Pub Date : 2021-10-20DOI: 10.3390/mol2net-07-11213
Manuel Pérez, W. Caicedo, L. Bravo, Ruth Arias, Matteo Radice, R. Abreu
{"title":"Some ancestral Amazonian plants for health and nutrition","authors":"Manuel Pérez, W. Caicedo, L. Bravo, Ruth Arias, Matteo Radice, R. Abreu","doi":"10.3390/mol2net-07-11213","DOIUrl":"https://doi.org/10.3390/mol2net-07-11213","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126916739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-19DOI: 10.3390/mol2net-07-11203
Sha He
Machine Learning (ML) is used to learn a system.
机器学习(ML)是用来学习系统的。
{"title":"Summary for PTML Chemoinformatics Linear Discriminant Analysis classification model for enantioselective reactions","authors":"Sha He","doi":"10.3390/mol2net-07-11203","DOIUrl":"https://doi.org/10.3390/mol2net-07-11203","url":null,"abstract":"Machine Learning (ML) is used to learn a system.","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130805549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-19DOI: 10.3390/mol2net-07-11204
Ruth Arias Gutiérrez, Manuel Lázaro Pérez Quintana
{"title":"The State University of Amazonia as an intercultural scenario","authors":"Ruth Arias Gutiérrez, Manuel Lázaro Pérez Quintana","doi":"10.3390/mol2net-07-11204","DOIUrl":"https://doi.org/10.3390/mol2net-07-11204","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130869801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-18DOI: 10.3390/mol2net-07-11196
K. Diéguez-Santana
Abstract. The rise of new infectious diseases, combined with an increase in antibiotic resistance among bacterial pathogens, poses a significant health danger to humans. This ever-increasing threat of bacterial resistance necessitates the development of novel techniques to overcome this barrier. One of the successful strategies for combating antibiotic resistance has been the conjugation of nanoparticles (NPs) with antimicrobial moieties such as antibiotics, peptides, or other biomolecules. However, Dual Antibacterial Drug-Nanoparticle (DADNP) discovery is a slow
{"title":"DADNP: Dual Antibacterial Drug-Nanoparticle Systems Machine learning Approach","authors":"K. Diéguez-Santana","doi":"10.3390/mol2net-07-11196","DOIUrl":"https://doi.org/10.3390/mol2net-07-11196","url":null,"abstract":"Abstract. The rise of new infectious diseases, combined with an increase in antibiotic resistance among bacterial pathogens, poses a significant health danger to humans. This ever-increasing threat of bacterial resistance necessitates the development of novel techniques to overcome this barrier. One of the successful strategies for combating antibiotic resistance has been the conjugation of nanoparticles (NPs) with antimicrobial moieties such as antibiotics, peptides, or other biomolecules. However, Dual Antibacterial Drug-Nanoparticle (DADNP) discovery is a slow","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"1062 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132155671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-18DOI: 10.3390/mol2net-07-11195
K. Diéguez-Santana, G. Casañola-Martín, James R. Green, B. Rasulev
{"title":"Perturbation-Theory Machine Learning (PTML) Models for Predicting Metabolic Reaction Networks","authors":"K. Diéguez-Santana, G. Casañola-Martín, James R. Green, B. Rasulev","doi":"10.3390/mol2net-07-11195","DOIUrl":"https://doi.org/10.3390/mol2net-07-11195","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121117624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-18DOI: 10.3390/mol2net-07-11193
Marcin Gralewski, B. Grabarek, Dorian Gładysz, Rafał Staszkiewicz
Abstract
摘要
{"title":"Alanine and aspartate aminotransferase and urea concentrations in patients with degenerative spine disease","authors":"Marcin Gralewski, B. Grabarek, Dorian Gładysz, Rafał Staszkiewicz","doi":"10.3390/mol2net-07-11193","DOIUrl":"https://doi.org/10.3390/mol2net-07-11193","url":null,"abstract":"Abstract","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128968795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-10DOI: 10.3390/mol2net-07-10913
G. Tenea, D. Olmedo, Pamela Ascanta, G. González
Introduction The contamination of food by microorganisms, their persistence, growth, multiplication, and/or toxin production has emerged as an important public health concern. The demand for consuming fresh and low-processed foods free of chemicals and pathogens is increasing. Despite advances in food safety, annually, more than 9 million persons developed illnesses caused by food contamination (Scallan et al., 2011). In Ecuador, the risk of diseases associated with food contaminations is increasing due to incorrect food manipulation, hygiene, and inappropriate storage conditions (Garzon et al., 2017). Although the vendors are continuously capacitated, no improvement on selling sites was made. The food is continuously sold on the street, near parks, transportation terminals, as a common habit. Along with the excessive use of chemicals for preservation, food safety is of concern. To overcome this problem, the application of natural preservation methods might be a suitable solution. Lactic acid bacteria are producing peptides or small proteins namely bacteriocins which could be the next generation of antimicrobials. Thus, their incorporation in food to prevent poisoning or spoilage has been an area of dynamic research in the last decade (Backialakshmi et al., 2015). Previously, we identified two native bacteriocinogenic strains, Lactiplantibacillus plantarum UTNGt2 and L. plantarum UTNCys5-4, producing peptides with a broad spectrum of antibacterial activity against several foodborne pathogens in vitro (Tenea and Pozo, 2019; Tenea and Guana, 2019). Moreover, the addition of those peptide extracts at the exponential phase of growth of the target bacteria (Staphylococcus aureus ATCC1026) results in a decrease of total cell viability with about 3.2-fold (log CFU/ml) order of magnitude at 6 h of incubation, indicating their bactericidal mode of action. In this study, the possible mechanism of action against Staphylococcus aureus was investigated through a series of cell biology analyses such as membrane permeabilization, cell integrity, and structural changes of the target cells. Altogether, the results demonstrated the effectiveness of peptides produced by native lactic acid bacteria to kill Staphylococcus and further investigation is need it to prove the effect in a food matrix.
微生物对食品的污染及其持续存在、生长、繁殖和/或产生毒素已成为一个重要的公共卫生问题。消费不含化学物质和病原体的新鲜和低加工食品的需求正在增加。尽管在食品安全方面取得了进步，但每年仍有超过900万人因食品污染而患病(Scallan et al.， 2011)。在厄瓜多尔，由于不正确的食品操作、卫生和不适当的储存条件，与食品污染相关的疾病风险正在增加(Garzon等人，2017)。虽然供应商的能力不断提高，但销售网站没有得到改善。这种食物在街上、公园附近、交通枢纽附近不断出售，这是一种常见的习惯。随着过度使用化学品来保存，食品安全也受到关注。为了克服这一问题，应用自然保存方法可能是一个合适的解决方案。乳酸菌正在产生多肽或小蛋白质，即细菌素，这可能是下一代抗菌剂。因此，在过去十年中，将它们加入食物中以防止中毒或变质一直是一个动态研究领域(Backialakshmi et al.， 2015)。此前，我们鉴定了两种天然产菌菌株，植物乳杆菌UTNGt2和植物乳杆菌UTNCys5-4，它们在体外产生对几种食源性病原体具有广谱抗菌活性的肽(Tenea和Pozo, 2019;Tenea和Guana, 2019)。此外，在目标细菌(金黄色葡萄球菌ATCC1026)生长的指数期添加这些肽提取物，在培养6 h时，细胞总活力下降约3.2倍(log CFU/ml)数量级，表明它们的杀菌方式。本研究通过一系列细胞生物学分析，如膜通透性、细胞完整性、靶细胞结构变化等，探讨其对金黄色葡萄球菌的可能作用机制。总之，这些结果证明了天然乳酸菌产生的肽对葡萄球菌的杀伤作用，需要进一步的研究来证明在食物基质中的效果。
{"title":"Antimicrobials from Native Lactic Acid Bacteria: A “Shotgun” Against Antibiotic-Resistant Staphylococcus aureus","authors":"G. Tenea, D. Olmedo, Pamela Ascanta, G. González","doi":"10.3390/mol2net-07-10913","DOIUrl":"https://doi.org/10.3390/mol2net-07-10913","url":null,"abstract":"Introduction The contamination of food by microorganisms, their persistence, growth, multiplication, and/or toxin production has emerged as an important public health concern. The demand for consuming fresh and low-processed foods free of chemicals and pathogens is increasing. Despite advances in food safety, annually, more than 9 million persons developed illnesses caused by food contamination (Scallan et al., 2011). In Ecuador, the risk of diseases associated with food contaminations is increasing due to incorrect food manipulation, hygiene, and inappropriate storage conditions (Garzon et al., 2017). Although the vendors are continuously capacitated, no improvement on selling sites was made. The food is continuously sold on the street, near parks, transportation terminals, as a common habit. Along with the excessive use of chemicals for preservation, food safety is of concern. To overcome this problem, the application of natural preservation methods might be a suitable solution. Lactic acid bacteria are producing peptides or small proteins namely bacteriocins which could be the next generation of antimicrobials. Thus, their incorporation in food to prevent poisoning or spoilage has been an area of dynamic research in the last decade (Backialakshmi et al., 2015). Previously, we identified two native bacteriocinogenic strains, Lactiplantibacillus plantarum UTNGt2 and L. plantarum UTNCys5-4, producing peptides with a broad spectrum of antibacterial activity against several foodborne pathogens in vitro (Tenea and Pozo, 2019; Tenea and Guana, 2019). Moreover, the addition of those peptide extracts at the exponential phase of growth of the target bacteria (Staphylococcus aureus ATCC1026) results in a decrease of total cell viability with about 3.2-fold (log CFU/ml) order of magnitude at 6 h of incubation, indicating their bactericidal mode of action. In this study, the possible mechanism of action against Staphylococcus aureus was investigated through a series of cell biology analyses such as membrane permeabilization, cell integrity, and structural changes of the target cells. Altogether, the results demonstrated the effectiveness of peptides produced by native lactic acid bacteria to kill Staphylococcus and further investigation is need it to prove the effect in a food matrix.","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"327 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133911155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-20DOI: 10.3390/mol2net-07-10885
A. Fatimi
{"title":"Patentability of hydrogels as biocompatible coatings for medical device biofabrication","authors":"A. Fatimi","doi":"10.3390/mol2net-07-10885","DOIUrl":"https://doi.org/10.3390/mol2net-07-10885","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117237694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-20DOI: 10.3390/mol2net-07-10884
A. Fatimi
{"title":"Development and innovation on hydrogels in the world: A scientific overview based on patent applications","authors":"A. Fatimi","doi":"10.3390/mol2net-07-10884","DOIUrl":"https://doi.org/10.3390/mol2net-07-10884","url":null,"abstract":"","PeriodicalId":136053,"journal":{"name":"Proceedings of MOL2NET'21, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 7th ed.","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123609980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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