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Giant Cell Fibroblastoma of Hand in an Adult: An Uncommon Presentation 成人手部巨细胞成纤维细胞瘤:一种不常见的表现
Pub Date : 2023-08-31 DOI: 10.58999/cijmr.v2i02.23
Akshay Surana, S. Nandedkar, Virendra K. Mehta
Giant cell fibroblastoma is a rare intermediate grade fibrohistiocytic tumour of childhood and even rarer in adults. It is seen in first decade of life. It is known for its recurrence, but its metastasis has never been reported. Giant cell fibroblastoma requires attention as it was previously misdiagnosed as sarcoma.  So histology  is mandatory and remains the gold standard for its diagnosis. We present a case of 21 year old female who presented with complains of painless lesion over the dorsal aspect of left hand.
巨细胞成纤维细胞瘤是一种罕见的儿童中级纤维组织细胞瘤,在成人中更为罕见。它多见于出生后的头十年。它以复发著称,但从未有转移的报道。巨细胞成纤维细胞瘤以前曾被误诊为肉瘤,因此需要引起重视。 因此,组织学检查是必须的,也是诊断的金标准。我们报告了一例 21 岁女性的病例,她主诉左手背出现无痛性病变。
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引用次数: 0
Measurement and Clinical Usefulness of Delta Bilirubin in Liver Disease 肝脏疾病中德尔塔胆红素的测量和临床用途
Pub Date : 2023-08-31 DOI: 10.58999/cijmr.v2i02.116
Anurag Kesarwani, Prashant Nichat, Nikhil Rajak, G. G. Potey
Delta bilirubin is albumin bound conjugated bilirubin that can be calculated by formula [Total bilirubin - (conjugated + unconjugated bilirubin)]. Newer technology like dry chemistry provide conjugated and unconjugated bilirubin fraction which is more specific and informative than direct and indirect bilirubin by conventional method in which only approximate values of conjugated bilirubin can be measured. In cholestasis conjugated bilirubin combines with albumin non enzymatically and form delta bilirubin in circulation and remains for long duration. The present review describes the usefulness of delta bilirubin in cholestasis, chronicity of liver diseases, in pediatric jaundice, transplant rejection and other jaundice condition.clinical correlation of delta bilirubin in all conditions have been summarized and their future perspectives are discussed.
德尔塔胆红素是与白蛋白结合的结合胆红素,其计算公式为[总胆红素-(结合胆红素+非结合胆红素)]。干化学等新技术可提供结合胆红素和非结合胆红素的分数,这比传统方法中的直接胆红素和间接胆红素更具特异性和信息量,因为传统方法只能测量出结合胆红素的近似值。胆汁淤积时,结合胆红素与白蛋白非酶结合,在血液循环中形成δ胆红素,并长期存在。本综述介绍了δ胆红素在胆汁淤积症、慢性肝病、小儿黄疸、移植排斥反应和其他黄疸病症中的作用,总结了δ胆红素在所有病症中的临床相关性,并讨论了其未来前景。
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引用次数: 0
Mullerian Duct Anomaly: Two Patients in Adolescent Age in C. R. Gardi Hospital 穆勒氏管异常:C. R. Gardi 医院的两名青少年患者
Pub Date : 2023-08-31 DOI: 10.58999/cijmr.v2i02.66
Aditi Vashistha, Suchika Agrawal, Surbhi Patidar, P. K. Roy, Case Reports
Clinical manifestations of Mullerian duct abnormalities vary greatly and can range from isolated abnormalities of a single reproductive organ to multiorgan aplasia. An early and precise diagnosis is essential because untreated symptoms may result in pelvic endometriosis, retrograde tubal reflux, and infertility. MRI and ultrasonography are the imaging modality that accurately helps in the diagnosis of mullerian duct anomalies. Two interesting cases came to C. R. Gardi OPD with Mullerian duct anomalies. The first case came with dysmenorrhea and a lower abdominal palpable mass upto 14 wk size was present, which was diagnosed to be bicornuate uterus, obstructed hemivagina. It is a diagnostic dilemma because menses were regular. Another case came with severe cyclic dysmenorrhea and was found to be a hematometra in the non-communicating rudimentary horn on the left side.
穆勒氏管异常的临床表现差异很大,从单个生殖器官的孤立异常到多器官增生都有可能。由于不及时治疗可能会导致盆腔子宫内膜异位症、输卵管逆行返流和不孕症,因此早期准确诊断至关重要。核磁共振成像和超声波检查是准确帮助诊断穆勒管异常的成像方式。C. R. Gardi 手术室接诊了两个有趣的穆勒氏管异常病例。第一个病例伴有痛经,下腹部可触及14周大小的肿块,被诊断为双角子宫、血道阻塞。由于月经规律,这是一个诊断难题。另一个病例伴有严重的周期性痛经,被发现是左侧不沟通的先天性宫角有血子宫。
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引用次数: 0
Drug – Alcohol (Ethyl Alcohol) Interactions 药物与酒精(乙醇)的相互作用
Pub Date : 2023-08-31 DOI: 10.58999/cijmr.v2i02.115
S. P. Dhaneria
Alcohol is the oldest recreational substance, and its consumption is increasing all over the world as it produces a pleasurable effect and also it allows people to relax and unwind. A large number of over the counter and prescription medicine interacts with Alcohol by Pharmacokinetic and/or Pharmacodynamic mechanisms. Alcohol consumption with drugs having CNS depressant property may lead to marked impairment in psychomotor performance and making the person’s injury prone. Alcohol consumption increases the systemic toxicity and organ dysfunction caused by certain drugs. Alcohol consumption may cause unpleasant manifestations with a few drugs/substances (didisulfiram-likeeaction). Alcohol may reduce the therapeutic effect of a few drugs. Awareness about the various interactions of Alcohol with drugs/medicines/food/herbals/occupational agents will ensure the safety of the people consuming Alcohol and may help the physician in clinical decision-making.
酒精是历史最悠久的娱乐性物质,由于它能产生愉悦的效果,还能让人放松和解压,其消费量在全世界不断增加。大量非处方药和处方药会通过药代动力学和/或药效学机制与酒精发生相互作用。酒精与具有中枢神经系统抑制特性的药物一起服用,可能会导致精神运动能力明显减弱,使人容易受伤。饮酒会增加某些药物的全身毒性和器官功能障碍。饮酒可能会使少数药物/物质产生不良反应(类似地索硫铵的作用)。酒精可能会降低少数药物的治疗效果。了解酒精与药物/药品/食品/草药/职业制剂的各种相互作用,可确保饮酒者的安全,并有助于医生做出临床决策。
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引用次数: 0
Post COVID-19 Vaccine-associated Complications COVID-19疫苗相关并发症
Pub Date : 2023-02-09 DOI: 10.58999/cijmr.v1i03.35
A. Tripathi, Ashish Sharma, Dr Himanshu Jain, Chandrakant Salve, Dr Aayush Malik, Tejaswini Dwivedi
The COVID-19 pandemic is being fought against worldwide; the major weapon against this pandemichas been the vaccine against it. There are reports of neurological complications and sequelae afterCOVID-19 vaccinations, some cases with ChAdOx1 nCov-19 is adenovirus vector-based vaccines. InIndia vaccination program against covid19 is using this vaccine by this vaccine. Reports of vaccineassociated side effects have emerged, which are rare but serious. This case series presents a few such cases reported in our hospitals:- RD Gardi Medical college (CR Gardi Hospital, Ujjain) and Charitable trust Hospital, Ujjain.
全球正在抗击新冠肺炎大流行;对付这种大流行病的主要武器是疫苗。有报道称,covid -19疫苗接种后出现神经系统并发症和后遗症,部分病例接种的是ChAdOx1 nCov-19腺病毒载体疫苗。在印度,针对covid - 19的疫苗接种计划正在使用这种疫苗。疫苗相关副作用的报道已经出现,虽然罕见但很严重。本病例系列介绍了在我们医院报告的一些此类病例:RD加尔迪医学院(乌贾因CR加尔迪医院)和乌贾因慈善信托医院。
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引用次数: 0
How to Deal with Sample Size Exploration and its reporting in Clinical Research? 临床研究中如何处理样本量的探索和报告?
Pub Date : 2023-02-09 DOI: 10.58999/cijmr.v1i03.65
S. Dwivedi
The minimum sample size required to answer a specific research question is unavoidable regardlessof study designs, more pertinent in case of randomized controlled trials. Sample size exploration isnot required in many situations, including a pilot study; it is simply decided as feasible or a rule ofthumb. However, in situations, including a conclusive study like the third and final phase of drugdevelopment, it becomes mandatory to ensure optimal power as well as level of confidence to thestudy. The present write-up aims to address various issues related to sample size considerations forclinical studies in a non-statistical language, focusing on making it easily understandable by medicalresearchers.
无论研究设计如何,回答特定研究问题所需的最小样本量都是不可避免的,在随机对照试验中更为相关。在许多情况下,不需要样本量的探索,包括试点研究;它只是被认为是可行的或经验法则。然而,在某些情况下,包括像药物开发的第三和最后阶段这样的结论性研究,必须确保研究的最佳功效和信心水平。本文旨在用一种非统计语言解决与临床研究的样本量考虑相关的各种问题,重点是使医学研究人员易于理解。
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引用次数: 0
Microbiological Profile and Antimicrobial Resistant Pattern among Isolates from Bloodstream Infection in a Tertiary Care Hospital 某三级医院血液感染分离株微生物学特征及耐药模式
Pub Date : 2023-02-09 DOI: 10.58999/cijmr.v1i03.27
Sonali Waske, Pratibha Singh, Soumendra Nath Mathy, Yogyata Maroyhi
Background- Blood stream infection is a very important cause of morbidity and mortality worldwide, especially in resource limited countries. It ranges from transient bacteremia to life-threatening septic shock. Blood culture is a gold standard method of diagnosis of infectious agents present in the blood.Method- This study was conducted From August 2021 to October 2021 at Ruxmaniben Deepchand Gardi medical and Ujjain Charitable trust Hospital, Ujjain (M.P.). All received blood samples were processed, isolates were identified, and antibiotic susceptibility testing was performed using the Vitek 2 Compact (Biomerieux) system in the Microbiology laboratory.Results- A total of 74(17%) pathogens were isolated from 432 blood samples. Gram-positive bacteria 47(64%) were predominant organisms obtained, followed by gram-negative bacteria 25(34%) and non-albicans candida species 2(2.7%). The predominant pathogens were Staphylococcus aureus 40(54%), Klebsiella pneumoniae and Pseudomonas aeruginosa 6(24%) each. Among Staphylococcus aureus isolates 36 (90%) were methicillin-resistant Staphylococcus aureus (MRSA). And among gram-negative bacteria, all isolates of K. pneumoniae were extensively drug-resistant. Majority of drug-resistant organisms were isolated from neonatal intensive care unit (%).Conclusion- Successful treatment of bloodstream infection depends on early diagnosis and appropriate use of antimicrobial agents.
背景-血流感染是世界范围内发病和死亡的重要原因,特别是在资源有限的国家。它的范围从短暂的菌血症到危及生命的感染性休克。血培养是诊断血液中感染因子的金标准方法。方法:本研究于2021年8月至2021年10月在Ujjain (mp)的Ruxmaniben Deepchand Gardi医疗和Ujjain慈善信托医院进行。对所有收到的血液样本进行处理,鉴定分离株,并在微生物学实验室使用Vitek 2 Compact (Biomerieux)系统进行抗生素敏感性试验。结果-从432份血样中共分离出74种病原菌(17%)。革兰氏阳性菌47种(64%),革兰氏阴性菌25种(34%),非白色念珠菌2种(2.7%)。主要病原菌为金黄色葡萄球菌40(54%)、肺炎克雷伯菌和铜绿假单胞菌6(24%)。其中36株(90%)为耐甲氧西林金黄色葡萄球菌(MRSA)。在革兰氏阴性菌中,所有分离株肺炎克雷伯菌均具有广泛耐药。大多数耐药菌来自新生儿重症监护病房(%)。结论:血液感染的成功治疗取决于早期诊断和适当使用抗菌药物。
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引用次数: 0
Undergraduate Medical Research: Perception of First MBBS Students 本科医学研究:第一届MBBS学生的感知
Pub Date : 2022-09-19 DOI: 10.58999/cijmr.v1i02.37
S. Bandaru, Dr. Sai Sailesh kumar Goothy, Anita Choudhary, M. V. K.
Background: Research is essential for the progress of the medical field. The research base should be developed from the undergraduate level itself. Though there are efforts taken by universities to fund Undergraduate research, the involvement of students is not up to the mark.Objective: The present study was undertaken to observe the perceptions of first-year medical students towards undergraduate research.Materials and methods: The present cross-sectional study was conducted at Alluri Sitaramaraju Academy of Medical Sciences (ASRAM) Medical College, Eluru, Andhra Pradesh. A total of 80 willing participants of first-year MBBS were included in the study. Informed consent was obtained duly from all participants. A standard questionnaire was given to students to answer by themselves.Results: 90% of students agreed that research helps them for better learning. 91% of students agreed that research upgrades their knowledge. 96% agreed that research is absolutely needed in the medical field. 23% reported that they will opt for research as a career option. 14% reported that they have knowledge about funding agencies of research. 70% of students reported that they need research to be inculcated in the curriculum.Conclusion: The study highlights that there is a strong need to increase awareness about medical research in undergraduate students and motivate them to apply for funding from agencies like Indian Council of Medical Research, Short Term Studentship and from university funding. Further detailed studies are recommended
背景:医学领域的进步离不开研究。研究基地应该从本科层次本身开始发展。虽然大学在资助本科生的研究方面做出了努力,但学生的参与并没有达到标准。目的:了解医一年级学生对本科科研工作的看法。材料和方法:本横断面研究在安得拉邦Eluru的Alluri Sitaramaraju医学科学院(ASRAM)医学院进行。共有80名自愿参加第一年MBBS的参与者被纳入研究。获得了所有参与者的知情同意。发给学生一份标准问卷,让他们自己回答。结果:90%的学生认为研究有助于他们更好地学习。91%的学生认为研究提升了他们的知识。96%的人同意医学领域绝对需要研究。23%的人表示,他们将选择研究作为职业选择。14%的人表示他们了解研究资助机构。70%的学生报告说,他们需要在课程中灌输研究。结论:该研究强调,迫切需要提高本科生对医学研究的认识,并激励他们向印度医学研究委员会、短期学生奖学金和大学资助等机构申请资助。建议进行更详细的研究
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引用次数: 0
Bilateral Pneumothorax in a case of severe COVID-19 Pneumonia with Pregnancy 重症COVID-19肺炎合并妊娠双侧气胸1例
Pub Date : 2022-09-19 DOI: 10.58999/cijmr.v1i02.30
B. Shah, Ravendra Singh, A. Julka, Swapnil Jain
A 19-year old patient with 8th-month pregnancy was admitted in our hospital with severe COVID infection. She was put on oxygen support and managed as per COVID protocol. She had spontaneous vaginal delivery and the baby was found to be COVID-negative. She developed initially left and later right-sided Pneumothorax. She had prolonged hospitalization and was managed with intercostal drains, NIV, Remdesivir and chest physiotherapy. The pneumothoraxes resolved and she made a satisfactory recovery and could be discharged on room air.
1例妊娠8个月的19岁患者因重症COVID感染入住我院。她被给予氧气支持,并按照COVID协议进行管理。她是自然阴道分娩的,婴儿被发现是阴性的。她先是左侧气胸,后来是右侧气胸。她长期住院,接受肋间引流、NIV、Remdesivir和胸部物理治疗。气胸消退,恢复良好,可在室内空气中出院。
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引用次数: 0
Self-Reliance is the best strategy for development 自力更生是最好的发展战略
Pub Date : 2022-09-19 DOI: 10.58999/cijmr.v1i02.46
V. Diwan
My association with R. D. Gardi Medical College is long. I was a classmate of Dr V. k. Mahadik from 1967 to 1971 as we graduated with MBBS. Later for different reasons I traveled to Zambia and worked for the Government of Zambia Ministry of Health at two districts, Mporokoso and Luwingu, both in the northern province. However, contact with Dr Mahadik was continuous. On my completion of contract in Zambia and on my way to the Bahamas, I visited Ujjain. With other friends, we had discussions about developing a healthcare institution in the form of a hospital. We wanted a cooperative hospital and even contributed funds to this end. However, politicians and individuals advised us to create a charitable trust and a hospital. There are many steps, hard work, and diplomacy, mostly by Dr Mahadik to achieve what is a medical college and other hospitals associated with this. Only a person with imagination, persistence, technical knowledge and patience knows how this could be achieved. In my view, Dr Mahadik has all these qualities.
我与dr . Gardi医学院合作已久。从1967年到1971年,我是V. k. Mahadik博士的同学,我们获得了医学学士学位。后来由于不同的原因,我去了赞比亚,在北部省份姆波罗科索和卢温古两个地区为赞比亚政府卫生部工作。然而,与马哈迪克博士的接触是持续的。我在赞比亚的合同结束后,在去巴哈马的路上,我去了乌贾因。我们和其他朋友讨论了发展医院形式的医疗机构。我们想要一个合作医院,甚至为此捐款。然而,政治家和个人建议我们创建慈善信托和医院。有许多步骤,艰苦的工作和外交,主要是由Mahadik博士实现的,这是一个医学院和其他医院相关的。只有具有想象力、毅力、技术知识和耐心的人才知道如何做到这一点。在我看来,马哈迪克博士具备所有这些品质。
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引用次数: 0
期刊
Central India Journal of Medical Research
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