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A Rare Case Report of Herpes Simplex Virus Encephalitis and Herpes Zoster Skin Lesion: Its Diagnosis and Treatment 单纯疱疹病毒脑炎和带状疱疹皮损的罕见病例报告:诊断与治疗
Pub Date : 2024-07-11 DOI: 10.56557/jocrims/2024/v10i18774
Akshatha, Bharathi, Greeshma Raju, S. V. Naik, Syed Mohammed Hussaini
Herpes Simplex Virus (HSV) encephalitis and Herpes Zoster skin lesions are both caused by different strains of the herpes virus. Herpes Simplex Virus (HSV) encephalitis is caused by the Herpes Simplex Virus (HSV), typically HSV-1, while Herpes Zoster, commonly known as shingles, is caused by the Varicella-Zoster Virus (VZV), which is also a member of the herpesvirus family. This is a case report of HSVE with HZ in a 65 year’s old male patient admitted to hospital with chief complaints of erythematous fluid filled rash over abdomen since 1 week, two episodes of generalised type seizures involved all four limbs and with altered sensorium since 1 day. His past medical history revealed that he was a known case of pulmonary tuberculosis (PTB) 2 years ago and taken antitubercular therapy (ATT) for 6 months and also he had developed chickenpox in his childhood. The patient was diagnosed with herpes skin lesion and herpes simplex virus encephalitis based on his USG report and clinical, neurological symptoms respectively. His laboratory tests revealed abnormal haematology and LFT parameters, USG abdomen showed grade 1 fatty changes with hepatomegaly, echogenic sediments in urinary bladder and herpes zoster eruption in dermatomal distribution, chest X-ray showed suggestive sequalae of pulmonary Koch’s. the treatment was initiated with Acyclovir, Levetiracetam, Tramadol, etc.
单纯疱疹病毒(HSV)脑炎和带状疱疹皮损都是由不同的疱疹病毒株引起的。单纯疱疹病毒(HSV)脑炎是由单纯疱疹病毒(HSV)(通常是 HSV-1)引起的,而带状疱疹(俗称带状疱疹)是由水痘-带状疱疹病毒(VZV)引起的,后者也是疱疹病毒家族的一员。这是一例HSVE合并HZ的病例报告,患者是一名65岁的男性,入院时主诉腹部一周以来出现红斑性液状皮疹,两度全身型癫痫发作累及四肢,一天以来感觉改变。既往病史显示,他两年前曾患过肺结核(PTB),并接受过 6 个月的抗结核治疗(ATT),童年时还出过水痘。根据他的 USG 报告以及临床和神经系统症状,患者被诊断为疱疹性皮肤损伤和单纯疱疹病毒脑炎。他的实验室检查显示血液学和低密度脂蛋白血症参数异常,腹部 USG 显示 1 级脂肪病变伴肝脏肿大,膀胱内有回声沉积物,皮肤上有带状疱疹糜烂,胸部 X 光检查显示有肺科氏病的提示性后遗症。
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引用次数: 0
Rare Skin Eruption Caused by Paracetamol: A Case of Acute Generalized Exanthematous Pustulosis 对乙酰氨基酚引起的罕见皮肤疹:急性全身性发疹性脓疱病1例
Pub Date : 2023-06-14 DOI: 10.56557/jocrims/2023/v9i18270
Naveen Kizhakkayil Tency, Archak Roy
Background: This case report aims to enhance clinicians' ability to identify and effectively manage rare skin eruptions, specifically focusing on Acute Generalized Exanthematous Pustulosis (AGEP) by providing valuable insights into the context of its diagnostic challenges and clinical implications. Presentation of Case: We present a case of AGEP in a 16-year-old Indian boy who developed generalized pustulosis after taking Paracetamol (Acetaminophen). The patient's diagnosis was initially delayed due to the resemblance of AGEP with other skin conditions. Furthermore, the inadvertent reintroduction of Paracetamol exacerbated the condition. Discussion: We discuss various treatment options and emphasize the importance of prompt and accurate diagnosis of AGEP by utilizing the AGEP validation. By employing this scoring system, clinicians can enhance their diagnostic accuracy and avoid unnecessary delays in treatment initiation. Conclusion: The prompt identification of AGEP using the AGEP validation score is crucial for timely management. This case report highlights the potential risks associated with common drugs like Paracetamol and emphasizes the need for vigilance in prescribing medications. Clinicians should be aware of the distinctive features of AGEP and consider it as a differential diagnosis in patients presenting with pustular skin eruptions following drug intake. Improved awareness and application of diagnostic tools can aid in better patient outcomes.
背景:本病例报告旨在提高临床医生识别和有效管理罕见皮肤疹的能力,特别是通过对其诊断挑战和临床意义提供有价值的见解,重点关注急性全发性脓疱病(AGEP)。病例介绍:我们报告一个16岁印度男孩的AGEP病例,他在服用扑热息痛(对乙酰氨基酚)后发展为全身脓疱病。由于AGEP与其他皮肤状况相似,患者的诊断最初被推迟。此外,无意中重新引入扑热息痛加重了病情。讨论:我们讨论了各种治疗方案,并强调利用AGEP验证及时准确诊断AGEP的重要性。通过采用这个评分系统,临床医生可以提高他们的诊断准确性,避免不必要的延迟治疗开始。结论:使用AGEP验证评分及时识别AGEP对及时管理至关重要。本病例报告强调了与扑热息痛等常见药物相关的潜在风险,并强调了在开处方时保持警惕的必要性。临床医生应该意识到AGEP的独特特征,并将其视为药物摄入后出现脓疱性皮肤疹的患者的鉴别诊断。提高对诊断工具的认识和应用有助于改善患者的预后。
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引用次数: 0
Periapical Pocket Cyst of Anterior Maxilla: A Case Report 上颌骨前尖周口袋囊肿1例
Pub Date : 2023-05-11 DOI: 10.56557/jocrims/2023/v9i18237
M. Mukherjee, Moumita Pal, Vineet Nair
Periapical cyst is an inflammatory odontogenic cyst of endodontic origin. It presents either as an epithelium lined closed pathological cavity (then it is called periapical true cyst) or the epithelium lined cavity is continuous with the root canal of the affected tooth (periapical pocket cyst). The treatment of choice for the majority of the periapical cysts is conventional root canal treatment. However large, true cysts respond less favorably to non-surgical treatment. We present a case of a 20 years old female patient who had a swelling in the upper lip region. A provisional diagnosis of periapical cyst was arrived at considering the clinical and radiographic features. Intra-operatively, the cyst was continuous with the root canal. Histopathological examination was done.
根尖周囊肿是一种牙髓源性炎症性囊肿。它要么表现为上皮衬里的封闭病理腔(称为根尖周真囊肿),要么表现为上皮衬里腔与患牙根管相连(根尖周袋囊肿)。大多数根尖周囊肿的治疗选择是传统的根管治疗。无论囊肿多大,对非手术治疗的反应都不太好。我们提出了一个20岁的女性患者谁有一个肿胀在上唇区域。考虑到临床和影像学特征,初步诊断为根尖周囊肿。术中,囊肿与根管连续。行组织病理学检查。
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引用次数: 0
A Case of Warthin Tumor Highlighting the Diagnostic Dilemmas Encountered 沃辛肿瘤1例:诊断困境
Pub Date : 2023-05-11 DOI: 10.56557/jocrims/2023/v9i18238
Gita Gangadharan Shrivastav, H. Aiyer, Garima Rawat
Introduction: Warthin’s tumour (WT) previously known as papillary cystadeno-lymphomatosum is the most frequent ‘monomorphic’ adenoma of the major salivary glands, representing about 2–15% of all parotid tumours. It is a benign epithelial salivary gland neoplasm affecting elderly individuals and commonly involves the inferior pole of parotid glands. Fine needle aspiration cytology is considered the first diagnostic approach for salivary gland lesions; however, the cytological findings in Warthin tumor can be dubious many a times. Case Presentation: We present a case of a female in sixth decade of life with left neck swelling which mimicked a necrotic lymph node on imaging and turned out to be Warthin tumor. Conclusion: In the present paper, we discuss the diagnostic dilemmas faced in a case of warthin tumor.
Warthin肿瘤(WT)以前被称为乳头状囊腺淋巴瘤,是主要唾液腺最常见的“单形态”腺瘤,约占所有腮腺肿瘤的2-15%。它是一种影响老年人的良性上皮性唾液腺肿瘤,通常累及腮腺的下极。细针抽吸细胞学被认为是唾液腺病变的第一诊断方法;然而,Warthin瘤的细胞学检查结果常常令人怀疑。病例介绍:我们报告一位60多岁的女性,左颈部肿大,影像学上表现为坏死淋巴结,结果证实为沃辛瘤。结论:本文讨论了一例warthin肿瘤的诊断困境。
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引用次数: 0
Clinical Observations of Hearing, Speech, Language and Swallowing Abilities in Locked-in Syndrome: A Case-based Study 闭锁综合征听力、言语、语言和吞咽能力的临床观察:一项基于病例的研究
Pub Date : 2023-05-05 DOI: 10.56557/jocrims/2023/v9i18233
H. Kumar, D. Darshan
Background: Locked-in Syndrome (LIS) is a rare neurological condition characterized by quadriplegia, mutism, and lower cranial nerve paralysis with intact eye movements and consciousness and communication through eye blink only. The irretrievable LIS condition differs from a coma, persistent vegetative state, and akinetic mutism with preserved volitional vertical eye movements and blinking involving a lack of conscious interaction with the environment. Reports and evidence on assessment and rehabilitation with LIS are scanty. Thus, this case study aims to highlight some of the challenges faced by speech-language pathologists in the assessment and management of LIS in a multidisciplinary rehabilitation center. This study also emphasizes the assessment protocol adapted to diagnose and strategies planned for intervention.  Case Description: A 58 years old male followed by an ischemic brain stroke diagnosed with LIS with a tracheostomy came to the department. Detailed history noted history revealed a brainstem stroke with pons involvement and a tracheostomy with percutaneous endoscopic gastrotomy and immobile vocal folds with limited epiglottic movements with impaired swallowing ability and severe aspiration. The clinical assessment was challenging and difficult to select appropriate assessment strategies for the condition. Detailed Speech, Swallow, and Language evaluations were carried out. The detailed evaluation reported the client with anarthria with tracheostomy secondary to locked-in syndrome. Conclusion: The present case report summarizes the need and findings of various evaluation procedures in the field of communication disorders. The role of an SLP is essential and a proper diagnostic protocol need to be considered along with spectacular observation while assessing LIS.
背景:闭锁综合征(LIS)是一种罕见的神经系统疾病,以四肢瘫痪、失语和下颅神经麻痹为特征,眼球运动完整,仅通过眨眼进行意识和交流。无法恢复的LIS情况不同于昏迷、持续植物人状态和动态缄默症,这些缄默症保留了自发性的垂直眼球运动和眨眼,涉及缺乏与环境的有意识的相互作用。关于LIS的评估和康复的报告和证据很少。因此,本案例研究旨在强调语言病理学家在多学科康复中心评估和管理LIS时面临的一些挑战。本研究还强调了适用于诊断的评估方案和计划干预的策略。病例描述:一名58岁男性,因缺血性脑卒中被诊断为LIS并行气管切开术。详细病史显示脑干中风累及脑桥,经皮内镜胃切开术行气管切开术,声带不动,会厌运动受限,吞咽能力受损,严重吸入性。临床评估具有挑战性,难以选择合适的评估策略。进行了详细的语音,吞咽和语言评估。详细的评估报告了该患者的气管无音伴继发于闭锁综合征的气管造口术。结论:本病例报告总结了沟通障碍领域各种评估程序的需要和发现。SLP的作用是必不可少的,在评估LIS时需要考虑适当的诊断方案以及壮观的观察。
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引用次数: 0
A Case Study of Tricuspid Endocarditis in Post-Partum Female 产后女性三尖瓣心内膜炎1例
Pub Date : 2023-04-28 DOI: 10.56557/jocrims/2023/v9i18221
Shyam Patel, R. Samar
Tricuspid valve endocarditis is uncommon thing compared to left-sided endocarditis which accounts for approximately 5-10 % of all cases of infective endocarditis. Tricuspid valve endocarditis is most commonly seen in patients who are addicted to intravenous drugs. Patients may present with symptoms like right- sided heart failure. Tricuspid endocarditis during pregnancy or peri-partum period is a rare entity with significant morbidity and mortality. Rheumatic heart disease was considered a significant risk factor previously which has changed over to intravenous drug abuse in recent decades. We hereby report a case of tricuspid native valve endocarditis complicating the post-partum period in a young female without underlying traditional risk factors, who improved with medical therapy alone.
与左侧心内膜炎相比,三尖瓣心内膜炎并不常见,左侧心内膜炎约占感染性心内膜炎病例的5- 10%。三尖瓣心内膜炎最常见于静脉注射药物成瘾的患者。患者可能出现右侧心力衰竭等症状。三尖瓣心内膜炎在妊娠期或围生期是一个罕见的实体,具有显著的发病率和死亡率。风湿性心脏病以前被认为是一个重要的危险因素,近几十年来已转变为静脉注射药物滥用。我们在此报告一个没有潜在的传统危险因素的年轻女性的三尖瓣原生心内膜炎合并产后期,谁与药物治疗单独改善。
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引用次数: 0
Placental Mesenchymal Dysplasia Co-existing with High Grade Villitis of Unknown Aetiology (VUE): A Very Rare Case Report and Literature Review 胎盘间充质发育不良并发高度不明原因绒毛炎1例罕见病例报告及文献复习
Pub Date : 2023-04-19 DOI: 10.56557/jocrims/2023/v9i18211
E. Aramabi, J. Rafi, N. Deole
The present case study reports about Placental mesenchymal dysplasia co-existing with high grade villitis of unknown aetiology (VUE). Placental Mesenchymal Dysplasia (PMD) is a rare placental lesion characterized by unusual abnormality of the stem villi of the placenta that could be mistaken for hydatidiform mole due to the presence of both cysts and normal-appearing parenchyma. A 30-year-old G2 P1 (full-term normal delivery) seen in fetal medicine clinic at 20 weeks within view of high risk on combined screening (low PAPP-A and high HCG). An ultrasound scan showed an appropriately grown baby with an abnormal placenta consisting of multiple lacunae more than 50% of the placental mass with increased thickness. A second opinion at tertiary care hospital confirmed the presence of prominent lakes on the placenta. Growth scans also showed IUGR with increasingly abnormal Doppler scans as the pregnancy progressed. At 35 weeks, EFW was < 3rd centile with static growth and patient had Induction of labour at 35 +4 weeks with vaginal delivery of a live male neonate weighing 2325g admitted to the neonatal intensive care unit (NICU) admission due to prematurity. The baby was discharged from NICU at day 5, achieving developmental milestones at the age of 23 weeks post-delivery.  On microscopic histological examination, the chorionic plate showed no significant abnormality. The villous architecture was highly abnormal, and some villi were markedly enlarged with myxoid stroma and central degeneration. There were very occasional foci of apparent trophoblastic proliferation with villous architecture abnormalities seen in the form of clusters of large, immature intermediate villi. These features were in keeping with mesenchymal dysplasia. A highly unusual finding in this context was a florid infiltrate of CD3 positive T cells consistent with high-grade villitis of unknown aetiology concluding very rare co-existence of both conditions.
本病例研究报告了胎盘间充质发育不良与病因不明的高级别绒毛炎共存的病例。胎盘间充质发育不良(PMD)是一种罕见的胎盘病变,其特征是胎盘干绒毛异常,由于囊肿和正常实质的存在,可能被误认为是葡萄胎。一个30岁的G2 P1(足月正常分娩)在胎儿医学诊所看到在20周的高风险联合筛查(低pap -A和高HCG)。超声扫描显示正常发育的婴儿胎盘异常,包括多个腔隙,占胎盘肿块的50%以上,厚度增加。三级医院的第二份意见证实胎盘上存在明显的湖泊。随着怀孕的进展,生长扫描也显示IUGR,多普勒扫描越来越异常。35周时,EFW < 3个百分点,静态生长,患者在35 +4周时引产,阴道分娩一名体重2325g的活男婴,因早产入院新生儿重症监护病房(NICU)。婴儿于第5天从新生儿重症监护室出院,在分娩后23周达到发育里程碑。显微组织学检查,绒毛膜板未见明显异常。绒毛结构高度异常,部分绒毛明显增大,伴黏液样间质和中央变性。偶见明显滋养层增生灶,绒毛结构异常,以大而不成熟的中间绒毛簇的形式出现。这些特征与间质发育不良一致。在这种情况下,一个非常不寻常的发现是CD3阳性T细胞的丰富浸润,与病因不明的高级别绒毛炎一致,这表明两种情况的共存是非常罕见的。
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引用次数: 0
A Case Study of Infantile Nystagmus Syndrome (Congenital) 婴儿眼球震颤综合征(先天性)1例
Pub Date : 2023-04-06 DOI: 10.56557/jocrims/2023/v9i18187
Vishal Ghosh, N. K. Gupta, A. Manoj
Infantile nystagmus (IN), formerly known as congenital nystagmus, is an involuntary to-and-fro movement of the eyes that persists throughout life. IN is one of three types of early-onset nystagmus that first appear in infancy, alongside fusion maldevelopment nystagmus syndrome and spasmus nutans syndrome. Patients with acquired nystagmus may also be seen by optometrists. The features of IN overlap largely with those of fusion maldevelopment nystagmus syndrome, spasmus nutans syndrome, and acquired nystagmus, yet the management for each subtype is different. We report a case of bilateral congenital sensory nystagmus with bilateral megalocornea with left-sided relative afferent pupil defect with left eye global enlargement in ap axis with reduced caliber in left optic artery with pseudo polycorea with reduced visual acuity in the bilateral eye with buphthalmos with haab striae.
婴儿眼球震颤(IN),以前被称为先天性眼球震颤,是一种持续一生的眼睛不自主的来回运动。IN是三种最早出现在婴儿期的早发性眼震之一,另外两种是融合性发育不良眼震综合征和痉挛综合征。获得性眼球震颤患者也可由验光师检查。IN的特征与融合性发育不良眼震综合征、痉挛综合征和获得性眼震的特征有很大的重叠,但每种亚型的治疗方法不同。我们报告一例双侧先天性感觉性眼球震颤伴双侧大角膜伴左侧相对传入瞳孔缺损,左眼视轴整体增大,左视动脉直径减小,伴假性多核,双侧视力下降,伴眼鼻伴haab纹。
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引用次数: 0
Methods to Spot Predatory Journals: A View Point 发现掠夺性期刊的方法:一个观点
Pub Date : 2023-03-20 DOI: 10.56557/jocrims/2023/v9i18166
J. Nnodim, K. E. Dunga, Uzah Glad
Predatory journals are publications that promote themselves as authentic scholarly journals but falsify their publishing procedures. They are sometimes referred to as fraudulent, deceitful, or pseudo-journals. Predatory publishing tactics include various violations of copyright or scholarly ethics, including false claims that peer review is provided, concealing information regarding Article Processing Charges (APCs), misrepresenting editorial board members, and more. The purpose of this review article is to help authors recognize and stay away from predatory journals because they are becoming more common.
掠夺性期刊是将自己标榜为真正的学术期刊,但伪造出版程序的出版物。它们有时被称为欺诈性、欺骗性或伪期刊。掠夺性出版策略包括各种侵犯版权或学术道德的行为,包括虚假声称提供了同行评议,隐瞒有关文章处理费(apc)的信息,歪曲编辑委员会成员,等等。这篇综述文章的目的是帮助作者认识并远离掠夺性期刊,因为它们正变得越来越普遍。
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引用次数: 1
A Case Report of Bilateral Ptosis as a Presentation in Diabetes Mellitus with Involvment in Corona Radiata 糖尿病伴放射状区累及双侧上睑下垂1例
Pub Date : 2023-03-14 DOI: 10.56557/jocrims/2023/v9i18154
A. Manoj, N. K. Gupta
Corona radiata is a highly cellular layer with an intracellular matrix consisting of proteins and a high concentration of carbohydrates, in particular. Infarcts can occur near the lateral angle of the lateral ventricle; this site is vulnerable because it is at the junction of the lateral lenticulo-striate artery, which perforates the long medullary penetrating arteries of the superior MCA. The syndrome may variously consist of pure hemiplegia and sensory loss in the face and arm. We report an adult male case presenting with isolated bilateral ptosis as a presentation of diabetes mellitus involving corona radiata.
辐射冕是一个高度细胞化的层,其细胞内基质主要由蛋白质和高浓度的碳水化合物组成。梗死可发生在侧脑室侧角附近;这个部位是脆弱的,因为它位于外侧透镜状纹状动脉的交界处,该动脉穿过上MCA的长髓质穿透动脉。这种综合征可能包括纯粹的偏瘫和面部和手臂的感觉丧失。我们报告了一个成年男性病例,以孤立的双侧上睑下垂作为糖尿病的表现,包括辐射冠。
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引用次数: 0
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Journal of Case Reports in Medical Science
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