Pub Date : 2026-02-01Epub Date: 2024-12-17DOI: 10.21037/hbsn-24-300
Sang Jin Kim, Boram Park, Jongman Kim, Kyunga Kim, YoungRok Choi, Geun Hong, Jun Yong Park, Young Seok Han, Nam-Joon Yi, Seung Heui Hong, Soon-Young Kim, Jung-Bun Park, Youngwon Hwang, Dong-Hwan Jung
Background: Highly urgent living donor liver transplantation (HU-LDLT) is vital for treating acute liver failure (ALF), acute-on-chronic liver failure (ACLF), and critically ill cirrhotic patients in life-threatening scenarios. The purpose of our study was to identify the characteristics of HU-LDLT patients, compare the outcomes of HU-LDLT patients with those of elective LDLT patients, and determine the risk factors that can influence the outcomes of HU-LDLT.
Methods: We retrospectively analyzed Korean Network for Organ Sharing (KONOS) data for consecutive HU-LDLT patients between 2017 and 2021. For comparison with the HU-LDLT group, patients who received elective LDLT except HU-LDLT at Samsung Medical Center during the same period were analyzed as the control group.
Results: The most common reasons for HU-LDLT were hepatic encephalopathy, a model for end-stage liver disease (MELD) score ≥35, and uncontrolled varix bleeding. Among the 419 HU-LDLT patients, 53 (12.6%) were pediatric. The cumulative 1-, 3-, and 5-year overall survival rates were 82.4%, 78.3%, and 74.8%, respectively, in the adult HU-LDLT group. The 1-year overall survival rate was 86.1% in the pediatric HU-LDLT group. The presence of chronic kidney disease, pre-transplant ventilator care, high pre-transplant MELD score, and re-transplantation were closely related to mortality in the adult group. Only hepatorenal syndrome (HRS) was a strong risk factor for graft failure in the adult group. The graft and overall survival in the adult HU-LDLT group were significantly lower than those in the control group.
Conclusions: High MELD scores, hepatic encephalopathy, and bleeding are the main reasons for HU-LDLT applications in Korea. Graft and overall survival curves in the HU-LDLT group are lower than in the elective LDLT group, but the HU-LDLT outcomes are considered acceptable.
{"title":"Outcomes of highly urgent living donor liver transplantation in Korean national data.","authors":"Sang Jin Kim, Boram Park, Jongman Kim, Kyunga Kim, YoungRok Choi, Geun Hong, Jun Yong Park, Young Seok Han, Nam-Joon Yi, Seung Heui Hong, Soon-Young Kim, Jung-Bun Park, Youngwon Hwang, Dong-Hwan Jung","doi":"10.21037/hbsn-24-300","DOIUrl":"10.21037/hbsn-24-300","url":null,"abstract":"<p><strong>Background: </strong>Highly urgent living donor liver transplantation (HU-LDLT) is vital for treating acute liver failure (ALF), acute-on-chronic liver failure (ACLF), and critically ill cirrhotic patients in life-threatening scenarios. The purpose of our study was to identify the characteristics of HU-LDLT patients, compare the outcomes of HU-LDLT patients with those of elective LDLT patients, and determine the risk factors that can influence the outcomes of HU-LDLT.</p><p><strong>Methods: </strong>We retrospectively analyzed Korean Network for Organ Sharing (KONOS) data for consecutive HU-LDLT patients between 2017 and 2021. For comparison with the HU-LDLT group, patients who received elective LDLT except HU-LDLT at Samsung Medical Center during the same period were analyzed as the control group.</p><p><strong>Results: </strong>The most common reasons for HU-LDLT were hepatic encephalopathy, a model for end-stage liver disease (MELD) score ≥35, and uncontrolled varix bleeding. Among the 419 HU-LDLT patients, 53 (12.6%) were pediatric. The cumulative 1-, 3-, and 5-year overall survival rates were 82.4%, 78.3%, and 74.8%, respectively, in the adult HU-LDLT group. The 1-year overall survival rate was 86.1% in the pediatric HU-LDLT group. The presence of chronic kidney disease, pre-transplant ventilator care, high pre-transplant MELD score, and re-transplantation were closely related to mortality in the adult group. Only hepatorenal syndrome (HRS) was a strong risk factor for graft failure in the adult group. The graft and overall survival in the adult HU-LDLT group were significantly lower than those in the control group.</p><p><strong>Conclusions: </strong>High MELD scores, hepatic encephalopathy, and bleeding are the main reasons for HU-LDLT applications in Korea. Graft and overall survival curves in the HU-LDLT group are lower than in the elective LDLT group, but the HU-LDLT outcomes are considered acceptable.</p>","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"15 1","pages":"3"},"PeriodicalIF":7.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-25DOI: 10.21037/hbsn-2025-aw-849
Guanmo Liu, Jie Li, Chenggang Zhang, Pan Li, Yihua Wang, Shihan He, Weiming Kang, Xin Ye
{"title":"Insights in efficacy of simple oral nutritional supplements after gastrectomy for gastric cancer.","authors":"Guanmo Liu, Jie Li, Chenggang Zhang, Pan Li, Yihua Wang, Shihan He, Weiming Kang, Xin Ye","doi":"10.21037/hbsn-2025-aw-849","DOIUrl":"10.21037/hbsn-2025-aw-849","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1038-1041"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-04DOI: 10.21037/hbsn-2025-552
Haizhou Qiu, Yang Huang, Yang Li, Li Jiang
{"title":"A puzzling mixed cystic-solid mass at the hepatic hilum.","authors":"Haizhou Qiu, Yang Huang, Yang Li, Li Jiang","doi":"10.21037/hbsn-2025-552","DOIUrl":"10.21037/hbsn-2025-552","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1105-1107"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expanding the ethnic and geographic spectrum of hereditary pancreatitis: first report of a Tibetan case with compound <i>SPINK1</i> variants.","authors":"Yonghao Chen, Zhen Yu, Jianing Li, Yangjin Ciren, Qiang Wang, Dong Wu","doi":"10.21037/hbsn-2025-526","DOIUrl":"10.21037/hbsn-2025-526","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1095-1098"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The limits of segmental dichotomy: rethinking how we classify and compare minimally invasive liver resections.","authors":"Víctor Lopez-Lopez, Cecilia Maina, Ricardo Robles-Campos","doi":"10.21037/hbsn-2025-464","DOIUrl":"10.21037/hbsn-2025-464","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1045-1048"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-14DOI: 10.21037/hbsn-2025-573
Daniel Azoulay
{"title":"Portal and hepatic vein(s) embolization as a preparation for major hepatectomy: Enough is enough or more is better?","authors":"Daniel Azoulay","doi":"10.21037/hbsn-2025-573","DOIUrl":"10.21037/hbsn-2025-573","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1059-1062"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing the risk of metabolic dysfunction-associated steatotic liver disease in type 2 diabetes: is the Fibrosis-4 index still a reliable tool?","authors":"Masato Yoneda, Takashi Kobayashi, Michihiro Iwaki, Naohiro Wada, Asako Nogami, Atsushi Nakajima","doi":"10.21037/hbsn-2025-439","DOIUrl":"10.21037/hbsn-2025-439","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1012-1015"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-25DOI: 10.21037/hbsn-2025-511
Adriana C Gamboa, Timothy E Newhook
{"title":"Should all patients be offered liver venous deprivation for insufficient future liver remnant hypertrophy prior to major hepatectomy?","authors":"Adriana C Gamboa, Timothy E Newhook","doi":"10.21037/hbsn-2025-511","DOIUrl":"10.21037/hbsn-2025-511","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1053-1055"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-22DOI: 10.21037/hbsn-2025-484
Xuehai Jia, Gang Xu, Li Jiang
{"title":"Rethinking the classical hepatic inflow occlusion time in hepatectomy for hepatocellular carcinoma under new circumstances.","authors":"Xuehai Jia, Gang Xu, Li Jiang","doi":"10.21037/hbsn-2025-484","DOIUrl":"10.21037/hbsn-2025-484","url":null,"abstract":"","PeriodicalId":12878,"journal":{"name":"Hepatobiliary surgery and nutrition","volume":"14 6","pages":"1099-1104"},"PeriodicalIF":7.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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