Immunity, Inflammation and Disease最新文献_第4页

The Relationship Between Novel Inflammatory Markers and Serum 25-Hydroxyvitamin D Among US Adults 美国成人新型炎症标志物与血清25-羟基维生素D的关系

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2025-01-14 DOI: 10.1002/iid3.70115

Hang Zhao, Yangyang Zhao, Yini Fang, Weibang Zhou, Wenjing Zhang, Jiecheng Peng

Background

Vitamin D is the focus of extensive medical research globally. Recent studies have investigated the correlation between serum 25-hydroxyvitamin D (25(OH)D) and common inflammatory markers. However, few studies have incorporated novel inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), platelet-to-high density lipoprotein cholesterol ratio (PHR), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response (SIRI), and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR). This study investigated these correlations among adults in the USA.

Methods

We ultimately included a total of 5308 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning 2007 to 2018. A multivariable linear regression model assessed the links between serum 25(OH)D and these novel inflammatory markers, with subgroup analyses for hypertension and diabetes. To further explore the relationship between the two, we applied smooth curve fittings and generalized additive models. Upon detecting nonlinear relationships, we used a recursive algorithm to pinpoint the inflection point.

Results

In our multivariate linear regression model, serum 25(OH)D concentrations were negatively correlated with NHR (β = −0.003, 95% CI: −0.005 to −0.001), NLR (β = −0.002, 95% CI: −0.003 to 0.000), SII (β = −0.579, 95% CI: −0.954 to −0.205), PHR (β = −0.171, 95% CI: −0.249 to −0.093), and PLR (β = −0.096, 95% CI: −0.051 to −0.040) among adults in the USA. Nevertheless, no significant association was found with SIRI (β = −0.001, 95% CI: −0.002 to 0.000). Subgroup analysis by hypertension and diabetes showed that in the hypertensive group, serum 25(OH)D was significantly and negatively associated with NHR, NLR, SII, SIRI, PHR, and PLR. However, no correlation was found in the diabetic group between serum 25(OH)D levels and these inflammatory markers.

Conclusions

Our research confirms that serum 25(OH)D levels are negatively correlated with several novel inflammatory markers among adults in the USA, suggesting potential directions for further research into vitamin D's role in inflammation.

背景：维生素D是全球广泛医学研究的焦点。最近的研究调查了血清25-羟基维生素D （25(OH)D）与常见炎症标志物之间的相关性。然而，很少有研究纳入新的炎症标志物，如血小板与淋巴细胞比值（PLR）、血小板与高密度脂蛋白胆固醇比值（PHR）、全身炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）、全身炎症反应（SIRI）和中性粒细胞与高密度脂蛋白胆固醇比值（NHR）。这项研究调查了美国成年人的这些相关性。方法：我们最终从2007年至2018年的国家健康与营养检查调查（NHANES）数据库中纳入了5308名参与者。多变量线性回归模型评估了血清25(OH)D与这些新型炎症标志物之间的联系，并对高血压和糖尿病进行了亚组分析。为了进一步探讨两者之间的关系，我们采用了光滑曲线拟合和广义加性模型。在检测非线性关系后，我们使用递归算法来确定拐点。结果：在我们的多元线性回归模型中，美国成人血清25(OH)D浓度与NHR （β = -0.003, 95% CI: -0.005 ~ -0.001）、NLR （β = -0.002, 95% CI: -0.003 ~ 0.000）、SII （β = -0.579, 95% CI: -0.954 ~ -0.205）、PHR （β = -0.171, 95% CI: -0.249 ~ -0.093）和PLR （β = -0.096, 95% CI: -0.051 ~ -0.040）呈负相关。然而，没有发现与SIRI有显著关联（β = -0.001, 95% CI: -0.002至0.000）。高血压和糖尿病亚组分析显示，高血压组血清25(OH)D与NHR、NLR、SII、SIRI、PHR、PLR呈显著负相关。然而，在糖尿病组中，血清25(OH)D水平与这些炎症标志物之间没有相关性。结论：我们的研究证实了美国成年人血清25(OH)D水平与几种新型炎症标志物呈负相关，这为进一步研究维生素D在炎症中的作用提供了潜在的方向。

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引用次数: 0

Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection 肝内CD161hiCD8+T细胞募集在慢性HBV感染中具有致病潜力。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2025-01-12 DOI: 10.1002/iid3.70118

Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang

Backgrounds and Aims

CD8+T cells are crucially associated with the fight against hepatitis B virus (HBV) infection. CD161 has been shown to express remarkably on HCV-specific CD8+T cells. However, the accurate function of CD161+CD8+T cells in HBV immunity or pathogenesis remains undetermined.

Methods

Blood samples were collected from 25 chronic hepatitis B (CHB) patients. Peripheral blood levels of CD161+CD8+T cells and their correlation with serum ALT levels were analyzed in CHB patients. To analyze the in vivo CD161+CD8+T cell's number, function, and intrahepatic recruitment characteristics, HBV replication mouse models were established. The expression of CD161 on HBV-specific CD8+T cells was also detected by analyzing CD161+CD8+T cell functions during infection.

Results

Patients with CHB infection had a markedly lower peripheral blood frequency of CD161+CD8+T cells than did healthy controls and negatively correlated with serum ALT level. Furthermore, compared to the control mice, the frequency of CD161+CD8+T cells was significantly decreased in the blood of acute and chronic HBV-replicating mice. Moreover, CHB-replicating mice had significantly increased hepatic levels of CD161+CD8+T cells, which was not observed in the acute group of mice. Additionally, the CD161+CD8+T cells were categorized into CD161^hi and CD161^intCD8+T cells and it was revealed that in the liver of CHB-replicating mice the primary recruited cells were CD161^hiCD8+T. Intrahepatic CD161^hiCD8+T cells demonstrated increased CXCR6 expression, enhanced production of cytokine IL-17 and TNF-ɑ, and reduced IFN-γ secretion. Accordingly, the CXCL16 mRNA expression in the liver tissue of CHB-replication mice was markedly higher than in acute HBV-replicating and control mice. The study also revealed that HBV-specific CD8+T cells were mainly CD161-CD8+T cells.

Conclusion

During HBV infection, the intrahepatic recruitment of CD161+CD8+T cells was mainly CD161^hiCD8+T cell subpopulation, which has a weak antiviral response, but increased pro-inflammatory effect, suggesting that CD161 may serve as a potential marker of liver-damaging T cells.

背景和目的：CD8+T 细胞与抗击乙型肝炎病毒（HBV）感染密切相关。CD161 已被证明在 HCV 特异性 CD8+T 细胞上显著表达。然而，CD161+CD8+T 细胞在 HBV 免疫或发病机制中的确切功能仍未确定：方法：采集了 25 名慢性乙型肝炎（CHB）患者的血样。方法：采集 25 名慢性乙型肝炎（CHB）患者的血样，分析其外周血 CD161+CD8+T 细胞水平及其与血清 ALT 水平的相关性。为了分析体内 CD161+CD8+T 细胞的数量、功能和肝内募集特征，建立了 HBV 复制小鼠模型。通过分析 CD161+CD8+T 细胞在感染过程中的功能，还检测了 CD161 在 HBV 特异性 CD8+T 细胞上的表达：结果：CHB 感染患者外周血 CD161+CD8+T 细胞的频率明显低于健康对照组，且与血清 ALT 水平呈负相关。此外，与对照组小鼠相比，急性和慢性 HBV 复制小鼠血液中 CD161+CD8+T 细胞的频率明显降低。此外，慢性 HBV 复制小鼠肝脏中的 CD161+CD8+T 细胞水平明显升高，而急性组小鼠未观察到这一现象。此外，CD161+CD8+T细胞被分为CD161hi和CD161intCD8+T细胞，结果显示，在CHB复制小鼠的肝脏中，主要被招募的细胞是CD161hiCD8+T细胞。肝内 CD161hiCD8+T 细胞的 CXCR6 表达增加，细胞因子 IL-17 和 TNF-ɑ 的产生增强，IFN-γ 的分泌减少。因此，CHB 复制小鼠肝组织中的 CXCL16 mRNA 表达明显高于急性 HBV 复制小鼠和对照组小鼠。研究还发现，HBV 特异性 CD8+T 细胞主要是 CD161-CD8+T 细胞：结论：在HBV感染期间，肝内招募的CD161+CD8+T细胞主要是CD161hiCD8+T细胞亚群，其抗病毒反应较弱，但促炎作用增强，提示CD161可作为肝损伤T细胞的潜在标志物。

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引用次数: 0

IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A-Mediated NLRP3 Inflammasome IGF2BP2通过m6a介导的NLRP3炎性体调控阿尔茨海默病的进展

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2025-01-09 DOI: 10.1002/iid3.70121

Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le

Background

Recent studies show that N6-methyladenosine (m6A) plays an important role in the pathogenesis of the Alzheimer's disease (AD), while the mechanisms involved were studied insufficiently.

Aims

The present study aimed to explore the effect of human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2), one of the m6A-binding proteins on the progression of AD.

Materials & Methods

The mRNA and protein expression level were determined using RT-qPCR and western blot, respectively. MTT assay was carried out to evaluate cell viability. The content of ROS, antioxidant enzymes, IL-1β and pyroptosis, as well as m6A contents were determined using relative commercial kit. The AD models were built using Aβ1-42 -stimulated hippocampal neuron in vitro and AD mice in vivo.

Results

Our results showed that IGF2BP2 was significantly upregulated in the Aβ1-42 -stimulated hippocampal neuron. IGF2BP2 inhibition reversed the decreased cell viability and the increased cell apoptosis induced by Aβ1-42. IGF2BP2 siRNA transfection alleviated Aβ1-42 induced pyroptosis and pyroptosis-related proteins upregulation. we also found that IGF2BP2 inhibition downregulated the expression of NLRP3 through m6A methylation. Furthermore, overexpression of NLRP3 partly reversed the effect of IGF2BP2 inhibition on Aβ1-42 -induced hippocampal neuron injury. In addition, IGF2BP2 improved cognitive function and alleviated Aβ1-42 neuronal injury in vivo.

Conclusion

Knockdown of IGF2BP2 inhibit neuronal damage and pyroptosis in the hippocampus cells, and improve cognitive function in AD partly through m6A-mediated NLRP3 inflammasome.

背景：近年来研究表明n6 -甲基腺苷（m6A）在阿尔茨海默病（AD）的发病过程中起重要作用，但其机制研究尚不充分。目的：本研究旨在探讨m6a结合蛋白之一的人胰岛素样生长因子2 (IGF2) mRNA结合蛋白2 （IGF2BP2）在AD进展中的作用。材料与方法：分别采用RT-qPCR和western blot检测mRNA和蛋白的表达水平。采用MTT法测定细胞活力。采用相应的商品化试剂盒测定活性氧（ROS）、抗氧化酶、IL-1β和焦腐酶的含量以及m6A的含量。采用a - β1-42刺激海马神经元建立AD模型和AD小鼠体内模型。结果：我们的研究结果显示，在Aβ1-42刺激的海马神经元中，IGF2BP2显著上调。抑制IGF2BP2逆转了Aβ1-42诱导的细胞活力下降和细胞凋亡增加。转染IGF2BP2 siRNA可减轻Aβ1-42诱导的焦亡及焦亡相关蛋白上调。我们还发现IGF2BP2抑制通过m6A甲基化下调NLRP3的表达。此外，NLRP3的过表达部分逆转了IGF2BP2抑制对Aβ1-42诱导的海马神经元损伤的作用。此外，IGF2BP2在体内可改善认知功能，减轻a - β1-42神经元损伤。结论：IGF2BP2下调可抑制海马细胞神经元损伤和焦亡，并通过m6a介导的NLRP3炎性体部分改善AD认知功能。

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引用次数: 0

Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats 异甜菊醇钠促进大鼠脊髓损伤模型的神经功能恢复。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2025-01-09 DOI: 10.1002/iid3.70110

Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

Background

Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown.

Methods

STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post-SCI, functional recovery was measured using the Basso, Beattie, and Bresnahan (BBB) scoring system along with the oblique plate test. Following these evaluations, spinal cord tissues were harvested for analysis. All behavioral testing occurred between 8 a.m. and 3 p.m.

Results

We found that STVNa improved spinal cord functional recovery in rats, as evidenced by enhanced BBB locomotor rating scale, angle of inclination, decreased cavity of spinal cord damage, and neuron death in vivo. In addition, STVNa reduced inflammation in rats following SCI, as demonstrated by a reduction in proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interleukin (IL)-1β. STVNa also reduced oxidative damage in SCI rats by lowering ROS while raising SOD levels.

Conclusion

These findings suggest that STVNa protects SCI rats through a variety of pathways. STVNa, in particular, may benefit the recovery of SCI by reducing oxidative stress and inflammation, leading to enhanced locomotor activity in rats with SCI.

背景：外伤性脊髓损伤（SCI）是一种无法治愈的疾病，是导致残疾的最大原因。在先前的研究中，异甜菊醇钠（STVNa）已被证明可以保护大鼠免受急性局灶性脑缺血；然而，STVNa对大鼠脊髓损伤恢复的影响尚不清楚。方法：脊髓损伤后腹腔注射STVNa，观察其是否有神经保护作用。在脊髓损伤后第7、14、21和28天，使用Basso、Beattie和Bresnahan （BBB）评分系统和斜板测试测量功能恢复情况。在这些评估之后，采集脊髓组织进行分析。所有的行为测试都发生在早上8点。下午3点。结果：我们发现STVNa能促进大鼠脊髓功能恢复，表现为血脑屏障运动评分、倾斜角度增强、脊髓损伤腔减少和神经元死亡。此外，STVNa减少了脊髓损伤后大鼠的炎症，如肿瘤坏死因子(TNF)-α，白细胞介素(IL)-6和白细胞介素(IL)-1β等促炎细胞因子的减少。STVNa还通过降低ROS和提高SOD水平来减轻脊髓损伤大鼠的氧化损伤。结论：这些发现提示STVNa通过多种途径保护脊髓损伤大鼠。特别是STVNa可能通过减少氧化应激和炎症，从而增强脊髓损伤大鼠的运动活性，从而有利于脊髓损伤的恢复。

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引用次数: 0

The Predictive Significance of Platelet-to-Lymphocyte Ratio for Miscarriage: A Systematic Review and Meta-Analysis 血小板与淋巴细胞比值对流产的预测意义：系统回顾和荟萃分析。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2025-01-07 DOI: 10.1002/iid3.70119

Xiaoyi Wang, Yanfang Zhao, Yangyang Fan, Yun Liu

Background

Miscarriage is a common complication of pregnancy, and its underlying pathophysiologic mechanisms remains unclear. The platelet-to-lymphocyte ratio (PLR), a prothrombotic and inflammatory marker, has been controversially discussed as a potential predictor of miscarriage. This systematic review and meta-analysis aimed to assess the predictive significance of the PLR in women with miscarriage compared to healthy pregnancies.

Material and Methods

Relevant studies were systematically searched in PubMed, Embase, Web of Sciencey, and Cochrane Library up to December 31, 2023. A systematic review and meta-analysis following PRISMA guidelines was conducted. Articles were identified, screened, and evaluated for quality to determine the predictive value of PLR for miscarriage.

Results

Fourteen eligible articles, comprising a total of 3745 patients, were included in the meta-analysis. The pooled analysis found comparable PLR levels between miscarriage and non-miscarriage groups (SMD = 0.25; 95% Confidence Interval (CI): −0.05 to 0.54). Subgroup analysis revealed significant differences in PLR levels in the missed miscarriage group (SMD = 0.29; 95% CI: 0.01–0.56). and in studies with sample sizes smaller than 200 (SMD = 0.31; 95% CI: 0.05–0.56). Other subgroups did not exhibit significant differences. Subgroup analysis of PLR levels and miscarriage risk demonstrated no significant differences across all subgroups.

Conclusion

PLR is not a reliable predictor of miscarriage in general. However, for missed miscarriage cases, elevated PLR levels may serve as a practical and cost-effective marker for prediction.

背景：流产是妊娠的常见并发症，其潜在的病理生理机制尚不清楚。血小板与淋巴细胞比率（PLR）是一种血栓形成和炎症标志物，作为流产的潜在预测指标一直存在争议。本系统综述和荟萃分析旨在评估与健康妊娠相比，PLR在流产妇女中的预测意义。材料和方法：系统检索PubMed， Embase, Web of science, Cochrane Library，截止2023年12月31日的相关研究。遵循PRISMA指南进行了系统评价和荟萃分析。对文章进行鉴定、筛选和质量评估，以确定PLR对流产的预测价值。结果：14篇符合条件的文章，共包括3745名患者，被纳入meta分析。合并分析发现，流产组和非流产组的PLR水平相当(SMD = 0.25；95%置信区间（CI）： -0.05 ~ 0.54)。亚组分析显示，漏流产组PLR水平差异有统计学意义(SMD = 0.29；95% ci: 0.01-0.56)。在样本量小于200的研究中(SMD = 0.31；95% ci: 0.05-0.56)。其他亚组无显著差异。亚组分析显示，所有亚组间PLR水平和流产风险无显著差异。结论：一般来说，PLR不是流产的可靠预测指标。然而，对于遗漏的流产病例，升高的PLR水平可以作为一种实用的、具有成本效益的预测指标。

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引用次数: 0

Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis 肥胖和慢性炎症：类风湿关节炎、脊椎关节炎和溃疡性结肠炎的影响。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2025-01-06 DOI: 10.1002/iid3.70080

Ada Corrado, Ilaria Guadagni, Giovanna Picarelli, Angela Variola

Background

Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), and ulcerative colitis (UC) exemplify prominent IMIDs, each presenting unique challenges for their management, that impact patient's quality of life (QoL). Obesity, marked by persistent low-grade inflammation, influences the progression, response to treatment, and clinical management of patients with RA, SpA, and UC. Besides, the emerging role of sarcopenic obesity, a special subtype of obesity with malnutrition, should be considered in the definition of the appropriated therapeutic interventions.

Methods

This narrative literature review summarizes recent evidence on the interplay between obesity-induced inflammation and IMIDs.

Results

Obesity contributes to elevated levels of proinflammatory cytokines, influencing the inflammatory pathways common to IMIDs. White adipose tissue, acting as an endocrine organ, produces cytokines like TNF-α and IL-6, fueling chronic inflammation. The dysregulation of adipokines, such as leptin and adiponectin, further complicates this interplay, impacting immune responses and metabolic processes.

Conclusions

Understanding the cross-talk between inflammatory pathways in obesity and IMIDs can provide insight into potential targets for intervention. This includes lifestyle modifications aimed to regulate weight gain, paving the way for comprehensive strategies to manage IMIDs in the context of obesity.

背景：免疫介导的炎症性疾病（IMIDs）是一组以免疫反应失调和持续炎症为特征的慢性疾病。类风湿关节炎（RA）、脊椎关节炎（SpA）和溃疡性结肠炎（UC）是典型的IMIDs，每一种都对其管理提出了独特的挑战，影响患者的生活质量（QoL）。肥胖，以持续的低度炎症为标志，影响RA、SpA和UC患者的进展、治疗反应和临床管理。此外，在确定适当的治疗干预措施时，应考虑到肌肉减少型肥胖（一种特殊的营养不良肥胖亚型）的新作用。方法：本文综述了最近关于肥胖引起的炎症与IMIDs之间相互作用的证据。结果：肥胖导致促炎细胞因子水平升高，影响IMIDs常见的炎症途径。白色脂肪组织作为内分泌器官，产生TNF-α和IL-6等细胞因子，助长慢性炎症。脂肪因子的失调，如瘦素和脂联素，使这种相互作用进一步复杂化，影响免疫反应和代谢过程。结论：了解肥胖和IMIDs炎症通路之间的相互作用可以帮助我们了解潜在的干预目标。这包括旨在调节体重增加的生活方式改变，为在肥胖背景下管理IMIDs的综合战略铺平道路。

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引用次数: 0

Correction to “Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11” 更正“脂肪组织IL-18的产生不依赖于Caspase-1和Caspase-11”。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2024-12-26 DOI: 10.1002/iid3.70095

L. Román-Domínguez, J. Salazar-León, K. F. Meza-Sosa, L. Pérez-Martínez, and G. Pedraza-Alva, “Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11,” Immunity, Inflammation and Disease 12, no. 4 (2024): e1241, https://doi.org/10.1002/iid3.1241.

In the “2.3 Glucose and insulin tolerance tests” section of the article, Tai's formula is incorrect. Please find the corrected formula below:

The authors provided the original raw data, which confirmed that despite the erroneously presented formula, the authors calculations were performed correctly, therefore the experimental results and corresponding conclusions mentioned in the paper remain unaffected.

We apologize for this mistake.

引用次数: 0

Phenotypic and Allelic Frequencies of ABO and Rh(D) Blood Antigens in Ghana: A Systematic Review 加纳ABO和Rh(D)血液抗原的表型和等位基因频率：系统回顾。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2024-12-25 DOI: 10.1002/iid3.70112

Charles Nkansah, Felix Osei-Boakye, Samuel K. Appiah, Gabriel Abbam, Moses Banyeh, Samira Daud, Richard V. Duneeh, Simon B. Bani, Boniface N. Ukwah, Charles A. Derigubah, Victor U. Usanga, Emmanuel Appiah-Kubi, Ejike F. Chukwurah

Background

ABO and Rh blood group systems are the most significant blood group systems recognized by the International Society of Blood Transfusion and are widely used for clinical and anthropological purposes. This systematic review determined the distribution and allelic frequency of ABO and Rh(D) antigens in Ghana.

Methods

Literature searches were performed in PubMed, Google Scholar, Web of Science, and ScienceDirect, up to February 20, 2024, and included studies published from 2000 to 2024 in all regions of Ghana. The search terms used to retrieve the preferred literature were “Blood Group/Antigen” and “ABO and Rh(D)” and “Distribution/Frequency/Prevalence,” coupled with the names of the different regions/districts/municipalities in Ghana. Similar blood group individuals from all the regions were added, and countrywide data were gathered. The Hardy−Weinberg model was used to estimate the allelic frequency of blood antigens.

Results

Blood group O (54.72%) was the predominant group in the Ghanaian population, followed by B (21.74%), A (19.65%), and AB (3.89%). Rh(D) antigen was present in 92.28% of the population, and only 7.72% were Rh(D) negative. The calculated allelic frequencies of A, B, O, Rh(D) positive, and Rh(D) negative were 0.1227, 0.1376, 0.7397, 0.7222, and 0.2778 for I^A(p), I^B(q), i(r), I^D(v), and I^d(u), respectively.

Conclusion

The phenotypic frequency of the ABO blood group occurred in the pattern O>B>A>AB, and the prevalence of the Rh(D) negative blood group was 7.72% in Ghana. Future nationwide studies are recommended to assess the distribution of ABO, Rh, and other blood group systems.

背景：ABO和Rh血型系统是国际输血学会认可的最重要的血型系统，广泛用于临床和人类学目的。本系统综述确定了加纳ABO和Rh(D)抗原的分布和等位基因频率。方法：文献检索在PubMed、b谷歌Scholar、Web of Science和ScienceDirect中进行，检索时间截止到2024年2月20日，包括2000年至2024年在加纳所有地区发表的研究。用于检索首选文献的搜索词是“血型/抗原”和“ABO和Rh(D)”和“分布/频率/患病率”，再加上加纳不同地区/区/市的名称。从所有地区加入相似血型的个体，并收集全国范围内的数据。采用Hardy-Weinberg模型估计血液抗原的等位基因频率。结果：加纳人群以O型血为主（54.72%），其次为B型血（21.74%）、A型血（19.65%）、AB型血（3.89%）。Rh(D)抗原阳性率为92.28%,Rh(D)阴性阳性率仅为7.72%。IA(p)、IB(q)、i(r)、ID(v)和ID(u)的A、B、O、Rh(D)阳性和Rh(D)阴性的等位基因频率分别为0.1227、0.1376、0.7397、0.7222和0.2778。结论：加纳ABO血型表型频率为O b> B>A>AB型，Rh(D)阴性血型患病率为7.72%。未来的全国性研究建议评估ABO， Rh和其他血型系统的分布。

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引用次数: 0

A Triple Therapeutic Regiment Consisted of Colchicine, Thalidomide and Total Glucosides of Paeony Is Effective and Well-Tolerated for Treating Mucocutaneous Involvement in Patients With Behcet's Disease 秋水仙碱、沙利度胺和芍药总苷三联疗法治疗白塞氏病粘膜皮肤受累有效且耐受性良好。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2024-12-25 DOI: 10.1002/iid3.70057

Jian-Fei Cai, Ya-Rong Wei, Yong Chen, Jun Zou, Shen Yan, Jian-Long Guan

Objective

This study aimed to investigate the efficacy and safety of a triple therapy consisting of colchicine, thalidomide and total glucosides of paeony (TGP) in Behcet's disease (BD) patients with mucocutaneous involvement.

Methods

Totally 355 newly diagnosed BD patients with mucocutaneous involvement were recruited, who received dexamethasone and colchicine for the first 2 weeks, then they were categorized into “sustained triple-therapy (ST)” (n = 231) and “colchicine to triple-therapy (CT)” (n = 124) groups respectively: for ST group, patients received colchicine, thalidomide plus TGP from Month (M)0.5 to M12; for CT group, patients received colchicine from M0.5 to M2, then switched to colchicine, thalidomide plus TGP from M3 to M12.

Results

The percentages of oral ulceration (at M1, M2) and genital ulceration (at M1) were lower in ST group compared to CT group, whereas there was no difference of other clinical manifestations (including uveitis, erythema nodosum, thrombosis, arterial involvement or nervous system involvement) at each time point between the two groups. For biochemical indexes, ESR was higher at M1 but rapidly reduced at M2 in ST group compared to CT group, while CRP level was similar at all time points between the two groups. For side effects, occurrences of drug-related cytopenia and diarrhea were increased, in ST group compared to CT group.

Conclusions

A triple therapy consisting of colchicine, thalidomide and TGP is more effective and equally tolerated compared to colchicine alone in treating BD patients with mucocutaneous involvement.

目的：探讨秋水草碱、沙利度胺和芍药总苷（TGP）三联疗法治疗白塞病（BD）皮肤粘膜受累的疗效和安全性。方法：招募355例新诊断的伴有皮肤粘膜受损伤的BD患者，前2周给予地塞米松和秋水仙碱治疗，然后将其分为“持续三联治疗”组。（n = 231）和秋水仙碱三联疗法（CT）（n = 124）组：ST组患者于第(M)0.5 ~ M12个月服用秋水仙碱、沙利度胺加TGP；CT组在M0.5 ~ M2范围内给予秋水仙碱治疗，M3 ~ M12范围内改为秋水仙碱+沙利度胺+ TGP治疗。结果：ST组口腔溃疡（M1、M2处）和生殖器溃疡（M1处）的比例均低于CT组，其他临床表现（葡萄膜炎、结节性红斑、血栓形成、动脉受累、神经系统受累）各时间点两组间无差异。生化指标方面，与CT组相比，ST组在M1处ESR较高，而在M2处ESR迅速降低，两组CRP水平在各时间点基本一致。副作用方面，与CT组相比，ST组药物相关性细胞减少和腹泻发生率增加。结论：与单用秋水仙碱相比，秋水仙碱、沙利度胺和TGP三联疗法治疗皮肤粘膜受累的BD患者更有效，耐受性也更强。

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引用次数: 0

“Exploring the Link Between Oral Lichen Planus and Xerostomia: A Systematic Literature Review” 探讨口腔扁平苔藓与口干症的关系：系统文献综述。

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease

Pub Date : 2024-12-19 DOI: 10.1002/iid3.70101

Farzaneh AghaHosseini, Maryam Tahmasebinasab, Mehdi Vatanpour

Introduction

Oral lichen planus (OLP) is a chronic disorder affecting the oral mucosa, potentially associated with xerostomia, either independently or concurrently. Research suggests that approximately 45% of patients with erythematous and ulcerative OLP may experience dry mouth sensations. The aim of this systematic review is to assess the current literature regarding the potential relationship or co-occurrence of xerostomia with OLP. Understanding this association is imperative for the development of comprehensive management strategies and the improvement of patient outcomes.

Method and Material

The study followed the PRISMA 2020 checklist and included human studies, specifically investigating xerostomia in patients with OLP. After screening 897 articles, 9 studies were selected based on predefined criteria Quality assessment was conducted using the Cochrane risk of bias tools: ROB 2 for RCTs and ROBINS-I for non-randomized studies Scale was conducted to evaluate potential biases in study design, selection, and outcomes.

Result

A systematic review of nine studies (1960–2023) examining xerostomia in OLP patients found a significant reduction in unstimulated salivary flow rates in many cases. Although evidence links xerostomia with OLP, a definitive causal relationship remains unestablished. Some studies highlighted Candida infection, altered saliva protein expression, and inflammation-related nerve damage as contributing factors to dry mouth in OLP patients.

Discussion and Conclusion

This systematic review examines the potential relationship between OLP and xerostomia, focusing on factors such as salivary flow, histopathological changes, and immune-related mechanisms. While some studies suggest a link between OLP and reduced saliva production, no definitive causal relationship has been established. The review identified significant research gaps, including inconsistent methodologies and a lack of standardized criteria. Future studies should explore different OLP forms, receptor interactions, immune responses, and neuropeptides to gain a better understanding of xerostomia's etiopathogenesis and improve management strategies for OLP patients.

口腔扁平苔藓（OLP）是一种影响口腔黏膜的慢性疾病，可能与口干症单独或并发相关。研究表明，大约45%的红斑性和溃疡性OLP患者可能会有口干的感觉。本系统综述的目的是评估目前有关口干症与OLP的潜在关系或共发的文献。了解这种关联对于制定综合管理策略和改善患者预后是必不可少的。方法和材料：该研究遵循PRISMA 2020检查表，包括人类研究，专门研究OLP患者的口干症。在筛选了897篇文章后，根据预先确定的标准选择了9项研究，使用Cochrane偏倚风险工具进行质量评估：随机对照试验使用ROB 2，非随机研究使用ROBINS-I，对研究设计、选择和结果中的潜在偏倚进行评估。结果：对9项研究（1960-2023）的系统回顾发现，在许多病例中，未受刺激的唾液流率显著降低。虽然有证据表明口干症与OLP有关，但明确的因果关系仍未确定。一些研究强调念珠菌感染、唾液蛋白表达改变和炎症相关神经损伤是导致OLP患者口干的因素。讨论与结论：本系统综述探讨了OLP与口干症之间的潜在关系，重点关注诸如唾液流动、组织病理改变和免疫相关机制等因素。虽然一些研究表明OLP和唾液分泌减少之间存在联系，但没有确定的因果关系。该审查发现了重大的研究差距，包括方法不一致和缺乏标准化标准。未来的研究应该探索不同的OLP形式、受体相互作用、免疫反应和神经肽，以更好地了解口干症的发病机制，并改善OLP患者的治疗策略。

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引用次数: 0