Pub Date : 2020-10-31DOI: 10.22159/ijs.2020.v8i2.39419
Akash S. Mali, Shravni Gosavi, G. Shukla
Cancer is linked with mutated genes, and the study of tumor-associated genetic alterations is gradually used for diagnostic and treatment purposes. The solid tumors are now obtained from biopsy and/or surgical or biopsy specimens. Tumor cells release circulating free DNA into the blood, but the majority of circulating DNA are often not of cancerous origin, and the detection of cancer-associated alleles in the blood has long been unbearable to achieve. Modern science has overwhelmed these restrictions, making it possible to identify both genetic and epigenetic aberrations. A liquid biopsy (LB) or blood sample can provide the genetic landscape of all cancerous lesions (primary and metastases) as well as offering the opportunity to systematically track genomic evolution. This communication will explore how LB is associated with personalized oncology to predict response to treatments and the development of acquired resistance.
{"title":"LIQUID BIOPSY: THERANOSTICS AND PERSONALIZED ONCOLOGY","authors":"Akash S. Mali, Shravni Gosavi, G. Shukla","doi":"10.22159/ijs.2020.v8i2.39419","DOIUrl":"https://doi.org/10.22159/ijs.2020.v8i2.39419","url":null,"abstract":"Cancer is linked with mutated genes, and the study of tumor-associated genetic alterations is gradually used for diagnostic and treatment purposes. The solid tumors are now obtained from biopsy and/or surgical or biopsy specimens. Tumor cells release circulating free DNA into the blood, but the majority of circulating DNA are often not of cancerous origin, and the detection of cancer-associated alleles in the blood has long been unbearable to achieve. Modern science has overwhelmed these restrictions, making it possible to identify both genetic and epigenetic aberrations. A liquid biopsy (LB) or blood sample can provide the genetic landscape of all cancerous lesions (primary and metastases) as well as offering the opportunity to systematically track genomic evolution. This communication will explore how LB is associated with personalized oncology to predict response to treatments and the development of acquired resistance.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84275254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-31DOI: 10.22159/ijas.2020.v8i6.39192
A. Khattak, S. M. Hassan, Shahzad Sharif Mughal
Recent probe of medicinal plants incorporated in traditional systems for curing infection and sustaining holistic health, has exposed good sum of therapeutic efficiency against deleterious infections and chronic illnesses. Rheum palmatum (Chinese Rhubarb, family Polygonaceae) is a significant medicinal herb, which finds an extensive use in Unani (Traditional) system of medicine. It has been traditionally employed as antiseptic, liver stimulant, diuretic, diabetes, stomachic, purgative/cathartic, anticholesterolemic, antitumor, Alzheimer’s, Parkinson’s, tonic, antidiabetic, and wound healer. The most vital components from Rheum palmatum are the phenolics, flavonoids, terpenoids, saponins, and anthraquinone derivatives such as aloe-emodin, chrysophanol, physcion, rhein, emodin and its glucorhein, and glycoside. Rhubarb also contains tannins which include hydrolysable-tannins, containing glycosidic or ester bonds composed of glucose, gallic acid, and other monosaccharide’s and condensed tannins, resulting principally from the flavone derivatives leukocyanidin and catechin. In recent years, new components such asrevandchinone-1, revandchinone-2, revandchinone-3, revandchinone-4, sulfemodin8-O-b-Dglucoside, and 6-methyl-rhein and aloe-emodin have been reported from the same class. It also encompasses some macro and micro mineral elements such as Ca, K, Mn, Fe, Co, Zn, Na, Cu, and Li. Anthraquinone derivatives demonstrate evidence of anti-microbial, antifungal, anti-proliferative, anti-Parkinson’s, immune enhancing, anticancer, antiulcer, antioxidant, and antiviral activities. This review article covers published study on therapeutic uses of different constituents from rhubarb.
最近对传统系统中用于治疗感染和维持整体健康的药用植物的研究，揭示了对有害感染和慢性疾病的良好治疗效果。大黄(中国大黄，蓼科)是一种重要的草药，在Unani(传统)医学系统中被广泛使用。它传统上被用作防腐剂，肝脏兴奋剂，利尿剂，糖尿病，胃，泻药/泻药，抗胆固醇，抗肿瘤，阿尔茨海默氏症，帕金森氏症，补品，抗糖尿病和伤口愈合剂。大黄中最重要的成分是酚类物质、类黄酮、萜类、皂苷和蒽醌衍生物，如芦荟大黄素、大黄酚、大黄素、大黄素及其糖苷和糖苷。大黄还含有单宁，其中包括水解单宁，含有葡萄糖、没食子酸和其他单糖和缩合单宁组成的糖苷或酯键，主要来自黄酮衍生物白色素和儿茶素。近年来，从同类植物中陆续报道了芦笋黄酮-1、芦笋黄酮-2、芦笋黄酮-3、芦笋黄酮-4、磺黄酮8- o -b-葡糖苷、6-甲基大黄素和芦荟大黄素等新成分。它还包括一些宏观和微观矿物元素，如Ca、K、Mn、Fe、Co、Zn、Na、Cu和Li。蒽醌衍生物具有抗微生物、抗真菌、抗增殖、抗帕金森病、增强免疫、抗癌、抗溃疡、抗氧化和抗病毒活性。本文综述了已发表的有关大黄不同成分的治疗用途的研究。
{"title":"GENERAL OVERVIEW OF PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL OF RHEUM PALMATUM (CHINESE RHUBARB)","authors":"A. Khattak, S. M. Hassan, Shahzad Sharif Mughal","doi":"10.22159/ijas.2020.v8i6.39192","DOIUrl":"https://doi.org/10.22159/ijas.2020.v8i6.39192","url":null,"abstract":"Recent probe of medicinal plants incorporated in traditional systems for curing infection and sustaining holistic health, has exposed good sum of therapeutic efficiency against deleterious infections and chronic illnesses. Rheum palmatum (Chinese Rhubarb, family Polygonaceae) is a significant medicinal herb, which finds an extensive use in Unani (Traditional) system of medicine. It has been traditionally employed as antiseptic, liver stimulant, diuretic, diabetes, stomachic, purgative/cathartic, anticholesterolemic, antitumor, Alzheimer’s, Parkinson’s, tonic, antidiabetic, and wound healer. The most vital components from Rheum palmatum are the phenolics, flavonoids, terpenoids, saponins, and anthraquinone derivatives such as aloe-emodin, chrysophanol, physcion, rhein, emodin and its glucorhein, and glycoside. Rhubarb also contains tannins which include hydrolysable-tannins, containing glycosidic or ester bonds composed of glucose, gallic acid, and other monosaccharide’s and condensed tannins, resulting principally from the flavone derivatives leukocyanidin and catechin. In recent years, new components such asrevandchinone-1, revandchinone-2, revandchinone-3, revandchinone-4, sulfemodin8-O-b-Dglucoside, and 6-methyl-rhein and aloe-emodin have been reported from the same class. It also encompasses some macro and micro mineral elements such as Ca, K, Mn, Fe, Co, Zn, Na, Cu, and Li. Anthraquinone derivatives demonstrate evidence of anti-microbial, antifungal, anti-proliferative, anti-Parkinson’s, immune enhancing, anticancer, antiulcer, antioxidant, and antiviral activities. This review article covers published study on therapeutic uses of different constituents from rhubarb.","PeriodicalId":13687,"journal":{"name":"Innovare Journal of Ayurvedic Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75703132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：