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Characteristics of paracetamol poisoning in a local health network and consistency of hospital management with national guidelines 一个地方医疗网络中扑热息痛中毒的特点以及医院管理与国家指导方针的一致性。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-12 DOI: 10.1111/imj.16592
Simon P. Hurley, Chris Horwood, Jake Mallon, Arduino A. Mangoni, Joshua M. Inglis

The management of paracetamol poisoning in our local health network and consistency with national guidelines is unclear. We conducted a 4-month retrospective study of all paracetamol poisonings identified in two South Australian hospitals. Most presentations were deliberate self-poisoning (90.7%) with immediate-release formulations (88.0%). Although most were managed in accordance with national guidelines, there were deficiencies in documentation of the poisoning details and patient weight as well as cases of underdosing of the antidote. Quality improvement initiatives are needed.

我们地方卫生网络对扑热息痛中毒的管理以及与国家指导方针的一致性尚不清楚。我们对南澳大利亚两家医院发现的所有扑热息痛中毒进行了为期4个月的回顾性研究。大多数病例为故意自毒(90.7%)和速释制剂(88.0%)。虽然大多数病例是按照国家指导方针处理的,但在中毒细节和患者体重以及解毒剂剂量不足的病例的记录方面存在缺陷。需要质量改进计划。
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引用次数: 0
Clinical outcomes of patients with non-tuberculous mycobacterial pulmonary disease in Auckland, New Zealand 新西兰奥克兰非结核分枝杆菌肺病患者的临床疗效。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-12 DOI: 10.1111/imj.16570
Charlotte Chen, Rebecca Davies, Christopher Lewis, Jennifer Paynter, Timothy Christmas, Mitzi Nisbet

This review of non-tuberculous mycobacterial pulmonary disease over an 11-year period identified 87 patients (74% women, mean age 66 years). Mycobacterium avium complex was isolated in 86% of patients. Antibiotics were commenced in 52% of patients; however, treatment was poorly tolerated with 36% terminating prematurely. Mortality was significant; death occurred in 31% of patients, with no relationship between death and treatment.

这项对 11 年间非结核分枝杆菌肺病的研究发现了 87 名患者(74% 为女性,平均年龄 66 岁)。86%的患者分离出了复合分枝杆菌。52%的患者开始接受抗生素治疗;然而,患者对治疗的耐受性很差,36%的患者提前终止了治疗。死亡率很高;31%的患者死亡,而死亡与治疗之间没有关系。
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引用次数: 0
The impact of obstructive sleep apnoea on post-operative outcomes 阻塞性睡眠呼吸暂停对术后预后的影响。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-10 DOI: 10.1111/imj.16595
Nicole Hersch, Samira Girgis, Guy Barrington Marks, Frances Smith, Peter R. Buchanan, Jonathan P. Williamson, Frances Garden, Hima Vedam

Background

Unrecognised obstructive sleep apnoea (OSA) has been associated with adverse cardiorespiratory perioperative outcomes. However, with changing anaesthetic and perioperative management, there is ongoing uncertainty about the importance of OSA as a risk factor for post-operative complications.

Methods

A cohort study involving subjects undergoing elective surgery was conducted. OSA was diagnosed with a limited channel sleep monitor. In subjects undergoing routine perioperative care, complications were identified based on the assessment of the attending clinical team. The primary outcome was a composite end-point of cardiorespiratory outcomes comprising myocardial infarction, atrial fibrillation, other arrhythmias, bradycardia, need for inotropic support, unplanned intensive care unit admission, pneumonia or respiratory failure.

Results

Four hundred seventy-two subjects were recruited, with 356 being included in the analyses; 281 (79%) had OSA and 66 (19%) had severe OSA. Subjects with OSA did not have a significantly higher incidence of complications (5.7%) compared to those without (2.7%, adjusted relative risk 1.89 (0.23–15.67)). Additionally, complications were not increased in those with severe OSA.

Conclusions

Unrecognised OSA was not associated with an increase in clinically evident cardiorespiratory complications in this cohort. The lower complication rates compared with earlier studies suggest that increased use of less invasive surgical techniques, improved pain management and increased awareness of OSA have had an impact in reducing postoperative complications in this group. Further research is needed to clarify the impact of severe OSA on post-operative outcomes in different surgical cohorts with varying risk profiles in order to develop optimal perioperative pathways.

背景:未被识别的阻塞性睡眠呼吸暂停(OSA)与不良的心肺围手术期预后相关。然而,随着麻醉和围手术期管理的改变,OSA作为术后并发症危险因素的重要性仍不确定。方法:对择期手术患者进行队列研究。通过有限通道睡眠监测仪诊断阻塞性睡眠呼吸暂停。在接受常规围手术期护理的受试者中,根据主治临床团队的评估确定并发症。主要终点是心肺结局的复合终点,包括心肌梗死、心房颤动、其他心律失常、心动过缓、需要肌力支持、计划外的重症监护病房入住、肺炎或呼吸衰竭。结果:共纳入472名受试者,其中356人被纳入分析;281例(79%)有OSA, 66例(19%)有重度OSA。OSA患者的并发症发生率(5.7%)没有明显高于无OSA患者(2.7%,校正相对危险度1.89(0.23-15.67))。此外,严重OSA患者的并发症没有增加。结论:在该队列中,未被识别的OSA与临床明显的心肺并发症的增加无关。与早期的研究相比,较低的并发症发生率表明,增加使用微创手术技术,改善疼痛管理和提高对OSA的认识对减少该组的术后并发症有影响。需要进一步的研究来阐明严重阻塞性睡眠呼吸暂停对具有不同风险特征的不同手术队列术后结果的影响,以便制定最佳的围手术期途径。
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引用次数: 0
Bacteraemia over 4 years in a Greater Western Sydney Metropolitan Local Health District: a retrospective descriptive study 大西悉尼大都会地方卫生区的4年菌血症:一项回顾性描述性研究。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-06 DOI: 10.1111/imj.16596
Vidthiya Menon

Background

Bacteraemia is associated with significant morbidity and mortality. Understanding local patterns of bacteraemia including pathogen distribution, infection source, clinical speciality team burden, susceptibility data and mortality rates can inform empiric antibiotic choices, prevention approaches and education strategies.

Aims

To obtain descriptive data from positive blood cultures identified from Nepean Blue Mountains Local Health District in Greater Western Sydney.

Methods

A retrospective descriptive study was performed from August 2018 to March 2023 with data extracted from electronic medical records.

Results

A total of 6720 isolates were identified from positive blood cultures, of which 71.2% were clinically significant. The median age was 69 years. A total of 74.6% of clinically significant isolates were acquired in the community. The most commonly isolated pathogen was Escherichia coli (31.3%), followed by Staphylococcus aureus (14.3%), and 8.6% of patients with clinically significant positive blood cultures were neutropenic. Neutropenic patients were more likely to have Pseudomonas aeruginosa as the causative pathogen (11.4%) compared to the entire study population (3.9%). The most commonly identified source of infection was the urinary tract. The 30-day all-cause mortality rate for clinically significant positive blood cultures was 16.8%, with higher mortality rates seen with Candida species (and species previously known as Candida), P. aeruginosa and Enterococcus species. 94% of bacteraemia from Enterobacterales tested susceptible in vitro to ampicillin and/or gentamicin. The rate of methicillin resistance in S. aureus was 24%.

Conclusions

This study provides valuable insight into the local epidemiology of bacteraemia, which will allow for targeted prevention, management and educational strategies to improve outcomes.

背景:菌血症与显著的发病率和死亡率相关。了解当地菌血症的模式,包括病原体分布、感染源、临床专科团队负担、敏感性数据和死亡率,可以为经验性抗生素选择、预防方法和教育策略提供信息。目的:从大西悉尼Nepean蓝山地方卫生区鉴定的阳性血培养中获得描述性数据。方法:从2018年8月至2023年3月进行回顾性描述性研究,数据提取自电子病历。结果:从阳性血培养中共分离出6720株,其中71.2%具有临床意义。平均年龄为69岁。74.6%的临床显著性分离株来自社区。最常见的分离病原菌为大肠杆菌(31.3%),其次为金黄色葡萄球菌(14.3%),8.6%临床显著血培养阳性患者为中性粒细胞减少。与整个研究人群(3.9%)相比,中性粒细胞减少患者更有可能将铜绿假单胞菌作为致病病原体(11.4%)。最常见的感染源是泌尿道。临床显著阳性血培养的30天全因死亡率为16.8%,念珠菌种(以前称为念珠菌种)、铜绿假单胞菌和肠球菌种的死亡率更高。94%的肠杆菌菌血症对氨苄西林和/或庆大霉素敏感。金黄色葡萄球菌耐甲氧西林率为24%。结论:本研究为细菌血症的当地流行病学提供了有价值的见解,这将允许有针对性的预防、管理和教育策略来改善结果。
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引用次数: 0
Faecal transplantation: the good, the bad and the ugly 粪便移植:好的,坏的和丑陋的。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-04 DOI: 10.1111/imj.16559
Hiu C. L. Sin, Craig Haifer

There continues to be significant interest from both clinicians and patients in using faecal transplantation, as the integral role of the gut microbiome is increasingly recognised in various disease conditions, both within and beyond the gut. This Clinical Perspectives article provides an overview of existing literature, factors limiting the use of faecal microbial transplantation in clinical practice and exciting new advancements on the horizon.

随着肠道微生物群在肠道内外各种疾病中的整体作用日益被认识到,临床医生和患者对使用粪便移植继续产生重大兴趣。本文综述了现有文献、限制粪便微生物移植在临床实践中的应用的因素以及令人兴奋的新进展。
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引用次数: 0
Patients with functional gastrointestinal disorders spend less time in tertiary care when managed by a single clinician: results of a multicentre audit in South Australia 由一名临床医生管理的功能性胃肠道疾病患者在三级护理中花费的时间更少:南澳大利亚多中心审计的结果。
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-02 DOI: 10.1111/imj.16591
Ryan M. Mathias, Samantha L. Plush, Elka J. S. Fairhead, Benjamin Ngoi, Louisa Edwards, Alice S. Day, Robert V. Bryant

Background and Aims

Functional gastrointestinal disorders (FGIDs) impact quality of life and represent a significant burden on healthcare services. Guidelines recommend an early, positive diagnosis to reduce harmful over-investigation in FGID patients. The aim of this multicentre study was to evaluate FGID management against current guidelines.

Methods

A multicentre, retrospective evaluation of patients with a primary diagnosis of FGID across two tertiary gastroenterology services over a 12-month period was performed. Time to diagnosis of a FGID, number of outpatient encounters, number and type of investigations performed and time to discharge from the outpatient service were assessed. Whether care was delivered by single or multiple clinicians was recorded. Statistical analysis was performed using Student's t test, logistic regression analysis and Kaplan–Meir curves.

Results

Between June 2021 and June 2022, 275 individual patients were reviewed primarily for FGID. Median time to FGID diagnosis was 70 days (interquartile range (IQR): 0–175), over a median of four outpatient encounters (IQR: 3–6), with an overall time in service of 182 days (IQR: 105–344). When care was delivered by a single rather than multiple clinicians, patients were more likely to receive a FGID diagnosis early (hazard ratio (HR): 1.6, 95% confidence interval (CI): 1.25–2.04, P < 0.0001), be discharged sooner (HR: 1.83, 95% CI: 1.44–2.33, P < 0.0001), with a trend towards less harmful investigations (odds ratio: 1.79, 95% CI: 0.96–3.58, P = 0.08).

Conclusions

Consistent delivery of clinical care reduces healthcare utilisation in the management of FGIDs. Further studies are needed to identify optimal care models for managing outpatients with FGIDs.

背景和目的:功能性胃肠疾病(fgid)影响生活质量,对医疗保健服务构成重大负担。指南建议对FGID患者进行早期阳性诊断,以减少有害的过度检查。这项多中心研究的目的是根据现行指南评估FGID的管理。方法:对两家三级胃肠病学服务机构12个月期间初步诊断为FGID的患者进行多中心回顾性评估。评估FGID的诊断时间、门诊就诊次数、进行调查的次数和类型以及从门诊出院的时间。记录是否由单个或多个临床医生提供护理。统计学分析采用Student’st检验、logistic回归分析和Kaplan-Meir曲线。结果:在2021年6月至2022年6月期间,对275名患者进行了主要的FGID检查。到FGID诊断的中位时间为70天(四分位数间距(IQR): 0-175),中位门诊次数为4次(IQR: 3-6),总服务时间为182天(IQR: 105-344)。当由一个而不是多个临床医生提供护理时,患者更有可能在早期得到FGID的诊断(风险比(HR): 1.6, 95%置信区间(CI): 1.25-2.04, P)。结论:一致的临床护理减少了FGID管理中的医疗保健利用。需要进一步的研究来确定管理FGIDs门诊患者的最佳护理模式。
{"title":"Patients with functional gastrointestinal disorders spend less time in tertiary care when managed by a single clinician: results of a multicentre audit in South Australia","authors":"Ryan M. Mathias,&nbsp;Samantha L. Plush,&nbsp;Elka J. S. Fairhead,&nbsp;Benjamin Ngoi,&nbsp;Louisa Edwards,&nbsp;Alice S. Day,&nbsp;Robert V. Bryant","doi":"10.1111/imj.16591","DOIUrl":"10.1111/imj.16591","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Functional gastrointestinal disorders (FGIDs) impact quality of life and represent a significant burden on healthcare services. Guidelines recommend an early, positive diagnosis to reduce harmful over-investigation in FGID patients. The aim of this multicentre study was to evaluate FGID management against current guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multicentre, retrospective evaluation of patients with a primary diagnosis of FGID across two tertiary gastroenterology services over a 12-month period was performed. Time to diagnosis of a FGID, number of outpatient encounters, number and type of investigations performed and time to discharge from the outpatient service were assessed. Whether care was delivered by single or multiple clinicians was recorded. Statistical analysis was performed using Student's <i>t</i> test, logistic regression analysis and Kaplan–Meir curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between June 2021 and June 2022, 275 individual patients were reviewed primarily for FGID. Median time to FGID diagnosis was 70 days (interquartile range (IQR): 0–175), over a median of four outpatient encounters (IQR: 3–6), with an overall time in service of 182 days (IQR: 105–344). When care was delivered by a single rather than multiple clinicians, patients were more likely to receive a FGID diagnosis early (hazard ratio (HR): 1.6, 95% confidence interval (CI): 1.25–2.04, <i>P</i> &lt; 0.0001), be discharged sooner (HR: 1.83, 95% CI: 1.44–2.33, <i>P</i> &lt; 0.0001), with a trend towards less harmful investigations (odds ratio: 1.79, 95% CI: 0.96–3.58, <i>P</i> = 0.08).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Consistent delivery of clinical care reduces healthcare utilisation in the management of FGIDs. Further studies are needed to identify optimal care models for managing outpatients with FGIDs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13625,"journal":{"name":"Internal Medicine Journal","volume":"55 2","pages":"260-269"},"PeriodicalIF":1.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes to diabetes therapy access on the Pharmaceutical Benefits Scheme: ensuring equitable access 药品福利计划中糖尿病治疗获取的变化:确保公平获取
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-02 DOI: 10.1111/imj.16578
Christopher S. Nguyen, Dev Kevat, Rahul D. Barmanray
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引用次数: 0
Management of malignant pleural effusions and drainage care: a hospital in the home and palliative care service 恶性胸腔积液的处理和引流护理:一家医院的居家和姑息治疗服务
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-02 DOI: 10.1111/imj.16579
Fiona Runacres, Scott Reeves, Harshan S. Jeyakumar, Philip George, June Song
{"title":"Management of malignant pleural effusions and drainage care: a hospital in the home and palliative care service","authors":"Fiona Runacres,&nbsp;Scott Reeves,&nbsp;Harshan S. Jeyakumar,&nbsp;Philip George,&nbsp;June Song","doi":"10.1111/imj.16579","DOIUrl":"https://doi.org/10.1111/imj.16579","url":null,"abstract":"","PeriodicalId":13625,"journal":{"name":"Internal Medicine Journal","volume":"54 12","pages":"2094-2095"},"PeriodicalIF":1.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point-of-care ultrasound: prime time has arrived 即时超声:黄金时代已经到来
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-02 DOI: 10.1111/imj.16581
Noor Lammoza, Nina Murphy, Nicole Evans, Harry Gibbs, Patrick Elliott
{"title":"Point-of-care ultrasound: prime time has arrived","authors":"Noor Lammoza,&nbsp;Nina Murphy,&nbsp;Nicole Evans,&nbsp;Harry Gibbs,&nbsp;Patrick Elliott","doi":"10.1111/imj.16581","DOIUrl":"https://doi.org/10.1111/imj.16581","url":null,"abstract":"","PeriodicalId":13625,"journal":{"name":"Internal Medicine Journal","volume":"54 12","pages":"2089-2090"},"PeriodicalIF":1.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home-based ambulatory video EEG monitoring: a cost-effective and underutilised diagnostic tool for people with seizure disorders in Australia 基于家庭的动态视频脑电图监测:澳大利亚癫痫患者的一种成本效益高且未充分利用的诊断工具
IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-02 DOI: 10.1111/imj.16582
Udaya Seneviratne, Lisa Gillinder, Thomas Kraemer, Andrew Lee, Simon Bower
{"title":"Home-based ambulatory video EEG monitoring: a cost-effective and underutilised diagnostic tool for people with seizure disorders in Australia","authors":"Udaya Seneviratne,&nbsp;Lisa Gillinder,&nbsp;Thomas Kraemer,&nbsp;Andrew Lee,&nbsp;Simon Bower","doi":"10.1111/imj.16582","DOIUrl":"https://doi.org/10.1111/imj.16582","url":null,"abstract":"","PeriodicalId":13625,"journal":{"name":"Internal Medicine Journal","volume":"54 12","pages":"2096-2097"},"PeriodicalIF":1.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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