Pub Date : 2021-11-18DOI: 10.56042/ijcb.v60i11.50058
{"title":"Spiro-heterocycles: A convenient synthesis and antimicrobial activity of some 3-(5-aryl/aryloxymethyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1',2-thiazolidin-4-ones","authors":"","doi":"10.56042/ijcb.v60i11.50058","DOIUrl":"https://doi.org/10.56042/ijcb.v60i11.50058","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80912417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-18DOI: 10.56042/ijcb.v60i11.33016
{"title":"Synthesis, characterization and biological evaluation of some 2-arylbenzoxazole acetic acid derivatives as potential anticancer agents","authors":"","doi":"10.56042/ijcb.v60i11.33016","DOIUrl":"https://doi.org/10.56042/ijcb.v60i11.33016","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73737952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-18DOI: 10.56042/ijcb.v60i11.33135
M. Hegab, Hala E M Tolana, E. Morsya, Alaa M Salehb, Farouk A Gada, Farouk M. E. Abdel-Megeida
The adducts 4a,b-7a , b have been obtained either by reducing α -chloro- β -oxosulfenyl chlorides 2a,b with iodide ion in the presence of dienes namely, 2-methyl-1,3-butadiene (isoperene), 2,3-dimethyl-1,3-butadiene, 1,2,3,4-tetrachlorocyclopentadiene, or 1,3-cyclohexadiene, respectively; or by thermolysis of oxadithiin derivatives 3a,b in the presence of the same aforementioned dienes presumably via the formation of the same intermediate A in both cases of compounds 2a,b and 3a,b . It is observed that α -chloro- β -oxosulfenyl chlorides 2a,b undergo straight forward substitution with potassium cyanide to give 8a,b . Direct oxidation of 2a,b with H 2 O 2 /AcOH affords 3,3-dichloropyran-4-ones 9a,b , while conversion of 2a,b to the sulfonamides 10a,b followed by oxidation provides 3-chloropyranones 11a,b . Antioxidant and antimicrobial evaluation of compounds 4a,b-6a,b shows moderate activiy. MIC of the derivative 6b reveals a remarkable inhibition of the pathogenic gram positive bacteria ( Staphylococcus aureus ) as well as gram negative E coli .
{"title":"Derivatization and biological activity studies of 3-chloro-3-chlorosulfenyl spiro tetrahydropyran/tetrahydrothiopyran-4,2'-chroman-4'-one","authors":"M. Hegab, Hala E M Tolana, E. Morsya, Alaa M Salehb, Farouk A Gada, Farouk M. E. Abdel-Megeida","doi":"10.56042/ijcb.v60i11.33135","DOIUrl":"https://doi.org/10.56042/ijcb.v60i11.33135","url":null,"abstract":"The adducts 4a,b-7a , b have been obtained either by reducing α -chloro- β -oxosulfenyl chlorides 2a,b with iodide ion in the presence of dienes namely, 2-methyl-1,3-butadiene (isoperene), 2,3-dimethyl-1,3-butadiene, 1,2,3,4-tetrachlorocyclopentadiene, or 1,3-cyclohexadiene, respectively; or by thermolysis of oxadithiin derivatives 3a,b in the presence of the same aforementioned dienes presumably via the formation of the same intermediate A in both cases of compounds 2a,b and 3a,b . It is observed that α -chloro- β -oxosulfenyl chlorides 2a,b undergo straight forward substitution with potassium cyanide to give 8a,b . Direct oxidation of 2a,b with H 2 O 2 /AcOH affords 3,3-dichloropyran-4-ones 9a,b , while conversion of 2a,b to the sulfonamides 10a,b followed by oxidation provides 3-chloropyranones 11a,b . Antioxidant and antimicrobial evaluation of compounds 4a,b-6a,b shows moderate activiy. MIC of the derivative 6b reveals a remarkable inhibition of the pathogenic gram positive bacteria ( Staphylococcus aureus ) as well as gram negative E coli .","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80723449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-18DOI: 10.56042/ijcb.v60i11.54954
G. Mallikarjun, A. Raju, J. Yadav
A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1 H and 13 C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d , 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 µg/mL. Further, compounds 12d , 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 µg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.
{"title":"Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases","authors":"G. Mallikarjun, A. Raju, J. Yadav","doi":"10.56042/ijcb.v60i11.54954","DOIUrl":"https://doi.org/10.56042/ijcb.v60i11.54954","url":null,"abstract":"A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1 H and 13 C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d , 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 µg/mL. Further, compounds 12d , 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 µg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79367601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-18DOI: 10.56042/ijcb.v60i11.33379
{"title":"Production and identification of intricate bioactive oligosaccharides from Nyctanthesarbor-tristis leaves by a combination of enzymatic, HPAEC and MALDI-TOF-MS techniques","authors":"","doi":"10.56042/ijcb.v60i11.33379","DOIUrl":"https://doi.org/10.56042/ijcb.v60i11.33379","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88248496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.56042/ijcb.v60i10.32409
{"title":"Ultrasonicated synthesis of some potent antimicrobial aryl sulphonamides","authors":"","doi":"10.56042/ijcb.v60i10.32409","DOIUrl":"https://doi.org/10.56042/ijcb.v60i10.32409","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74045772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.56042/ijcb.v60i10.31793
Pramod D Jawale Patila, Sopan M Wagalgavea, Mohammad Al Kobaisid, Shailesh S Birajdara, Rajesh S Bhosalef, Rajita D Inglec, R. Pawarc, Sheshanath V Bhosalee, S. Bhosale
Pramod D Jawale Patil, Sopan M Wagalgave, Mohammad Al Kobaisi, Shailesh S Birajdar, Rajesh S Bhosale, Rajita D Ingle, Rajendra P Pawar, Sheshanath V Bhosale & Sidhanath V Bhosale* a Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India c Department of Chemistry, Deogiri College, Aurangabad 431 005, India d Department of Chemistry and Biotechnology, FSET, Swinburne University of Technology, Hawthorn VIC 3122, Australia e School of Chemical Sciences, Goa University, Taleigao Plateau, Goa 403 206, India f Department of Chemistry, Indrashil University, Kadi, Mehsana 382 740, India E-mail: bhosale@iict.res.in
Pramod D Jawale Patil, Sopan M Wagalgave, Mohammad Al Kobaisi, Shailesh S Birajdar, Rajesh S Bhosale, Rajita D Ingle, Rajendra P Pawar, Sheshanath V Bhosale & Sidhanath V Bhosale* a聚合物和功能材料部，csir -印度化学技术研究所，海得拉巴500007，印度;科学与创新研究学院(AcSIR)， Ghaziabad 201002，印度;2 .果阿大学化学科学学院，塔莱高高原，果阿403 206;2 .英德拉希尔大学化学系，梅哈萨纳卡迪382 740，印度e -mail: bhosale@iict.res.in
{"title":"An efficient naphthalimide based receptor for selective detection of Hg2+and Pb2+ions","authors":"Pramod D Jawale Patila, Sopan M Wagalgavea, Mohammad Al Kobaisid, Shailesh S Birajdara, Rajesh S Bhosalef, Rajita D Inglec, R. Pawarc, Sheshanath V Bhosalee, S. Bhosale","doi":"10.56042/ijcb.v60i10.31793","DOIUrl":"https://doi.org/10.56042/ijcb.v60i10.31793","url":null,"abstract":"Pramod D Jawale Patil, Sopan M Wagalgave, Mohammad Al Kobaisi, Shailesh S Birajdar, Rajesh S Bhosale, Rajita D Ingle, Rajendra P Pawar, Sheshanath V Bhosale & Sidhanath V Bhosale* a Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India c Department of Chemistry, Deogiri College, Aurangabad 431 005, India d Department of Chemistry and Biotechnology, FSET, Swinburne University of Technology, Hawthorn VIC 3122, Australia e School of Chemical Sciences, Goa University, Taleigao Plateau, Goa 403 206, India f Department of Chemistry, Indrashil University, Kadi, Mehsana 382 740, India E-mail: bhosale@iict.res.in","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90528044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.56042/ijcb.v60i10.48917
{"title":"A convenient metal free approach towards the synthesis of dihydropyrimidones mediated by achiral nicotinic acid without solvent","authors":"","doi":"10.56042/ijcb.v60i10.48917","DOIUrl":"https://doi.org/10.56042/ijcb.v60i10.48917","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88091075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.56042/ijcb.v60i10.32325
B. Popatkar, Ankita A Mane, G. Meshram
One-pot multicomponent reaction between aromatic aldehyde, hydroxylamine hydrochloride and ethyl acetoacetate/ methyl acetoacetate for the synthesis of isoxazoles derivatives by employing tomato fruit extract as a catalytic medium has been developed. Tomato fruit extract was found to be a favorable catalytic medium for the synthesis of titled compounds. Mild reaction condition, ease of separation, moderate to high yield of the product, and short reaction time makes this method more attractive over earlier reported methods for the synthesis of isoxazoles derivatives.
{"title":"Tomato fruit extract: an environmentally benign catalytic medium for the synthesis of isoxazoles derivatives","authors":"B. Popatkar, Ankita A Mane, G. Meshram","doi":"10.56042/ijcb.v60i10.32325","DOIUrl":"https://doi.org/10.56042/ijcb.v60i10.32325","url":null,"abstract":"One-pot multicomponent reaction between aromatic aldehyde, hydroxylamine hydrochloride and ethyl acetoacetate/ methyl acetoacetate for the synthesis of isoxazoles derivatives by employing tomato fruit extract as a catalytic medium has been developed. Tomato fruit extract was found to be a favorable catalytic medium for the synthesis of titled compounds. Mild reaction condition, ease of separation, moderate to high yield of the product, and short reaction time makes this method more attractive over earlier reported methods for the synthesis of isoxazoles derivatives.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77131096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.56042/ijcb.v60i10.32090
{"title":"Synthesis and biological evaluation of azetidinone derivatives with pyrazolone moiety","authors":"","doi":"10.56042/ijcb.v60i10.32090","DOIUrl":"https://doi.org/10.56042/ijcb.v60i10.32090","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72660643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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