Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_135
F R Appelbaum, J Nemunaitis, J W Singer, C D Buckner, R Storb, E D Thomas
{"title":"Use of recombinant human granulocyte macrophage colony-stimulating factor to speed engraftment and treat graft failure following marrow transplantation in man.","authors":"F R Appelbaum, J Nemunaitis, J W Singer, C D Buckner, R Storb, E D Thomas","doi":"10.1007/978-3-642-74643-7_135","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_135","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"736-40"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_109
M J Keating, H Kantarjian, E Estey, W Plunkett, J Trujillo, K B McCredie
{"title":"Karyotype of leukemia cells consistently predicts for response to therapy and survival following salvage therapy in acute myeloblastic leukemia.","authors":"M J Keating, H Kantarjian, E Estey, W Plunkett, J Trujillo, K B McCredie","doi":"10.1007/978-3-642-74643-7_109","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_109","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"593-603"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_119
B Löwenberg, W L van Putten, L F Verdonck, A W Dekker, G C de Gast, R Willemze, F E Zwaan, J Abels, P Sonneveld, J van der Lelie
We have prospectively compared the values of autologous BMT (auto-BMT) and allogeneic marrow transplantation (allo-BMT) in patients (age 15-60 years) with acute myeloid leukemia (AML) who attained complete remission (CR) following remission-induction therapy. In 90/117 cases CR was reached. In 32 of those complete responders auto-BMT was undertaken and in 21 eligible cases HLA-matched allo-BMT. AML relapse was the predominant cause of failure after auto-BMT (17/32). The incidence of relapse after allo-BMT was 6/21. Patients treated with auto-BMT and allo-BMT have an overall survival of 37% and 66% at 3 years posttransplant (P = 0.05). Survival of the nongrafted complete responders is less than 10%. Allo-BMT in adult patients with AML in first complete remission provides a superior outcome when directly compared with the results of auto-BMT.
{"title":"Autologous bone marrow transplantation in acute myeloid leukemia in first remission: first Dutch prospective study.","authors":"B Löwenberg, W L van Putten, L F Verdonck, A W Dekker, G C de Gast, R Willemze, F E Zwaan, J Abels, P Sonneveld, J van der Lelie","doi":"10.1007/978-3-642-74643-7_119","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_119","url":null,"abstract":"<p><p>We have prospectively compared the values of autologous BMT (auto-BMT) and allogeneic marrow transplantation (allo-BMT) in patients (age 15-60 years) with acute myeloid leukemia (AML) who attained complete remission (CR) following remission-induction therapy. In 90/117 cases CR was reached. In 32 of those complete responders auto-BMT was undertaken and in 21 eligible cases HLA-matched allo-BMT. AML relapse was the predominant cause of failure after auto-BMT (17/32). The incidence of relapse after allo-BMT was 6/21. Patients treated with auto-BMT and allo-BMT have an overall survival of 37% and 66% at 3 years posttransplant (P = 0.05). Survival of the nongrafted complete responders is less than 10%. Allo-BMT in adult patients with AML in first complete remission provides a superior outcome when directly compared with the results of auto-BMT.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"655-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_120
N C Gorin, P Aegerter, B Auvert
{"title":"Autologous bone marrow transplantation for acute leukemia in remission: an analysis of 1322 cases.","authors":"N C Gorin, P Aegerter, B Auvert","doi":"10.1007/978-3-642-74643-7_120","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_120","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"660-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_3
C R Bartram, J W Janssen
{"title":"Clonal analysis of human leukemias by molecular genetic approaches.","authors":"C R Bartram, J W Janssen","doi":"10.1007/978-3-642-74643-7_3","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_3","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_80
M Freund, M De Boben, H Diedrich, A Ganser, G Heil, A Heyll, M Henke, W Hiddemann, U Knauf, P Koch
Thirty-three patients with ALL/AUL in first relapse were treated with an induction of prednisone, vindesine, daunorubicin, Erwinia asparaginase, i.t. MTX (phase I), high-dose cytarabine, and etoposide (phase II). Twenty-one (64%) achieved a complete remission, one a partial remission. Side effects of induction-phase I were predominantly hematological with subsequent infections and gastrointestinal toxicity. In phase II some patients had additional cutaneous, ocular, and hepatic toxicity. The treatment efficiently induced remissions with tolerable toxicity in relapsed ALL. The disease-free survival, however, needs to be improved.
{"title":"Treatment of relapsed acute lymphocytic leukemia in adults.","authors":"M Freund, M De Boben, H Diedrich, A Ganser, G Heil, A Heyll, M Henke, W Hiddemann, U Knauf, P Koch","doi":"10.1007/978-3-642-74643-7_80","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_80","url":null,"abstract":"<p><p>Thirty-three patients with ALL/AUL in first relapse were treated with an induction of prednisone, vindesine, daunorubicin, Erwinia asparaginase, i.t. MTX (phase I), high-dose cytarabine, and etoposide (phase II). Twenty-one (64%) achieved a complete remission, one a partial remission. Side effects of induction-phase I were predominantly hematological with subsequent infections and gastrointestinal toxicity. In phase II some patients had additional cutaneous, ocular, and hepatic toxicity. The treatment efficiently induced remissions with tolerable toxicity in relapsed ALL. The disease-free survival, however, needs to be improved.</p>","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"432-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-74643-7_80","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_81
H Riehm, H Gadner, G Henze, B Kornhuber, F Lampert, D Niethammer, A Reiter, G Schellong
{"title":"Results and significance of six randomized trials in four consecutive ALL-BFM studies.","authors":"H Riehm, H Gadner, G Henze, B Kornhuber, F Lampert, D Niethammer, A Reiter, G Schellong","doi":"10.1007/978-3-642-74643-7_81","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_81","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"439-50"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-74643-7_81","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1990-01-01DOI: 10.1007/978-3-642-74643-7_87
G Henze, R Fengler, A Reiter, J Ritter, H Riehm
{"title":"Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia.","authors":"G Henze, R Fengler, A Reiter, J Ritter, H Riehm","doi":"10.1007/978-3-642-74643-7_87","DOIUrl":"https://doi.org/10.1007/978-3-642-74643-7_87","url":null,"abstract":"","PeriodicalId":12936,"journal":{"name":"Haematology and blood transfusion","volume":"33 ","pages":"483-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13335936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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