Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_41
U Creutzig, G Niederbiermann, J Ritter, J Harbott, H Löffler, G Schellong
{"title":"Prognostic significance of eosinophilia in acute myelomonocytic leukemia in relation to induction treatment.","authors":"U Creutzig, G Niederbiermann, J Ritter, J Harbott, H Löffler, G Schellong","doi":"10.1007/978-3-642-74643-7_41","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_41","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"226-32"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13472976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_11
G Heil, E Gunsilius, A N Raghavachar, E Kurrle, D Hoelzer, H Heimpel, E Thiel
{"title":"Correlation between the expression of myelomonocytic surface antigens and ultrastructural demonstration of early myeloperoxidase expression in null-AL(L) cells.","authors":"G Heil, E Gunsilius, A N Raghavachar, E Kurrle, D Hoelzer, H Heimpel, E Thiel","doi":"10.1007/978-3-642-74643-7_11","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_11","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13311097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_45
M C Petti, G Broccia, F Caronia, F Di Raimondo, G Fioritoni, S Ladogana, G Leone, V Liso, M Musso, A Neri
{"title":"Therapy of acute myelogenous leukemia in adults.","authors":"M C Petti, G Broccia, F Caronia, F Di Raimondo, G Fioritoni, S Ladogana, G Leone, V Liso, M Musso, A Neri","doi":"10.1007/978-3-642-74643-7_45","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_45","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"249-53"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_58
G Ehninger, E Fackler-Schwalbe, M Freund, G Heil, M Henke, D Hoelzer, R Hoffmann, E Kurrle, H Link, A Lösch
{"title":"Combination of mitoxantrone and etoposide in patients aged over 60 years with untreated acute myelogenous leukemia.","authors":"G Ehninger, E Fackler-Schwalbe, M Freund, G Heil, M Henke, D Hoelzer, R Hoffmann, E Kurrle, H Link, A Lösch","doi":"10.1007/978-3-642-74643-7_58","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_58","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"316-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_134
E H Estey, H M Kantarjian, M Beran, K B McCredie, M J Keating, A Deisseroth, J U Gutterman
We gave 4 days of high-dose Ara-C followed 2 days later by rHUGM-CSF (which continued until the neutrophil count was greater than 1000/microliters) to 12 patients with newly diagnosed AML and a relatively poor prognosis. Six CRs occurred, there were four deaths during induction, and in only one case was there an rHUGM-CSF-associated growth of leukemia. The pattern of hematologic recovery was variable but in some patients rHUGM-CSF seemed to accelerate normal myelopoiesis following chemotherapy. Continued investigation of rHUGM-CSF and chemotherapy in AML is warranted.
{"title":"Treatment of poor-prognosis, newly diagnosed acute myelogenous leukemia with high-dose cytosine arabinoside (Ara-C) and rHUGM-CSF.","authors":"E H Estey, H M Kantarjian, M Beran, K B McCredie, M J Keating, A Deisseroth, J U Gutterman","doi":"10.1007/978-3-642-74643-7_134","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_134","url":null,"abstract":"<p><p>We gave 4 days of high-dose Ara-C followed 2 days later by rHUGM-CSF (which continued until the neutrophil count was greater than 1000/microliters) to 12 patients with newly diagnosed AML and a relatively poor prognosis. Six CRs occurred, there were four deaths during induction, and in only one case was there an rHUGM-CSF-associated growth of leukemia. The pattern of hematologic recovery was variable but in some patients rHUGM-CSF seemed to accelerate normal myelopoiesis following chemotherapy. Continued investigation of rHUGM-CSF and chemotherapy in AML is warranted.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"732-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_124
R P Gale, A Butturini
We analyzed LFS in adults, adolescents, and children with ALL treated by using different therapies and therapeutic strategies. In most instances, the strategy of initial chemotherapy followed by transplantation in those who relapse produced the highest LFS. Results of HLA-identical transplants were generally superior to those of autotransplants. However, many persons do not have donors and should be considered for autotransplants or possibly for transplants from partially or fully HLA-matched related or unrelated donors. These persons are also potential candidates for evolving therapeutic strategies such as immune therapy or lymphoid growth factors.
{"title":"Treatment strategies for acute lymphoblastic leukemia.","authors":"R P Gale, A Butturini","doi":"10.1007/978-3-642-74643-7_124","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_124","url":null,"abstract":"<p><p>We analyzed LFS in adults, adolescents, and children with ALL treated by using different therapies and therapeutic strategies. In most instances, the strategy of initial chemotherapy followed by transplantation in those who relapse produced the highest LFS. Results of HLA-identical transplants were generally superior to those of autotransplants. However, many persons do not have donors and should be considered for autotransplants or possibly for transplants from partially or fully HLA-matched related or unrelated donors. These persons are also potential candidates for evolving therapeutic strategies such as immune therapy or lymphoid growth factors.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"684-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_96
K M Sullivan, J Meyers, F B Petersen, R Bowden, G C Counts, M Banaji, M Schubert, J Clark, R A Clift, F R Appelbaum
It is now almost 2 decades after the first successful human marrow transplants from HLA-identical siblings for the treatment of life-threatening hematologic diseases. Results have improved, especially for patients transplanted earlier in the course of disease. However, major problems remain in supporting patients through the transplant. More effective and less toxic conditioning regimens are needed. Acceleration of hematopoietic and immunologic reconstitution by use of various cytokines holds promise for decreasing infectious morbidity and mortality. Improved regimens to control acute and chronic GVHD and prevent opportunistic infections will play a major role in the advancement of supportive care of the marrow transplant recipient.
{"title":"Supportive care of the marrow transplant recipient: the Seattle Experience.","authors":"K M Sullivan, J Meyers, F B Petersen, R Bowden, G C Counts, M Banaji, M Schubert, J Clark, R A Clift, F R Appelbaum","doi":"10.1007/978-3-642-74643-7_96","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_96","url":null,"abstract":"<p><p>It is now almost 2 decades after the first successful human marrow transplants from HLA-identical siblings for the treatment of life-threatening hematologic diseases. Results have improved, especially for patients transplanted earlier in the course of disease. However, major problems remain in supporting patients through the transplant. More effective and less toxic conditioning regimens are needed. Acceleration of hematopoietic and immunologic reconstitution by use of various cytokines holds promise for decreasing infectious morbidity and mortality. Improved regimens to control acute and chronic GVHD and prevent opportunistic infections will play a major role in the advancement of supportive care of the marrow transplant recipient.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"539-45"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_100
M E Essink, W Hiddemann, M von Eiff, T Büchner, J van de Loo
{"title":"Effect of antifungal therapy on hematological recovery after intensive antileukemic chemotherapy.","authors":"M E Essink, W Hiddemann, M von Eiff, T Büchner, J van de Loo","doi":"10.1007/978-3-642-74643-7_100","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_100","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"558-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13473554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_16
K H Pflüger, A Grüber, M Welslau, H Köppler, K Havemann
{"title":"Transferrin derivatives with growth factor activities in acute myeloblastic leukemia: an autocrine/paracrine pathway.","authors":"K H Pflüger, A Grüber, M Welslau, H Köppler, K Havemann","doi":"10.1007/978-3-642-74643-7_16","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_16","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13475528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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