Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.32001
{"title":"Synthesis, computational studies and antioxidant activity of some 3-(2-alkylamino-4-aminothiazole-5-oyl) pyridines","authors":"","doi":"10.56042/ijcb.v60i4.32001","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.32001","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"48 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73268083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.39062
{"title":"Selective aerobic oxidation of benzylic and allylic alcohols catalyzed by Cu(OAc)2/TEMPO/Et2NH","authors":"","doi":"10.56042/ijcb.v60i4.39062","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.39062","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"15 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90503584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.38425
{"title":"Synthesis and biological evaluation of thiazolidinedione derivatives of chalcones and flavones as antihyperglycemic and antidyslipidemic agents","authors":"","doi":"10.56042/ijcb.v60i4.38425","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.38425","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"44 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74498650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.37131
{"title":"Design, synthesis and evaluation of thiazole based amides for their antitubercular and PknG inhibitory activity","authors":"","doi":"10.56042/ijcb.v60i4.37131","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.37131","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"30 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74280595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.33705
{"title":"Synthesis and antimicrobial activities of thiadiazole containing quinoline derivatives","authors":"","doi":"10.56042/ijcb.v60i4.33705","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.33705","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88903453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.29285
{"title":"Synthesis, characterization and evaluation of new thiazole derivatives as anthelmintic agents","authors":"","doi":"10.56042/ijcb.v60i4.29285","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.29285","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"2 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84586617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.56042/ijcb.v60i4.32326
{"title":"Silica sulfuric acid catalyzed green synthesis of 1,2- dihydro-1-aryl naphtho[1,2-e][1,3]-oxazin-3-one and 1,2- dihydro-1-methyl naphtho[1,2-e][1,3]-oxazin-3-one as potent antibacterial agents","authors":"","doi":"10.56042/ijcb.v60i4.32326","DOIUrl":"https://doi.org/10.56042/ijcb.v60i4.32326","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"12 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90037031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-16DOI: 10.56042/ijcb.v60i3.34731
R. Manickam, G. Jagadeesan, G. Srinivasan
Thiophene containing molecules have been distinguished as potential candidates in the largely emergent chemical world of heterocyclic compounds that show likely pharmacological characteristics. The knowledge of a mixture of synthetic pathways and the different physicochemical parameters of such compounds describe the especial interest of medicinal chemists to produce combinatorial collections and carry out in-depth efforts in the search of lead molecules. Among the various group of compounds studied, thiophene moieties stand out as unique in features due to their biological, pharmacological and medicinal properties. Synthesis, crystal structure, conformation and density functional theory of 2-(2-phenylanthracen-9-yl)thiophene derivative have been investigated in detail. Thiophene moiety are in planar conformation and having C-H…O type of hydrogen bonds and Van der Waals forces. Density functional theory has been applied to the thiophene derivative. Thiophene compounds score highly against the targeted protein and can be compared to the co-crystal ligand. Hirshfeld surface studies have been used to confirm and quantify the supramolecular features.
{"title":"Synthesis, crystal structure, density functional theory, Hirshfeld surface analysis and molecular docking studies of 2-(2-phenylanthracen-9-yl)thiophene derivatives","authors":"R. Manickam, G. Jagadeesan, G. Srinivasan","doi":"10.56042/ijcb.v60i3.34731","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.34731","url":null,"abstract":"Thiophene containing molecules have been distinguished as potential candidates in the largely emergent chemical world of heterocyclic compounds that show likely pharmacological characteristics. The knowledge of a mixture of synthetic pathways and the different physicochemical parameters of such compounds describe the especial interest of medicinal chemists to produce combinatorial collections and carry out in-depth efforts in the search of lead molecules. Among the various group of compounds studied, thiophene moieties stand out as unique in features due to their biological, pharmacological and medicinal properties. Synthesis, crystal structure, conformation and density functional theory of 2-(2-phenylanthracen-9-yl)thiophene derivative have been investigated in detail. Thiophene moiety are in planar conformation and having C-H…O type of hydrogen bonds and Van der Waals forces. Density functional theory has been applied to the thiophene derivative. Thiophene compounds score highly against the targeted protein and can be compared to the co-crystal ligand. Hirshfeld surface studies have been used to confirm and quantify the supramolecular features.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"18 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79174150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-16DOI: 10.56042/ijcb.v60i3.31392
S. Singh
In recent years, the thioisatin (benzo[b]thiophene-2,3-diones) have attracted considerable attention due to their ability to act as intermediates in the preparation of a series of fused spiroheterocycles. The benzothiophenic frameworks are important targets in synthetic and medicinal chemistry because this fragment is a key moiety in a wide number of natural and synthetic agents. Subsequently the present study deals with the synthesis of a variety of spiroheterocycles for which different strategies have been evolved viz. [4+2] photocycloaddition (spiropyrans), cyclocondensation (benzodiazocine), nucleophilic cyclization (spirothioazolidinones) and air oxidation (disulfides). semicarbazide reacts with thioisatin at 3‑position (thiosemicarbazones, 2-hydroxy-(2 H )-3,3-diaryl- and 3-hydroxy-3 H -2,2-diaryl-benzo[b]thiophenes hydroxyl compounds), 4,9-dimethylthiophanthrenes.
近年来，硫代硫代(苯并[b]噻吩-2,3-二酮)由于能够作为中间体制备一系列融合螺杂环而引起了相当大的关注。苯并噻吩框架是合成化学和药物化学中的重要靶点，因为该片段是许多天然和合成药物的关键片段。随后，本研究涉及各种螺旋杂环的合成，其中不同的策略已发展为[4+2]光环加成(螺旋吡喃)，环缩合(苯二氮杂辛)，亲核环化(螺旋噻唑烷酮)和空气氧化(二硫化物)。缩氨基脲与硫代嘌呤反应生成3位(巯基氨基脲，2-羟基-(2 H)-3,3-二芳基-和3-羟基-3 H -2,2-二芳基-苯并[b]噻吩羟基化合物)，4,9-二甲基噻吩。
{"title":"A short review: Chemistry of thioisatin and its derivatives","authors":"S. Singh","doi":"10.56042/ijcb.v60i3.31392","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.31392","url":null,"abstract":"In recent years, the thioisatin (benzo[b]thiophene-2,3-diones) have attracted considerable attention due to their ability to act as intermediates in the preparation of a series of fused spiroheterocycles. The benzothiophenic frameworks are important targets in synthetic and medicinal chemistry because this fragment is a key moiety in a wide number of natural and synthetic agents. Subsequently the present study deals with the synthesis of a variety of spiroheterocycles for which different strategies have been evolved viz. [4+2] photocycloaddition (spiropyrans), cyclocondensation (benzodiazocine), nucleophilic cyclization (spirothioazolidinones) and air oxidation (disulfides). semicarbazide reacts with thioisatin at 3‑position (thiosemicarbazones, 2-hydroxy-(2 H )-3,3-diaryl- and 3-hydroxy-3 H -2,2-diaryl-benzo[b]thiophenes hydroxyl compounds), 4,9-dimethylthiophanthrenes.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"39 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89150665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-16DOI: 10.56042/ijcb.v60i3.34156
{"title":"Synthesis and antimicrobial activity of chalcone containing polystyrene","authors":"","doi":"10.56042/ijcb.v60i3.34156","DOIUrl":"https://doi.org/10.56042/ijcb.v60i3.34156","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":"94 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86712452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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