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Insulin amyloidosis: an under-recognised entity 胰岛素淀粉样变性:一种认识不足的疾病
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-03 DOI: 10.1111/imj.16496
Hana A. Kawatu, Lavinia Hallam, Miriam Blackburn
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引用次数: 0
Multiple sclerosis presenting with ocular flutter 多发性硬化症伴有眼球跳动
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-03 DOI: 10.1111/imj.16497
Anuran Mukherjee, Girish B. Kulkarni, Raghavendra Kenchaiah, Subasree Ramakrishnan, Ajay Asranna
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引用次数: 0
Resolution of symptoms of binge eating disorder associated with semaglutide treatment for obesity and type 1 diabetes 用塞马鲁肽治疗肥胖症和 1 型糖尿病可缓解暴饮暴食症的症状
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-03 DOI: 10.1111/imj.16499
Joanna Y. Gong, John M. Wentworth
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引用次数: 0
Active deprescribing attitudes and practices in a large regional tertiary health service: a mixed methods study 大型地区三级医疗服务机构的主动取消处方的态度和做法:一项混合方法研究。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-02 DOI: 10.1111/imj.16512
Michael Robinson, Venkat Vangaveti, Alexandra Edelman, Andrew J. Mallett

In this pilot study, we explored current attitudes and deprescribing practices of clinicians in a large regional health service through a mixed methods approach. Respondents included doctors, pharmacists and nurse practitioners, who outlined three themes including professional and organisational contexts, disconnect between goals and practices and factors influencing deprescribing.

在这项试点研究中,我们采用混合方法探讨了一个大型地区医疗服务机构的临床医生目前的态度和去处方化实践。受访者包括医生、药剂师和执业护士,他们概述了三个主题,包括专业和组织背景、目标与实践之间的脱节以及影响去处方化的因素。
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引用次数: 0
The experience of an adult diabetic foot unit continuing face-to-face consults during the COVID-19 pandemic 成人糖尿病足科在 COVID-19 大流行期间继续进行面对面会诊的经验。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-31 DOI: 10.1111/imj.16514
Joanna Y. Gong, Lucy Collins, Rahul D. Barmanray, Nang S. K. Pang, Minh V. Le, Paul R. Wraight

Background and Aims

The COVID-19 pandemic significantly disrupted lower limb diabetes care. We aimed to map trends in diabetes-related lower limb amputation and hospitalisation rates through the COVID-19 pandemic.

Methods

We performed a retrospective cohort study of all individuals who underwent a lower limb amputation for a diabetes-related foot complication from 2018 to 2021 at the Royal Melbourne Hospital, a quaternary hospital in Australia. Hospitalisation rates with a diabetes-related foot complication were collected for comparison. The start of the COVID-19 epoch was defined as 16 March 2020, when a state of emergency was declared in Melbourne.

Results

During the study period, 360 lower limb amputations for diabetes-related foot complications were performed in 247 individuals. The median monthly number of amputations remained stable prior to and during the COVID-19 epoch; there was a median of 8.0 amputations per month (interquartile range (IQR) = 6.5–11) before COVID-19, compared to 6.5 amputations (IQR = 5.0–8.3) during the COVID-19 epoch (P = 0.23). Hospitalisation with a diabetes-related foot complication significantly increased from a median monthly rate of 11 individuals (IQR = 9.0–14) before COVID-19 to 19 individuals (IQR = 14–22) during the COVID-19 epoch (p < 0.001).

Conclusions

Despite increased hospitalisations for diabetes-related foot complications during COVID-19, there was not a corresponding increase in amputation rates. Face-to-face care of diabetes-related foot complications was prioritised at this centre and may have contributed to stable amputation rates during the pandemic.

背景和目的:COVID-19 大流行严重扰乱了下肢糖尿病护理。我们旨在绘制 COVID-19 大流行期间糖尿病相关下肢截肢率和住院率的趋势图:该研究还收集了糖尿病足相关并发症的住院率以进行比较。COVID-19年代的起始时间被定义为2020年3月16日,当时墨尔本宣布进入紧急状态:在研究期间,共有 247 人因糖尿病足并发症而进行了 360 例下肢截肢手术。在COVID-19事件之前和期间,每月截肢次数的中位数保持稳定;在COVID-19事件之前,每月截肢次数的中位数为8.0次(四分位距(IQR)=6.5-11),而在COVID-19事件期间,每月截肢次数的中位数为6.5次(IQR=5.0-8.3)(P=0.23)。与糖尿病相关的足部并发症住院率从 COVID-19 前的每月中位数 11 例(IQR = 9.0-14 例)显著增加到 COVID-19 期间的每月中位数 19 例(IQR = 14-22 例)(P = 0.23):尽管 COVID-19 期间因糖尿病足并发症住院的人数有所增加,但截肢率并未相应增加。该中心将糖尿病足并发症的面对面治疗作为优先事项,这可能是大流行期间截肢率保持稳定的原因之一。
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引用次数: 0
International students' perspectives on medical school and internship: ‘Oh international? Are you international?’ 留学生对医学院和实习的看法:"哦,国际学生?你是国际学生吗?
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-31 DOI: 10.1111/imj.16491
Kendra D. Selvanderan, Josephine S. Thomas

Background

International students account for a significant proportion of medical graduates Australia-wide, and most opting to remain in Australia for their first year of practice (Internship). Hence, understanding this particular demographic's perspectives is crucial for curriculum and workforce planning. Despite this, very few studies have addressed this demographic, and none have explored the impact of the COVID-19 pandemic on international medical students specifically.

Aim

A qualitative design was used to explore the perspectives of final-year international medical students at an Australian medical school as they prepared for transition to internship during the COVID-19 pandemic.

Methods

Participants engaged in a semi-structured interview about the pandemic's personal and professional implications. The data were analysed using inductive thematic analysis.

Results

Seven out of 34 final-year international medical students at the University of Adelaide participated. The main themes identified were that isolation was magnified, institutional support was lacking and that uncertainty was challenging. The pandemic did not deter participants from pursuing an Australian internship, as Australia was considered a desirable place for internship compared to their home countries.

Conclusions

While the COVID-19 pandemic exacerbated the situation, many of the challenges identified by international students already existed. Issues such as social isolation, racial discrimination, financial hardship and lack of institutional support have been prevalent for decades. Insights from this study reveal a need to improve the medical school experience. Australian Universities have a responsibility to ensure fair treatment of international students by training faculty, implementing support programmes and ensuring an inclusive and culturally safe learning environment.

背景:国际学生在全澳医学毕业生中占很大比例,而且大多数选择留在澳大利亚进行第一年实习。因此,了解这一特殊群体的观点对于课程和劳动力规划至关重要。尽管如此,针对这一人群的研究却寥寥无几,而且没有一项研究专门探讨了 COVID-19 大流行对国际医科学生的影响。目的:采用定性设计的方法探讨了澳大利亚一所医学院的应届国际医科学生在 COVID-19 大流行期间准备过渡到实习阶段时的观点:方法: 参与者就大流行对个人和专业的影响进行了半结构化访谈。采用归纳式主题分析法对数据进行分析:阿德莱德大学 34 名毕业班国际医学生中有 7 人参加了访谈。确定的主要主题是:孤立感加剧、缺乏机构支持以及不确定性具有挑战性。大流行并没有阻止参与者到澳大利亚实习,因为与他们的祖国相比,澳大利亚被认为是一个理想的实习地:尽管 COVID-19 大流行加剧了这种情况,但留学生们发现的许多挑战早已存在。几十年来,社会隔离、种族歧视、经济困难和缺乏机构支持等问题一直普遍存在。这项研究揭示了改善医学院体验的必要性。澳大利亚大学有责任通过培训教师、实施支持计划以及确保包容性和文化安全的学习环境,确保留学生得到公平对待。
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引用次数: 0
Genetic testing for familial hyperaldosteronism type 1 in Aotearoa/New Zealand 奥特亚罗瓦/新西兰家族性醛固酮增多症 1 型的基因检测。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-31 DOI: 10.1111/imj.16511
Marianne S. Elston, Jade A. U. Tamatea, Richard I. King, Chris M. Florkowski, Veronica Boyle

Background

Primary aldosteronism (PA) is the most common secondary endocrine cause of hypertension with familial hyperaldosteronism type 1 (FH-1), a rare heritable subtype. Timely identification of FH-1 is important because of an increased risk of vascular events in affected individuals and because it provides the opportunity to guide appropriate treatment. Genetic testing is recommended if onset is at a young age (<20 years), there is a family history of PA or early cerebrovascular events occur.

Aims

To assess national rates of testing for FH-1, whether this varied over time and by region.

Methods

De-identified data were obtained on genetic testing performed for FH-1 from 1 April 2010 to 30 October 2023 (163 months) from the Canterbury Health Laboratories database, the sole national testing laboratory for FH-1.

Results

A total of 147 tests were performed, of which 19 (12.9%) were positive. Eleven of the positive tests were requested by one region. Testing rates varied from 0.00 to 0.63 per 100 000 people per annum. Most tests were requested by endocrinology services. Testing increased over time from an average of 4.6 tests per annum in the first 5 years of the period studied to 17.7 tests in the most recent 5 years. Limitations include lack of ethnicity data, information on testing indications and testing rates for other familial PA subtypes.

Conclusions

Testing for FH-1 has increased over time but remains low. Testing for familial forms of PA should be considered in those in whom PA was diagnosed at a young age or with a suggestive family history.

背景:原发性醛固酮增多症(PA)是高血压最常见的继发性内分泌病因,家族性高醛固酮增多症 1 型(FH-1)是一种罕见的遗传亚型。及时发现 FH-1 非常重要,因为受影响的个体发生血管事件的风险会增加,而且这也为指导适当的治疗提供了机会。如果发病年龄较小,建议进行基因检测(目的:评估全国的 FH-1 检测率,以及是否随时间和地区的不同而有所变化:方法:从坎特伯雷健康实验室数据库中获取了2010年4月1日至2023年10月30日(163个月)期间进行的FH-1基因检测的去身份化数据,坎特伯雷健康实验室是全国唯一的FH-1检测实验室:共进行了 147 次检测,其中 19 次(12.9%)呈阳性。其中 11 项阳性检测由一个地区申请。每年每 10 万人的检测率从 0.00 到 0.63 不等。大多数检测都是由内分泌科申请的。随着时间的推移,检测次数不断增加,从研究期间前 5 年的平均每年 4.6 次增加到最近 5 年的 17.7 次。不足之处包括缺乏种族数据、检测适应症信息以及其他家族性 PA 亚型的检测率:结论:随着时间的推移,FH-1 的检测率有所上升,但仍然很低。对于那些在年轻时就被诊断出 PA 或有家族史的人,应考虑对家族性 PA 进行检测。
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引用次数: 0
Does basic physician trainee selection predict successful progression in the Royal Australasian College of Physicians adult medicine training programme? A retrospective cohort study 基础医师培训学员的选择能否预测成人医学培训项目的成功进展?一项回顾性队列研究。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-30 DOI: 10.1111/imj.16507
Jeffrey J. Post

Background

The optimal selection process for basic physician trainees (BPTs) is unclear.

Aims

To assess an adult BPT selection process, including a standardised recruitment interview assessing clinical decision-making and situational judgement.

Methods

A retrospective multi-year cohort study of applicants who were selected for interview during the annual recruitment for 2011–2015 clinical years in an adult basic physician training network in NSW. The predictive capacity of the final recruitment assessment score was compared with success in the Royal Australasian College of Physicians (RACP) adult medicine clinical examination within 2 years.

Results

Four hundred thirty-six applicants were selected for interview (84–91 in each year). Summary mean post-interview scores ranged from 1.25 to 10, with the median ranging between 7 and 8. Median scores were higher in those who passed the examination than those who did not (7.75 vs 6.43, P < 0.0001). Those who did not sit for the examination in the relevant year or never sat for the examination had similar median scores (7 vs 6.75, P = 0.11). Those not deemed eligible for recruitment were less likely to pass the clinical examination within 2 years than those on the eligibility list (odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.25–0.57). Applicants with mean scores lower than 8 were less likely to pass than those in the top band (8.1–10); scores between 6.1 and 8 OR 0.42 (95% CI = 0.26–0.68), 4.1–6 OR 0.23 (95% CI = 0.13–0.41) and 2.1–4 OR 0.24 (95% CI = 0.10–0.60).

Conclusion(s)

The predictive capacity of the selection process for success in the RACP clinical examination within the minimum time period is high.

背景:目的:评估成人基础医师培训生的遴选流程,包括评估临床决策和情景判断的标准化招聘面试:方法:对新南威尔士州成人基础医师培训网络 2011-2015 临床年年度招聘中被选中参加面试的申请人进行回顾性多年队列研究。将最终招聘评估分数的预测能力与两年内通过澳大拉西亚皇家医学院(RACP)成人医学临床考试的情况进行了比较:共有 436 名申请人被选中参加面试(每年 84-91 人)。面试后的平均得分介于 1.25 分至 10 分之间,中位数介于 7 分至 8 分之间。通过考试者的中位数分数高于未通过考试者(7.75 对 6.43,P 结论(s)):遴选过程对在最短时间内成功通过 RACP 临床考试的预测能力很高。
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引用次数: 0
The Australian Team Approach to Polypharmacy Evaluation and Reduction (AusTAPER) hospital study: effect of a collaborative medication review on the number of current regular medicines for older hospital inpatients 澳大利亚多药评估与减少团队方法(AusTAPER)医院研究:合作用药审查对老年住院患者当前常规药物数量的影响。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-29 DOI: 10.1111/imj.16510
Christopher Etherton-Beer, Amy Page, Deirdre Criddle, George Somers, Lynne Parkinson, Rhonda Clifford, Dee Mangin

Background and Aims

Potentially harmful polypharmacy is a growing public health concern. This article aims to evaluate the effectiveness of a structured Team Approach to Polypharmacy Evaluation and Reduction (AusTAPER) framework.

Methods

We recruited patients at metropolitan hospitals for a randomised controlled trial with 12 months of follow-up. The intervention included a comprehensive medicines history, multidisciplinary meeting and medicines review prior to discharge, with engagement with the participants' general practitioner extending after discharge. The primary outcome was the change in the number of regular medicines used at 12 months from baseline. A cost consequence was performed to estimate costs per participant during the study period.

Results

There were 98 participants enrolled in the study. The number of regular medicines was significantly reduced from baseline in both groups (−1.7 ± 4.3, t = 2.38, P = 0.02 in the control group vs −2.7 ± 3.6, t = 4.48, P = 0.0001 in the intervention group), although there was no statistical difference detected between the two groups (1.0 (SE 0.9), t = 1.03, P = 0.31). The intervention was estimated to cost AU$644.17 and was associated with cost savings of AU$552.53 per participant in sustained reduced medicines cost. Health outcomes and healthcare costs were similar in both groups.

Discussion

Medicines were significantly reduced in both groups, with a trend to a larger reduction in medicines at 12 months in the intervention group. The intervention cost was approximately offset by sustained reduced medicines cost, although these results should be regarded cautiously because of the absence of significance in the differences in outcomes between groups.

背景和目的:潜在有害的多药滥用是一个日益严重的公共卫生问题。本文旨在评估结构化团队评估和减少多种药物使用方法(AusTAPER)框架的有效性:方法:我们在大都市医院招募患者,进行为期 12 个月的随机对照试验。干预措施包括出院前的全面用药史、多学科会议和用药审查,出院后与参与者的全科医生保持联系。主要结果是 12 个月后常规用药数量与基线相比的变化。研究还对每位参与者在研究期间的成本进行了估算:结果:共有 98 人参加了这项研究。与基线相比,两组的常规用药量均有显著减少(对照组为-1.7 ± 4.3,t = 2.38,P = 0.02;干预组为-2.7 ± 3.6,t = 4.48,P = 0.0001),但两组之间未发现统计学差异(1.0 (SE 0.9),t = 1.03,P = 0.31)。据估计,干预措施的成本为 644.17 澳元,每位参与者在持续降低药品成本方面可节省 552.53 澳元。两组的健康结果和医疗成本相似:讨论:两组患者的用药量均有明显减少,干预组在 12 个月内的用药量减少幅度更大。干预成本大约被持续减少的药品成本所抵消,但由于组间结果差异不明显,因此应谨慎看待这些结果。
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引用次数: 0
Learning to be a colour-blind doctor 学做色盲医生
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-08-29 DOI: 10.1111/imj.16509
Matthew D. Jose

Colour-vision deficiency is common among medical students, doctors and their patients. Although it can influence choice of careers, it can also put patient safety at risk if not recognised and adapted to early in a health professional's working life. Simple recommendations to support medical students, doctors and their patients are provided to support better health outcomes.

色觉缺陷在医学生、医生及其病人中很常见。虽然它会影响职业选择,但如果在医疗专业人员的工作生涯中没有及早认识和适应,也会危及患者的安全。本文提供了一些简单的建议,以帮助医学生、医生及其患者获得更好的健康结果。
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引用次数: 0
期刊
Internal Medicine Journal
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