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Zinc may have a potential role in taste malfunctions treatment for COVID-19 patients. Journal Review article 锌可能在COVID-19患者的味觉功能障碍治疗中发挥潜在作用。期刊评论文章
Pub Date : 2020-01-01 DOI: 10.15761/IFNM.1000296
Jumanah S. Al-Awfi
The novel COVID-19 virus has ongoing signs and symptoms, one of the signs and symptoms that is discovered recently is loss of taste, some pieces of research suggested that COVID-19 patients may have zinc deficiency however the main undiscovered concern is whether the virus is a causative or those patients had deficiency pre COVID-19, approximately they found 57.4% COVID-19 patients have low zinc serum levels which may indicate an advantage to administer a therapeutic approach for zinc deficiency for those patients. Pervious research experienced with common cold symptoms and zinc administration and resulted in conflicting data. More recently, Cochran review indicates zinc may be useful for common cold patients only if administered within 24 hours onset of symptoms. It was known previously for upper respiratory tract infections to cause loss of taste; this concern might be
新型COVID-19病毒有持续的体征和症状,最近发现的体征和症状之一是味觉丧失,一些研究表明COVID-19患者可能缺锌,但主要未被发现的问题是该病毒是病因还是这些患者在COVID-19之前缺锌。大约他们发现57.4%的COVID-19患者血清锌水平低,这可能表明对这些患者实施锌缺乏症的治疗方法具有优势。以往的研究经历了普通感冒症状和锌的服用,并导致了相互矛盾的数据。最近,Cochran综述指出,锌只有在症状出现24小时内才可能对普通感冒患者有用。以前人们知道上呼吸道感染会导致味觉丧失;这种担忧可能是
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引用次数: 2
Targeted nutrigenomics as a means of breast cancer management: from DNA methylation to microRNAs 靶向营养基因组学作为乳腺癌管理的一种手段:从DNA甲基化到microrna
Pub Date : 2020-01-01 DOI: 10.15761/IFNM.1000288
R. Hashemi, S. Arefhosseini, G. Folkerts, S. Varasteh, M. Morshedi
Breast Cancer (BC) is the most prevalent cancer affecting females and the leading cause of death around the world. The World Health Organization (WHO) has announced that the incidence of BC increases approximately 1.8-2 % annually. Hence, it is important that new prevention and treatment strategies involving epigenetics and nutrigenomics are explored. Epigenetics refers to potential changes in gene expression and chromatin structure without alteration of DNA sequence, but still modulates the expression of a particular phenotype. Nutrigenomics determines the effect of dietary habits on cancer risk and tumor behavior, both in progression and inhibition of cancer. The modulation of chromatin structure is an essential component in the regulation of transcriptional activation and repression. Therefore, identifying the regulators of gene expression changes during cancer progression is essential for early diagnosis and inhibition of this malignancy. The methylation of promoter genes, as well as the interplay between microRNAs (miRNAs) and messenger RNAs (mRNAs) of target genes, is the primary component of epigenetics. Any defect in these processes is considered a crucial mechanism for gene and pathway dysregulation in all human cancers, including BC. Nutritional genomic and epigenetic mechanisms may play a pivotal role in prevention as well as early diagnosis of BC, especially for closely related female family members of BC patients. It seems cytosine methylation in Cytosine-phosphate-Guanine dinucleotide (CpG) Islands reflects changes in balance tissues rigidity. Hypo- and hypermethylation of CpG Islands (CGIs) play a crucial role in development of BC via up-regulation of oncogenes and down-regulation of tumor suppressor genes (TSGs). These could be the most effective mechanisms to distinguish BC from other types of cancer. beneficial effects of some nutritional components on the function and structure of non-coding RNA and DNA methylation. We also discuss the role of nutrigenomics as a non-invasive method to explore the epigenetic mechanisms involved in BC and also in the prevention, treatment, early diagnosis, and distinguishing a variety of cancers from each other. In addition, the importance of non-coding RNAs, including miRNAs in body fluids, also need to be further clarified.
乳腺癌(BC)是影响女性的最普遍的癌症,也是世界上导致死亡的主要原因。世界卫生组织(WHO)宣布,BC的发病率每年增加约1.8- 2%。因此,探索涉及表观遗传学和营养基因组学的新的预防和治疗策略是很重要的。表观遗传学是指基因表达和染色质结构的潜在变化而不改变DNA序列,但仍然调节特定表型的表达。营养基因组学确定了饮食习惯对癌症风险和肿瘤行为的影响,包括癌症的进展和抑制。染色质结构的调节是调控转录激活和抑制的重要组成部分。因此,确定癌症进展过程中基因表达变化的调节因子对于早期诊断和抑制这种恶性肿瘤至关重要。启动子基因的甲基化以及靶基因的microRNAs (miRNAs)和信使rna (mrna)之间的相互作用是表观遗传学的主要组成部分。这些过程中的任何缺陷都被认为是所有人类癌症(包括BC)中基因和通路失调的关键机制。营养基因组和表观遗传机制可能在BC的预防和早期诊断中发挥关键作用,特别是对BC患者的近亲属女性家庭成员。胞嘧啶-磷酸-鸟嘌呤二核苷酸(CpG)岛胞嘧啶甲基化反映了平衡组织刚性的变化。CpG岛的低甲基化和高甲基化通过上调癌基因和下调肿瘤抑制基因(TSGs)在BC的发展中起着至关重要的作用。这些可能是区分BC和其他类型癌症最有效的机制。一些营养成分对非编码RNA和DNA甲基化功能和结构的有益影响。我们还讨论了营养基因组学作为一种非侵入性方法的作用,以探索BC的表观遗传机制,以及在预防、治疗、早期诊断和区分各种癌症方面的作用。此外,包括体液中的mirna在内的非编码rna的重要性也需要进一步明确。
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引用次数: 0
Effects of dietary phytoestrogens on the developmental reprogramming of steroid-hormone influenced traits: Medicinal and evolutionary aspects 膳食植物雌激素对类固醇激素影响性状的发育重编程的影响:医学和进化方面
Pub Date : 2020-01-01 DOI: 10.15761/IFNM.1000275
G. Csaba
Nutritional phytoestrogens are weak estrogens, which entering into the human organism are able to reprogram the developmental program in sensitive periods of life (perinatally, at weaning, at puberty and in certain systems (e.g. immune system) during the whole life. Consequently they could cause (by faulty hormonal imprinting) lifelong alterations in the binding capacity of hormone receptors, inclination to diseases, manifestation of diseases etc. At the same time by adult age employment they can help healing of certain diseases. In some human cultures the consumption of phytoestrogens (isoflavones, as soy genistein or daidzein) is regular (in Asian countries) for thousand years, and this could contribute to the differences between the physiology of races. At present the consumption of soy (and isoflavones=phytoestrogens in them) is exponentially growing in European and American countries, what could influence the future (evolutionary) development (and uniformization) of endocrine (and endocrine-directed) systems of man. Some transformations of life-periods are observed (e.g. early menarche) and more are expected, however without serious attention. Considering this, phytoestrogens are the Troian horse of endocrine disruptors. Studying from medicinal aspect, the irregular (undosed) eating of phytoestrogens especially which does not attend the sensitive life-periods, can influence the endocrine system as well, as the strongly endocrine-regulated systems, which can be manifested in lower risk of later manifested diseases, as tumors or geriatric alterations however, it can cause reproductive and immune-deficiencies. The positive and mainly negative character of phytoestrogens have to be propagated for doctors and laymen alike. As phytoestrogens could cause different durable pathological alterations, the label on their presence (and effects?) in commercial foods, would be advisable.
营养性植物雌激素是一种弱雌激素,进入人体机体后,能够在生命的敏感时期(围产期、断奶期、青春期)以及整个生命中的某些系统(如免疫系统)重新编程发育程序。因此,它们可能(通过错误的激素印记)导致激素受体结合能力的终身改变、疾病倾向、疾病表现等。同时,通过成年就业,他们可以帮助治愈某些疾病。在一些人类文化中,植物雌激素(异黄酮,如大豆染料木黄酮或大豆黄酮)的摄入已经有几千年的历史了,这可能会导致种族之间生理上的差异。目前,欧洲和美洲国家大豆(以及大豆中的异黄酮=植物雌激素)的消费量呈指数级增长,这可能影响人类内分泌(和内分泌指导)系统的未来(进化)发展(和统一)。观察到一些生命周期的转变(例如,月经初潮提前),预计会有更多的转变,但没有得到认真的注意。考虑到这一点,植物雌激素是内分泌干扰物中的特洛伊木马。从医学角度研究,不规律(不给药)食用植物雌激素,特别是不进入敏感的生命期,也会影响内分泌系统,因为内分泌系统受到强烈的调节,这可以表现为较低的后期表现疾病的风险,如肿瘤或老年病变,但它可以引起生殖和免疫缺陷。植物雌激素的阳性和主要阴性特征必须向医生和外行人进行宣传。由于植物雌激素可能引起不同的持久的病理改变,因此建议在商业食品中标明它们的存在(和影响?)
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引用次数: 0
Effect of nutrition behaviour change intervention on improving micronutrients concentration and linear growth of children age 6 to 59 months in central highland of Ethiopia: Cluster randomized control trial 营养行为改变干预对改善埃塞俄比亚中部高原6 ~ 59月龄儿童微量营养素浓度和线性生长的影响:整群随机对照试验
Pub Date : 2020-01-01 DOI: 10.15761/IFNM.1000287
Abebe Ferede, T. Belachew, M. Abera
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引用次数: 0
Biological and histopathological characteristics of heat and biochemical processed Kariya (Hildegardia bateri) seedsBiological and histopathological characteristics of heat and biochemical processed Kariya (Hildegardia bateri) seeds 热生化处理的山黧豆(Hildegardia bateri)种子的生物学和组织病理学特性热生化处理山黧豆(Hildegardia bateri)种子的生物学和组织病理学特性
Pub Date : 2020-01-01 DOI: 10.15761/IFNM.1000290
A. V. Ikujenlola, Olamide Esther Aluko, S. Gbadamosi, D. Adeyemi
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引用次数: 0
Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran. 食用米糠对大肠癌幸存者血浆和尿液代谢组的调节作用
Pub Date : 2019-04-05 DOI: 10.15761/IFNM.1000252
Iman Zarei, Renee C Oppel, Erica C Borresen, Regina J. Brown, E. Ryan
Rice bran has bioactive phytochemicals with cancer protective actions that involve metabolism by the host and the gut microbiome. Globally, colorectal cancer (CRC) is the third leading cause of cancer-related death and the increased incidence is largely attributed to poor dietary patterns, including low daily fiber intake. A dietary intervention trial was performed to investigate the impact of rice bran consumption on the plasma and urine metabolome of CRC survivors. Nineteen CRC survivors participated in a randomized-controlled trial that included consumption of heat-stabilized rice bran (30 g/day) or a control diet without rice bran for 4 weeks. A fasting plasma and first void of the morning urine sample were analyzed by non-targeted metabolomics using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After 4 weeks of either rice bran or control diets, 12 plasma and 16 urine metabolites were significantly different between the groups (p≤0.05). Rice bran intake increased relative abundance of plasma mannose (1.373-fold) and beta-citrylglutamate (BCG) (1.593-fold), as well as increased urine N-formylphenylalanine (2.191-fold) and dehydroisoandrosterone sulfate (DHEA-S) (4.488-fold). Diet affected metabolites, such as benzoate, mannose, eicosapentaenoate (20:5n3) (EPA), and N-formylphenylalanine have been previously reported for cancer protection and were identified from the rice bran food metabolome. Nutritional metabolome changes following increased consumption of whole grains such as rice bran warrants continued investigation for colon cancer control and prevention attributes as dietary biomarkers for positive effects are needed to reduce high risk for colorectal cancer recurrence.
米糠具有生物活性的植物化学物质,具有抗癌作用,涉及宿主和肠道微生物群的代谢。在全球范围内,结直肠癌(CRC)是癌症相关死亡的第三大原因,发病率的增加主要归因于不良的饮食模式,包括每日纤维摄入量低。进行了一项饮食干预试验,以研究米糠摄入对结直肠癌幸存者血浆和尿液代谢组的影响。19名结直肠癌幸存者参加了一项随机对照试验,其中包括连续4周食用热稳定米糠(30克/天)或不食用米糠的对照饮食。采用超高效液相色谱-串联质谱法(UHPLC-MS/MS)对空腹血浆和晨尿进行非靶向代谢组学分析。饲喂米糠饲粮和对照组饲粮4周后,12种血浆代谢物和16种尿液代谢物组间差异显著(p≤0.05)。米糠摄入增加了血浆甘露糖(1.373倍)和β -柠檬酸谷氨酸(BCG)(1.593倍)的相对丰度,增加了尿n -甲酰苯丙氨酸(2.191倍)和硫酸脱氢异雄酮(DHEA-S)(4.488倍)的相对丰度。饮食影响代谢物,如苯甲酸盐、甘露糖、二十碳五烯酸(20:5n3) (EPA)和n -甲酰苯基丙氨酸,先前已报道具有抗癌作用,并从米糠食品代谢组中鉴定出来。随着米糠等全谷物消费的增加,营养代谢组的变化值得继续研究结肠癌控制和预防属性,因为需要积极作用的饮食生物标志物来降低结直肠癌复发的高风险。
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引用次数: 14
Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers. 佛手柑(Citrus bergamia)降低高胆固醇和心血管疾病标志物的临床应用。
Pub Date : 2019-03-01 Epub Date: 2019-02-28 DOI: 10.15761/IFNM.1000249
Mirielle C Nauman, Jeremy J Johnson

The bergamot is a citrus fruit native to southern Italy with traditional uses that include improving immune response and cardiovascular function. There are a variety of phytochemicals that have been found in the bergamot including brutieridin and melitidin as well as other flavonoids, flavones O-glucosides and C-glucosides. Multiple clinical trials have provided evidence that different forms of orally administered bergamot can reduce total cholesterol and low-density lipoprotein cholesterol. In vitro mechanistic studies have provided evidence that polyphenols from the bergamot can alter the function of AMPK and pancreatic cholesterol ester hydrolase (pCEH). The use of bergamot in multiple clinical trials has consistently shown that it is well tolerated in studies ranging from 30 days to 12 weeks. This mini-review reports on the clinical studies performed with different forms of bergamot along with their effectiveness in reducing total cholesterol and LDL cholesterol in patients with hypercholesterolemia.

佛手柑是一种原产于意大利南部的柑橘类水果,传统用途包括改善免疫反应和心血管功能。在佛手柑中发现了多种植物化学物质,包括苦苣苔素和苦苣苔素以及其他类黄酮,o -葡萄糖苷和c -葡萄糖苷。多项临床试验提供证据表明,不同形式的口服佛手柑可以降低总胆固醇和低密度脂蛋白胆固醇。体外机制研究表明,佛手柑多酚可以改变AMPK和胰腺胆固醇酯水解酶(pCEH)的功能。佛手柑在多个临床试验中的使用一致表明,在30天至12周的研究中,佛手柑具有良好的耐受性。这篇小型综述报告了不同形式佛手柑在降低高胆固醇血症患者总胆固醇和低密度脂蛋白胆固醇方面的有效性的临床研究。
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引用次数: 29
Nitrate supplementation in thoroughbred racehorses: Addition of beetroot juice to the equine diet and effects on the gut metabolome 纯种马的硝酸盐补充:在马的日粮中添加甜菜根汁及其对肠道代谢组的影响
Pub Date : 2019-03-01 DOI: 10.15761/IFNM.1000246
R. Waring, J. Hunter, C. Turner, C. Batty, P. Ramzan
Beetroot juice (BJ), a source of nitrate, was added to the diet of thoroughbred racehorses for a four-week period. Analysis of nitrate/nitrite in plasma showed no significant differences between control and dosed groups. SIFT/MS (selected ion-flow tube/mass spectrometry) was used to analyse the faecal metabolome. The levels and types of volatile organic compounds (VOCs) were compared using headspace sampling of faeces from control and beetroot-supplemented equines, However, there were no significant differences apart from raised levels of acetonitrile in samples from the animals dosed with BJ. The conclusion was that racehorses appear not to have nitrate transporters and that addition of BJ to equine diets would not improve performance
甜菜根汁(BJ)是一种硝酸盐的来源,被添加到纯种马的饮食中,为期四周。血浆硝酸盐/亚硝酸盐分析显示对照组和给药组之间无显著差异。采用SIFT/MS(选择离子流管/质谱法)分析粪便代谢组。通过对对照组和补充甜菜根的马的粪便进行顶空采样,比较了挥发性有机化合物(VOCs)的水平和类型。然而,除了服用BJ的马的粪便中乙腈的水平升高外,没有显著差异。结论是,赛马似乎没有硝酸盐转运体,在马的饮食中添加BJ不会提高性能
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引用次数: 1
Diabetes peer-education on food choices part I: Development of framework 糖尿病同伴教育的食物选择第一部分:框架的发展
Pub Date : 2019-01-01 DOI: 10.15761/IFNM.1000240
Nwose Eu, Onokade M, A. O, Igumbor Eo
Medical nutrition therapy (MNT) for diabetes has paved its way through many randomized trials, meta-analysis and observational studies [1]. There is now the established concept of nutrition counseling in MNT, which is focused on supporting clients to set priorities, establish goals, and create their individual food menu plans [2]. Indeed, it is also speculated that lifestyle including dietary habit vis-à-vis MNT interventions work better than metformin in reducing the incidence of type 2 diabetes [3]. It has been proposed that peer-support education is probably a better option than general public health lectures that is provided by the healthcare professional [4-6], especially for selfmanagement that considers cultural and geographical factors [7].
医学营养疗法(MNT)治疗糖尿病已经通过许多随机试验、荟萃分析和观察性研究铺平了道路[1]。现在MNT中已经有了营养咨询的概念,其重点是支持客户设定优先事项,建立目标,并创建他们的个人食物菜单计划[2]。事实上,也有人推测包括饮食习惯在内的生活方式vs -à-vis MNT干预在降低2型糖尿病发病率方面比二甲双胍更有效[3]。有人提出,同伴支持教育可能是比医疗保健专业人员提供的一般公共卫生讲座更好的选择[4-6],特别是对于考虑文化和地理因素的自我管理[7]。
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引用次数: 1
Promoting African indigenous vegetables and its medical nutrition properties: A mini-narrative review based on Ukwani communities of Delta State Nigeria 促进非洲本土蔬菜及其医疗营养特性:以尼日利亚三角洲州Ukwani社区为基础的小型叙述审查
Pub Date : 2019-01-01 DOI: 10.15761/ifnm.1000256
Ishiekwene Ic, D. Te, J. Odoko, Nwose Eu
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引用次数: 6
期刊
Integrative Food, Nutrition and Metabolism
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