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LncRNA Peg13 Alleviates Myocardial Infarction/Reperfusion Injury through Regulating MiR-34a/Sirt1-Mediated Endoplasmic Reticulum Stress LncRNA Peg13 通过调节 MiR-34a/Sirt1 介导的内质网应激减轻心肌梗死/再灌注损伤
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-31 DOI: 10.1536/ihj.23-453
Yonghong Wang, Jian Luo, Huiqiong Yang, Yanfei Liu

Myocardial infarction/reperfusion (I/R) injury significantly impacts the health of older individuals. We confirmed that the level of lncRNA Peg13 was downregulated in I/R injury. However, the detailed function of Peg13 in myocardial I/R injury has not yet been explored.

To detect the function of Peg13, in vivo model of I/R injury was constructed. RT-qPCR was employed to investigate RNA levels, and Western blotting was performed to assess levels of endoplasmic reticulum stress and apoptosis-associated proteins. EdU staining was confirmed to assess the cell proliferation.

I/R therapy dramatically produced myocardial injury, increased the infarct area, and decreased the amount of Peg13 in myocardial tissues of mice. In addition, hypoxia/reoxygenation (H/R) notably induced the apoptosis and promoted the endoplasmic reticulum (ER) stress of HL-1 cells, while overexpression of Peg13 reversed these phenomena. Additionally, Peg13 may increase the level of Sirt1 through binding to miR-34a. Upregulation of Peg13 reversed H/R-induced ER stress via regulation of miR-34a/Sirt1 axis.

LncRNA Peg13 reduces ER stress in myocardial infarction/reperfusion injury through mediation of miR-34a/Sirt1 axis. Hence, our research might shed new lights on developing new strategies for the treatment of myocardial I/R injury.

心肌梗死/再灌注(I/R)损伤严重影响老年人的健康。我们证实,lncRNA Peg13的水平在I/R损伤中下调。为了检测Peg13的功能,我们构建了I/R损伤的体内模型。为了检测Peg13的功能,研究人员构建了I/R损伤体内模型,采用RT-qPCR检测RNA水平,并进行Western印迹以评估内质网应激和细胞凋亡相关蛋白的水平。I/R疗法会显著造成心肌损伤,增加梗死面积,减少小鼠心肌组织中Peg13的含量。此外,缺氧/复氧(H/R)显著诱导 HL-1 细胞凋亡并促进内质网(ER)应激,而过表达 Peg13 则可逆转这些现象。此外,Peg13 还可能通过与 miR-34a 结合提高 Sirt1 的水平。LncRNA Peg13通过调控miR-34a/Sirt1轴降低心肌梗死/再灌注损伤中的ER应激。因此,我们的研究可能为开发治疗心肌I/R损伤的新策略提供新的启示。
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引用次数: 0
Sirtuin 6 Deacetylates Apoptosis-Associated Speck-Like Protein (ASC) to Inhibit Endothelial Cell Pyroptosis in Atherosclerosis Sirtuin 6 可使凋亡相关斑点样蛋白 (ASC) 去乙酰化,从而抑制动脉粥样硬化中的内皮细胞猝死现象
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-334
Jian Huang, Shuilin Dong, Yanhui Wu, Huiming Yi, Wei Zhang, Xi Ai

Endothelial cell dysfunction is the main pathology of atherosclerosis (AS). Sirtuin 6 (SIRT6), a deacetylase, is involved in AS progression. This study aimed to investigate the impacts of SIRT6 on the pyroptosis of endothelial cells and its underlying mechanisms. ApoE−/− mice were fed a high-fat diet (HFD) to establish the AS mouse model, atherosclerotic lesions were evaluated using oil red O staining, and blood lipids and inflammatory factors were measured using corresponding kits. Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL) to establish the cell model, and pyroptosis was evaluated by flow cytometry, ELISA, and western blot. Immunoprecipitation (IP), co-IP, western blot, and immunofluorescence were used to detect the molecular mechanisms. The results showed that SIRT6 expression was downregulated in the blood of HFD-induced mice and ox-LDL-induced HUVECs. Overexpression of SIRT6 reduced atherosclerotic lesions, blood lipids, and inflammation in vivo and suppressed pyroptosis of HUVECs in vitro. Moreover, SIRT6 interacted with ASC to inhibit the acetylation of ASC, thus, reducing the interaction between ASC and NLRP3. Moreover, SIRT6 inhibits endothelial cell pyroptosis in the aortic roots of mice by deacetylating ASC. In conclusion, SIRT6 deacetylated ASC to inhibit its interaction with NLRP3 and then suppressed pyroptosis of endothelial cells, thus, decelerating the progression of AS. The findings provide new insights into the function of SIRT6 in AS.

内皮细胞功能障碍是动脉粥样硬化(AS)的主要病理现象。Sirtuin 6(SIRT6)是一种去乙酰化酶,参与了动脉粥样硬化的进展。本研究旨在探讨 SIRT6 对内皮细胞热解的影响及其内在机制。用高脂饮食(HFD)喂养载脂蛋白E-/-小鼠建立强直性脊柱炎小鼠模型,用油红O染色法评估动脉粥样硬化病变,用相应的试剂盒测定血脂和炎症因子。用氧化低密度脂蛋白(ox-LDL)处理人脐静脉内皮细胞(HUVECs)以建立细胞模型,并用流式细胞术、ELISA和Western印迹法评估热蛋白沉积。免疫沉淀(IP)、共沉淀(co-IP)、Western 印迹和免疫荧光用于检测分子机制。结果表明,SIRT6在HFD诱导的小鼠血液和氧化-LDL诱导的HUVECs中表达下调。过表达 SIRT6 可减少体内动脉粥样硬化病变、血脂和炎症,抑制体外 HUVECs 的热凋亡。此外,SIRT6 与 ASC 相互作用,抑制了 ASC 的乙酰化,从而减少了 ASC 与 NLRP3 之间的相互作用。此外,SIRT6 还能通过去乙酰化 ASC 来抑制小鼠主动脉根部内皮细胞的脓毒症。总之,SIRT6通过使ASC去乙酰化来抑制其与NLRP3的相互作用,进而抑制内皮细胞的热凋亡,从而减缓强直性脊柱炎的进展。这些发现为SIRT6在强直性脊柱炎中的功能提供了新的见解。
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引用次数: 0
A Surviving Case of Myocardial Infarction with Ventricular Septal Rupture and Ventricular Aneurysm following Gastrointestinal Bleeding 胃肠道出血后心肌梗死伴室间隔破裂和心室动脉瘤的存活病例
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-586
Misa Kusumoto, Jumpei Yamamoto, Sakura Kaneda, Takuya Matsushiro, Masaya Yamamoto, Hisao Hara, Nobuyuki Inoue, Yukio Hiroi

A 55-year-old man presented to the emergency department with worsening shortness of breath 1 month after a gastrointestinal bleed. He had congestive heart failure, and an electrocardiogram suggested ischemic heart disease involvement. Echocardiography revealed a ventricular septal defect complicated by a left ventricular aneurysm in the inferior-posterior wall. Conservative treatment was started, but hemodynamic collapse occurred on the third day of admission and coronary angiography revealed a revascularizing lesion in the right fourth posterior descending coronary artery. Subsequently, his hemodynamic status continued to deteriorate, even with an Impella CP® heart pump, so ventricular septal defect patch closure and left ventricular aneurysm suture were performed. His condition improved and he was discharged on day 23 of admission and was not readmitted within 6 months after the procedure. Hemodynamic management of ventricular septal defects requires devices that reduce afterload, and clinicians should be aware of the risk of myocardial infarction after gastrointestinal bleeding.

一名 55 岁的男子在消化道出血 1 个月后因呼吸急促加重到急诊科就诊。他患有充血性心力衰竭,心电图显示他患有缺血性心脏病。超声心动图显示,室间隔缺损并发左室下后壁动脉瘤。他开始接受保守治疗,但入院第三天就出现了血流动力学衰竭,冠状动脉造影显示右侧第四冠状动脉后降支有血管再通病变。随后,即使使用 Impella CP® 心脏泵,他的血流动力学状况仍在继续恶化,因此对他进行了室间隔缺损修补关闭术和左心室动脉瘤缝合术。他的病情有所好转,入院第 23 天就出院了,术后 6 个月内没有再入院。室间隔缺损的血流动力学治疗需要能降低后负荷的设备,临床医生应注意消化道出血后心肌梗死的风险。
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引用次数: 0
Impact of Cancer History on Temporal Changes in the Cardiopulmonary Exercise Test of Patients with Cardiovascular Disease 癌症史对心血管疾病患者心肺运动测试时间变化的影响
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.24-037
Keisuke Satogami, Junko Morimoto, Takaya Naraoka, Motoki Taniguchi, Takahiro Nishi, Yoshinori Asae, Akira Taruya, Atsushi Tanaka

The elevated risk of cardiovascular disease (CVD) in cancer patients and survivors is likely the result of normal age-related pathologies coupled with the direct and indirect effects of cancer therapy that extend across multiple systems. The purpose of this study was to investigate the impact of cardiac rehabilitation (CR) on CVD patients with a history of cancer.

In this study, patients who had participated in the outpatient CR program were enrolled and were divided into 2 groups (cancer survivor group and no-cancer group) based on their history of cancer. The cardiopulmonary exercise test (CPET) was performed at the beginning (baseline) and at the end of the CR program (follow-up). The results of CPET at baseline and those at follow-up were analyzed retrospectively.

A total of 105 patients were analyzed in this study. The cancer survivor group had 25 patients, and the non-cancer group 80. At baseline, peak oxygen uptake (peak VO2) (14.7 [11.9 to 17.6] mL/kg/minute versus 11.3 [9.7 to 14.7] mL/kg/minute; P = 0.003) was significantly lower in cancer survivors. The percent changes in peak VO2 between baseline and follow-up were not significantly different between the 2 groups (7.9 % [−11.5 to 24.5] versus 9.4 % [−7.5 to 27.3] P = 0.520).

The percent changes in peak VO2 of CR participants were not significantly different despite their cancer history.

癌症患者和幸存者罹患心血管疾病(CVD)的风险升高可能是正常年龄相关病理变化加上癌症治疗对多个系统的直接和间接影响的结果。本研究的目的是调查心脏康复(CR)对有癌症病史的心血管疾病患者的影响。在本研究中,参加过门诊CR项目的患者被纳入其中,并根据他们的癌症病史分为两组(癌症幸存者组和非癌症组)。在 CR 项目开始时(基线)和结束时(随访)进行了心肺运动测试(CPET)。本研究共分析了 105 名患者。癌症幸存者组有 25 名患者,非癌症组有 80 名患者。基线时,癌症幸存者的峰值摄氧量(峰值 VO2)(14.7 [11.9 至 17.6] 毫升/千克/分钟对 11.3 [9.7 至 14.7] 毫升/千克/分钟;P = 0.003)明显低于非癌症幸存者。尽管有癌症病史,但 CR 参与者的峰值 VO2 百分比变化在两组之间没有明显差异(7.9% [-11.5 至 24.5] 对 9.4% [-7.5 至 27.3] P = 0.520)。
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引用次数: 0
Potential Effects of Ischemic Postconditioning and Changes in Heat Shock Protein 72 in Patients with Acute Myocardial Infarction without Prodromal Angina 缺血后条件和热休克蛋白 72 变化对无心绞痛前兆的急性心肌梗死患者的潜在影响
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-651
Toshiharu Takeuchi, Yuya Kitani, Akiho Minoshima, Hisanobu Ota, Naoki Nakagawa, Kazuhiro Sumitomo, Yoshinao Ishii, Naoyuki Hasebe

The effectiveness of ischemic postconditioning (iPoC) in patients with ST-elevation myocardial infarction (STEMI) without ischemic preconditioning has not been determined. Therefore, we investigated the impact of iPoC and its potential mechanism related to heat shock protein 72 (HSP72) induction on myocardial salvage in patients with STEMI without prodromal angina (PA).

We retrospectively analyzed data from 102 patients with STEMI with successful reperfusion among 323 consecutive patients with acute coronary syndrome. Among these, 55 patients with iPoC (iPoC (+) ) underwent 4 cycles of 60-second inflation and 30-second deflation of the angioplasty balloon. Both the iPoC (+) and iPoC (-) groups were divided into 2 further subgroups: patients with PA (PA (+) ) and those without (PA (-) ). We analyzed HSP72 levels in neutrophils, which were measured until 48 hours after reperfusion. I-123 β-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) scintigraphy was performed within a week of reperfusion therapy. In 64% of patients, thallium-201 (TL) scintigraphy was performed 6-8 months after STEMI onset.

Using BMIPP and TL, in the PA (-) subgroups, the iPoC (+) group had a significantly greater myocardial salvage ratio than the iPoC (-) group. iPoC was identified as an independent predictor of the myocardial salvage ratio. The HSP72 increase ratio was significantly elevated in the iPoC (+) PA (-) group. Importantly, the myocardial salvage effect in patients without PA was significantly correlated with the HSP72 increase ratio, which was greater in patients with iPoC.

These results suggest the potential impact of iPoC via HSP72 induction on myocardial salvage; however, the effects may be limited to patients with STEMI without PA.

缺血后条件(iPoC)对未进行缺血预处理的 ST 段抬高型心肌梗死(STEMI)患者的有效性尚未确定。因此,我们研究了 iPoC 及其与热休克蛋白 72(HSP72)诱导相关的潜在机制对无前驱心绞痛(PA)的 STEMI 患者心肌救治的影响。我们回顾性分析了 323 例急性冠状动脉综合征连续患者中 102 例成功再灌注的 STEMI 患者的数据。其中,55 名 iPoC(iPoC (+) )患者接受了 4 个周期的血管成形术球囊充气 60 秒和放气 30 秒。iPoC (+) 组和 iPoC (-) 组又分为两个亚组:有 PA(PA (+) )和无 PA(PA (-) )的患者。我们对中性粒细胞中的 HSP72 水平进行了分析,直到再灌注后 48 小时。在再灌注治疗后一周内进行了 I-123 β-甲基-对碘苯基-十五烷酸(BMIPP)闪烁扫描。使用 BMIPP 和 TL,在 PA(-)亚组中,iPoC(+)组的心肌挽救率显著高于 iPoC(-)组。iPoC 被确定为心肌挽救率的独立预测因子。iPoC (+) PA (-) 组的 HSP72 增加比率明显升高。重要的是,无 PA 患者的心肌救治效果与 HSP72 升高比值显著相关,而 iPoC 患者的 HSP72 升高比值更高。这些结果表明,iPoC 通过 HSP72 诱导对心肌救治有潜在影响;但这种影响可能仅限于无 PA 的 STEMI 患者。
{"title":"Potential Effects of Ischemic Postconditioning and Changes in Heat Shock Protein 72 in Patients with Acute Myocardial Infarction without Prodromal Angina","authors":"Toshiharu Takeuchi, Yuya Kitani, Akiho Minoshima, Hisanobu Ota, Naoki Nakagawa, Kazuhiro Sumitomo, Yoshinao Ishii, Naoyuki Hasebe","doi":"10.1536/ihj.23-651","DOIUrl":"https://doi.org/10.1536/ihj.23-651","url":null,"abstract":"</p><p>The effectiveness of ischemic postconditioning (iPoC) in patients with ST-elevation myocardial infarction (STEMI) without ischemic preconditioning has not been determined. Therefore, we investigated the impact of iPoC and its potential mechanism related to heat shock protein 72 (HSP72) induction on myocardial salvage in patients with STEMI without prodromal angina (PA).</p><p>We retrospectively analyzed data from 102 patients with STEMI with successful reperfusion among 323 consecutive patients with acute coronary syndrome. Among these, 55 patients with iPoC (iPoC (+) ) underwent 4 cycles of 60-second inflation and 30-second deflation of the angioplasty balloon. Both the iPoC (+) and iPoC (-) groups were divided into 2 further subgroups: patients with PA (PA (+) ) and those without (PA (-) ). We analyzed HSP72 levels in neutrophils, which were measured until 48 hours after reperfusion. I-123 β-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) scintigraphy was performed within a week of reperfusion therapy. In 64% of patients, thallium-201 (TL) scintigraphy was performed 6-8 months after STEMI onset.</p><p>Using BMIPP and TL, in the PA (-) subgroups, the iPoC (+) group had a significantly greater myocardial salvage ratio than the iPoC (-) group. iPoC was identified as an independent predictor of the myocardial salvage ratio. The HSP72 increase ratio was significantly elevated in the iPoC (+) PA (-) group. Importantly, the myocardial salvage effect in patients without PA was significantly correlated with the HSP72 increase ratio, which was greater in patients with iPoC.</p><p>These results suggest the potential impact of iPoC via HSP72 induction on myocardial salvage; however, the effects may be limited to patients with STEMI without PA.</p>\u0000<p></p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"2 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Coronary Artery Perforation Caused by Manual Cardiopulmonary Resuscitation in the Catheterization Laboratory 导管室人工心肺复苏术导致冠状动脉穿孔一例
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-549
Kei Morishita, Takatoshi Unno, Takahiko Murakami, Kensuke Okada, Hiroshi Matsunaga, Kazuo Asada, Yasutoshi Omori, Akiko Ishihara, Yoshiro Kamoi, Takahiro Tanaka

Cardiopulmonary resuscitation (CPR) is essential for the survival of cardiac arrest patients, but it can cause severe traumatic complications. In the catheterization laboratory, various physical constraints complicate the appropriate performance of CPR. However, we are not aware of reports of CPR complications in this setting. Here, we report a case of coronary artery perforation (CAP) caused by manual CPR in the catheterization laboratory. The patient, a 68-year-old woman, initially underwent successful percutaneous coronary intervention (PCI) for unstable angina. Back in the ward, the patient experienced acute stent thrombosis, which resulted in cardiac arrest, and another PCI was performed under ongoing manual CPR. Although revascularization was successful, sudden CAP occurred, leading to cardiac tamponade. Despite extensive treatment efforts, the patient died 18 hours later.

Initially, the compression site of CPR was on the midline of the sternum; however, the compression site shifted to the left, to just above the left anterior descending artery, by the time that CAP was detected via angiography. This corresponded to the area where rib fractures were observed upon computed tomography, suggesting the possibility of traumatic CAP due to manual CPR. The physical constraints in the catheterization laboratory can lead to an inappropriate CPR technique and severe traumatic complications.

心肺复苏术(CPR)对心脏骤停患者的存活至关重要,但它可能导致严重的创伤并发症。在导管室,各种物理限制使心肺复苏术的适当实施变得复杂。然而,我们还没有在这种情况下进行心肺复苏并发症的报道。在此,我们报告了一例在导管室手动心肺复苏术导致的冠状动脉穿孔(CAP)病例。患者是一名 68 岁的女性,最初因不稳定型心绞痛成功接受了经皮冠状动脉介入治疗(PCI)。回到病房后,患者出现急性支架血栓,导致心脏骤停,在持续的人工心肺复苏下又进行了一次 PCI。虽然血管再通手术取得了成功,但突然发生了 CAP,导致心脏填塞。最初,心肺复苏的压迫部位位于胸骨中线;然而,在通过血管造影检测到 CAP 时,压迫部位向左移动,位于左前降支动脉上方。这与计算机断层扫描中观察到的肋骨骨折区域相对应,表明人工心肺复苏可能导致创伤性 CAP。导管室的物理限制可能会导致不恰当的心肺复苏技术和严重的创伤性并发症。
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引用次数: 0
A Randomized Controlled Study of Enhanced External Counterpulsation with Cardiac Rehabilitation in Patients with Nonobstructive Coronary Artery Disease and Coronary Microvascular Dysfunction Clinical Durative Effect 非阻塞性冠状动脉疾病和冠状动脉微血管功能障碍患者强化体外反搏与心脏康复的随机对照研究 临床持续效果
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-454
Yuanzhuo Zhang, Xiaoyan Yin, Lei Ren

Treatment with enhanced external counterpulsation (EECP) or cardiac rehabilitation (CR) benefits patients with coronary heart disease; this paper intends to explore the feasibility of EECP combined with CR in patients with nonobstructive coronary heart disease (NOCAD) and coronary microcirculation disorders (CMD).

In January 2021-2022 month June our income NOCAD patients as the research object, the line of cardiac magnetic resonance (CMR), myocardial perfusion reserve (MPR) < 2.0 coronary microcirculation disorders (CMD, 80 cases). Random indicator method 80 CMD patients divided into two groups, 40 cases in each. Usual treatment group: conventional drugs and CR therapy. EECP treatment group: on the basis of standard treatment group, employ EECP therapy. Comparing the two groups before and after the treatment curative effect cardiac function index, endothelial unction index, adverse cardiovascular events, etc.

After EECP treatment, the treatment group showed a higher effective rate compared to the usual treatment group (P < 0.05). EECP group curative effect, left ventricular ejection fraction,plasma NO and vascular endothelial growth factor levels higher than the usual group, the incidence of adverse cardiovascular events is lower than the usual group. The difference was statistically significant (P < 0.05).

EECP combined with cardiac rehabilitation in patients with CMD symptoms has better effect and safety and provides reference for treatment of CMD patients.

增强体外反搏(EECP)或心脏康复(CR)治疗对冠心病患者有益,本文拟探讨EECP联合CR治疗非梗阻性冠心病(NOCAD)和冠状动脉微循环障碍(CMD)患者的可行性。以2021年1月-2022年6月我院收治的NOCAD患者为研究对象,行心脏磁共振(CMR)、心肌灌注储备(MPR)<2.0冠状动脉微循环障碍(CMD,80例)。随机指标法 80 例 CMD 患者分为两组,每组 40 例。常规治疗组:常规药物和 CR 治疗。EECP 治疗组:在标准治疗组的基础上,采用 EECP 治疗。比较两组治疗前后疗效心功能指标、内皮功能指标、心血管不良事件等。EECP治疗后,治疗组有效率高于常规治疗组(P< 0.05)。EECP组疗效、左室射血分数、血浆NO和血管内皮生长因子水平高于常规组,心血管不良事件发生率低于常规组,差异有统计学意义(P<0.05)。EECP联合心脏康复治疗CMD症状患者效果更好,安全性更高,为CMD患者的治疗提供了参考。
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引用次数: 0
Triglyceride-Glucose Index Predicts Major Adverse Cardiovascular and Cerebrovascular Events in Patients with Atrial Fibrillation 甘油三酯-葡萄糖指数可预测心房颤动患者的主要不良心血管和脑血管事件
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-413
Chunhui Yin, Qiqi Hou, Qi Qi, Quanle Han, Xiaoyao Wang, Shouling Wu, Kangbo Li

This study aimed to explore the relationship between the trajectory of the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) in patients with atrial fibrillation (AF).

This prospective study included 1979 patients with AF, who were initially selected from the Kailuan study. Patients of AF were split into four groups according to the value of TyG index. The clinical endpoint was MACCE, including myocardial infarction and ischemic stroke. Cox proportional hazard models were employed to examine the hazard ratio (HR) and 95% confidence interval (CI) for MACCE in various trajectory groups.

The mean age of all patients with AF was 67.65 ± 11.15 years, and 1752 (88.53%) were male. Over a median follow-up duration of 5.31 years, in total 227 MACCE were recorded. MACCE cumulative incidence in Quartile 4 (26.96%) was significantly higher than those in other quartiles (P = 0.023). Multivariate Cox proportional hazards regression analysis showed that a higher TyG index (Quartile 4) was significantly and positively linked to MACCE in patients with AF (P = 0.023, HR: 2.103; 95% CI: 1.107-3.994).

The evaluated TyG index is significantly associated with an increased risk of MACCE in patients with AF.

本研究旨在探讨甘油三酯-葡萄糖(TyG)指数的变化轨迹与心房颤动(房颤)患者主要不良心脑血管事件(MACCE)发生率之间的关系。根据TyG指数值,房颤患者被分为四组。临床终点为MACCE,包括心肌梗死和缺血性卒中。所有房颤患者的平均年龄为(67.65±11.15)岁,男性患者为 1752 人(88.53%)。中位随访时间为 5.31 年,共记录到 227 例 MACCE。四分位数 4 的 MACCE 累计发生率(26.96%)明显高于其他四分位数(P = 0.023)。多变量 Cox 比例危险回归分析显示,TyG 指数越高(四分位数 4)与房颤患者的 MACCE 呈显著正相关(P = 0.023,HR:2.103;95% CI:1.107-3.994)。
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引用次数: 0
PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-κB Axis PLIN5 通过调节 PIR/NF-κB 轴抑制心肌细胞的脂肪毒性和铁变态反应
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.24-002
Xiaoyu Shen, Jiamei Zhang, Zhou Zhou, Ruiqun Yu

Cardiomyocyte lipotoxicity and ferroptosis are the key to the development of diabetic cardiomyopathy (DCM). Perilipin 5 (PLIN5) is perceived as a significant target of DCM. This study aimed to focus on the role and mechanism of PLIN5 on lipotoxicity and ferroptosis in DCM.

Following transfection, mouse cardiomyocytes HL-1 were induced by 0.1 mM palmitic acid (PA) to set up lipotoxic cardiomyocyte models. The cell viability and lipid accumulation were evaluated by cell counting kit-8 assay and Oil red O staining, respectively. Ferrous ion (Fe2+), glutathione (GSH), malondialdehyde (MDA), and reactive oxygen species (ROS) levels were determined to verify the effects of PLIN5 or Pirin (PIR) on ferroptosis. Quantitative real-time reverse transcription polymerase chain reaction or Western blot was performed for quantitative analysis.

PLIN5 overexpression promoted the viability, GSH level, and expression of GPX4/PIR/intracellular P65, yet suppressed lipid accumulation, level of Fe2+/MDA/ROS, and expression of interleukin (IL) -1β/IL-18/intranuclear P65 in PA-stimulated HL-1 cells. PIR silencing counteracted the roles of PLIN5 overexpression in PA-stimulated HL-1 cells.

PLIN5 suppresses lipotoxicity and ferroptosis in cardiomyocyte via modulating PIR/NF-κB axis, hinting its potential as a therapeutic target in DCM.

心肌细胞脂肪毒性和铁蛋白沉积是糖尿病心肌病(DCM)发病的关键。Perilipin 5(PLIN5)被认为是 DCM 的一个重要靶点。转染小鼠心肌细胞HL-1后,用0.1 mM棕榈酸(PA)诱导建立脂毒性心肌细胞模型。细胞计数试剂盒-8测定法和油红O染色法分别评价了细胞活力和脂质积累。测定亚铁离子(Fe2+)、谷胱甘肽(GSH)、丙二醛(MDA)和活性氧(ROS)水平,以验证 PLIN5 或 Pirin (PIR) 对铁变态反应的影响。在 PA 刺激的 HL-1 细胞中,PLIN5 的过表达促进了活力、GSH 水平和 GPX4/PIR/ 细胞内 P65 的表达,但抑制了脂质积累、Fe2+/MDA/ROS 水平和白细胞介素(IL)-1β/IL-18/核内 P65 的表达。PLIN5通过调节PIR/NF-κB轴抑制了心肌细胞的脂肪毒性和铁变态反应,提示了其作为DCM治疗靶点的潜力。
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引用次数: 0
Descriptions of Etiology, Clinical Course, and Prognosis of Patients Presenting with Pericardial Effusion 心包积液患者的病因、临床表现和预后描述
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-511
Koichiro Hori, Yuko Kato, Shinya Suzuki, Naomi Hirota, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Junji Yajima, Takeshi Yamashita, Tokuhisa Uejima, Yuji Oikawa

Pericardial effusion (PE) presentation varies from an incidental finding to a life-threatening situation; thus, its etiology and clinical course remain unknown. The aim of the present study was to retrospectively investigate these factors.

We analyzed 171 patients (0.4%) who presented with PE among 34,873 patients who underwent echocardiography between 2011 and 2021 at our hospital. Clinical and prognostic information was retrieved from electronic medical records. The primary endpoints were all-cause death, hospitalization due to heart failure (HF), and other cardiovascular events such as cardiovascular death, acute coronary syndrome, elective percutaneous coronary intervention, and stroke.

The etiologies of PE were as follows: idiopathic (32%), HF-related (18%), iatrogenic (11%), cardiac surgery-related (10%), radiation therapy-related (9%), malignancy (8%), pericarditis/myocarditis (8%), myocardial infarction-related (2%), and acute aortic dissection (2%). Patients with idiopathic/HF etiology were more likely to be older than the others.

During a mean follow-up period of 2.5 years, all-cause death occurred in 21 patients (12.3%), cardiovascular events in 10 patients (5.8%), and hospitalization for HF in 24 patients (14.0%). All-cause death was frequently observed in patients with malignancy (44% per person-year). Cardiovascular events were mostly observed in patients with radiation therapy-related and malignancy (8.6% and 7.3% per person-year, respectively).

The annual incidence of hospitalization for HF was the highest in patients with HF-related (25.1% per person-year), followed by radiation therapy-related (10.4% per person-year).

This retrospective study is the first, to the best of our knowledge, to reveal the contemporary prevalence of PE, its cause, and outcome in patients who visited a cardiovascular hospital in an urban area of Japan.

心包积液(PE)的表现形式多种多样,从偶然发现到危及生命,因此,其病因和临床过程仍然不明。本研究旨在对这些因素进行回顾性研究。我们分析了 2011 年至 2021 年期间在我院接受超声心动图检查的 34873 名患者中出现 PE 的 171 名患者(0.4%)。临床和预后信息均来自电子病历。主要终点是全因死亡、心力衰竭(HF)住院以及其他心血管事件,如心血管死亡、急性冠状动脉综合征、择期经皮冠状动脉介入治疗和中风。PE的病因如下:特发性(32%)、HF相关(18%)、先天性(11%)、心脏手术相关(10%)、放射治疗相关(9%)、恶性肿瘤(8%)、心包炎/心肌炎(8%)、心肌梗死相关(2%)和急性主动脉夹层(2%)。在平均 2.5 年的随访期间,21 名患者(12.3%)全因死亡,10 名患者(5.8%)发生心血管事件,24 名患者(14.0%)因心房颤动住院。恶性肿瘤患者经常出现全因死亡(44%/人-年)。心血管事件主要发生在放疗相关患者和恶性肿瘤患者身上(分别为每人每年 8.6% 和 7.3%)。心房颤动相关患者的年度心房颤动住院率最高(每人每年 25.1%),其次是放疗相关患者(每人每年 10.4%)。
{"title":"Descriptions of Etiology, Clinical Course, and Prognosis of Patients Presenting with Pericardial Effusion","authors":"Koichiro Hori, Yuko Kato, Shinya Suzuki, Naomi Hirota, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Junji Yajima, Takeshi Yamashita, Tokuhisa Uejima, Yuji Oikawa","doi":"10.1536/ihj.23-511","DOIUrl":"https://doi.org/10.1536/ihj.23-511","url":null,"abstract":"</p><p>Pericardial effusion (PE) presentation varies from an incidental finding to a life-threatening situation; thus, its etiology and clinical course remain unknown. The aim of the present study was to retrospectively investigate these factors.</p><p>We analyzed 171 patients (0.4%) who presented with PE among 34,873 patients who underwent echocardiography between 2011 and 2021 at our hospital. Clinical and prognostic information was retrieved from electronic medical records. The primary endpoints were all-cause death, hospitalization due to heart failure (HF), and other cardiovascular events such as cardiovascular death, acute coronary syndrome, elective percutaneous coronary intervention, and stroke.</p><p>The etiologies of PE were as follows: idiopathic (32%), HF-related (18%), iatrogenic (11%), cardiac surgery-related (10%), radiation therapy-related (9%), malignancy (8%), pericarditis/myocarditis (8%), myocardial infarction-related (2%), and acute aortic dissection (2%). Patients with idiopathic/HF etiology were more likely to be older than the others.</p><p>During a mean follow-up period of 2.5 years, all-cause death occurred in 21 patients (12.3%), cardiovascular events in 10 patients (5.8%), and hospitalization for HF in 24 patients (14.0%). All-cause death was frequently observed in patients with malignancy (44% per person-year). Cardiovascular events were mostly observed in patients with radiation therapy-related and malignancy (8.6% and 7.3% per person-year, respectively).</p><p>The annual incidence of hospitalization for HF was the highest in patients with HF-related (25.1% per person-year), followed by radiation therapy-related (10.4% per person-year).</p><p>This retrospective study is the first, to the best of our knowledge, to reveal the contemporary prevalence of PE, its cause, and outcome in patients who visited a cardiovascular hospital in an urban area of Japan.</p>\u0000<p></p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"47 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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International heart journal
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