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Advances on Catalytic Approaches towards the Synthesis of Quinoline Derivatives Using Povarov Reaction 用Povarov反应催化合成喹啉衍生物的研究进展
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/rev-23-1004
Chandi C. Malakar, K. Kant, Sourav Banerjee, Chandresh K. Patel, S. Kalita, N. Aljaar, Reetu Reetu, Priyadarshini Naik
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引用次数: 0
Chiral Benzimidazolium N-Heterocyclic Carbene Ligands with Hydroxyamide- or Hydroxyalkyl-Functionalized Wingtip for Cu-Catalyzed Asymmetric Allylic Alkylation 手性苯并咪唑n杂环卡宾配体与羟基酰胺或羟基烷基功能化翼尖铜催化的不对称烯丙基烷基化
4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14880
Satoshi Sakaguchi, Shota Takayanagi
{"title":"Chiral Benzimidazolium N-Heterocyclic Carbene Ligands with Hydroxyamide- or Hydroxyalkyl-Functionalized Wingtip for Cu-Catalyzed Asymmetric Allylic Alkylation","authors":"Satoshi Sakaguchi, Shota Takayanagi","doi":"10.3987/com-23-14880","DOIUrl":"https://doi.org/10.3987/com-23-14880","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135441411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Synthesis of Quinazoline-2,4(1H,3H)-Diones from 2-Aminobenzonitriles and Co2 Catalyzed by 2-Hydroxypyridine Anion-Based Ionic Liquid at Atmospheric Pressure 常压下2-羟基吡啶阴离子液体催化2-氨基苯并腈和Co2高效合成喹唑啉-2,4(1H,3H)-二酮
4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14892
Qi Feng, Lele Li, Jiayi Jin, Wanyao Hu, Jiayi Huang
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引用次数: 0
Synthesis and Antitumor Activity of Heterocylic Aurone and Its Analogue Indanone Derivatives 杂环金酮及其类似物吲哚酮衍生物的合成及抗肿瘤活性研究
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-22-14764
H. Akber Aisa, C. Niu, Heng Wu, Ayitila Maimaitijiang, Dan-Jie Tang, Baoxing Xie
– Based on non-classical bioisosterism and the rule of alkene insertion, thirty-five heterocyclic aurones and its analogue indanones derivatives were designed and synthesized. They were evaluated for inhibitory activity against HELA, HT-29 and A549 and HepG2 human cancer cell lines. Among them, twenty-five compounds exhibited moderate to excellent antitumor activity. The minimum value of IC 50 was 1.649±0.083 μM (compound B1 ). The SAR showed that aurone with B ring as aromatic heterocycles such as 4-bromothiophene, quinoline, carbazole and indanone derivatives and some or indanone were more potent than others. Besides, the introduction of acetylated glycosides was beneficial to the activity. Compounds A1 , B1 , C5 , C8 , C10 , C11 , C12 and D1 were promising antitumor agents. Among them, compounds molecular docking studies were performed between B1 , C8 and potential targets Aurora B (PBD: 2BFY). On the basis, the chemical and physical properties, as well as ADMET of active compounds were predicted and analyzed. And it showed that most of compounds had good pharmacokinetic profiles and high safety profiles
-基于非经典生物等构和烯烃插入规律,设计合成了35个杂环金酮及其类似物吲哚酮衍生物。测定了它们对HELA、HT-29、A549和HepG2人癌细胞的抑制活性。其中25个化合物具有中等至优异的抗肿瘤活性。IC 50最小值为1.649±0.083 μM(化合物B1)。SAR结果表明,4-溴噻吩、喹啉、咔唑和吲哚酮衍生物等含B环的芳香杂环的呋喃酮具有较强的药效。此外,乙酰化糖苷的引入有利于活性的提高。化合物A1、B1、C5、C8、C10、C11、C12和D1是有前景的抗肿瘤药物。其中,化合物B1、C8与潜在靶点Aurora B (PBD: 2BFY)进行了分子对接研究。在此基础上,对活性化合物的理化性质和ADMET进行了预测和分析。结果表明,大多数化合物具有良好的药动学特征和较高的安全性
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引用次数: 1
Supramolecular Self-Assembly Based on Symmetric Tetramethyl-Substituted Cucurbit[6]uril and Small Aromatic Amines 基于对称四甲基取代葫芦b[6]和小芳胺的超分子自组装
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-22-14771
Qianjun Zhang, Lin Zhang, Jun Zheng, Xuan Wang, Z. Tao
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引用次数: 0
12-epi-Briacavatolide B, a New Briarane Diterpenoid from the Octocoral Briareum stechei 12-epi-Briacavatolide B,一种新的briacavatolide二萜类化合物
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-22-14792
P. Sung, Chia-Jung Liu, Hsin-Tzu Liu, Thanh Hao Huynh, Z. Wen, Chia-Ching Liaw, Jih-Jung Chen, J. Su
{"title":"12-epi-Briacavatolide B, a New Briarane Diterpenoid from the Octocoral Briareum stechei","authors":"P. Sung, Chia-Jung Liu, Hsin-Tzu Liu, Thanh Hao Huynh, Z. Wen, Chia-Ching Liaw, Jih-Jung Chen, J. Su","doi":"10.3987/com-22-14792","DOIUrl":"https://doi.org/10.3987/com-22-14792","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70399051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sulfate Radical Anion (SO4˙ˉ) Mediated Degradation of Some Over-the-Counter Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) at Neutral Ph in Aqueous Environment 硫酸根阴离子(SO4˙离子)介导的非处方非甾体抗炎药(NSAIDs)在水环境中性Ph下的降解
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14804
Joydev K. Laha, Neelam Manral, Sagar Badoni, Mandeep Kaur Hunjan, Upma Gulati
{"title":"Sulfate Radical Anion (SO4˙ˉ) Mediated Degradation of Some Over-the-Counter Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) at Neutral Ph in Aqueous Environment","authors":"Joydev K. Laha, Neelam Manral, Sagar Badoni, Mandeep Kaur Hunjan, Upma Gulati","doi":"10.3987/com-23-14804","DOIUrl":"https://doi.org/10.3987/com-23-14804","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70400340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Pot Synthesis of Carbazoles by a Domino Reaction Using Microwave Heating and Antiproliferative Activities of Constituents from Murraya Plants Against Cancer Stem Cells 微波加热多米诺反应一锅法合成咔唑及其对肿瘤干细胞的抗增殖活性
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14816
Seikou Nakamura, Kouta Ugawa, Momona Nakao, Chikako Sawada, Takahiro Matsumoto, Takahiro Kitagawa, Yutaro Ohki, Kousuke Araki
{"title":"One-Pot Synthesis of Carbazoles by a Domino Reaction Using Microwave Heating and Antiproliferative Activities of Constituents from Murraya Plants Against Cancer Stem Cells","authors":"Seikou Nakamura, Kouta Ugawa, Momona Nakao, Chikako Sawada, Takahiro Matsumoto, Takahiro Kitagawa, Yutaro Ohki, Kousuke Araki","doi":"10.3987/com-23-14816","DOIUrl":"https://doi.org/10.3987/com-23-14816","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70400586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of 2-Anilino-2,4,4,6,6-pentachlorocyclotriphosphazenes (N3P3Cl5(NAr(R))) 2-苯胺-2,4,4,6,6-五氯环三磷杂烯(N3P3Cl5(NAr(R)))的合成
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14849
M. Kuroboshi*, Ryota Takahashi, Hideo Tanaka
{"title":"Synthesis of 2-Anilino-2,4,4,6,6-pentachlorocyclotriphosphazenes (N3P3Cl5(NAr(R)))","authors":"M. Kuroboshi*, Ryota Takahashi, Hideo Tanaka","doi":"10.3987/com-23-14849","DOIUrl":"https://doi.org/10.3987/com-23-14849","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70401319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fischer Glycosidation Using Organotitanium Catalyst Orgatix 有机钛催化剂的Fischer糖苷化
IF 0.6 4区 化学 Q4 Chemistry Pub Date : 2023-01-01 DOI: 10.3987/com-23-14866
Minoru Izumi, Nana Yanagida, Keita Kato, Mako Matsushita
{"title":"Fischer Glycosidation Using Organotitanium Catalyst Orgatix","authors":"Minoru Izumi, Nana Yanagida, Keita Kato, Mako Matsushita","doi":"10.3987/com-23-14866","DOIUrl":"https://doi.org/10.3987/com-23-14866","url":null,"abstract":"","PeriodicalId":13166,"journal":{"name":"Heterocycles","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70401474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Heterocycles
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