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Utility of toluidine blue stain in bullous mastocytosis 甲苯胺蓝染色在大疱性肥大细胞增多症中的应用
IF 0.2 Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_123_21
T. Santosh, K. Josephain, Hima Gopinath
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引用次数: 0
Crusted scabies with molluscum contagiosum: As dermatological markers and first sign of HIV in a 12-Year-Old Girl 结痂性疥疮与传染性软疣:作为皮肤病标志物和艾滋病毒的第一个迹象在一个12岁的女孩
IF 0.2 Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_13_22
S. Jain, Avinash Sharma, Neha Sharma, R. Kushwaha
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引用次数: 0
Acro-osteolysis: A rare complication of jadassohn–lewandowski syndrome 肢端骨溶解:jadassohn-lewandowski综合征的罕见并发症
IF 0.2 Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_166_21
Mona Sharma, Priyanka Hemrajani, B. Sharath Kumar
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引用次数: 0
Familial reactive perforating collagenosis: Clinical, dermoscopy, and histopathological features in two siblings 家族性反应性穿孔性胶原病:两个兄弟姐妹的临床、皮肤镜检查和组织病理学特征
IF 0.2 Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_17_22
A. Inamadar, Warood Albadri, Bhargavi M Uttmani
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引用次数: 0
Epidemiology and clinical pattern of eczemas among children and adolescents – A hospital-based cross-sectional study in the desert Region of Western India 儿童和青少年湿疹的流行病学和临床模式——印度西部沙漠地区一项基于医院的横断面研究
IF 0.2 Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_170_20
M. Sivasankari, S. Arora, Dharmesh, R. Vishnuprasad, Magesh Kumar
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引用次数: 0
Darier Disease with Acrokeratosis Verruciformis of Hopf and their Aggravation on Lithium Therapy for Bipolar Disorder 双相情感障碍锂治疗伴疣状角化角化的肾结石及其加重
Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_60_22
Avinash Sharma, Brij Kishore Saini, Suresh Kumar Jain, Ramesh Kumar Kushwaha
Abstract Darier disease (DD) and acrokeratosis verruciformis of Hopf are rare autosomal dominant skin disorders. Both are caused by a single gene mutation, i.e., ATP2A2 located on chromosome 12, which is expressed in the skin and brain. However, both the diseases are clinically and histopathologically distinct. DD is associated with many neuropsychiatric conditions such as depression, bipolar disorder (BPD), and seizures. Lithium is commonly used as a mood stabilizer in psychiatry and is reported to aggravate DD. We report a case of a 17-year-old female with DD and acrokeratosis verruciformis with associated with BPD Type 1 presenting with an aggravation of skin lesions after starting lithium therapy.
摘要:Darier病(DD)和疣状肢角化病是一种罕见的常染色体显性皮肤病。两者都是由单个基因突变引起的,即位于12号染色体上的ATP2A2,该基因在皮肤和大脑中表达。然而,这两种疾病在临床和组织病理学上是不同的。DD与许多神经精神疾病有关,如抑郁症、双相情感障碍(BPD)和癫痫发作。锂通常被用作精神病学中的情绪稳定剂,据报道会加重DD。我们报告了一名17岁的女性,患有DD和疣状角化角化,并伴有BPD 1型,在开始锂治疗后,皮肤病变加重。
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引用次数: 0
Mechanic’s Hands and Hiker’s Feet in a Child with Juvenile Dermatomyositis Overlap Syndrome 少年皮肌炎重叠综合征儿童的机械师手和徒步旅行者脚
Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_99_22
T. Vasanthi, Ramkumar Ramamoorthy, Mahesh Janarthanan
A 10-year-old boy presented with a history of rashes on his palms and soles for 1 year. He had difficulty in walking, climbing stairs, and worsening of skin lesions for 2 months. On examination, he had hyperkeratotic, scaly lesions with fissures on his hands and feet suggestive of mechanic’s hands [Figure 1a] and hiker’s feet [Figure 1b]. Fingernails appeared dystrophic with pitting [Figure 2a]. Musculoskeletal examination showed severe proximal muscle weakness with a positive Gower’s sign. His investigations revealed Hemoglobin (Hb) – 13.4 g/dl (12–15), white blood cell count – 13,300/cumm (4000–11,000), neutrophil – 61% (45–70), lymphocyte – 28% (20–40), platelets – 3.65/cumm (1.5 to 4.5), erythrocyte sedimentation rate (ESR) – 42 mm/h (4-–12), C-reactive protein (CRP) – 2 mg/L (<5), aspartate transaminase (AST) – 435 U/L (8-48), alanine transaminase (ALT) – 1753(7-55), creatine phosphokinase (CPK) – 5336 IU/L (20-200), and lactate dehydrogenase (LDH) – 1536 U/L (110-295); renal functions were normal. Antinuclear antibody (ANA) was positive by indirect immunofluorescence method 1:320, 3 +. Antibody screen for myositis profile revealed strong positivity for PM-Scl antibodies. Magnetic resonance imaging of the thighs revealed altered signal intensity within muscles suggestive of inflammatory myositis and high-resolution computed tomography of the chest revealed fibrosis in the anterior segment of the right middle lobe and posterior basal segment of the right lower lobe. He was diagnosed with dermatomyositis overlap syndrome and commenced on steroids, monthly intravenous (IV) cyclophosphamide, weekly subcutaneous methotrexate, and sunscreen. With treatment, there was improvement in muscle strength, complete resolution of skin changes; with nails initially showing demarcation of area of normal growth from the dystrophic part [Figure 2b] and later completely normal nails [Figure 2c].Figure 1: (a) Mechanic’s hands, (b) Hiker’s feetFigure 2: (a) dystrophic nails with pitting, (b) post treatment resolution of skin changes and nails showing demarcation between area of normal growth and dystrophic part, (c) complete resolution of skin and nail changesThe term mechanic’s hands is used to describe hyperkeratotic lesions that maybe present in the hands and fingers of patients with inflammatory myositis.[1] Equivalent lesions present in the feet were later termed hiker’s feet.[2] These findings are mostly associated with the presence of anti-Jo-1 synthetase antibody and rarely in dermatomyositis overlap syndromes.[3] The disease course tends to be chronic and may require the administration of high-dose steroids, followed by a taper, disease-modifying agents, and/or rituximab. Declaration of consent The authors certify that they have obtained all appropriate consent forms, duly signed by the parent(s)/guardian(s) of the patient. In the form, the parent(s)/guardian(s) has/have given his/her/their consent for the images and other clinical information of their c
一个10岁的男孩提出了他的手掌和脚底皮疹的历史1年。行走、爬楼梯困难,皮肤病变加重2个月。经检查,他的手和脚有角化过度,鳞状病变和裂缝,提示技工的手[图1a]和徒步旅行者的脚[图1b]。指甲出现营养不良,有麻点[图2a]。肌肉骨骼检查显示严重的近端肌无力,伴有高尔氏征阳性。他的调查显示血红蛋白(Hb) - 13.4 g/dl(12 - 15),白细胞计数- 13,300/cumm(4000-11,000),中性粒细胞- 61%(45-70),淋巴细胞- 28%(20-40),血小板- 3.65/cumm(1.5至4.5),红细胞沉降率(ESR) - 42 mm/h (4- 12), c反应蛋白(CRP) -2 mg/L(<5),天冬氨酸转氨酶(AST) - 435 U/L(8-48),丙氨酸转氨酶(ALT) - 1753(7-55),肌酸磷酸激酶(CPK) - 5336 IU/L(20-200),乳酸脱氢酶(LDH) - 1536 U/L (110-295);肾功能正常。间接免疫荧光法1:32,3 +检测抗核抗体(ANA)阳性。肌炎抗体筛选显示PM-Scl抗体强阳性。大腿磁共振成像显示肌肉内信号强度改变提示炎症性肌炎,胸部高分辨率计算机断层扫描显示右中叶前段和右下叶后基段纤维化。他被诊断为皮肌炎重叠综合征,并开始使用类固醇,每月静脉注射(IV)环磷酰胺,每周皮下注射甲氨蝶呤和防晒霜。经过治疗,肌肉力量得到改善,皮肤变化完全消失;指甲最初显示正常生长区域与营养不良部分的界限[图2b],后来指甲完全正常[图2c]。图1:(a)机械师的手,(b)登山者的脚图2:(a)带点蚀的营养不良指甲,(b)治疗后皮肤变化和指甲的分辨率显示正常生长区域和营养不良部分之间的界限,(c)皮肤和指甲变化的完全分辨率机械师的手这个术语用于描述炎症性肌炎患者的手和手指可能出现的角化过度病变。[1]脚上出现的类似病变后来被称为徒步旅行者的脚。[2]这些发现大多与抗jo -1合成酶抗体的存在有关,很少出现在皮肌炎重叠综合征中。[3]病程往往是慢性的,可能需要给药大剂量类固醇,随后逐渐减少,疾病调节剂,和/或利妥昔单抗。作者证明他们已经获得了所有适当的同意书,并由患者的父母/监护人正式签署。在此表格中,家长/监护人已经/已经同意其孩子的图像和其他临床信息将在杂志上报道。家长明白他们孩子的名字和首字母不会被公布,并会尽力隐藏他们的身份,但不能保证匿名。财政支持及赞助无。利益冲突没有利益冲突。
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引用次数: 0
Accessory Tragi: An Association of Goldenhar Syndrome 附件视网膜:与Goldenhar综合征有关
Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_38_22
Ashok N. Kumar, Roja Renuka Sane, Shreya Srinivasan
Accessory Tragus also known as preauricular ear tag, supernumerary pinna, and rudimentary ear, is a congenital developmental anomaly due to a minor aberration in the first branchial arch leading to external ear malformation.[1] It has been associated with syndromes such as Goldenhar syndrome, Treacher-Collins syndrome, VACTERL syndrome, Townes-Brocks syndrome, and Wolf-Hirschhorn syndrome.[2] An 18-month-old female child presented with three skin-colored asymptomatic, firm, pedunculated lesions over the left side of the face, two near the left ear, in the pre-auricular area and one, a few centimeters away from the angle of the mouth [Figure 1]. A pigmented growth was seen over the lateral aspect of the epibulbar region, suggestive of an epibulbar dermoid [Figure 2]. There was also mild left-sided malar hypoplasia confined to the midportion alone [Figure 3]. There were no vertebral [Figure 4] or facial nerve abnormalities. A probable diagnosis of Goldenhar syndrome was made based on the clinical features mentioned above.Figure 1: Clinical image of accessory tragi over the left side of the faceFigure 2: Epibulbar dermoidFigure 3: Left-sided malar hypoplasiaFigure 4: Clinical image of the back showing no abnormalitiesGoldenhar syndrome is an autosomal dominant disorder in which accessory tragus is a constant finding. It was initially described by Goldenhar as a triad of epibulbar dermoids, preauricular appendages, and pretragal fistulae and was later expanded to include vertebral anomalies, imparting the term, “Oculoauriculovertebral dysplasia.” This syndrome is also associated with microtia, microphthalmia, anophthalmia, facial asymmetry, mandibular hypoplasia along with renal, cardiac, gastrointestinal, hearing, and speech abnormalities.[3] There have been no fixed diagnostic criteria or age of presentation of the various clinical features of this syndrome thus calling for mandatory lifelong follow-up and a multidisciplinary approach. This case has been reported to highlight the importance of identifying the syndromic associations of a child with accessory tragi. Declaration of consent The authors certify that they have obtained all appropriate consent forms, duly signed by the parent(s)/guardian(s) of the patient. In the form, the parent(s)/guardian(s) has/have given his/her/their consent for the images and other clinical information of their child to be reported in the journal. The parents understand that the names and initials of their child/children will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
副耳屏也被称为耳前耳标、附耳廓和初级耳,是一种先天性发育异常,由于第一鳃弓的轻微异常导致外耳畸形它与诸如Goldenhar综合征、iter - collins综合征、VACTERL综合征、townes - broks综合征和Wolf-Hirschhorn综合征等综合征有关1例18个月大的女婴,左侧面部出现3个皮肤色、无症状、坚硬、带蒂病变,其中2个靠近左耳,位于耳前区,1个位于距口角几厘米处[图1]。外球区域外侧可见色素生长,提示外球皮样病变[图2]。轻度的左侧颧发育不全仅局限于中部[图3]。无椎体[图4]或面神经异常。根据上述的临床特征,对Goldenhar综合征做出可能的诊断。图1:面部左侧副耳屏的临床表现图2:球外皮样病变图3:左侧颧发育不全图4:背部临床表现未见异常goldenhar综合征是一种常染色体显性遗传病,常可见副耳屏。Goldenhar最初将其描述为球外皮样、耳前附件和耳前瘘的三联征,后来扩大到包括椎体异常,并将其称为“眼-耳-椎体发育不良”。该综合征还与小畸形、小眼症、无眼症、面部不对称、下颌发育不全以及肾脏、心脏、胃肠道、听力和语言异常有关目前尚无固定的诊断标准或该综合征各种临床特征的呈现年龄,因此需要强制性的终身随访和多学科方法。本病例的报道强调了识别儿童副耳屏综合征相关性的重要性。作者证明他们已经获得了所有适当的同意书,并由患者的父母/监护人正式签署。在此表格中,家长/监护人已经/已经同意其孩子的图像和其他临床信息将在杂志上报道。家长明白他们孩子的名字和首字母不会被公布,并会尽力隐藏他们的身份,但不能保证匿名。财政支持及赞助无。利益冲突没有利益冲突。
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引用次数: 0
Baby Acne: Investigating Online Search Interest 婴儿痤疮:调查在线搜索兴趣
Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_6_23
Anjali Mishra, Mitchell A. Taylor
Neonatal acne, also referred to as “baby acne,” is a common dermatological condition characterized by the presence of small red papules or pustules on the face in the first 3 months of life.[1] While the condition is generally benign, it can lead to heightened anxiety among parents and caregivers. Google Trends offers an opportunity to explore public interest in neonatal acne, as it provides insights into search frequency, seasonality, and geographic distribution of queries. By leveraging this data, health-care professionals can gain a better understanding of the public’s information-seeking behavior and tailor educational resources to meet the needs of concerned parents effectively. Using Google Trends, we gathered the United States search data to examine the search volumes for the term “baby acne” spanning from January 2004 to December 2022 [Figure 1]. Google Trends provides data on search volumes, presented as a relative percentage ranging from 0 to 100, which is based on the total number of searches within a specific geographic area and time frame. In addition, Google Trends enabled us to pinpoint the states with the highest relative search volumes (RSVs) throughout the 2004–2022 period.Figure 1: Google Trends relative search volume for “baby acne” between 2004 and 2022, in the United StatesThe data show a consistent upward trend in searches for “baby acne” from 2004 to 2022. Notably, since 2011, there has been a cyclic pattern with search volumes peaking during late spring and summer months. The highest number of searches occurred in July (7 out of 19 years), followed by June (6 out of 19), May (4 out of 19 years), and April (3 out of 19 years). The top five states with the highest RSVs for “baby acne” include North Dakota, South Dakota, Mississippi, Louisiana, and Nebraska. The rise in online searches for the term baby acne reflects the growing popularity of online parenting communities. Reports analyzing parent behaviors on the internet showed that over 70% of parents have turned to search engines to find medical information for their children.[2] Facial eruptions can be divided into non-infectious and infectious etiologies, with at least 18 other diagnoses in the differentials.[1] While some causes are self-limiting, others such as pustular psoriasis require early diagnosis and treatment to prevent life-threatening complications. Thus, it is important for dermatologists and pediatricians to provide proper education to parents and avoid delay in treatment. The temporal and regional patterns observed may indicate that environmental factors play a role in neonatal acne exacerbation. While neonatal acne is thought to be caused by hormonal changes following birth, environmental factors such as heat and moisture may also play a role.[3] Exposure to high levels of humidity contributes to increase sweating, which can clog the enlarged neonate pores and trap bacteria on the skin surface, further promoting the development of neonatal acne.[1] Inter
新生儿痤疮,也被称为“婴儿痤疮”,是一种常见的皮肤病,其特征是在生命的前3个月在脸上出现小的红色丘疹或脓疱虽然这种情况通常是良性的,但它会导致父母和照顾者的焦虑加剧。谷歌Trends提供了一个机会来探索公众对新生儿痤疮的兴趣,因为它提供了对搜索频率、季节性和地理分布查询的见解。通过利用这些数据,保健专业人员可以更好地了解公众寻求信息的行为,并定制教育资源,以有效地满足有关家长的需求。使用谷歌Trends,我们收集了美国的搜索数据,以检查2004年1月至2022年12月期间“婴儿痤疮”一词的搜索量[图1]。谷歌Trends提供有关搜索量的数据,以相对百分比表示,范围从0到100,这是基于特定地理区域和时间框架内的搜索总数。此外,谷歌Trends使我们能够确定2004-2022年期间相对搜索量(rsv)最高的州。图1:2004年至2022年美国“婴儿痤疮”的相对搜索量趋势数据显示,2004年至2022年“婴儿痤疮”的搜索量呈持续上升趋势。值得注意的是,自2011年以来,搜索量在春末和夏季达到峰值一直是一种循环模式。搜索次数最多的是7月(19年中的7次),其次是6月(19年中的6次)、5月(19年中的4次)和4月(19年中的3次)。“婴儿痤疮”的rsv最高的五个州包括北达科他州、南达科他州、密西西比州、路易斯安那州和内布拉斯加州。“婴儿痤疮”一词在网上的搜索量上升,反映出在线育儿社区越来越受欢迎。分析父母上网行为的报告显示,超过70%的父母通过搜索引擎为孩子查找医疗信息面部出疹可分为非感染性和感染性两种病因,至少有18种其他诊断作为鉴别虽然有些原因是自限性的,但其他原因,如脓疱性牛皮癣,需要早期诊断和治疗,以防止危及生命的并发症。因此,皮肤科医生和儿科医生向家长提供适当的教育,避免延误治疗是很重要的。观察到的时间和区域模式可能表明环境因素在新生儿痤疮恶化中起作用。虽然新生儿痤疮被认为是由出生后的荷尔蒙变化引起的,但环境因素,如高温和潮湿也可能起作用暴露在高湿度的环境中会增加出汗,这会堵塞扩大的新生儿毛孔,使细菌滞留在皮肤表面,进一步促进新生儿痤疮的发展有趣的是,新生儿痤疮的rsv最高的州位于落基山脉以东,夏季雷暴频发,降水多通过了解热量和湿度对新生儿痤疮的影响,父母和医疗保健提供者可以采取积极措施,促进婴儿在这个过渡阶段的皮肤健康。财政支持及赞助无。利益冲突没有利益冲突。
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引用次数: 0
Staphylococcal scalded skin syndrome following vermilion application 朱砂敷后的葡萄球菌性烫伤皮肤综合征
IF 0.2 Q4 DERMATOLOGY Pub Date : 2023-01-01 DOI: 10.4103/ijpd.ijpd_9_22
Shikha R. Shah, H. Vyas, Bela J. Shah
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引用次数: 0
期刊
Indian Journal of Paediatric Dermatology
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