Pub Date : 2019-06-28DOI: 10.26452/ijrls.v9i2.1329
B. Naveen, K RajaSheker, A. Anilkumar, G. Abhilash
There are few defence mechanisms by which the body identifies and recovers from any physical injuries or external damage-causing stress and stimuli. This is through inflammation wherein the pain and the healing enzymes release into the bloodstream and cause pain and swelling that causes protection from those damages. The most important of the causative factors of the inflammation is the oxidative damage and the physiological stress. There were investigations on the herbs that were used in the treatment of diseases and were claimed to contain very limited or without side effects. Thus, they gained importance these days and were used in the treatment of major diseases like cancer and heart problems. Even though their use was extended from the traditional forms to advanced medicine, their scientific establishment of the proof and validate them for their activities is utmost important. Thus there were gaining interest in the medical and research field to perform the researches on the herbs and medicinal plants to prove their activity. The plant leaves of Pistacia atlantica were extracted with ethanol and water mixture using an ultrasonication. It was tested for the anti-inflammatory potential in various doses like 100, 200, 400 and 600 mg.kg body weight in the swiss albino rats in the cotton pellet induced granuloma method and the extracts showed significant dose-dependent activity compared with the standard indomethacin drug.
{"title":"Inflammation lowering property of pistacia atlantica in cotton pellet granuloma","authors":"B. Naveen, K RajaSheker, A. Anilkumar, G. Abhilash","doi":"10.26452/ijrls.v9i2.1329","DOIUrl":"https://doi.org/10.26452/ijrls.v9i2.1329","url":null,"abstract":"There are few defence mechanisms by which the body identifies and recovers from any physical injuries or external damage-causing stress and stimuli. This is through inflammation wherein the pain and the healing enzymes release into the bloodstream and cause pain and swelling that causes protection from those damages. The most important of the causative factors of the inflammation is the oxidative damage and the physiological stress. There were investigations on the herbs that were used in the treatment of diseases and were claimed to contain very limited or without side effects. Thus, they gained importance these days and were used in the treatment of major diseases like cancer and heart problems. Even though their use was extended from the traditional forms to advanced medicine, their scientific establishment of the proof and validate them for their activities is utmost important. Thus there were gaining interest in the medical and research field to perform the researches on the herbs and medicinal plants to prove their activity. The plant leaves of Pistacia atlantica were extracted with ethanol and water mixture using an ultrasonication. It was tested for the anti-inflammatory potential in various doses like 100, 200, 400 and 600 mg.kg body weight in the swiss albino rats in the cotton pellet induced granuloma method and the extracts showed significant dose-dependent activity compared with the standard indomethacin drug.","PeriodicalId":133571,"journal":{"name":"International Journal of Review in Life Sciences","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131661652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.26452/ijrls.v9i1.1256
Irfana Asma S, Ravichandran S., Bhavani J, Satheesh Kumar D, Chandrasekaran A R, Saraladevi V
Physical injuries or wounds are the physical damage to the skin. The human body naturally possesses the wound healing ability to heal physical damages. The wound healing was initiated in the human body in various mechanisms, and it occurs in three phases. The plants like Musa and Tridax have been evaluated for the wound healing activity, and the extracts were seen toxic to the body too. So in this research, the ointment formulation was prepared using the extracts of the two plants that are extracted with water as the solvent. The polyherbal ointment was prepared using the herbal extracts that were extracted from the parts of Tridax and Musa using the distilled water as a solvent. The prepared ointments showed a better activity compared to the crude extracts and the standard drug too.
{"title":"The wound healing ability of the prepared ointment incorporating herbal Extracts","authors":"Irfana Asma S, Ravichandran S., Bhavani J, Satheesh Kumar D, Chandrasekaran A R, Saraladevi V","doi":"10.26452/ijrls.v9i1.1256","DOIUrl":"https://doi.org/10.26452/ijrls.v9i1.1256","url":null,"abstract":"Physical injuries or wounds are the physical damage to the skin. The human body naturally possesses the wound healing ability to heal physical damages. The wound healing was initiated in the human body in various mechanisms, and it occurs in three phases. The plants like Musa and Tridax have been evaluated for the wound healing activity, and the extracts were seen toxic to the body too. So in this research, the ointment formulation was prepared using the extracts of the two plants that are extracted with water as the solvent. The polyherbal ointment was prepared using the herbal extracts that were extracted from the parts of Tridax and Musa using the distilled water as a solvent. The prepared ointments showed a better activity compared to the crude extracts and the standard drug too.","PeriodicalId":133571,"journal":{"name":"International Journal of Review in Life Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130640311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.26452/ijrls.v9i3.1349
Sagar R., Chandrudu J, Madhubhushan M, Seshaiah S
In adults, a fragment of diabetic individuals with βcell autoantibodies has initially non Insulin requiring diabetes clinically performing as type 2 diabetes mellitus (T2DM), named latent autoimmune diabetes in maturity (LADA) which on later years requires Insulin. LADA is either unnoticed or misdiagnosed in many cases. The occurrence GAD autoantibodies and positive levels of C-peptide analysis are tested to determine and finalize the patients’ Insulin dependency. The frequency of βcell autoantibodies (GAD) and C-Peptide analysis was determined in 31 Type 2 diabetic adults. The type of diabetes was classified by doing a Postprandial Blood Glucose test. Ten Type 1 diabetic patients and 10 ordinary people were also subjected to the three tests for comparative study. Twenty-three per cent of the adults with T2DM were tested positive for GAD autoantibody, and 61 per cent were tested positive (who came in T1DM range) for C-peptide analysis among them. 19% of the patients were tested positive for both GAD antibody and C-peptide analysis. Patients had the common symptoms of polyuria, polyphagia and polydipsia. In T2DM patients, 61% were females, and 39% were males, and all were non-obese. β‐cell autoantibodies were evident in a subcategory of initially non‐insulin needy diabetic adults with the clinical entrance of T2DM. This proves the existence and necessity for change in Insulin dependency.
{"title":"C-Peptide compound analysis in type 2 diabetic patients","authors":"Sagar R., Chandrudu J, Madhubhushan M, Seshaiah S","doi":"10.26452/ijrls.v9i3.1349","DOIUrl":"https://doi.org/10.26452/ijrls.v9i3.1349","url":null,"abstract":"In adults, a fragment of diabetic individuals with βcell autoantibodies has initially non Insulin requiring diabetes clinically performing as type 2 diabetes mellitus (T2DM), named latent autoimmune diabetes in maturity (LADA) which on later years requires Insulin. LADA is either unnoticed or misdiagnosed in many cases. The occurrence GAD autoantibodies and positive levels of C-peptide analysis are tested to determine and finalize the patients’ Insulin dependency. The frequency of βcell autoantibodies (GAD) and C-Peptide analysis was determined in 31 Type 2 diabetic adults. The type of diabetes was classified by doing a Postprandial Blood Glucose test. Ten Type 1 diabetic patients and 10 ordinary people were also subjected to the three tests for comparative study. Twenty-three per cent of the adults with T2DM were tested positive for GAD autoantibody, and 61 per cent were tested positive (who came in T1DM range) for C-peptide analysis among them. 19% of the patients were tested positive for both GAD antibody and C-peptide analysis. Patients had the common symptoms of polyuria, polyphagia and polydipsia. In T2DM patients, 61% were females, and 39% were males, and all were non-obese. β‐cell autoantibodies were evident in a subcategory of initially non‐insulin needy diabetic adults with the clinical entrance of T2DM. This proves the existence and necessity for change in Insulin dependency.","PeriodicalId":133571,"journal":{"name":"International Journal of Review in Life Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131463487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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