-0

Abstract

Purpose

Myopia prevalence is increasing globally, with the highest rates found in Asia. Data from European countries is scarce. We aimed to investigate whether the prevalence of myopia is rising in our meridians.

Methods

Data from male military conscripts for the recruitment period of 2008–2017 were retrospectively analyzed. Year of recruitment, conscripts’ birth year, visual acuity, refractive status (spherical equivalent), and spectacle wear (yes/no) were available.

Results

The dataset contained data of a total of 355,657 male conscripts, who had been recruited in the years 2008 to 2017. The mean number of conscripts per year was 35,566 (MD = 35,440, SD = 1249), reaching a minimum number of 33,998 conscripts in 2017 and a maximum of 37,594 in 2011. Mean age at recruitment was 19.7 years (MD = 19.0 years, SD = 1.1 years). Overall, the number of conscripts wearing spectacles remained stable over the observation time; on average 29.6% (n = 10,540; MD = 10,472; SD = 492) of conscripts wore glasses at recruitment. Of 21.8% (n = 77,698) of conscripts, data on the refractive status was available: The mean spherical equivalent for both right and left eyes was -2.3D (MD = -2 D, SD = 2.4 D). No decrease in mean spherical equivalent per recruitment year was noted over the observation period. Estimated myopia prevalence reached an average of 27.5% (SD = 0.8%) and did not increase during the observation period.

Conclusion

In summary, no change in spherical equivalent refractive errors of male Swiss army conscripts was found for the years 2008–2017. Equally, the percentage of spectacle wearers (MN = 29.6%) and estimated myopia prevalence (MN = 27.5%) did not significantly increase during the observation time.

Trial registration: BASEC 2019-00060 (18/01/2019)

摘要 目的 近视发病率在全球范围内呈上升趋势,其中亚洲的发病率最高。欧洲国家的数据很少。我们旨在调查近视患病率是否在我国经区有所上升。 方法 回顾性分析了 2008-2017 年期间应征入伍的男性数据。数据包括征兵年份、应征者出生年份、视力、屈光状态(球面等效)和佩戴眼镜情况(是/否)。 结果 数据集包含 2008 年至 2017 年期间招募的 355 657 名应征男兵的数据。每年应征入伍的平均人数为 35 566 人(MD = 35 440,SD = 1249),2017 年应征入伍人数最少,为 33 998 人,2011 年最多,为 37 594 人。征兵时的平均年龄为 19.7 岁(MD = 19.0 岁,SD = 1.1 岁)。总体而言,戴眼镜的新兵人数在观察期间保持稳定;平均 29.6%(n = 10,540; MD = 10,472; SD = 492)的新兵在入伍时戴眼镜。21.8%的应征者(n = 77 698)有屈光状态数据:左右眼的平均球面等效视力均为-2.3D(MD = -2 D,SD = 2.4 D)。在观察期间,每招募一年的平均球面等值没有下降。估计近视率平均为 27.5%(SD = 0.8%),在观察期内没有增加。 结论 综上所述,2008 年至 2017 年期间,瑞士男性应征入伍者的球面等效屈光不正没有发生变化。同样,在观察期间,佩戴眼镜的比例(MN = 29.6%)和估计近视率(MN = 27.5%)也没有显著增加。试验注册:BASEC 2019-00060 (18/01/2019)
{"title":"Following prevalence of myopia in a large Swiss military cohort over the last decade: where is the European “myopia boom”?","authors":"","doi":"10.1007/s00417-024-06467-0","DOIUrl":"https://doi.org/10.1007/s00417-024-06467-0","url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Purpose</h3> <p>Myopia prevalence is increasing globally, with the highest rates found in Asia. Data from European countries is scarce. We aimed to investigate whether the prevalence of myopia is rising in our meridians.</p> </span> <span> <h3>Methods</h3> <p>Data from male military conscripts for the recruitment period of 2008–2017 were retrospectively analyzed. Year of recruitment, conscripts’ birth year, visual acuity, refractive status (spherical equivalent), and spectacle wear (yes/no) were available.</p> </span> <span> <h3>Results</h3> <p>The dataset contained data of a total of 355,657 male conscripts, who had been recruited in the years 2008 to 2017. The mean number of conscripts per year was 35,566 (MD = 35,440, SD = 1249), reaching a minimum number of 33,998 conscripts in 2017 and a maximum of 37,594 in 2011. Mean age at recruitment was 19.7 years (MD = 19.0 years, SD = 1.1 years). Overall, the number of conscripts wearing spectacles remained stable over the observation time; on average 29.6% (<em>n</em> = 10,540; MD = 10,472; SD = 492) of conscripts wore glasses at recruitment. Of 21.8% (<em>n</em> = 77,698) of conscripts, data on the refractive status was available: The mean spherical equivalent for both right and left eyes was -2.3D (MD = -2 D, SD = 2.4 D). No decrease in mean spherical equivalent per recruitment year was noted over the observation period. Estimated myopia prevalence reached an average of 27.5% (SD = 0.8%) and did not increase during the observation period.</p> </span> <span> <h3>Conclusion</h3> <p>In summary, no change in spherical equivalent refractive errors of male Swiss army conscripts was found for the years 2008–2017. Equally, the percentage of spectacle wearers (MN = 29.6%) and estimated myopia prevalence (MN = 27.5%) did not significantly increase during the observation time.</p> <p><strong>Trial registration</strong>: BASEC 2019-00060 (18/01/2019)</p> <p><span> <span> <img alt=\"\" src=\"https://static-content.springer.com/image/MediaObjects/417_2024_6467_Figa_HTML.png\"/> </span> </span></p> </span>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rehabilitation of amblyopia using a digital platform for visual training combined with patching in children: a prospective study 前瞻性研究:利用数字平台对儿童进行视觉训练,并结合视力矫正治疗弱视
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06475-0
Carlos J. Hernández-Rodríguez, Patricia Ferrer-Soldevila, Alberto Artola-Roig, David P. Piñero

Purpose

To assess the possible benefits of the use of perceptual learning and dichoptic therapy combined with patching in children with amblyopia over the use of only patching.

Methods

Quasi-experimental multicentric study including 52 amblyopic children. Patients who improved their visual acuity (VA) by combining spectacles and patching were included in patching group (PG: 20 subjects), whereas those that did not improved with patching performed visual training (perceptual learning + dichoptic therapy) combined with patching, being assigned to the visual treatment group (VT: 32 subjects). Changes in VA, contrast sensitivity (CS), and stereopsis were monitored during a 6-month follow-up in each group.

Results

Significant improvements in VA were found in both groups at 1 month (p < 0.01). The total improvement of VA was 0.18 ± 0.16 and 0.31 ± 0.35 logMAR in PG and VT groups, respectively (p = 0.317). The Wilcoxon effect size was slightly higher in VT (0.48 vs. 0.54) at 6 months. An enhancement in CS was observed in the amblyopic eye of the VT group for all spatial frequencies at 1 month (p < 0.001). Likewise, the binocular function score also increased significantly in VT group (p = 0.002). A prediction equation of VA improvement at 1 month in VT group was obtained by multiple linear regression analysis (p < 0.001, R2 = 0.747).

Conclusions

A combined treatment of visual training and patching is effective for obtaining a predictable improvement of VA, CS, and binocularity in patching-resistant amblyopic children.

目的 评估在弱视儿童中结合使用知觉学习和二分法疗法以及视力贴片疗法可能比仅使用视力贴片疗法带来的益处。方法 包括 52 名弱视儿童在内的多中心准实验研究。通过眼镜和视力矫正治疗提高视力(VA)的患者被归入视力矫正组(PG:20 名受试者),而那些视力矫正后没有提高的患者则被归入视觉治疗组(VT:32 名受试者)。在为期 6 个月的随访中,对每组受试者的视力、对比敏感度(CS)和立体视的变化进行了监测。结果发现,两组受试者的视力在 1 个月后均有显著改善(p < 0.01)。PG 组和 VT 组的视力总改善分别为 0.18 ± 0.16 和 0.31 ± 0.35 logMAR(p = 0.317)。6 个月时,VT 组的 Wilcoxon 效应大小略高(0.48 对 0.54)。在 1 个月时,VT 组弱视眼所有空间频率的 CS 均有所提高(p < 0.001)。同样,VT 组的双眼功能评分也显著增加(p = 0.002)。通过多元线性回归分析,得出了 VT 组 1 个月时视力改善的预测方程(p < 0.001,R2 = 0.747)。
{"title":"Rehabilitation of amblyopia using a digital platform for visual training combined with patching in children: a prospective study","authors":"Carlos J. Hernández-Rodríguez, Patricia Ferrer-Soldevila, Alberto Artola-Roig, David P. Piñero","doi":"10.1007/s00417-024-06475-0","DOIUrl":"https://doi.org/10.1007/s00417-024-06475-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To assess the possible benefits of the use of perceptual learning and dichoptic therapy combined with patching in children with amblyopia over the use of only patching.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Quasi-experimental multicentric study including 52 amblyopic children. Patients who improved their visual acuity (VA) by combining spectacles and patching were included in patching group (PG: 20 subjects), whereas those that did not improved with patching performed visual training (perceptual learning + dichoptic therapy) combined with patching, being assigned to the visual treatment group (VT: 32 subjects). Changes in VA, contrast sensitivity (CS), and stereopsis were monitored during a 6-month follow-up in each group.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Significant improvements in VA were found in both groups at 1 month (<i>p</i> &lt; 0.01). The total improvement of VA was 0.18 ± 0.16 and 0.31 ± 0.35 logMAR in PG and VT groups, respectively (<i>p</i> = 0.317). The Wilcoxon effect size was slightly higher in VT (0.48 vs. 0.54) at 6 months. An enhancement in CS was observed in the amblyopic eye of the VT group for all spatial frequencies at 1 month (<i>p</i> &lt; 0.001). Likewise, the binocular function score also increased significantly in VT group (<i>p</i> = 0.002). A prediction equation of VA improvement at 1 month in VT group was obtained by multiple linear regression analysis (<i>p</i> &lt; 0.001, <i>R</i><sup>2</sup> = 0.747).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>A combined treatment of visual training and patching is effective for obtaining a predictable improvement of VA, CS, and binocularity in patching-resistant amblyopic children.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety, structure and function five years after hESC-RPE patch transplantation in acute neovascular AMD with submacular haemorrhage 急性新生血管性黄斑变性伴黄斑下出血患者移植 hESC-RPE 补丁五年后的安全性、结构和功能
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06463-4
Taha Soomro, Odysseus Georgiadis, Peter J. Coffey, Lyndon da Cruz
{"title":"Safety, structure and function five years after hESC-RPE patch transplantation in acute neovascular AMD with submacular haemorrhage","authors":"Taha Soomro, Odysseus Georgiadis, Peter J. Coffey, Lyndon da Cruz","doi":"10.1007/s00417-024-06463-4","DOIUrl":"https://doi.org/10.1007/s00417-024-06463-4","url":null,"abstract":"","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic impact of hyperreflective foci in nonsyndromic retinitis pigmentosa 非综合征视网膜色素变性中高反射灶的预后影响
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06474-1
Raquel Félix, Nuno Gouveia, João Bernardes, Rufino Silva, Joaquim Murta, João Pedro Marques

Purpose

To evaluate the prognostic impact of hyperreflective foci (HRF) on spectral-domain optical coherence tomography (SD-OCT) in nonsyndromic retinitis pigmentosa (RP).

Methods

Retrospective, single-center cohort study including genetically-tested RP patients with a minimum follow-up of 24 months. Clinical data including demographics, genetic results and best-corrected visual acuity (BCVA) at baseline and follow-up were collected. Horizontal and vertical SD-OCT scans were analyzed by 2 independent graders. Outer nuclear layer (ONL) thickness and ellipsoid zone (EZ) width were manually measured in horizontal and vertical scans. HRF were classified according to location: outer retinal layers within the central 3mm (central-HRF), outer retinal layers beyond the central 3mm (perifoveal-HRF), and choroid (choroidal-HRF). Central macular thickness (CMT), central point thickness (CPT) and choroidal thickness (CT) at baseline and follow-up were also recorded.

Results

A total of 175 eyes from 94 RP patients (47.9% female, mean age 50.7±15.5 years) were included, with a mean follow-up of 29.24±7.17 months. Mean ETDRS (early treatment diabetic retinopathy study) BCVA decreased from 61.09±23.54 to 56.09±26.65 (p=0.082). At baseline, 72 eyes (41.1%) showed central-HRF, 110 eyes (62.9%) had perifoveal-HRF and 149 eyes (85.1%) exhibited choroidal-HRF. Central-HRF and perifoveal-HRF were associated with worse final BCVA, as well as greater BCVA deterioration (all p<0.0029). Only central-HRF were associated with a worse final CMT (p<0.001). Shorter EZ widths were associated with all types of HRF (p<0.05). Perifoveal and choroidal-HRF predicted smaller final EZ areas (p<0.01).

Conclusion

HRF are highly prevalent in RP patients and appear to have a negative prognostic impact in visual function and EZ area.

目的评估光谱域光学相干断层扫描(SD-OCT)对非综合征性视网膜色素变性(RP)患者高反射灶(HRF)预后的影响。方法回顾性、单中心队列研究,包括至少随访 24 个月的经过基因检测的 RP 患者。研究收集了基线和随访时的临床数据,包括人口统计学、基因检测结果和最佳矫正视力(BCVA)。水平和垂直 SD-OCT 扫描由两名独立的分级人员进行分析。水平和垂直扫描中的核外层(ONL)厚度和椭圆体区(EZ)宽度由人工测量。HRF根据位置分类:中央3毫米以内的视网膜外层(中央-HRF)、中央3毫米以外的视网膜外层(眼周-HRF)和脉络膜(脉络膜-HRF)。结果 共纳入 94 名 RP 患者(47.9% 为女性,平均年龄(50.7±15.5)岁)的 175 只眼睛,平均随访时间为(29.24±7.17)个月。平均 ETDRS(早期治疗糖尿病视网膜病变研究)BCVA 从 61.09±23.54 降至 56.09±26.65(P=0.082)。基线时,72 只眼睛(41.1%)显示中央-HRF,110 只眼睛(62.9%)显示眼底周围-HRF,149 只眼睛(85.1%)显示脉络膜-HRF。中心-HRF 和眼底周围-HRF 与最终 BCVA 变差以及 BCVA 恶化程度增加有关(所有 p<0.0029)。只有中央-HRF 与最终 CMT 的恶化有关(p<0.001)。较短的 EZ 宽度与所有类型的 HRF 都相关(p<0.05)。结论HRF在RP患者中非常普遍,似乎对视觉功能和EZ面积的预后有负面影响。
{"title":"Prognostic impact of hyperreflective foci in nonsyndromic retinitis pigmentosa","authors":"Raquel Félix, Nuno Gouveia, João Bernardes, Rufino Silva, Joaquim Murta, João Pedro Marques","doi":"10.1007/s00417-024-06474-1","DOIUrl":"https://doi.org/10.1007/s00417-024-06474-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To evaluate the prognostic impact of hyperreflective foci (HRF) on spectral-domain optical coherence tomography (SD-OCT) in nonsyndromic retinitis pigmentosa (RP).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Retrospective, single-center cohort study including genetically-tested RP patients with a minimum follow-up of 24 months. Clinical data including demographics, genetic results and best-corrected visual acuity (BCVA) at baseline and follow-up were collected. Horizontal and vertical SD-OCT scans were analyzed by 2 independent graders. Outer nuclear layer (ONL) thickness and ellipsoid zone (EZ) width were manually measured in horizontal and vertical scans. HRF were classified according to location: outer retinal layers within the central 3mm (central-HRF), outer retinal layers beyond the central 3mm (perifoveal-HRF), and choroid (choroidal-HRF). Central macular thickness (CMT), central point thickness (CPT) and choroidal thickness (CT) at baseline and follow-up were also recorded.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 175 eyes from 94 RP patients (47.9% female, mean age 50.7±15.5 years) were included, with a mean follow-up of 29.24±7.17 months. Mean ETDRS (early treatment diabetic retinopathy study) BCVA decreased from 61.09±23.54 to 56.09±26.65 (<i>p</i>=0.082). At baseline, 72 eyes (41.1%) showed central-HRF, 110 eyes (62.9%) had perifoveal-HRF and 149 eyes (85.1%) exhibited choroidal-HRF. Central-HRF and perifoveal-HRF were associated with worse final BCVA, as well as greater BCVA deterioration (all <i>p</i>&lt;0.0029). Only central-HRF were associated with a worse final CMT (<i>p</i>&lt;0.001). Shorter EZ widths were associated with all types of HRF (<i>p</i>&lt;0.05). Perifoveal and choroidal-HRF predicted smaller final EZ areas (<i>p</i>&lt;0.01).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>HRF are highly prevalent in RP patients and appear to have a negative prognostic impact in visual function and EZ area.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral vitrectomy in patients with proliferative diabetic retinopathy—characteristics and surgical outcomes 增殖性糖尿病视网膜病变患者的双侧玻璃体切除术的特点和手术效果
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06462-5
Yun Hsia, Chung-May Yang

Purpose

Comparing characteristics and outcomes of patients with bilateral proliferative diabetic retinopathy (PDR) undergoing concurrent and sequential vitrectomy.

Methods

Patients having bilateral vitrectomy were classified into concurrent (requiring bilateral surgery simultaneously) and sequential (indicating vitrectomy in one eye later) groups. Clinical characteristics and outcomes were compared, and correlation between the first and second-operated eyes was analyzed.

Results

One hundred eight and 126 eyes were in the concurrent and sequential groups, respectively. The sequential group was older (50 vs. 45 years, P = 0.017), had less retinal detachment (54 vs. 77%, P < 0.001), and better visual outcomes (0.79 vs. 1.30, P = 0.021), especially the second-operated eyes. The concurrent group had weaker correlations of disease severity (phi coefficient: 0.36 vs. 0.61) and post-operative visual acuity (r: 0.12 vs. 0.34) between the first- and second-operated eyes than the sequential group. Prior intravitreal injection of anti-vascular endothelial growth factor (odds ratio [OR] 0.37, 95% confidence interval [CI] 0.15–0.86, P = 0.025) predicted better outcomes, while post-operative neovascular glaucoma predicted worse outcomes (OR 6.5, 95% CI 1.7–27.9, P = 0.008).

Conclusions

PDR patients requiring surgery concurrently were younger and had more severe diseases and worse outcomes. However, poor outcomes in the first eye did not predict similar outcomes in the second eye.

方法 将接受双侧玻璃体切除术的患者分为同期组(需要同时进行双侧手术)和顺序组(表示稍后在一只眼上进行玻璃体切除术),比较双侧增殖性糖尿病视网膜病变(PDR)患者同时接受玻璃体切除术和顺序接受玻璃体切除术的特征和结果。结果 同时手术组和顺序手术组分别有 188 眼和 126 眼。顺序组的年龄较大(50 岁对 45 岁,P = 0.017),视网膜脱离较少(54% 对 77%,P <0.001),视觉效果较好(0.79 对 1.30,P = 0.021),尤其是第二次手术的眼睛。与顺序组相比,同期组第一只眼和第二只眼的疾病严重程度(phi 系数:0.36 vs. 0.61)和术后视力(r:0.12 vs. 0.34)的相关性较弱。曾在玻璃体内注射抗血管内皮生长因子(几率比[OR]0.37,95% 置信区间[CI]0.15-0.86,P = 0.025)预示着较好的预后,而术后新生血管性青光眼预示着较差的预后(OR 6.5,95% CI 1.7-27.9,P = 0.008)。然而,第一只眼睛的不良预后并不能预测第二只眼睛的类似预后。
{"title":"Bilateral vitrectomy in patients with proliferative diabetic retinopathy—characteristics and surgical outcomes","authors":"Yun Hsia, Chung-May Yang","doi":"10.1007/s00417-024-06462-5","DOIUrl":"https://doi.org/10.1007/s00417-024-06462-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Comparing characteristics and outcomes of patients with bilateral proliferative diabetic retinopathy (PDR) undergoing concurrent and sequential vitrectomy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Patients having bilateral vitrectomy were classified into concurrent (requiring bilateral surgery simultaneously) and sequential (indicating vitrectomy in one eye later) groups. Clinical characteristics and outcomes were compared, and correlation between the first and second-operated eyes was analyzed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>One hundred eight and 126 eyes were in the concurrent and sequential groups, respectively. The sequential group was older (50 vs. 45 years, <i>P</i> = 0.017), had less retinal detachment (54 vs. 77%, <i>P</i> &lt; 0.001), and better visual outcomes (0.79 vs. 1.30, <i>P</i> = 0.021), especially the second-operated eyes. The concurrent group had weaker correlations of disease severity (phi coefficient: 0.36 vs. 0.61) and post-operative visual acuity (<i>r</i>: 0.12 vs. 0.34) between the first- and second-operated eyes than the sequential group. Prior intravitreal injection of anti-vascular endothelial growth factor (odds ratio [OR] 0.37, 95% confidence interval [CI] 0.15–0.86, <i>P</i> = 0.025) predicted better outcomes, while post-operative neovascular glaucoma predicted worse outcomes (OR 6.5, 95% CI 1.7–27.9, <i>P</i> = 0.008).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>PDR patients requiring surgery concurrently were younger and had more severe diseases and worse outcomes. However, poor outcomes in the first eye did not predict similar outcomes in the second eye.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"371 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in intraocular pressure following intravitreal dexamethasone implant in patients with history of glaucoma filtration surgery 有青光眼滤过手术史的患者在玻璃体内植入地塞米松后眼压的变化
Pub Date : 2024-04-05 DOI: 10.1007/s00417-024-06468-z
Dong Kyu Lee, Joo Yong Lee, Se Joon Woo, Yong Sok Ji, Christopher Seungkyu Lee

Purpose

This study aimed to evaluate changes in intraocular pressure following intravitreal dexamethasone implant injection, specifically in patients undergoing glaucoma filtration surgery.

Methods

The degree of increase in intraocular pressure was compared retrospectively among three groups. Group 1 comprised patients who underwent prior glaucoma filtration surgery (54 eyes). Group 2 included patients with or suspected glaucoma without such surgical history (20 eyes). Group 3 included patients without glaucoma (33 eyes). Pressure measurements were taken before the injection and at 1, 2, 3, and 6 months post-injection. A subgroup analysis was performed for pressure > 35 mmHg, > 30 mmHg, > 25 mmHg, and a difference > 10 mmHg between the peak and baseline pressure.

Results

Group 1 consistently displayed lower pressures compared with Group 2, with significant difference at both 1- and 6-month post-injections (15.09 mmHg vs. 18.10 mmHg, P = 0.042 and 13.91 mg vs. 17.25 mmHg, P = 0.040). The proportion of patients in Group 1 and Group 3 with pressures > 25 mmHg, > 30 mmHg, and a difference > 10 mmHg did not significantly differ (15.6% vs. 9.5%, P = 0.231; 3.1% vs. 2.3%, P = 0.867; and 17.1% vs. 7.1%, P = 0.231). Notably, Group 2 exhibited a significantly higher proportion within each category (> 25 mmHg, 24.0%; > 30 mmHg, 20.0%; > 10 mmHg difference, 28.0%).

Conclusion

Intravitreal dexamethasone implant did not increase the risk of elevated intraocular pressure in patients with a history of glaucoma filtration surgery compared with patients with suspected glaucoma; the risk was similar to those without glaucoma.

目的 本研究旨在评估玻璃体内注射地塞米松植入物后眼压的变化,特别是接受青光眼滤过手术患者的眼压变化。第一组包括曾接受青光眼滤过手术的患者(54 眼)。第二组包括无此类手术史的青光眼患者或疑似青光眼患者(20 眼)。第 3 组包括无青光眼的患者(33 眼)。在注射前和注射后 1、2、3 和 6 个月测量眼压。结果 第一组的眼压始终低于第二组,注射后 1 个月和 6 个月的眼压差异显著(15.09 mmHg 对 18.10 mmHg,P = 0.042;13.91 mg 对 17.25 mmHg,P = 0.040)。第 1 组和第 3 组中血压大于 25 mmHg、大于 30 mmHg 和相差大于 10 mmHg 的患者比例没有显著差异(15.6% 对 9.5%,P = 0.231;3.1% 对 2.3%,P = 0.867;17.1% 对 7.1%,P = 0.231)。结论与疑似青光眼患者相比,有青光眼滤过手术史的患者使用静脉滴注地塞米松不会增加眼压升高的风险,其风险与无青光眼患者相似。
{"title":"Changes in intraocular pressure following intravitreal dexamethasone implant in patients with history of glaucoma filtration surgery","authors":"Dong Kyu Lee, Joo Yong Lee, Se Joon Woo, Yong Sok Ji, Christopher Seungkyu Lee","doi":"10.1007/s00417-024-06468-z","DOIUrl":"https://doi.org/10.1007/s00417-024-06468-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study aimed to evaluate changes in intraocular pressure following intravitreal dexamethasone implant injection, specifically in patients undergoing glaucoma filtration surgery.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The degree of increase in intraocular pressure was compared retrospectively among three groups. Group 1 comprised patients who underwent prior glaucoma filtration surgery (54 eyes). Group 2 included patients with or suspected glaucoma without such surgical history (20 eyes). Group 3 included patients without glaucoma (33 eyes). Pressure measurements were taken before the injection and at 1, 2, 3, and 6 months post-injection. A subgroup analysis was performed for pressure &gt; 35 mmHg, &gt; 30 mmHg, &gt; 25 mmHg, and a difference &gt; 10 mmHg between the peak and baseline pressure.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Group 1 consistently displayed lower pressures compared with Group 2, with significant difference at both 1- and 6-month post-injections (15.09 mmHg vs. 18.10 mmHg, <i>P</i> = 0.042 and 13.91 mg vs. 17.25 mmHg, <i>P</i> = 0.040). The proportion of patients in Group 1 and Group 3 with pressures &gt; 25 mmHg, &gt; 30 mmHg, and a difference &gt; 10 mmHg did not significantly differ (15.6% vs. 9.5%, <i>P</i> = 0.231; 3.1% vs. 2.3%, <i>P</i> = 0.867; and 17.1% vs. 7.1%, <i>P</i> = 0.231). Notably, Group 2 exhibited a significantly higher proportion within each category (&gt; 25 mmHg, 24.0%; &gt; 30 mmHg, 20.0%; &gt; 10 mmHg difference, 28.0%).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Intravitreal dexamethasone implant did not increase the risk of elevated intraocular pressure in patients with a history of glaucoma filtration surgery compared with patients with suspected glaucoma; the risk was similar to those without glaucoma.</p>\u0000","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ESASO classification relevance in the diagnosis and evolution in diabetic macular edema patients after dexamethasone implant treatment ESASO分类与地塞米松植入治疗后糖尿病黄斑水肿患者的诊断和病情发展的相关性
Pub Date : 2024-04-04 DOI: 10.1007/s00417-024-06473-2
Almudena Moreno-Martínez, Cristina Blanco-Marchite, Fernando Andres-Pretel, Francisco López-Martínez, Antonio Donate-Tercero, Eva González-Aquino, Carlos Cava-Valenciano, Giacomo Panozzo, Sergio Copete

Purpose

To assess the clinical relevance of The European School for Advanced Studies in Ophthalmology (ESASO) classification in patients with diabetic macular edema (DME) after their first dexamethasone implant (DEXI) treatment.

Methods

Retrospective real-world study conducted on consecutive DME patients who underwent DEXI treatment and were controlled at month-2. Subjects were initially classified according to the ESASO classification stages. The outcomes were anatomical biomarkers with spectral-domain optical coherence tomography (SD-OCT) and best-corrected visual acuity (BCVA).

Results

A total of 128 patients were classified according to ESASO classification stages as early (7; 5.5%), advanced (100; 78.1%), and severe (21; 16.4%). At baseline, there were significant differences between stages in BCVA, central macular thickness (CMT), and tomography anatomical biomarkers (p < 0.05). Initial BCVA (logMAR) was 0.33 ± 0.10, 0.58 ± 0.34, and 0.71 ± 0.35 in the early, advanced, and severe stages, respectively (p < 0.05). At month-2, BCVA was 0.17 ± 0.15, 0.46 ± 0.29, and 0.69 ± 0.27 in those classified as early, advanced, and severe stages, respectively. At month-2, DME was resolved or improved in 6 (85.7%), 60 (60%), and 12 (60%) patients classified as early, advanced, and severe stages, respectively.

Conclusions

There was a good correlation between BCVA and ESASO classification stages. Patients in the severe stage did not achieve visual acuity improvement over the study period.

目的 评估欧洲眼科高等研究学院(ESASO)对首次接受地塞米松植入剂(DEXI)治疗后的糖尿病性黄斑水肿(DME)患者进行分期的临床意义。研究对象最初根据 ESASO 分级进行分类。结果 共有128名患者根据ESASO分期被分为早期(7人,占5.5%)、晚期(100人,占78.1%)和重度(21人,占16.4%)。基线时,各分期在 BCVA、黄斑中心厚度 (CMT) 和断层扫描解剖生物标记物方面存在显著差异(P < 0.05)。早期、晚期和重度患者的初始 BCVA(logMAR)分别为 0.33 ± 0.10、0.58 ± 0.34 和 0.71 ± 0.35(p < 0.05)。第 2 个月时,早期、晚期和重度患者的 BCVA 分别为 0.17 ± 0.15、0.46 ± 0.29 和 0.69 ± 0.27。第 2 个月时,早期、晚期和重度患者中分别有 6 人(85.7%)、60 人(60%)和 12 人(60%)的 DME 得到缓解或改善。重度患者在研究期间视力没有改善。
{"title":"ESASO classification relevance in the diagnosis and evolution in diabetic macular edema patients after dexamethasone implant treatment","authors":"Almudena Moreno-Martínez, Cristina Blanco-Marchite, Fernando Andres-Pretel, Francisco López-Martínez, Antonio Donate-Tercero, Eva González-Aquino, Carlos Cava-Valenciano, Giacomo Panozzo, Sergio Copete","doi":"10.1007/s00417-024-06473-2","DOIUrl":"https://doi.org/10.1007/s00417-024-06473-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To assess the clinical relevance of The European School for Advanced Studies in Ophthalmology (ESASO) classification in patients with diabetic macular edema (DME) after their first dexamethasone implant (DEXI) treatment.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Retrospective real-world study conducted on consecutive DME patients who underwent DEXI treatment and were controlled at month-2. Subjects were initially classified according to the ESASO classification stages. The outcomes were anatomical biomarkers with spectral-domain optical coherence tomography (SD-OCT) and best-corrected visual acuity (BCVA).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 128 patients were classified according to ESASO classification stages as early (7; 5.5%), advanced (100; 78.1%), and severe (21; 16.4%). At baseline, there were significant differences between stages in BCVA, central macular thickness (CMT), and tomography anatomical biomarkers (<i>p</i> &lt; 0.05). Initial BCVA (logMAR) was 0.33 ± 0.10, 0.58 ± 0.34, and 0.71 ± 0.35 in the early, advanced, and severe stages, respectively (<i>p</i> &lt; 0.05). At month-2, BCVA was 0.17 ± 0.15, 0.46 ± 0.29, and 0.69 ± 0.27 in those classified as early, advanced, and severe stages, respectively. At month-2, DME was resolved or improved in 6 (85.7%), 60 (60%), and 12 (60%) patients classified as early, advanced, and severe stages, respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>There was a good correlation between BCVA and ESASO classification stages. Patients in the severe stage did not achieve visual acuity improvement over the study period.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large language models as assistance for glaucoma surgical cases: a ChatGPT vs. Google Gemini comparison 作为青光眼手术病例辅助工具的大型语言模型:ChatGPT 与 Google Gemini 的比较
Pub Date : 2024-04-04 DOI: 10.1007/s00417-024-06470-5
Matteo Mario Carlà, Gloria Gambini, Antonio Baldascino, Francesco Boselli, Federico Giannuzzi, Fabio Margollicci, Stanislao Rizzo

Purpose

The aim of this study was to define the capability of ChatGPT-4 and Google Gemini in analyzing detailed glaucoma case descriptions and suggesting an accurate surgical plan.

Methods

Retrospective analysis of 60 medical records of surgical glaucoma was divided into “ordinary” (n = 40) and “challenging” (n = 20) scenarios. Case descriptions were entered into ChatGPT and Bard’s interfaces with the question “What kind of surgery would you perform?” and repeated three times to analyze the answers’ consistency. After collecting the answers, we assessed the level of agreement with the unified opinion of three glaucoma surgeons. Moreover, we graded the quality of the responses with scores from 1 (poor quality) to 5 (excellent quality), according to the Global Quality Score (GQS) and compared the results.

Results

ChatGPT surgical choice was consistent with those of glaucoma specialists in 35/60 cases (58%), compared to 19/60 (32%) of Gemini (p = 0.0001). Gemini was not able to complete the task in 16 cases (27%). Trabeculectomy was the most frequent choice for both chatbots (53% and 50% for ChatGPT and Gemini, respectively). In “challenging” cases, ChatGPT agreed with specialists in 9/20 choices (45%), outperforming Google Gemini performances (4/20, 20%). Overall, GQS scores were 3.5 ± 1.2 and 2.1 ± 1.5 for ChatGPT and Gemini (p = 0.002). This difference was even more marked if focusing only on “challenging” cases (1.5 ± 1.4 vs. 3.0 ± 1.5, p = 0.001).

Conclusion

ChatGPT-4 showed a good analysis performance for glaucoma surgical cases, either ordinary or challenging. On the other side, Google Gemini showed strong limitations in this setting, presenting high rates of unprecise or missed answers.

方法对 60 份青光眼手术病历进行回顾性分析,将其分为 "普通"(40 份)和 "挑战"(20 份)两种情况。将病例描述输入 ChatGPT 和 Bard 的界面,问题为 "您会实施哪种手术?",并重复三次以分析答案的一致性。收集答案后,我们评估了与三位青光眼外科医生统一意见的一致程度。此外,我们还根据全球质量评分(GQS)对回答的质量进行了分级,从1分(质量差)到5分(质量优)不等,并对结果进行了比较。结果ChatGPT在35/60个病例(58%)中的手术选择与青光眼专家的意见一致,而Gemini在19/60个病例(32%)中的手术选择与青光眼专家的意见不一致(P = 0.0001)。Gemini 无法完成任务的有 16 例(27%)。小梁切除术是两个聊天机器人最常见的选择(ChatGPT 和 Gemini 分别为 53% 和 50%)。在 "具有挑战性 "的病例中,ChatGPT 在 9/20 个选择(45%)中与专家意见一致,表现优于 Google Gemini(4/20,20%)。总体而言,ChatGPT 和 Gemini 的 GQS 分数分别为 3.5 ± 1.2 和 2.1 ± 1.5(p = 0.002)。结论 ChatGPT-4 对普通或高难度青光眼手术病例的分析性能良好。另一方面,Google Gemini 在这种情况下表现出很强的局限性,不精确或漏答率很高。
{"title":"Large language models as assistance for glaucoma surgical cases: a ChatGPT vs. Google Gemini comparison","authors":"Matteo Mario Carlà, Gloria Gambini, Antonio Baldascino, Francesco Boselli, Federico Giannuzzi, Fabio Margollicci, Stanislao Rizzo","doi":"10.1007/s00417-024-06470-5","DOIUrl":"https://doi.org/10.1007/s00417-024-06470-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The aim of this study was to define the capability of ChatGPT-4 and Google Gemini in analyzing detailed glaucoma case descriptions and suggesting an accurate surgical plan.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Retrospective analysis of 60 medical records of surgical glaucoma was divided into “ordinary” (<i>n</i> = 40) and “challenging” (<i>n</i> = 20) scenarios. Case descriptions were entered into ChatGPT and Bard’s interfaces with the question “What kind of surgery would you perform?” and repeated three times to analyze the answers’ consistency. After collecting the answers, we assessed the level of agreement with the unified opinion of three glaucoma surgeons. Moreover, we graded the quality of the responses with scores from 1 (poor quality) to 5 (excellent quality), according to the Global Quality Score (GQS) and compared the results.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>ChatGPT surgical choice was consistent with those of glaucoma specialists in 35/60 cases (58%), compared to 19/60 (32%) of Gemini (<i>p</i> = 0.0001). Gemini was not able to complete the task in 16 cases (27%). Trabeculectomy was the most frequent choice for both chatbots (53% and 50% for ChatGPT and Gemini, respectively). In “challenging” cases, ChatGPT agreed with specialists in 9/20 choices (45%), outperforming Google Gemini performances (4/20, 20%). Overall, GQS scores were 3.5 ± 1.2 and 2.1 ± 1.5 for ChatGPT and Gemini (<i>p</i> = 0.002). This difference was even more marked if focusing only on “challenging” cases (1.5 ± 1.4 vs. 3.0 ± 1.5, <i>p</i> = 0.001).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>ChatGPT-4 showed a good analysis performance for glaucoma surgical cases, either ordinary or challenging. On the other side, Google Gemini showed strong limitations in this setting, presenting high rates of unprecise or missed answers.</p>","PeriodicalId":12748,"journal":{"name":"Graefe's Archive for Clinical and Experimental Ophthalmology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140588393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Graefe's Archive for Clinical and Experimental Ophthalmology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1