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Antigen receptor rearrangement and expression in acute leukemias. 急性白血病抗原受体重排及表达。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_8
M Volkmann, P Mar, K Pachmann, E Thiel, B Emmerich

Twenty-two leukemias, 11 of which were undifferentiated with respect to surface antigen markers, were investigated for their antigen receptor gene rearrangement, transcription products of these antigen receptor genes, and surface antigen pattern of the cells. Among the three less-differentiated groups rearrangement was observed in 2/10 cases for the TCR beta-chain and in 4/11 cases for the heavy-chain gene. TCR beta-mRNA, however, was expressed in seven out of eight cases and the mu heavy-chain mRNA in eight out of ten cases investigated. Also mRNA of TCR alpha, the rearrangement of which could not be detected with our probes, was expressed as frequently as TCR beta. Although rearrangement of the appropriate gene was found regularly in the more mature leukemias, transcription of these genes was lower or even lacking. These findings indicate that expression of antigen receptor mRNA in undifferentiated leukemias can be activated by events other than maturational rearrangement.

对22例白血病(其中11例表面抗原标记未分化)进行了抗原受体基因重排、抗原受体基因转录产物和细胞表面抗原模式的研究。在三个低分化组中，2/10的TCR β链重排，4/11的重链基因重排。然而，TCR β -mRNA在8例中有7例表达，mu重链mRNA在10例中有8例表达。此外，我们的探针无法检测到重排的TCR α mRNA的表达频率与TCR β相同。虽然在更成熟的白血病中发现了适当基因的重排，但这些基因的转录较低甚至缺乏。这些发现表明，抗原受体mRNA在未分化白血病中的表达可被成熟重排以外的事件激活。
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引用次数: 1
Predictive models for achievement of complete remission and duration of first remission in adult acute myeloid leukemia. 成人急性髓性白血病实现完全缓解和首次缓解持续时间的预测模型。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_51
A Heinecke, M C Sauerland, T Büchner

Achievement of CR. Using the data of 501 patients treated identically with the TAD9 regimen we could not find any factor of predictive value besides age and state of health. The effect of FAB-M seems to be spurious as it disappeared using prospective data. Duration of Relapse-Free Survival. In patients with monthly maintenance, the maintenance overrides the possible effects of the considered factors. In patients without monthly maintenance we only found a slight effect of WBC.

CR的实现:使用与TAD9方案相同的501例患者的数据，除了年龄和健康状况外，我们没有发现任何具有预测价值的因素。FAB-M的效果似乎是虚假的，因为它在前瞻性数据中消失了。无复发生存期。在每月维持的患者中，维持压倒了考虑的因素可能产生的影响。在没有每月维持的患者中，我们只发现白细胞的轻微影响。
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引用次数: 3
Clonal analysis of human leukemias by molecular genetic approaches. 用分子遗传学方法分析人白血病克隆。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_3
C R Bartram, J W Janssen
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引用次数: 2
Karyotype of leukemia cells consistently predicts for response to therapy and survival following salvage therapy in acute myeloblastic leukemia. 白血病细胞的核型一致地预测对治疗的反应和挽救治疗后的生存在急性髓母细胞白血病。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_109
M J Keating, H Kantarjian, E Estey, W Plunkett, J Trujillo, K B McCredie
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引用次数: 2
Autologous bone marrow transplantation in acute myeloid leukemia in first remission: first Dutch prospective study. 自体骨髓移植治疗急性髓系白血病首次缓解:荷兰首次前瞻性研究。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_119
B Löwenberg, W L van Putten, L F Verdonck, A W Dekker, G C de Gast, R Willemze, F E Zwaan, J Abels, P Sonneveld, J van der Lelie

We have prospectively compared the values of autologous BMT (auto-BMT) and allogeneic marrow transplantation (allo-BMT) in patients (age 15-60 years) with acute myeloid leukemia (AML) who attained complete remission (CR) following remission-induction therapy. In 90/117 cases CR was reached. In 32 of those complete responders auto-BMT was undertaken and in 21 eligible cases HLA-matched allo-BMT. AML relapse was the predominant cause of failure after auto-BMT (17/32). The incidence of relapse after allo-BMT was 6/21. Patients treated with auto-BMT and allo-BMT have an overall survival of 37% and 66% at 3 years posttransplant (P = 0.05). Survival of the nongrafted complete responders is less than 10%. Allo-BMT in adult patients with AML in first complete remission provides a superior outcome when directly compared with the results of auto-BMT.

我们前瞻性地比较了自体骨髓移植(auto-BMT)和同种异体骨髓移植(alloc -BMT)在15-60岁急性髓性白血病(AML)患者在缓解诱导治疗后获得完全缓解(CR)的价值。117例患者中有90例达到CR。在32例完全应答者中进行了自体bmt，在21例符合条件的患者中进行了hla匹配的同种异体bmt。急性髓性白血病复发是自体骨髓移植失败的主要原因(17/32)。术后复发率为6/21。auto-BMT和alloo - bmt治疗的患者移植后3年的总生存率分别为37%和66% (P = 0.05)。未移植的完全应答者的存活率低于10%。在首次完全缓解的成年AML患者中，与auto-BMT的结果直接相比，alloo - bmt提供了更好的结果。
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引用次数: 5
Autologous bone marrow transplantation for acute leukemia in remission: an analysis of 1322 cases. 自体骨髓移植治疗急性白血病1322例疗效分析。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_120
N C Gorin, P Aegerter, B Auvert
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引用次数: 50
Results and significance of six randomized trials in four consecutive ALL-BFM studies. 四项连续ALL-BFM研究中六项随机试验的结果和意义。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_81
H Riehm, H Gadner, G Henze, B Kornhuber, F Lampert, D Niethammer, A Reiter, G Schellong
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引用次数: 220
Treatment of acute lymphoblastic leukemia: protocol Fralle 83-85. 急性淋巴细胞白血病的治疗:方案Fralle 83-85。
Haematology and blood transfusion
Pub Date : 1990-01-01
G Schaison, D Olive, G Leverger, J P Vannier, L de Lumley, A Bancillon, G Cornu
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引用次数: 0
Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia. 早期强化再诱导治疗对低风险急性淋巴细胞白血病儿童无事件生存的影响。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_87
G Henze, R Fengler, A Reiter, J Ritter, H Riehm
{"title":"Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia.","authors":"G Henze,&nbsp;R Fengler,&nbsp;A Reiter,&nbsp;J Ritter,&nbsp;H Riehm","doi":"10.1007/978-3-642-74643-7_87","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_87","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"483-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Risk of CNS relapse after systemic relapse of childhood acute lymphoblastic leukemia. 儿童急性淋巴细胞白血病全身复发后中枢神经系统复发的风险。
Haematology and blood transfusion
Pub Date : 1990-01-01 DOI: 10.1007/978-3-642-74643-7_92
R Fengler, R Hartmann, U Bode, G Janka, H Jürgens, H Riehm, G Henze
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引用次数: 11
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