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Synthesis, Characterization, Molecular Docking Studies and Antimicrobial Activity of Azomethine Derivatives of 1,3-Substituted Pyrazoles 1,3-取代吡唑类亚甲基衍生物的合成、表征、分子对接研究及抗菌活性研究
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-11-02 DOI: 10.3987/com-23-14877
Hissana Ather, Aysha A. Ali Theban, Fareeaa Ashar, Boshra Yahya A. Mohammad Essa, Yomna Ali A. Albarqi, Ghadah Saad A. Alshehri, and Renad Abdulhadi M. Almodawi
Two different series of azomethine derivatives of 1,3-substitued pyrazoles were synthesized from the intermediates 3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (3a) and 3-(furan-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde (3b) by the condensation of various substituted anilines. The intermediates were obtained from the appropriate phenylhydrazones via Vilsmeier–Haack reaction. The synthesized compounds were characterized by IR, 1H NMR and MASS spectral studies. Molecular docking studies results revealed that 4a7 and 4a8 showed highest binding affinity against fungal target secreted aspartic proteinase (Sap) 1 (2QZW) and compounds 4a8 and 4a5 showed highest binding affinity against bacterial target glucosamine-6-phosphate synthase (2VF5). In vitro antimicrobial activity of corresponding azomethine derivatives were assessed on Gram-positive and Gram-negative bacteria. Antifungal activity was assessed on Candida albicans. The results revealed that six out of fifteen compounds screened have shown good antimicrobial activity. Among them, 4a1, 4a4, 4a6 and 4a7 shown good inhibition against Candida albicans.
以3-(4-氯苯基)-1-苯基- 1h -吡唑-4-醛(3a)和3-(呋喃-2-基)-1-苯基- 1h -吡唑-4-醛(3b)为中间体,通过不同取代苯胺的缩合反应,合成了两个不同系列的1,3取代吡唑的亚甲基衍生物。中间体由相应的苯腙通过Vilsmeier-Haack反应得到。合成的化合物通过IR、1H NMR和质谱进行了表征。分子对接研究结果显示,化合物4a7和4a8对真菌分泌的靶天冬氨酸蛋白酶(Sap) 1 (2QZW)具有最高的结合亲和力,化合物4a8和4a5对细菌靶葡萄糖胺-6-磷酸合成酶(2VF5)具有最高的结合亲和力。测定相应的亚甲胺衍生物对革兰氏阳性菌和革兰氏阴性菌的体外抑菌活性。评估对白色念珠菌的抗真菌活性。结果表明,筛选的15个化合物中有6个具有良好的抗菌活性。其中4a1、4a4、4a6和4a7对白色念珠菌有较好的抑制作用。
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引用次数: 0
Synthesis of New Glycoluril Derivatives via Ring-Closing Metathesis 合环复合法合成新的甘醇衍生物
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-11-02 DOI: 10.3987/com-23-14912
Sambasivarao Kotha and Deepshikha Singh
Tetra-N-allylation of glycoluril reactions followed by ring-closing metathesis has been used to generate new concave-shaped glycoluril derivatives. The advantages of this method are mild conditions, single-product formation and good yield.
用四氮四烯丙基化反应和合环复合反应制备了新的凹形糖脲衍生物。该方法具有条件温和、单产、收率高的优点。
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引用次数: 0
Diastereoselective Synthesis of 2,8-Dioxabicyclo[3.3.1]Nonane Derivatives via I 1,2 -二氧杂环[3.3.1]壬烷衍生物的非对映选择性合成
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-11-01 DOI: 10.3987/com-23-14891
-Mediated Cascade Reactions
The highly diastereoselective one-pot synthesis generating a variety of 9,9-dimethyl-2,8-dioxabicyclo[3.3.1]nonane derivatives up to dr >19:1 has been established by the reaction of a 2’-methoxylchalcone with isobutyraldehyde via a spontaneous sequential one-pot Michael addition/aldol reaction/demethylative bicyclization in the presence of molecular iodine.
在碘分子存在下,2 ' -甲氧基查尔酮与异丁醛通过自发的连续一锅迈克尔加成反应/醛醇反应/去甲基双环化反应,建立了高度非对映选择性的一锅合成方法,生成了多种达dr >19:1的9,9-二甲基-2,8-二氧杂环[3.3.1]壬烷衍生物。
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引用次数: 0
Briastecholide N: a New Chlorine-Containing Briarane Diterpenoid Deriving from Cultured Briastecholide N:一种新的含氯Briarane二萜
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-10-30 DOI: 10.3987/com-23-14911
You-Ying Chen, Yueh-Wen Liu, Su-Ying Chien, Yu-Cheng Chen, Fu-Ching Chiu, Po-Wei Huang, I-Li Su, Zhi-Hong Wen, Hung-Tsung Lee, and Ping-Jyun Sung
A new chlorine-containing briarane-type diterpenoid, briastecholide N (1) was isolated from cultured octocoral Briareum stechei via chemical screening. The structure of 1 was corroborated by 2D NMR experiments and confirmed backed by single-crystal X-ray diffraction analysis. The study found that 1 is capable of increasing the release of alkaline phosphatse (ALP) at 10 μM.
通过化学筛选,从培养的八月牙Briareum stechei中分离到一种新的含氯briarane型二萜类化合物briastecholide N(1)。通过二维核磁共振实验和单晶x射线衍射分析证实了1的结构。研究发现,1能增加10 μM下碱性磷酸酶(ALP)的释放。
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引用次数: 0
Synthetic Studies toward 11- 对11-的综合研究
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-10-24 DOI: 10.3987/rev-23-1018
-Debenzoyltashironin
11-O-Debenzoyltashironin is a highly oxygenated allo-cedrane sesquiterpenoid with seven contiguous chiral centers in a compact fused ring, and shows remarkable neurite extension activity. Total syntheses of the title and related compounds are reviewed.
11- o- debenzoyl - lashironin是一种高氧合的异丙雪松烷倍半萜类化合物,具有7个连续的手性中心,具有显著的神经突伸展活性。综述了该化合物及其相关化合物的全合成方法。
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引用次数: 0
A Facile Synthesis and Anticancer Activity of ( ()的简易合成及其抗癌活性
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-10-18 DOI: 10.3987/com-23-14909
)-Diethyl 2-Styrylquinoline-3,4-dicarboxylates
In the present investigation, a simple and flexible synthesis of a series of novel (E)-diethyl 2-styrylquinoline-3,4-dicarboxylates 3a-q has been achieved for the first time in good yields, involving one-pot sequential Arbuzov/Horner–Emmons reaction sequence using the newly-synthesized diethyl 2-(bromomethyl)quinoline-3,4-dicarboxylate as the substrate. The latter was obtained by NBS-mediated radical bromination reaction of the readily available diethyl 2-methylquinoline-3,4-dicarboxylate. A primary in vitro evaluation for their antiproliferative activity against human cancer cell lines (A549, HT29 and T24) revealed that the compound 3k with 3,4,5-trimethoxystyryl moiety represented the most active molecule against the tested A549 cell lines in this round of effort with the IC50 values of 2.38 µmol•L-1, being higher than the reference cisplatin.
本研究首次以新合成的2-(溴乙基)喹啉-3,4-二羧酸二乙酯为底物,采用一锅序Arbuzov/ Horner-Emmons反应顺序,简单灵活地合成了一系列新的(E)-二乙基- 2-苯基喹啉-3,4-二羧酸酯3a-q,收率较高。二甲基喹啉-3,4-二羧酸二乙酯是通过nbs介导的自由基溴化反应得到的。体外初步评价其对人肿瘤细胞株(A549、HT29和T24)的抗增殖活性,结果表明,具有3,4,5-三甲氧基苯乙烯基片段的化合物3k对A549细胞株的IC50值为2.38µmol•L-1,高于参比顺铂。
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引用次数: 0
Simultaneous Denitrative C–C Bond Formation and Construction of Pyrazole Ring Leading to 1,1'-Diphenyl-4,4'-bipyrazole 同时反硝化C-C键形成和吡唑环的构建导致1,1'-二苯基-4,4'-联吡唑
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-22-14772
N. Nishiwaki, Kento Iwai, Nana Hatayama
–  -Formyl-  -nitroenamine reacts with phenylhydrazine to afford 1,1'-diphenyl-4,4'-bipyrazole. The unusual C–C bond formation was found to proceed in an ionic mechanism initiated by excess amount of hydrazine. This reaction is interesting from a viewpoint of synthetic chemistry because it simultaneously involves the construction of a pyrazole ring and the formation of a C–C bond under neutral conditions.  -Formyl-
-b -甲酰基-b -硝基胺与苯肼反应生成1,1'-二苯基-4,4'-联吡唑。发现异常的C-C键形成是在过量的联氨引发的离子机制下进行的。从合成化学的角度来看,这个反应很有趣,因为在中性条件下,它同时涉及吡唑环的构造和C-C键的形成。b -甲酰基- b -硝基胺(1)具有多种功能,如a, b -不饱和醛,硝基烯和烯胺。推挽性质产生高度电子偏置的C-C双键,该双键可与亲核试剂或亲电试剂反应,形成多功能杂环框架
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引用次数: 0
A New Compound Embeloside A with Hypoglycemic Potential from the Fruits of Embelia Oblongifolia Hemsl. 从桔梗果实中提取具有降血糖作用的新化合物桔梗苷A。
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-22-14799
Lei Yu, Haifeng Wang, Yuqing Sun, Ying Xu, Bing Liu, Ning Chen, Yingjie Liu, Dongxue Wang
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引用次数: 0
Organic Base-Catalyzed Cascade Reaction of Electron-Deficient Cyclopentadienone with Prop-2-yn-1-ols: Formation of 3-Methylenetetrahydrofuran Ring Condensed with Cyclopentenone 有机碱催化缺电子环戊二酮与丙-2-炔-1-醇的级联反应:与环戊烯酮缩合形成3-亚甲基四氢呋喃环
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14811
K. Yamaguchi
procedure, bicyclic compounds
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引用次数: 0
Synthesis and Biological Evaluation of 5-Methylpyrimidine Derivatives as Dual Inhibitors of EGFR and Src for Cancer Treatment 5-甲基嘧啶衍生物作为EGFR和Src双重抑制剂治疗癌症的合成和生物学评价
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14824
Longjia Yan, Yaqing Zuo, Kehui Chen, Ying Xu, Y. Le
{"title":"Synthesis and Biological Evaluation of 5-Methylpyrimidine Derivatives as Dual Inhibitors of EGFR and Src for Cancer Treatment","authors":"Longjia Yan, Yaqing Zuo, Kehui Chen, Ying Xu, Y. Le","doi":"10.3987/com-23-14824","DOIUrl":"https://doi.org/10.3987/com-23-14824","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70401116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Heterocycles
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