{"title":"Sarcoidosis of the hypothalamus. A case report with a review of the literature.","authors":"A Heffernan, M Cullen, R Towers, D K O'Donovan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16044444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G D Bryant, T M Siler, F C Greenwood, J L Pasteels, C Robyn, P O Hubinont
A protein fraction with prolactin bioactivities was obtained from the culture medium of human fetal pituitary tissue in long term cultures and termed Pasteels human prolactin (PHP) for convenience. An antiserum was prepared against this human prolactin and used to develop a radioimmunoassay for the material in human plasma. The antigen available (220 µg)was tested against antisera to human growth hormone and to human placental lactogen and in radioimmunoassays for these hormones. The results suggested that the human prolactin fraction contained some immunoreactive human growth hormone (1%). The resulting antibodies in the antihuman prolactin serum could be neutralized by the addition of human growth hormone. The human prolactin also generated antibodies, binding 131I-labelled human prolactin, which were not neutralized by human growth hormone. This binding was inhibited by plasma from a normal male, 2 normal females and by plasma from a lactating woman after breast feeding. An increase in plasma concentration of the inhibitor, immunologically similar to the human prolactin fraction, was obtained after phenothiazine injection. In the 7 plasma samples tested for human prolactin only 1 contained a detectable concentration of immunoreactive growth hormone. Immunoreactive human placental lactogen (human chorionic somatomammotropin) or any material cross-reacting with anti-HCS serum was undetectable in these plasma samples by a sensitive radioimmunoassay. It is suggested that human plasmas contain detectable amounts of a material immunologically similar to a prolactin fraction isolated from tissue cultures of fetal pituitaries. The fraction and the plasma inhibitor are distinguishable by immunoassay from human growth hormone and from human placental lactogen.
{"title":"Radioimmunoassay of a human pituitary prolactin in plasma.","authors":"G D Bryant, T M Siler, F C Greenwood, J L Pasteels, C Robyn, P O Hubinont","doi":"10.1159/000178230","DOIUrl":"https://doi.org/10.1159/000178230","url":null,"abstract":"A protein fraction with prolactin bioactivities was obtained from the culture medium of human fetal pituitary tissue in long term cultures and termed Pasteels human prolactin (PHP) for convenience. An antiserum was prepared against this human prolactin and used to develop a radioimmunoassay for the material in human plasma. The antigen available (220 µg)was tested against antisera to human growth hormone and to human placental lactogen and in radioimmunoassays for these hormones. The results suggested that the human prolactin fraction contained some immunoreactive human growth hormone (1%). The resulting antibodies in the antihuman prolactin serum could be neutralized by the addition of human growth hormone. The human prolactin also generated antibodies, binding 131I-labelled human prolactin, which were not neutralized by human growth hormone. This binding was inhibited by plasma from a normal male, 2 normal females and by plasma from a lactating woman after breast feeding. An increase in plasma concentration of the inhibitor, immunologically similar to the human prolactin fraction, was obtained after phenothiazine injection. In the 7 plasma samples tested for human prolactin only 1 contained a detectable concentration of immunoreactive growth hormone. Immunoreactive human placental lactogen (human chorionic somatomammotropin) or any material cross-reacting with anti-HCS serum was undetectable in these plasma samples by a sensitive radioimmunoassay. It is suggested that human plasmas contain detectable amounts of a material immunologically similar to a prolactin fraction isolated from tissue cultures of fetal pituitaries. The fraction and the plasma inhibitor are distinguishable by immunoassay from human growth hormone and from human placental lactogen.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 3","pages":"139-52"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A method for the determination of progesterone in human plasma by competitive protein-binding is described. This method consists of extraction with petroleum ether, HTLC to purify the extracts and CBG
{"title":"The measurement of progesterone in human plasma by competitive protein-binding radioassay.","authors":"C Fassorra, M Luisi","doi":"10.1159/000178231","DOIUrl":"https://doi.org/10.1159/000178231","url":null,"abstract":"A method for the determination of progesterone in human plasma by competitive protein-binding is described. This method consists of extraction with petroleum ether, HTLC to purify the extracts and CBG","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 3","pages":"153-63"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N I Robin, S R Hagen, F Collaço, S Refetoff, H A Selenkow
Thyroxine by displacement analysis (T4D) along with the resin-T3 (RT3) and resin-T4 (RT4) ratios were determined analytically on serum samples from 160 ‘normal’, 50 hypothyroid and 70 hyperthyroid per
{"title":"Serum tests for measurement of thyroid function.","authors":"N I Robin, S R Hagen, F Collaço, S Refetoff, H A Selenkow","doi":"10.1159/000178240","DOIUrl":"https://doi.org/10.1159/000178240","url":null,"abstract":"Thyroxine by displacement analysis (T4D) along with the resin-T3 (RT3) and resin-T4 (RT4) ratios were determined analytically on serum samples from 160 ‘normal’, 50 hypothyroid and 70 hyperthyroid per","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 5","pages":"266-79"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effect of chlorpropamide and water deprivation test on free water clearance was investigated in 10 patients with diabetes insipidus. It was found that in patients in whom negativation of free wate
{"title":"Effect of chlorpropamide and water deprivation on free water clearance in patients with diabetes insipidus.","authors":"M L Batrinos, G J Tolis, G Traïanos","doi":"10.1159/000178248","DOIUrl":"https://doi.org/10.1159/000178248","url":null,"abstract":"The effect of chlorpropamide and water deprivation test on free water clearance was investigated in 10 patients with diabetes insipidus. It was found that in patients in whom negativation of free wate","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 6","pages":"366-70"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patterns of reproduction in human populations living at high altitudes are discussed. While there appears to be little impairment of gametogenesis in either sex in resident highland populations, there
{"title":"Reproduction in human high altitude populations.","authors":"E J Clegg, G A Harrison","doi":"10.1159/000178221","DOIUrl":"https://doi.org/10.1159/000178221","url":null,"abstract":"Patterns of reproduction in human populations living at high altitudes are discussed. While there appears to be little impairment of gametogenesis in either sex in resident highland populations, there","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 1","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16044445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Incubation in vitro of natural (ovine) or synthetic TRF (PCA-His-Pro-NH2) with rat blood, plasma, or reconstituted lyophilized serum destroys the biological activity. Ina
{"title":"In vitro plasma inactivation of thyrotropin releasing factor (TRF) and related peptides. Its inhibition by various means and by the synthetic dipeptide PCA-His-OME.","authors":"W W Vale, R Burgus, T F Dunn, R Guillemin","doi":"10.1159/000178234","DOIUrl":"https://doi.org/10.1159/000178234","url":null,"abstract":"Incubation in vitro of natural (ovine) or synthetic TRF (PCA-His-Pro-NH2) with rat blood, plasma, or reconstituted lyophilized serum destroys the biological activity. Ina","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 4","pages":"193-203"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16095860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Girard, J B Baumann, M Stahl, P W Nars, U Bühler, H Wick
Insulin-induced hypoglycemia has been used in 109 children with a variety of disorders to assess the hypothalamo-pituitary adrenal axis.The patients were divided into 3 groups: (1) patients with growth retardation and with various disorders where an involvement of the hypothalamo-pituitary region was suspected; (2) obese patients; (3) specific syndromes: spontaneous hypoglycemia, anorexia nervosa, Turner’s syndrome, craniopharyngioma. Glucose, free fatty acids, cortisol and growth hormone were measured before injection of insulin, and at 20-min-intervals thereafter for a period of 2–4 h. The findings, particularly in obesity and in syndromes other than growth disorders have shown, that a series of factors have to be considered for a correct interpretation of the hormonal response to hypoglycemia. The limits for normal, reduced or absent response are given and as a simple screening for growth hormonee deficiency, a growth hormone estimation without stimulation can be used. The test has been found safe under clinical conditions and to provide reliable information about growth hormone and ACTH, respectively cortisol reaction.
{"title":"Experience with insulin-induced hypoglycemia as a provocative test for growth hormone and cortisol secretion in children.","authors":"J Girard, J B Baumann, M Stahl, P W Nars, U Bühler, H Wick","doi":"10.1159/000178247","DOIUrl":"https://doi.org/10.1159/000178247","url":null,"abstract":"Insulin-induced hypoglycemia has been used in 109 children with a variety of disorders to assess the hypothalamo-pituitary adrenal axis.The patients were divided into 3 groups: (1) patients with growth retardation and with various disorders where an involvement of the hypothalamo-pituitary region was suspected; (2) obese patients; (3) specific syndromes: spontaneous hypoglycemia, anorexia nervosa, Turner’s syndrome, craniopharyngioma. Glucose, free fatty acids, cortisol and growth hormone were measured before injection of insulin, and at 20-min-intervals thereafter for a period of 2–4 h. The findings, particularly in obesity and in syndromes other than growth disorders have shown, that a series of factors have to be considered for a correct interpretation of the hormonal response to hypoglycemia. The limits for normal, reduced or absent response are given and as a simple screening for growth hormonee deficiency, a growth hormone estimation without stimulation can be used. The test has been found safe under clinical conditions and to provide reliable information about growth hormone and ACTH, respectively cortisol reaction.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 6","pages":"338-65"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The authors describe an anomalous post-infarctual evolution, already revealed by Sotgiu in 1959 and defined the’ postinfarctual anedematous syndrome’ (SAPI). The syndrome, present in about 12% of MI, demonstrates a clinical picture characterized by a global hypometabolism, absence of edema and state of continuous sub-collapse; an endocrine picture characterized by a corticomedullary adrenal, thyroid and hypophisis hypoactivity. The results confirm that, in contrast to other myocardial infarction cases, in patients with SAPI low values of cortisol, aldosterone and catecholamines exist, with alteration of the glycocorticoid and adrenergic amine circadian-biorhythm. The pharmacodynamic tests, demonstrating the integrity of the adrenal gland, have revealed an alteration of the hypothalamic-pituitary function. According to the authors, the occurrence of SAPI might be interpreted on the basis of a particular vulnerability of the hypothalamic-pituitary system (often depending upon the senile age of the subjects) which is probably amplified by the stress created by the myocardial necrosis.
{"title":"Further contribution to the understanding of the post-infarctual anedematous syndrome.","authors":"A Lodi, P Bernardi, G C Descovich, F M Gritti","doi":"10.1159/000178227","DOIUrl":"https://doi.org/10.1159/000178227","url":null,"abstract":"The authors describe an anomalous post-infarctual evolution, already revealed by Sotgiu in 1959 and defined the’ postinfarctual anedematous syndrome’ (SAPI). The syndrome, present in about 12% of MI, demonstrates a clinical picture characterized by a global hypometabolism, absence of edema and state of continuous sub-collapse; an endocrine picture characterized by a corticomedullary adrenal, thyroid and hypophisis hypoactivity. The results confirm that, in contrast to other myocardial infarction cases, in patients with SAPI low values of cortisol, aldosterone and catecholamines exist, with alteration of the glycocorticoid and adrenergic amine circadian-biorhythm. The pharmacodynamic tests, demonstrating the integrity of the adrenal gland, have revealed an alteration of the hypothalamic-pituitary function. According to the authors, the occurrence of SAPI might be interpreted on the basis of a particular vulnerability of the hypothalamic-pituitary system (often depending upon the senile age of the subjects) which is probably amplified by the stress created by the myocardial necrosis.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 2","pages":"100-14"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The endometrium of 1,000 sterile women were histologically evaluated, by premenstrual or menstrual biopsy or curettage. Nearly 20% showed corporal or cervical polyps. The intrauterine intervention is also of therapeutic value. Endometrial response after administration of oral contraceptives was not favourable in the cases of hormonal sterility.The author concludes that in the diagnosis of sterility no histological examination ofthe endometrium is in error.
{"title":"The analysis of the endometrium of 1,000 sterile women.","authors":"G Silló-Seidl","doi":"10.1159/000178225","DOIUrl":"https://doi.org/10.1159/000178225","url":null,"abstract":"The endometrium of 1,000 sterile women were histologically evaluated, by premenstrual or menstrual biopsy or curettage. Nearly 20% showed corporal or cervical polyps. The intrauterine intervention is also of therapeutic value. Endometrial response after administration of oral contraceptives was not favourable in the cases of hormonal sterility.The author concludes that in the diagnosis of sterility no histological examination ofthe endometrium is in error.","PeriodicalId":13017,"journal":{"name":"Hormones","volume":"2 2","pages":"70-5"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000178225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16096616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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