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Dengue, a hyperendemic arbovirus thriving in tropical and sub-tropical climates globally, has seen a significant surge in Brazil over the past 5 years. Presently, the country faces an epidemic, posing a huge challenge to Public Health authorities due to the potentially lethal nature of severe infections. Based on Hahnemannian concepts and on the historically reported efficacy of homeopathy in fighting epidemics, this study aimed to provide supporting evidence for a homeopathic genus epidemicus approach to prevent severe forms of dengue. Symptoms related to the severe phase of the disease were prioritised in the repertorisation: China officinalis (Chin) received the highest total symptoms score (43 points from 21 symptoms) followed by Arsenicum album (31/13) and Phosphorus (29/14). In the asymptomatic population exposed to the etiological agent, the use of Chin might contribute as an additional strategy in the prophylaxis of dengue.

Homeopathic repertories are essential tools in remedy diagnosis, helping practitioners match patient symptoms with those produced by remedies. However, repertories often need to be revised due to omissions, misinterpretations, and incomplete representation of remedy symptoms. Despite their importance, the sensitivity of repertories - their ability to correctly identify remedies based on corresponding rubrics - has never been systematically estimated. Addressing this gap is crucial to ensuring repertories' accuracy, reliability and validity in homeopathic practice.We adopted the sensitivity formula used in medical diagnostics, where true positives indicate correct remedy identification and false negatives represent failures. This method was applied to Kent's repertory for Allium cepa using symptoms from Hering's Guiding Symptoms of our Materia Medica. We extracted the rubrics and identified the non-representing rubrics and omissions. We created a Python script that generated combinations of rubrics based on Allen's 'three-legged stool rule'. We calculated the sensitivity as the ratio of true positives to total combinations.Of the 525 symptoms of Allium cepa, we extracted 364 rubrics from Kent's repertory, with 161 symptoms omitted. Among the extracted rubrics, 111 failed to represent Allium cepa. The Python script generated 23,979,550 combinations, of which 21,050,260 (87.78%) were false negatives, and 2,929,290 (12.2%) were true positives.The sensitivity of Kent's repertory for Allium cepa was estimated as 12.2%. The method can thus effectively estimate the sensitivity for given remedies in a homeopathic repertory. Applying this method to other remedies would enhance a repertory's diagnostic accuracy and could lead to the development of artificial intelligence-driven tools for repertorial analysis.

To improve the nutritional efficiency of ruminants and promote well-being in a natural and effective manner, the use of additives such as homeopathic products and yeast has been increasingly incorporated into diets, especially in grazing systems.To evaluate the effects of homeopathic products and yeast on the performance of Pantaneira cows maintained in rotational grazing on Mombaça grass in the Pantanal, Brazil.Sixty cows were assigned to a completely randomized design with four treatments and 15 replicates. The treatments were: CTL: control (without additives); HOM: homeopathic (4 g/kg Entero 100, 4 g/kg Figotonus, and 4 g/kg Convert H); YEA: yeast (24 g/kg Saccharomyces cerevisiae); and HY: homeopathic + yeast (4 g/kg Entero 100, 4 g/kg Figotonus, 4 g/kg Convert H + 24 g/kg S. cerevisiae). The variables measured included forage and supplement intake, diet digestibility, weight gain, and feed conversion. Data were subjected to analysis of variance (ANOVA), followed by Tukey and Duncan tests, with a significance level set at 5%.Cows in the HY treatment group showed higher average daily gains and better feed conversion compared to the CTL treatment (p ≤ 0.05). They exhibited higher digestibility of dry matter, crude protein, neutral detergent fiber, acid detergent fiber, and ether extract, as well as higher levels of total digestible nutrients and digestible energy (p ≤ 0.05).The inclusion of 4 g/kg Entero 100, 4 g/kg Figotonus, 4 g/kg Convert H, and 24 g/kg S. cerevisiae improved nutrient digestibility, body weight gain and feed conversion in Pantaneira cows.

This study presents and analyzes the content of an online Evidence Gap Map (EGM), "Clinical Effectiveness of Homeopathy, 1st Edition", which graphically represents evidence from systematic reviews (SRs) of human clinical trials in homeopathy that were published from 1991 to 2021. The EGM was built according to the guidelines of the International Initiative for Impact Evaluation (3ie), adapted for complex interventions, to represent visually relevant evidence and research gaps.The interventions, classified as rows, are characterized in the EGM not only by the homeopathic therapeutic strategy but also by individual medicines and potencies. The outcomes are listed in columns. The associations between both are represented by "bubbles" that refer to the corresponding SRs and whose colors indicate their quality level.From 239 citations identified, 51 SRs underwent complete characterization for the final construction of the EGM. A further in-depth quality analysis of each SR was performed to list the studied intervention/outcome associations described in each mentioned trial. At this step, those trials considered to have a high risk of bias by the authors of each SR were excluded from the EGM inputs.The methodological quality of each of the EGM's SRs was evaluated using the AMSTAR-2 criteria for level of confidence in an SR's results. Intervention-outcome associations were categorized into one of five effects of a homeopathic intervention: positive, potentially positive, ineffective, inconclusive, or negative.The EGM presents research evidence across a wide range of medical conditions, with substantial heterogeneity of homeopathic interventions and clinical outcomes. Forty-two of the 51 SRs yielded inconclusive findings. AMSTAR-2 analysis identified seven high-quality SRs, in which reliable primary studies presenting positive or potentially positive results for different categories of homeopathy are cited and related to specific clinical conditions: fibromyalgia, otitis media, diarrhea, respiratory infections, menopausal syndrome, irritable bowel syndrome, and attention deficit hyperactivity disorder in children.The EGM "Clinical Effectiveness of Homeopathy, 1st Edition" presents visually relevant research evidence that is scattered across a large number of medical conditions, showing substantial heterogeneity of homeopathic interventions, clinical outcomes, and research quality. To enhance the precision and relevance of future research, we recommend that the individualized homeopathic approach under investigation be standardized to the greatest extent feasible, and to use measures of well-being and quality of life as primary outcomes.

In 2020, a 26,849-ha state park in Mato Grosso do Sul state, Brazil, had 30% of its area damaged by fire. A homeopathic complex formulation was applied at strategic point locations in the park's springs or watercourses, aiming to mitigate the fire damage to the flora and fauna as quickly as possible. The duration of the homeopathic signal at each point was assessed using an established solvatochromic dye technique.To evaluate the timing and the nature of the signal at each of nine point locations. We could thus identify the presence of any signal variations due to specified environmental features within the park.Water samples were harvested from each intervention point at different times, filtered, frozen, and sent to the laboratory, where they were prepared to 1cH using filtered 30% ethanol. Methylene violet was chosen among six dyes since it was found in preliminary tests that it could trace the homeopathic complex used. In addition to simple sample testing, samples were submitted to a static and unidirectional magnetic field of 2400 Gauss (240 mT) for 15 minutes immediately before reading, which enhanced the method's sensitivity. One-way analysis of variance/Tukey test was used to identify dye absorbance changes following the analysis of water samples from the watercourse system. A correlation matrix and the Spearman r test were employed to evaluate any correlation between tracking and the pre-existing anthropic interventions at harvesting points. In all cases, α = 0.05.Four tracking patterns using the sample magnetization process were observed in relation to water samples and their effect on methylene violet solutions: no response (P2, P4), early transitory response (P5, P6, P8), late response (P1, P9), and constant response (P3, P7). P2 and P4, which could not be tracked, were correlated with permanent local anthropic disturbance.Methylene violet was the best dye to track the homeopathic complex prepared specifically for this case. Tracking was facilitated by prior magnetic treatment of samples, but anthropic disturbances to the environment seem to interfere with it.

Uterine fibroids are benign gynecological tumours that arise in the uterine smooth muscle tissue and are characterized by the production of excessive quantities of extracellular matrix. Various therapeutic options, from medical management to surgical intervention, exist for uterine fibroids, for which homeopathy has emerged as a promising therapeutic option in patient-centered care.A 40-year-old woman presented with complaints of heavy menstrual bleeding, with pain in the pelvic region and back. She was diagnosed as a case of bulky uterus with uterine fibroid. The patient opted for homeopathic management and was prescribed Thuja occidentalis based on individualization, miasmatic analysis and repertorial totality.After treatment, there was regression in size of the fibroid within 5 months, with complete resolution and restoration of the uterus to normal size within 9 months. Changes were validated through ultrasonography, which added objective evidence to the positive outcome. The Modified Naranjo Criteria for Homeopathy (MONARCH) inventory total score was +9, which indicated causal attribution of clinical outcome to the homeopathic intervention.This case study has illustrated the clinical benefits of homeopathy in the management of a patient with uterine fibroids, reaffirming the need for further research to explore its value as a therapeutic option for individuals seeking alternative or complementary approaches for appropriate medical conditions.

Medical professionals do not sufficiently realise how much scientific responsibility they take when certified science fails. They must make the best choice for the individual patient based on their own experience and that of their colleagues. This 'next best choice' requires basic knowledge about heuristic bias and statistics. The best solutions based on experience could then be classified according to their reliability and expected effectiveness. This requires probability and conditional probability calculations that result in Bayesian updating of the likelihood of individual cures. Practitioners could have considerable influence on medical decision-making by applying Bayesian probability. The high quality and large quantity of combined experience can ultimately be translated into treatment algorithms, to be tested in daily practice. To achieve this, we need better scientific training of practitioners and a suitable infrastructure of the professional community.

Assessment of relationship between polar symptoms (PS), such as weather, activity or food, and homeopathic medicines in chronic cough has produced some confusing outcomes. Statistical variation in the data partly explains the seemingly conflicting outcomes in prognostic factor research (PFR) of PS. Classification of statistical probability and selection of statistically reliable data can reduce conflicting outcomes.To make an inventory of statistically reliable PS and their relationship with homeopathic medicines in chronic cough.A prospective observational cohort study was conducted at 10 outpatient centers of the Central Council for Research in Homoeopathy, India. Patients with chronic cough were followed for 12 months. Effect of treatment was assessed using the ORIDL (Outcome in Relation to Impact on Daily Living) instrument, with symptom severity and health status evaluated respectively via the Cough Severity Index and EuroQoL 5D-5L. Prevalence and likelihood ratios (LRs) of PS were calculated for general and medicine-specific populations. Cumulative binomial probability (CBP) was used to determine whether symptom prevalence among good responders to specific medicines significantly differed from that of the general population.Some LRs were unexpectedly low, which could be explained by asymmetry of frequency distributions, resulting in high prevalence of one symptom pole. CBP for homeopathic medicines was subsequently performed, with 131 symptoms classified as 'certain' or 'probable': 21 symptoms for Arsenicum album, 23 for Bryonia, 11 for Calcarea carbonica, 3 for Lycopodium, 15 for Natrium muriaticum, 5 for Nux vomica, 17 for Phosphorus, 13 for Pulsatilla, 10 for Silicea, and 13 for Sulphur.Conflicting outcomes in PFR of PS can partly be explained by statistical variation. A classification of reliability was not feasible when expressed using the classical 95% confidence interval but could be achieved by CBP, resulting in certain and probable PS for 10 medicines. We still need clinical expertise and corroboration for future research. Practitioners need scientific training to prevent bias and use research instruments such as Likert scales and questionnaires.

It is essential to homeopathy that medicines' indicating symptoms and signs are accurately determined. In recent times, it has become apparent that the traditional assessment of indicating symptoms based on their absolute occurrence criteria (attributing a symptom to a medicine when it has been observed in several cases of responders) is flawed. A Bayesian approach using various study methods has been increasingly applied in this field of research.In this publication, the feasibility of building a homeopathic Materia Medica and a Repertory based on best cases' data is explored.Cases' data were extracted from the 'Best Chronic Homeopathic Cases' database. A common unification language was agreed, with clearly defined inclusion criteria of symptoms and medicines for analysis. Count, prevalence, likelihood ratio (LR), and cumulative binomial probability were calculated for each symptom-medicine combination, with adjustment for outliers. A Nat-m Bayesian Materia Medica was developed using defined criteria of statistical significance for validating the indicating symptoms. A Bayesian Homeopathic Repertory application (app) was developed.A total of 794 cases, 2,663 symptoms and 101 different medicines were extracted from the database. A total of 794 cases, 587 symptoms and 41 medicines were included for analysis, resulting in a matrix of 24,067 LRs. A total of 102 Nat-m symptoms were validated as indicating the medicine and 8 symptoms as contraindicating it.It is possible to detect and validate accurately the indicating symptoms of homeopathic medicines with a Bayesian assessment of data from the best clinical cases. It is also possible to develop a Bayesian Homeopathic Repertory and a Bayesian Homeopathic Materia Medica from these data. Skilled homeopaths with different cultural backgrounds, experience and preferences are encouraged to engage in this path of research.