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Single-Cell Transcriptomic Analysis Reveals Myocardial Fibrosis Mechanism of Doxorubicin-Induced Cardiotoxicity 单细胞转录组分析揭示多柔比星诱发心脏毒性的心肌纤维化机制
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-302
Yige Huyan, Xiao Chen, Yuan Chang, Xiumeng Hua, Xuexin Fan, Dan Shan, Zhenyu Xu, Menghao Tao, Hang Zhang, Sheng Liu, Jiangping Song

Myocardial fibrosis is a pathological feature of doxorubicin-induced chronic cardiotoxicity that severely affects the prognosis of oncology patients. However, the specific cellular and molecular mediators driving doxorubicin-induced cardiac fibrosis, and the relative impact of different cell populations on cardiac fibrosis, remain unclear.

This study aimed to explore the mechanism of doxorubicin-induced cardiotoxicity and myocardial fibrosis and to find potential therapeutic targets. Single-cell RNA sequencing was used to analyze the transcriptome of non-cardiomyocytes from normal and doxorubicin-induced chronic cardiotoxicity in mouse model heart tissue.

We established a mouse model of doxorubicin-induced cardiotoxicity with a well-defined fibrotic phenotype. Analysis of single-cell sequencing results showed that fibroblasts were the major origin of extracellular matrix in doxorubicin-induced myocardial fibrosis. Further resolution of fibroblast subclusters showed that resting fibroblasts were converted to matrifibrocytes and then to myofibroblasts to participate in the myocardial remodeling process in response to doxorubicin treatment. Ctsb expression was significantly upregulated in fibroblasts after doxorubicin-induced.

This study provides a comprehensive map of the non-cardiomyocyte landscape at high resolution, reveals multiple cell populations contributing to pathological remodeling of the cardiac extracellular matrix, and identifies major cellular sources of myofibroblasts and dynamic gene-expression changes in fibroblast activation. Finally, we used this strategy to detect potential therapeutic targets and identified Ctsb as a specific target for fibroblasts in doxorubicin-induced myocardial fibrosis.

心肌纤维化是多柔比星诱导的慢性心脏毒性的病理特征,严重影响肿瘤患者的预后。本研究旨在探索多柔比星诱导心脏毒性和心肌纤维化的机制,并寻找潜在的治疗靶点。我们建立了一个多柔比星诱导的心脏毒性小鼠模型,该模型具有明确的纤维化表型。单细胞测序结果分析表明,在多柔比星诱导的心肌纤维化中,成纤维细胞是细胞外基质的主要来源。对成纤维细胞亚群的进一步解析显示,静止的成纤维细胞在多柔比星治疗后转化为亚纤维细胞,然后转化为肌成纤维细胞,参与心肌重塑过程。这项研究以高分辨率提供了非心肌细胞的全面图谱,揭示了导致心脏细胞外基质病理性重塑的多种细胞群,并确定了成肌纤维细胞的主要细胞来源以及成纤维细胞活化过程中的动态基因表达变化。最后,我们利用这一策略检测了潜在的治疗靶点,并确定 Ctsb 是多柔比星诱导的心肌纤维化中成纤维细胞的特异性靶点。
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引用次数: 0
Long-Term Maintenance of Normal Serum Vitamin B1 Levels Is Associated with Better Outcomes in Patients with Heart Failure 血清维生素 B1 水平长期维持正常与改善心力衰竭患者的预后有关
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-550
Junko Morimoto, Keisuke Satogami, Takaya Naraoka, Akira Taruya, Atsushi Tanaka

Deficiency of vitamin B1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we investigated the efficacy of long-term maintenance of normal blood VB1 levels in preventing adverse outcomes in patients with HF.

This study included 88 consecutive patients with HF who received guideline-directed medical therapy at Arida Municipal Hospital. The patients were divided into 3 groups: a control group with normal VB1 levels and no VB1 supplementation (normal group, n = 25), and those presenting with VB1 deficiency, who either required short-term VB1 supplementation (short-term supplementation group, n = 25), or long-term maintenance of normal blood VB1 levels (long-term maintenance group, n = 38). The time to the first appearance of composite outcomes, including cardiovascular death and hospitalization for HF, was compared between the 3 groups.

VB1 deficiency was observed in 63 (72%) patients. The Kaplan-Meier curve showed that the long-term maintenance group had better outcomes than the other 2 groups. In the multivariate analysis, long-term maintenance of normal blood VB1 levels and age were independent predictors of composite outcomes.

VB1 deficiency is frequently observed, and the long-term maintenance of normal blood VB1 levels may result in better outcomes in patients with HF. Our results suggest that the detection of VB1 deficiency and long-term restoration of VB1 levels may be part of the overall therapeutic strategy for HF.

维生素 B1(VB1)是人体必需的微量营养素,缺乏维生素 B1 会导致心力衰竭(HF)。最近的一项随机对照试验显示,短期补充维生素 B1 未能改善心力衰竭的预后。在本研究中,我们探讨了长期维持血液中正常的 VB1 水平对预防心力衰竭患者不良预后的疗效。患者被分为 3 组:VB1 水平正常且未补充 VB1 的对照组(正常组,n = 25),以及需要短期补充 VB1(短期补充组,n = 25)或长期维持正常血液 VB1 水平(长期维持组,n = 38)的 VB1 缺乏患者。对三组患者首次出现心血管死亡和因心房颤动住院等综合结果的时间进行了比较。63 名(72%)患者出现 VB1 缺乏。卡普兰-梅耶曲线显示,长期维持治疗组的疗效优于其他两组。在多变量分析中,长期维持正常的血液 VB1 水平和年龄是综合预后的独立预测因素。我们的研究结果表明,检测 VB1 缺乏并长期恢复 VB1 水平可能是心房颤动整体治疗策略的一部分。
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引用次数: 0
Role of Sleep-Disordered Breathing and Epicardial Connections in the Recurrence of Atrial Fibrillation 睡眠呼吸紊乱和心外膜连接在心房颤动复发中的作用
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-653
Eiji Nyuta, Masao Takemoto, Yoshibumi Antoku, Takahiro Mito, Togo Sakai, Tomohiro Takiguchi, Shota Ikeda, Tokushi Koga, Takuya Tsuchihashi

The presence of epicardial connections (ECs) between the pulmonary veins (PVs) and atrium may contribute to atrial fibrillation (AF) recurrence. This study aimed to determine the impact of sleep-disordered breathing (SDB) on the presence of ECs and the interplay between SDB and ECs on AF recurrence.

We retrospectively reviewed 400 consecutive non-valvular AF patients. Among them, 235 patients exhibiting a 3% oxygen desaturation index (ODI) of ≥ 10 events/hour underwent polysomnography to evaluate the SDB severity, measured by the apnea-hypopnea index (AHI). To facilitate the ablation of AF and ECs, a high-density mapping catheter (HDMC) was employed. AF recurrence was evaluated over a 12-month period post-AF ablation.

The key findings included: 1) 63% of AF patients with ECs had SDB with an AHI ≥ 20 events/hour. 2) Despite achieving complete PV isolations and precise EC ablation using an HDMC, SDB presence was associated with an increased AF recurrence. 3) Continuous positive airway pressure therapy for SDB improved AF recurrence among the AF patients with both ECs and SDB (57% versus 73%; P = 0.016). 4) AHI (odds ratio [OR] = 1.91, ≥ 28.4 events/hour) and left atrial volume (LAV) (OR = 1.42, ≥ 128.3 mL) were independent predictors of the presence of ECs, and AHI (OR = 1.44, ≥ 27.8 events/hour) was an independent predictor of the presence of AF recurrence.

It is essential for physicians to recognise the potential complexity of ECs and SDB in AF patients. Thus, screening and treating SDB in AF patients presenting with ECs might play a pivotal role in suppressing AF recurrence.

肺静脉(PV)和心房之间存在心外膜连接(EC)可能会导致心房颤动(AF)复发。本研究旨在确定睡眠呼吸紊乱(SDB)对心外膜连接的影响,以及睡眠呼吸紊乱和心外膜连接对房颤复发的相互作用。其中,235 名患者的 3% 氧饱和度指数(ODI)≥ 10 次/小时,他们接受了多导睡眠图检查,以评估 SDB 的严重程度,SDB 的测量方法是呼吸暂停-低通气指数(AHI)。为便于消融房颤和心电图,采用了高密度映射导管(HDMC)。在房颤消融术后的 12 个月内对房颤复发情况进行了评估:主要发现包括:1)63% 的心房颤动患者伴有 ECs,且 AHI ≥ 20 次/小时。2)尽管使用 HDMC 实现了完全的 PV 隔离和精确的 EC 消融,但 SDB 的存在与房颤复发率增加有关。3)针对 SDB 的持续气道正压治疗改善了同时存在 EC 和 SDB 的房颤患者的房颤复发率(57% 对 73%;P = 0.016)。4)AHI(几率比 [OR] = 1.91,≥ 28.4 事件/小时)和左心房容积(LAV)(OR = 1.42,≥ 128.3 mL)是出现 ECs 的独立预测因素,而 AHI(OR = 1.44,≥ 27.8 事件/小时)是出现房颤复发的独立预测因素。因此,在出现心电图的房颤患者中筛查和治疗 SDB 可能对抑制房颤复发起到关键作用。
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引用次数: 0
Comparative Analysis of the Anti-Inflammatory Effects of Liraglutide and Dulaglutide 利拉鲁肽和度拉鲁肽抗炎效果的比较分析
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-05-15 DOI: 10.1536/ihj.23-576
Yi Hou, Yini Fan, Yuan Cheng, Xiaoyue Peng, Chunyan Shan, Yanhui Yang

Inflammation plays a pathophysiological role in atherosclerosis and its clinical consequences. In addition to glycemic control, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are of wide concern for cardioprotective effects. The structure, half-life, homology, and clinical efficacy of GLP-1RAs exhibit remarkable disparity. Several studies have compared the disparities in anti-inflammatory effects between daily and weekly GLP-1RAs. This study aimed to compare the similarities and differences between liraglutide and dulaglutide in terms of inhibiting atherosclerotic inflammation and improving co-cultured endothelial cell function. The expression of inflammation markers was examined by immunofluorescence, Western blotting, and real-time PCR. The tube-forming ability of endothelial cells was tested on Matrigel. The results verify that 10/50/100 nmol/L liraglutide and 100 nmol/L dulaglutide markedly suppressed the expression of inflammatory factors in LPS-induced atherosclerosis after 24 and 72 hours, respectively. Moreover, they promoted the polarization of M1 macrophages toward the M2 phenotype and improved the function of co-cultured endothelial cells. Both liraglutide and dulaglutide ameliorate atherosclerosis development. The difference between the two resided in the extended intervention duration required to observe the effect of dulaglutide, and liraglutide demonstrated a superior dose-dependent manner. We provide a potential strategy to understand the dynamics of drug action and possible timing administration.

炎症在动脉粥样硬化及其临床后果中起着病理生理作用。除了控制血糖外,胰高血糖素样肽-1 受体激动剂(GLP-1RAs)的心脏保护作用也受到广泛关注。GLP-1RAs 的结构、半衰期、同源性和临床疗效存在显著差异。有几项研究比较了每日服用和每周服用 GLP-1RAs 在抗炎效果上的差异。本研究旨在比较利拉鲁肽和度拉鲁肽在抑制动脉粥样硬化炎症和改善共培养内皮细胞功能方面的异同。研究人员通过免疫荧光、Western 印迹和实时 PCR 检测了炎症标志物的表达。在 Matrigel 上测试了内皮细胞的成管能力。结果证实,10/50/100 nmol/L 利拉鲁肽和100 nmol/L 度拉鲁肽分别在24小时和72小时后明显抑制了LPS诱导的动脉粥样硬化中炎症因子的表达。此外,它们还能促进 M1 巨噬细胞向 M2 表型极化,并改善共培养内皮细胞的功能。利拉鲁肽和度拉鲁肽都能改善动脉粥样硬化的发展。两者的区别在于观察度拉鲁肽效果所需的干预时间更长,而且利拉鲁肽表现出更优越的剂量依赖性。我们为了解药物作用的动态和可能的给药时机提供了一种潜在的策略。
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引用次数: 0
Coexistence Case of Papillary Fibroelastoma and Lambl's Excrescence of the Left Heart, Which Is Occasionally Associated with Significant Stroke. 乳头状纤维母细胞瘤与左心兰布尔赘生物并存病例,偶尔伴有严重中风。
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-30 Epub Date: 2024-03-12 DOI: 10.1536/ihj.23-570
Takatoshi Unno, Ryuichi Kato, Masao Kuwada, Mitsunori Ishino, Takahiko Nagase, Takahisa Tanaka, Chiyo Yoshino, Takafumi Nishida, Yoshinori Yoshida, Ryo Oyama, Takafumi Kikuchi, Takayuki Tatebayashi, Sadahito Kuwao

Papillary fibroelastoma (PFE) is a benign tumor that arises mostly from left-sided valves. PFE can cause stroke, and surgical resection may be needed. Lambl's excrescence (LE) is a filiform valvular lesion and is considered a possible cause of stroke. A 79-year-old man with light-headedness and left-sided hemiparesis was diagnosed with stroke. Transesophageal echocardiography (TEE) revealed a round-shaped mobile mass in the left ventricular outflow tract (LVOT), which was considered the cause of the stroke. Surgical resection was performed transaortically, and during surgery, a mass was incidentally detected on the noncoronary cusp (NCC), which was also resected followed by aortic valve replacement. Pathology confirmed that the mass in the LVOT was a PFE and that the filiform mass on the NCC was LE. We herein report a rare case of PFE in the LVOT and coexisting LE on the NCC. A careful examination via TEE helps to identify other possible causes of stroke hidden behind the obvious cause.

乳头状纤维母细胞瘤(PFE)是一种良性肿瘤,多发于左侧瓣膜。PFE可导致中风,可能需要手术切除。Lambl's excrescence(LE)是一种丝状瓣膜病变,被认为可能导致中风。一名 79 岁的男性因头重脚轻和左侧偏瘫被诊断为中风。经食道超声心动图(TEE)显示,左室流出道(LVOT)内有一个圆形移动肿块,这被认为是中风的原因。在手术过程中,意外发现非冠状动脉尖(NCC)上有一个肿块,也进行了切除,随后进行了主动脉瓣置换术。病理证实 LVOT 中的肿块是 PFE,而 NCC 上的丝状肿块是 LE。我们在此报告一例罕见的 LVOT 内 PFE 和 NCC 上 LE 并存的病例。通过 TEE 进行仔细检查有助于识别隐藏在明显病因背后的其他可能的卒中病因。
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引用次数: 0
Spontaneous Remission Without Steroid Therapy in Isolated Cardiac Sarcoidosis with Severe Left Ventricular Systolic Dysfunction. 伴有严重左心室收缩功能障碍的孤立性心脏肉样瘤病无需类固醇治疗即可自发缓解
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-30 Epub Date: 2024-03-12 DOI: 10.1536/ihj.23-399
Takaya Ozawa, Kenji Goto, Katsuya Miura, Kazunari Kobayashi, Yuetsu Kikuta, Katsumasa Sato, Masahito Taniguchi, Shigeki Hiramatsu, Hideo Takebayashi, Seiichi Haruta

Spontaneous remission is often observed in extracardiac cases of sarcoidosis, such as skin sarcoidosis. However, for cardiac sarcoidosis (CS), the prognosis is unfavorable. Although corticosteroids are the first-line treatment for CS, data regarding the natural history of isolated CS are limited. We describe a rare case of isolated CS with severe left ventricular systolic dysfunction that improved without steroid therapy.

在心脏外的肉样瘤病例(如皮肤肉样瘤病)中,常常可以观察到自发性缓解。然而,心脏肉样瘤病(CS)的预后并不乐观。尽管皮质类固醇是治疗 CS 的一线疗法,但有关孤立性 CS 自然史的数据却很有限。我们描述了一例罕见的伴有严重左心室收缩功能障碍的孤立性 CS 病例,该病例在没有接受类固醇治疗的情况下病情得到了改善。
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引用次数: 0
Clinical Features and Outcomes of Shoshin Beriberi. Shoshin Beriberi 的临床特征和疗效。
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-30 Epub Date: 2024-03-12 DOI: 10.1536/ihj.23-459
Yoshiki Mizuguchi, Hideyuki Mouri, Taisuke Jo, Yohei Hashimoto, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takumi Taniguchi

Shoshin beriberi is a fulminant form of wet beriberi, but there are no large-scale studies detailing the clinical features of this disease. We investigated the clinical features and outcomes of Shoshin beriberi using data from a nationwide database in Japan.Using the Diagnosis Procedure Combination database, we identified patients with Shoshin beriberi between July 2010 and March 2021. We retrospectively investigated the characteristics, comorbidities, treatment, and in-hospital mortality of patients with Shoshin beriberi. The chi-square test or Fisher's exact test was used for categorical variables, and the Mann-Whitney U-test was used for continuous variables.We identified 62 patients with Shoshin beriberi. The median (interquartile range) age was 63 (48-69) years. Furthermore, 54 patients were male (87%). The most common comorbidity was alcohol-related disorder (34%). The median (interquartile range) length of hospital and intensive care unit stays were 17 (range, 10-35) and 5 (range, 1-9) days, respectively. The proportion of patients who received venoarterial extracorporeal membrane oxygenation, intra-aortic balloon pump, continuous renal replacement therapy, and mechanical ventilation was 11, 5, 29, and 63%, respectively. Among the patients with Shoshin beriberi, 53% received 2 or more catecholamines or inotropes. The in-hospital mortality was 23%. Impaired consciousness at admission was significantly related to in-hospital death (P < 0.001).The present study is the first and largest to describe the clinical features of patients with Shoshin beriberi using a nationwide database. Impaired consciousness at admission was significantly associated with in-hospital death.

少信脚气病是湿性脚气病的一种暴发性形式,但目前还没有大规模研究详细说明这种疾病的临床特征。我们利用日本全国性数据库中的数据研究了庄信脚气病的临床特征和预后。我们利用诊断程序组合数据库,确定了2010年7月至2021年3月期间的庄信脚气病患者。我们利用诊断程序组合数据库,确定了2010年7月至2021年3月期间的手足口病患者,并对手足口病患者的特征、合并症、治疗和院内死亡率进行了回顾性调查。对分类变量采用卡方检验或费雪精确检验,对连续变量采用曼-惠特尼U检验。中位数(四分位数间距)年龄为 63(48-69)岁。此外,54 名患者为男性(87%)。最常见的合并症是酒精相关疾病(34%)。住院时间和重症监护室住院时间的中位数(四分位距)分别为 17 天(10-35 天)和 5 天(1-9 天)。接受静脉体外膜氧合、主动脉内球囊泵、持续肾脏替代治疗和机械通气的患者比例分别为 11%、5%、29% 和 63%。在患有 Shoshin beriberi 的患者中,53% 接受了 2 种或 2 种以上儿茶酚胺或肌注。院内死亡率为 23%。入院时意识障碍与院内死亡明显相关(P < 0.001)。入院时意识障碍与院内死亡密切相关。
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引用次数: 0
Comparison of the Pre-Established and Finally Selected Treatment Strategies for Endovascular Treatment in Femoropopliteal Artery Lesions. 股腘动脉病变血管内治疗的预设治疗策略与最终选定治疗策略的比较。
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-30 Epub Date: 2024-03-12 DOI: 10.1536/ihj.23-167
Michiaki Higashitani, Daisuke Ueshima, Kenji Suzuki, Yasutaka Yamauchi, Mitsugu Hirokami, Yoshinori Tsubakimoto, Akihiko Takahashi, Taku Kato, Hiroshi Ando, Masato Nakamura

This study aimed to compare lower limb events associated with preplanned and finally selected treatment strategies-the validity and usefulness of the physician-chosen strategy were verified.We examined the data of 1003 patients in the registry of multicenter endovascular treatment for superficial femoral and popliteal artery disease study and prospectively enrolled patients who underwent endovascular treatment (EVT) of the femoropopliteal (FP) artery between February 2017 and June 2018 from 67 Japanese institutes. The outcome measures were major adverse limb events (MALE) and target vessel revascularization.The EVT strategies were classified into balloon angioplasty-alone (37.3%), primary stenting (26.7%), and provisional stenting (36.0%) groups. In the initial strategy analysis for the balloon angioplasty-alone, primary stenting, and provisional stenting groups, two-year rates of freedom from MALE (95% confidence interval) were 0.680 (0.620-0.732), 0.754 (0.688-0.808), and 0.798 (0.746-0.840), respectively. Additionally, the rate of MALE was significantly higher among patients in the balloon angioplasty-alone group than among those in the primary or provisional stenting groups in the initial strategy analysis (P = 0.007). Changes in treatment strategy were more frequent in the primary stenting group than in the other groups. Furthermore, the rate of MALE did not significantly differ among the three groups in the final strategy analysis (P = 0.56).Limb outcomes for the final applied strategy did not differ among the three strategies. Additionally, the physician's selection bias was mostly appropriate in the EVT of the FP artery.

本研究旨在比较预先计划的治疗策略和最终选择的治疗策略相关的下肢事件--验证医生选择策略的有效性和实用性。我们研究了股浅动脉和腘动脉疾病多中心血管内治疗注册研究中 1003 例患者的数据,并前瞻性地纳入了 2017 年 2 月至 2018 年 6 月期间接受股浅动脉(FP)血管内治疗(EVT)的日本 67 家机构的患者。结果指标为肢体主要不良事件(MALE)和靶血管血运重建。EVT策略分为单纯球囊血管成形术组(37.3%)、初级支架植入组(26.7%)和临时支架植入组(36.0%)。在对单纯球囊血管成形术组、初级支架植入术组和临时支架植入术组的初始策略分析中,两年内免于MALE的比率(95%置信区间)分别为0.680(0.620-0.732)、0.754(0.688-0.808)和0.798(0.746-0.840)。此外,在初始策略分析中,单纯球囊血管成形术组患者的MALE率明显高于主要或临时支架组患者(P = 0.007)。与其他组相比,主要支架植入组患者更频繁地改变治疗策略。此外,在最终策略分析中,三组的MALE率没有显著差异(P = 0.56)。此外,医生的选择偏差在 FP 动脉的 EVT 中大多是适当的。
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引用次数: 0
Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner. Circ_0020887 沉默以 MiR-370-3p/CYP1B1 依赖性方式对抗缺氧诱导的心肌细胞损伤。
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-30 Epub Date: 2024-03-12 DOI: 10.1536/ihj.23-325
Huiqin Chen, Zhendong Cheng, Meiai Wang, Qian Huang, Dandan Zheng, Qiuhong Huang, Kefeng Cai

Targeting circular RNA has been a novel approach to preventing and limiting acute myocardial infarction (AMI). Here, we planned to investigate the role and mechanism of circ_0020887 in AMI progression.Hypoxic injury in human cardiomyocytes (AC16) was measured using cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, flow cytometry, and colorimetric assay kits. RNA and protein expressions were determined using real-time quantitative PCR and western blotting. Direct interplay between RNAs was determined using dual-luciferase reporter, RNA pull-down, and RIP assays.In the plasma and hypoxia-induced AC16 cells of patients with AMI, circ_0020887 and miR-370-3p were upregulated and downregulated, respectively, concomitant with the upregulation of cytochrome P450 1B1 (CYP1B1). Circ_0020887 interference could inhibit hypoxia-induced AC16 cell apoptosis, oxidative stress, and inflammatory response. Circ_0020887 could sponge miR-370-3p, and miR-370-3p could target CYP1B1. The inhibition effect of circ_0020887 knockdown on hypoxia-induced AC16 cell injury could be reversed by the miR-370-3p inhibitor. Besides, CYP1B1 overexpression also overturned the suppressive effect of miR-370-3p on hypoxia-induced AC16 cell apoptosis, oxidative stress, and inflammatory response.In conclusion, circ_0020887 regulated the miR-370-3p/CYP1B1 axis to regulate hypoxia-induced cardiomyocyte injury, confirming that circ_0020887 might promote cardiomyocyte injury.

靶向环状 RNA 是预防和限制急性心肌梗死(AMI)的一种新方法。在这里,我们计划研究circ_0020887在AMI进展中的作用和机制。使用细胞计数试剂盒-8测定法、5-乙炔基-2'-脱氧尿苷测定法、流式细胞术和比色测定试剂盒测定人心肌细胞(AC16)的缺氧损伤。使用实时定量 PCR 和 Western 印迹法测定 RNA 和蛋白质的表达。在AMI患者的血浆和缺氧诱导的AC16细胞中,circ_0020887和miR-370-3p分别上调和下调,同时细胞色素P450 1B1 (CYP1B1)上调。Circ_0020887干扰可抑制缺氧诱导的AC16细胞凋亡、氧化应激和炎症反应。Circ_0020887能海绵化miR-370-3p,而miR-370-3p能靶向CYP1B1。miR-370-3p抑制剂可以逆转circ_0020887敲除对缺氧诱导的AC16细胞损伤的抑制作用。总之,circ_0020887调控miR-370-3p/CYP1B1轴调节缺氧诱导的心肌细胞损伤,证实了circ_0020887可能促进心肌细胞损伤。
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引用次数: 0
H-type Hypertension Status and Influencing Factors of the Elderly People Over 80 Years Old Based on Random Forest Model. 基于随机森林模型的 80 岁以上老年人的 H 型高血压状况及其影响因素
IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-03-30 Epub Date: 2024-03-12 DOI: 10.1536/ihj.23-488
Xiaobo Zhang, Botang Guo, Hong Zhu, Dahe Li, Yuanyuan Zhao, Qi Liu, Jingbo Hou

Hypertension is a common chronic disease in elderly people over 80 years old. Clinically, H-type hypertension occurs when hypertension coexists with hyperhomocysteinemia level of ≥ 10 umol/L. Effective identification of risk factors for H-type hypertension in the elderly can greatly improve patient prognosis.Consecutively, 494 patients with hypertension admitted to the Fourth Affiliated Hospital of Harbin Medical University from January 2019 to December 2021 were selected as the study population. They were divided into H-type hypertension (n = 197) and non-H-type hypertension groups (n = 297). Patient data were collected, including basic information, history, and clinical data. The random forest model and LASSO analysis were used to screen the influencing factors for H-type hypertension. Multiple stepwise regression analysis was used to analyze the selected variables.A total of 197 elderly people over 80 years old suffered from H-type hypertension, with an incidence rate of 39.88%. The random forest model and LASSO analysis results showed that the top 8 independent variables in importance ranking were ejection fraction (EF), fibrinogen, glycated hemoglobin (HbA1c), B-type natriuretic peptide, creatinine, fasting blood glucose, uric acid, and serum triiodothyronine levels. The results of multivariate analysis showed that EF was the protective factor, while fibrinogen, HbA1c, and creatinine were the risk factors for H-type hypertension in elderly people over 80 years old (P < 0.05).Healthcare professionals can indirectly assess the prevalence of H-type hypertension by focusing on EF, fibrinogen, creatinine, and HbA1c in elderly hypertensive patients. This provided proactive intervention and medical services to improve prognosis outcomes.

高血压是 80 岁以上老年人常见的慢性疾病。临床上,当高血压合并高同型半胱氨酸血症水平≥10 umol/L时,即为H型高血压。连续选取2019年1月至2021年12月哈尔滨医科大学附属第四医院收治的494例高血压患者作为研究对象。他们被分为H型高血压组(197人)和非H型高血压组(297人)。收集患者数据,包括基本信息、病史和临床数据。采用随机森林模型和 LASSO 分析筛选 H 型高血压的影响因素。共有 197 名 80 岁以上老人患有 H 型高血压,发病率为 39.88%。随机森林模型和 LASSO 分析结果显示,重要性排名前 8 位的自变量分别是射血分数(EF)、纤维蛋白原、糖化血红蛋白(HbA1c)、B 型钠尿肽、肌酐、空腹血糖、尿酸和血清三碘甲状腺原氨酸水平。多变量分析结果显示,EF 是 80 岁以上老年人 H 型高血压的保护因素,而纤维蛋白原、HbA1c 和肌酐则是 H 型高血压的危险因素(P < 0.05)。医护人员可通过关注老年高血压患者的EF、纤维蛋白原、肌酐和HbA1c,间接评估H型高血压的患病率,从而提供积极的干预和医疗服务,改善预后效果。
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International heart journal
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