Background and objective: Cachexia-induced skeletal muscle atrophy is a critical manifestation in Kirsten rat sarcoma viral oncogene homologue (KRAS)-mutant pancreatic cancer (PC) patients, predominantly characterized by a shift in metabolic equilibrium towards catabolism that accelerates protein degradation in myofibers and leads to muscle atrophy. This metabolic reprogramming not only supports tumor growth but also precipitates energy depletion in skeletal muscle tissues. Exploring these mechanisms reveals potential therapeutic targets in the metabolic and proteolytic pathways associated with KRAS-mutant PC.
Methods: A comprehensive search for literature was conducted in PubMed, Web of Science, Google Scholar and other search engines up to May 21st, 2024. Studies on PC models and patients were included.
Key content and findings: The crosstalk between KRAS-mutant PC and skeletal muscle atrophy can be categorized into four principal domains: (I) KRAS-driven metabolic reprogramming in cancer cells leads to the depletion of muscle energy reserves, thereby influencing the reallocation of myofiber energy towards fueling cancer cell; (II) KRAS-mutant cancer cells rely on nutrient-scavenging pathways, resulting in altered cytokine profiles, increased ubiquitin mRNA expression and autophagy-lysosome pathway, which facilitate myotube degradation and inhibit muscle regeneration, thereby disrupting muscular homeostasis and causing a one-way nutrient flux; (III) tumor-induced oxidative stress inflicts damage on myotubes, highlighting the detrimental effects of reactive oxygen species on muscle structure; (IV) KRAS-mutant cancer cells remodulate immune cell dynamics within the tumor environment, thereby reshaping host immunity. Together, these findings illuminate the intricate interplay between KRAS-mutant PC and skeletal muscle atrophy, mapping the pathophysiological framework that is crucial for understanding sarcopenia and related disorders.
Conclusions: This comprehensive analysis advances our understanding of the complex etiology of cancer cachexia and stimulates the development of targeted therapeutic strategies.
{"title":"Deciphering molecular crosstalk mechanisms between skeletal muscle atrophy and KRAS-mutant pancreatic cancer: a literature review.","authors":"Yuquan Guo, Siyang Han, Weisheng Yu, Yaolin Xu, Ying Ying, Huaxiang Xu, Haokang Feng, Xu'an Wang, Wenchuan Wu, Dansong Wang, Liang Liu, Xu Han, Wenhui Lou","doi":"10.21037/hbsn-24-282","DOIUrl":"10.21037/hbsn-24-282","url":null,"abstract":"<p><strong>Background and objective: </strong>Cachexia-induced skeletal muscle atrophy is a critical manifestation in Kirsten rat sarcoma viral oncogene homologue (KRAS)-mutant pancreatic cancer (PC) patients, predominantly characterized by a shift in metabolic equilibrium towards catabolism that accelerates protein degradation in myofibers and leads to muscle atrophy. This metabolic reprogramming not only supports tumor growth but also precipitates energy depletion in skeletal muscle tissues. Exploring these mechanisms reveals potential therapeutic targets in the metabolic and proteolytic pathways associated with KRAS-mutant PC.</p><p><strong>Methods: </strong>A comprehensive search for literature was conducted in PubMed, Web of Science, Google Scholar and other search engines up to May 21<sup>st</sup>, 2024. Studies on PC models and patients were included.</p><p><strong>Key content and findings: </strong>The crosstalk between KRAS-mutant PC and skeletal muscle atrophy can be categorized into four principal domains: (I) KRAS-driven metabolic reprogramming in cancer cells leads to the depletion of muscle energy reserves, thereby influencing the reallocation of myofiber energy towards fueling cancer cell; (II) KRAS-mutant cancer cells rely on nutrient-scavenging pathways, resulting in altered cytokine profiles, increased ubiquitin mRNA expression and autophagy-lysosome pathway, which facilitate myotube degradation and inhibit muscle regeneration, thereby disrupting muscular homeostasis and causing a one-way nutrient flux; (III) tumor-induced oxidative stress inflicts damage on myotubes, highlighting the detrimental effects of reactive oxygen species on muscle structure; (IV) KRAS-mutant cancer cells remodulate immune cell dynamics within the tumor environment, thereby reshaping host immunity. Together, these findings illuminate the intricate interplay between KRAS-mutant PC and skeletal muscle atrophy, mapping the pathophysiological framework that is crucial for understanding sarcopenia and related disorders.</p><p><strong>Conclusions: </strong>This comprehensive analysis advances our understanding of the complex etiology of cancer cachexia and stimulates the development of targeted therapeutic strategies.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"78-95"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-08DOI: 10.21037/hbsn-24-615
Wen-Bo Zou, Xiu-Ping Zhang, Zhi-Ming Zhao, Yin-Zhe Xu, Rong Liu
{"title":"Recognizing significance of propensity score matching and clinical practice in evaluating oncological survivals of pancreatic cancer.","authors":"Wen-Bo Zou, Xiu-Ping Zhang, Zhi-Ming Zhao, Yin-Zhe Xu, Rong Liu","doi":"10.21037/hbsn-24-615","DOIUrl":"10.21037/hbsn-24-615","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"179-180"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-08DOI: 10.21037/hbsn-2024-638
Daisuke Asano, Daisuke Ban
{"title":"Based on the results of a large retrospective study comparing laparoscopic liver surgery and robotic liver surgery, is it time for the next step in robotic liver resection?","authors":"Daisuke Asano, Daisuke Ban","doi":"10.21037/hbsn-2024-638","DOIUrl":"10.21037/hbsn-2024-638","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"128-130"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-06DOI: 10.21037/hbsn-2024-648
Takayuki Anazawa, Kei Yamane, Etsuro Hatano
{"title":"Future directions based on evaluation of long-term efficacy of total pancreatectomy and autologous islet transplantation.","authors":"Takayuki Anazawa, Kei Yamane, Etsuro Hatano","doi":"10.21037/hbsn-2024-648","DOIUrl":"10.21037/hbsn-2024-648","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"102-105"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-10DOI: 10.21037/hbsn-2024-658
Ilaria Milani, Frida Leonetti, Danila Capoccia
{"title":"Non-invasive liver disease assessments: can they replace liver biopsy?","authors":"Ilaria Milani, Frida Leonetti, Danila Capoccia","doi":"10.21037/hbsn-2024-658","DOIUrl":"10.21037/hbsn-2024-658","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"147-150"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-08DOI: 10.21037/hbsn-24-382
Bangjie Chen, Gongbu Pan, Tao Xu
{"title":"Where is the future of xenotransplantation headed?","authors":"Bangjie Chen, Gongbu Pan, Tao Xu","doi":"10.21037/hbsn-24-382","DOIUrl":"10.21037/hbsn-24-382","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"169-171"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-09DOI: 10.21037/hbsn-2024-652
Charlotte Rondé-Roupie, Stylianos Tzedakis
{"title":"Evolving concepts in the management of hepatocellular carcinoma: from 'stage hierarchy' to the 'multiparametric therapeutic hierarchy' approach.","authors":"Charlotte Rondé-Roupie, Stylianos Tzedakis","doi":"10.21037/hbsn-2024-652","DOIUrl":"10.21037/hbsn-2024-652","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"118-120"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-09DOI: 10.21037/hbsn-2024-662
Cosimo Sperti, Amanda Belluzzi
{"title":"International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas: what is the breaking news?","authors":"Cosimo Sperti, Amanda Belluzzi","doi":"10.21037/hbsn-2024-662","DOIUrl":"10.21037/hbsn-2024-662","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"155-158"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-01-17DOI: 10.21037/hbsn-2024-659
Beata Jabłońska
{"title":"Long-term results of total pancreatectomy and autologous islet transplantation for chronic pancreatitis: total pancreatectomy with autologous islet transplantation (TPAIT) preserves long-term islet graft functions in 10-year follow-up.","authors":"Beata Jabłońska","doi":"10.21037/hbsn-2024-659","DOIUrl":"10.21037/hbsn-2024-659","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 1","pages":"114-117"},"PeriodicalIF":6.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号