– Fentanyl, a selective agonist of opioid μ receptors, is a broadly used clinical agent for anesthesia and pain relief. Despite its clinical benefits, the abuse of fentanyl and its derivatives causes a number of health concerns, which are increasing at an alarming rate; its abuse has become a serious social problem. These compounds are often difficult to obtain as reagents
{"title":"Comprehensive Synthesis of 20 Fentanyl Derivatives for Their Rapid Differentiation by GC-MS Analysis","authors":"Takashi Misawa, Genichiro Tsuji, Takashi Kurohara, T. Ito, Hidetomo Yokoo, Maiko Kawamura, Takuji Shoda, Ruri Hanajiri-kikura, Yosuke Demizu","doi":"10.3987/com-22-14760","DOIUrl":"https://doi.org/10.3987/com-22-14760","url":null,"abstract":"– Fentanyl, a selective agonist of opioid μ receptors, is a broadly used clinical agent for anesthesia and pain relief. Despite its clinical benefits, the abuse of fentanyl and its derivatives causes a number of health concerns, which are increasing at an alarming rate; its abuse has become a serious social problem. These compounds are often difficult to obtain as reagents","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70398293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catalyst-Free Green Synthesis of Phthalazinones at Room Temperature","authors":"Mengtao Ma, Weiwei Yao, K. Lv, Zixi Xie, Xi Chen","doi":"10.3987/com-22-14778","DOIUrl":"https://doi.org/10.3987/com-22-14778","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70398603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acid, Metal and Peroxide-Free Synthesis of 2,4,5-Trisubstituted Imidazoles Commencing from Internal Alkenes Using an Iodine/DMSO System","authors":"V. Jeena, Nonhlelo Majola","doi":"10.3987/com-22-14781","DOIUrl":"https://doi.org/10.3987/com-22-14781","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70398709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lars Hagberg, R. Ringom, T. Blizzard, C. Sandström, Per H. Svensson
{"title":"On the Reacitivty of 2-Methylene-3-quinuclidinone in Water","authors":"Lars Hagberg, R. Ringom, T. Blizzard, C. Sandström, Per H. Svensson","doi":"10.3987/com-22-14797","DOIUrl":"https://doi.org/10.3987/com-22-14797","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70399196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhushan B. Popatkar, Vikas V. Borge, Ramchandra G. Thorat, Arun K. Kadu, Vikas M. Bangade, Gangadhar A. Meshram, Parag S. Panse
{"title":"Cysteine Catalyzed Water Mediated Eco-Friendly Approach for the Synthesis of 5-Substituted 1H-Tetrazole and Its Derivatives","authors":"Bhushan B. Popatkar, Vikas V. Borge, Ramchandra G. Thorat, Arun K. Kadu, Vikas M. Bangade, Gangadhar A. Meshram, Parag S. Panse","doi":"10.3987/com-23-14805","DOIUrl":"https://doi.org/10.3987/com-23-14805","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70399963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Biological Assessment of Novel Heterocyclic Nucleoside Analogues Using Microwave-Assisted Hantzsch Reaction","authors":"Abdelaaziz Ouahrouch, Jamal Krim, M. Taourirte","doi":"10.3987/com-23-14853","DOIUrl":"https://doi.org/10.3987/com-23-14853","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70400979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of 1,2-Dicarbonyls from Five-Membered Cyclic Enamines and Arylglyoxal Hydrates under Metal-Free Conditions","authors":"Wei-Qiang Fan","doi":"10.3987/com-23-14827","DOIUrl":"https://doi.org/10.3987/com-23-14827","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70401126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Selective Protection and De-Protection of Phenolic Hydroxyl Groups of Naringenin","authors":"Guo-Chun Zhou, X. Hu","doi":"10.3987/com-23-14868","DOIUrl":"https://doi.org/10.3987/com-23-14868","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70401611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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