{"title":"Effects of neutral and dibasic amino acids on the in vitro release of insulin.","authors":"A Lernmark","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 1","pages":"22-30"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15671023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E C Abbott, V H James, R A Parker, W S Peart, R Fraser
RO1–8307, a heparinoid with low anticoagulant activity, was injected into male rats on a controlled diet. The width of the zona glomerulosa decreased, in relation to dosage and duration of treatment. Other endocrine organs were histologically unchanged, but there was involution of the thymus in rats given large doses. Vacuolation occurred in the proximal convoluted renal tubule, without derangement of tubule function. Coincident with the histologically altered zona glomerulosa was a marked reduction in aldosterone levels in the adrenal venous plasma, without significant change in deoxycorticosterone or corticosterone levels. Plasma sodium and potassium values were unchanged. The juxtaglomerular index increased in most animals, but extractable renin, measured by direct bioassay, increased significantly only with maximal dosage of RO1-8307. The findings confirm the hypothesis that heparin and heparinoids with diuretic properties act selectively on the zona glomerulosa to reduce aldosterone secretion, but the exact mechanism remains unknown.
{"title":"The effect of a sulphated mucopolysaccharide (RO1-8307) on adrenal and kidney morphology and function in the rat.","authors":"E C Abbott, V H James, R A Parker, W S Peart, R Fraser","doi":"10.1159/000178263","DOIUrl":"https://doi.org/10.1159/000178263","url":null,"abstract":"RO1–8307, a heparinoid with low anticoagulant activity, was injected into male rats on a controlled diet. The width of the zona glomerulosa decreased, in relation to dosage and duration of treatment. Other endocrine organs were histologically unchanged, but there was involution of the thymus in rats given large doses. Vacuolation occurred in the proximal convoluted renal tubule, without derangement of tubule function. Coincident with the histologically altered zona glomerulosa was a marked reduction in aldosterone levels in the adrenal venous plasma, without significant change in deoxycorticosterone or corticosterone levels. Plasma sodium and potassium values were unchanged. The juxtaglomerular index increased in most animals, but extractable renin, measured by direct bioassay, increased significantly only with maximal dosage of RO1-8307. The findings confirm the hypothesis that heparin and heparinoids with diuretic properties act selectively on the zona glomerulosa to reduce aldosterone secretion, but the exact mechanism remains unknown.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 3","pages":"129-43"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15233391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Vigneri, D Papalia, V Pezzino, S Squatrito, L Motta, P Polosa
In order to study thyrotropin releasing hormone (TRH)-thyroid hormone interaction, we examined thyrotropin (TSH) behaviour after synthetic TRH administration in 24 euthyroid subjects, 3 patients with
{"title":"Triiodothyronine and thyrotropin-releasing hormone interaction on TSH release in man.","authors":"R Vigneri, D Papalia, V Pezzino, S Squatrito, L Motta, P Polosa","doi":"10.1159/000178275","DOIUrl":"https://doi.org/10.1159/000178275","url":null,"abstract":"In order to study thyrotropin releasing hormone (TRH)-thyroid hormone interaction, we examined thyrotropin (TSH) behaviour after synthetic TRH administration in 24 euthyroid subjects, 3 patients with","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 4","pages":"250-6"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15732505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The antidiuretic action of chlorpropamide has been amply confirmed since the observations of Arduino and his colleagues in Brazil (1966). We have studied the initial and long-term response of 21 patients with the syndrome of diabetes insipidus. There was a consistent decrease in free water clearance usually to a negative value, which was unaffected by salt restriction. Other clinical studies in these patients, including hypertonic saline infusion, vasopressin administration, water loading and the pharmacological administration of alcohol produced data consistent with the proposed mechanism of action, to potentiate the normal effect of circulating vasopressin on the distal nephron. Free water clearance also became increasingly negative in 4 of 5 normal subjects, but was unaffected in 2 patients with polyuria due to diabetes mellitus. There was a consistent decrease in fluid intake relative to urine output during the initial phase of treatment of diabetes insipidus, suggesting a possible effects via a thirst mechanism, but this effect was not clearly demonstrated in normal subjects. The subsequent clinical course over 3 years of these patients, emphasising the danger of hypoglycaemia in coincident hypopituitarism and in children is discussed.
{"title":"Clinical observations on the mechanism of the antidiuretic action of chlorpropamide in vasopressin-sensitive diabetes insipidus and in normal subjects.","authors":"D R Hadden, S K Bhatia, D A Montgomery","doi":"10.1159/000178259","DOIUrl":"https://doi.org/10.1159/000178259","url":null,"abstract":"The antidiuretic action of chlorpropamide has been amply confirmed since the observations of Arduino and his colleagues in Brazil (1966). We have studied the initial and long-term response of 21 patients with the syndrome of diabetes insipidus. There was a consistent decrease in free water clearance usually to a negative value, which was unaffected by salt restriction. Other clinical studies in these patients, including hypertonic saline infusion, vasopressin administration, water loading and the pharmacological administration of alcohol produced data consistent with the proposed mechanism of action, to potentiate the normal effect of circulating vasopressin on the distal nephron. Free water clearance also became increasingly negative in 4 of 5 normal subjects, but was unaffected in 2 patients with polyuria due to diabetes mellitus. There was a consistent decrease in fluid intake relative to urine output during the initial phase of treatment of diabetes insipidus, suggesting a possible effects via a thirst mechanism, but this effect was not clearly demonstrated in normal subjects. The subsequent clinical course over 3 years of these patients, emphasising the danger of hypoglycaemia in coincident hypopituitarism and in children is discussed.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 2","pages":"77-96"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15732011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human chorionic somato-mammotropin (HCS) was injected intravenously (25 mg/kg) into hypophysectomized dogs and caused a sluggish rise in the concentration of plasma free fatty acids (FFA), which becam
{"title":"The effect of dihydroergotamine on lipolysis stimulated by human chorionic somato-mammotropin in hypophysectomized dogs.","authors":"A M Sirek, O V Sirek, A Sirek","doi":"10.1159/000178272","DOIUrl":"https://doi.org/10.1159/000178272","url":null,"abstract":"Human chorionic somato-mammotropin (HCS) was injected intravenously (25 mg/kg) into hypophysectomized dogs and caused a sluggish rise in the concentration of plasma free fatty acids (FFA), which becam","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 4","pages":"221-7"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15753476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A patient with Bartter’s Syndrome with hypernatremia, chronic low grade fever, fluctuating endocrine functions is presented. The fluetuating endocrine functions suggest a hypothalamic dysfunction. It appeared in this patient that the Bartter’s Syndrome and the changing endocrine functions co-existed rather than one being the causeof the other.
{"title":"Bartter's syndrome with possible hypothalamic dysfunction.","authors":"J H Kim","doi":"10.1159/000178258","DOIUrl":"https://doi.org/10.1159/000178258","url":null,"abstract":"A patient with Bartter’s Syndrome with hypernatremia, chronic low grade fever, fluctuating endocrine functions is presented. The fluetuating endocrine functions suggest a hypothalamic dysfunction. It appeared in this patient that the Bartter’s Syndrome and the changing endocrine functions co-existed rather than one being the causeof the other.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"3 2","pages":"65-76"},"PeriodicalIF":0.0,"publicationDate":"1972-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15756284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Homotransplantation of European hamster (Cricetus cricetus) adrenal cortex fragments was made into the testes of animals which were later adrenalectomized. It was revealed that the
{"title":"Activity of adrenal cortex homotransplanted into testes of adrenalectomized hamsters.","authors":"B Canguilhem, A Petrovic","doi":"10.1159/000178245","DOIUrl":"https://doi.org/10.1159/000178245","url":null,"abstract":"Homotransplantation of European hamster (Cricetus cricetus) adrenal cortex fragments was made into the testes of animals which were later adrenalectomized. It was revealed that the","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 6","pages":"321-6"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the hypothalamus of white rats ganglion cell groups can be observed which show enzyme histochemical properties (low SDH and CYO, moderate G6PDH and TPND and marked LDH and MDH activity) similar to those of the supraoptic and paraventricular nuclei performing secretory function. These cell groups are the accessory magnocellular cell groups, those radiating from the paraventricular nucleus, all the cells of the nucleus tuberomamillaris as well as cells located in the area of the nucleus periventricularis arcuatus, cells situated inframamillarily and arranged peri- and parafornically in the infundibular plane. From the histoenzymological point of view several similar traits can be observed between these cell groups and the epiphysis as well as the special ependymal parts or organs of the third ventricle. On the basis of analogy it is conceivable that also the said cell groups of the hypothalamus perform secretory function.
{"title":"Comparative study of the histoenzymological properties of the supraoptic and paraventricular nuclei and of other nuclear regions of the hypothalamus, the epithalamus-epiphysis region and the subfornical organ.","authors":"D Bara, J Skaliczki, J Ormos","doi":"10.1159/000178232","DOIUrl":"https://doi.org/10.1159/000178232","url":null,"abstract":"In the hypothalamus of white rats ganglion cell groups can be observed which show enzyme histochemical properties (low SDH and CYO, moderate G6PDH and TPND and marked LDH and MDH activity) similar to those of the supraoptic and paraventricular nuclei performing secretory function. These cell groups are the accessory magnocellular cell groups, those radiating from the paraventricular nucleus, all the cells of the nucleus tuberomamillaris as well as cells located in the area of the nucleus periventricularis arcuatus, cells situated inframamillarily and arranged peri- and parafornically in the infundibular plane. From the histoenzymological point of view several similar traits can be observed between these cell groups and the epiphysis as well as the special ependymal parts or organs of the third ventricle. On the basis of analogy it is conceivable that also the said cell groups of the hypothalamus perform secretory function.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 3","pages":"164-83"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In rats, the catabolism normally induced by chronic dihydrotachysterol (DHT) intoxication is counteracted (in approximately decreasing order of activity) by: norbolethone, ethylestrenol, CS-1 and preg
{"title":"Influence of various catatoxic steroids upon chronic dihydrotachysterol intoxication.","authors":"H Selye","doi":"10.1159/000178229","DOIUrl":"https://doi.org/10.1159/000178229","url":null,"abstract":"In rats, the catabolism normally induced by chronic dihydrotachysterol (DHT) intoxication is counteracted (in approximately decreasing order of activity) by: norbolethone, ethylestrenol, CS-1 and preg","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 3","pages":"129-38"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15253870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glucose-6-phosphate content in mammalian pancreatic beta-cells. Effects of various stimulators and inhibitors of insulin release.","authors":"L A Idahl","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 6","pages":"371-7"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15480323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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