{"title":"Determination of Favipiravir in Human Plasma by Using Liquid Chromatography-Tandem Mass Spectrometry: Application to Pharmacokinetic Studies","authors":"Saraner Nihal, Guney Berrak, Sevici Gamze, Saglam Onursal","doi":"10.35840/2633-8912/2416","DOIUrl":"https://doi.org/10.35840/2633-8912/2416","url":null,"abstract":"","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78703236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anderle Heinz, Herbinger Karin, Zlabinger Stefan, Weber Alfred
{"title":"\"Goldberg Validations\": Refractometric Protein Concentration Calibration of Pooled Source Plasma and Validation of Clinical Serum Protein Refractometers","authors":"Anderle Heinz, Herbinger Karin, Zlabinger Stefan, Weber Alfred","doi":"10.35840/2633-8912/2418","DOIUrl":"https://doi.org/10.35840/2633-8912/2418","url":null,"abstract":"","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87678097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharaf Ragab Y, Salem Waheed M, Ali Alaa E, Amin Alaa S
{"title":"Utilization of Aluminon for Determination of Ultra-trace Levels of Copper in Environmental, Biological, and Water Samples via Cloud Point Extraction Coupled with Spectrophotometry","authors":"Sharaf Ragab Y, Salem Waheed M, Ali Alaa E, Amin Alaa S","doi":"10.35840/2633-8912/2413","DOIUrl":"https://doi.org/10.35840/2633-8912/2413","url":null,"abstract":"","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83132446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, the development of three-dimensional impedance-based biochemical sensors for detection of chemicals and biological agents in aqueous solutions is presented. The sensors are made of a stack of suspended electrodes that allow the solution to occupy the space between them and create a larger interface area between the aqueous solution and the electrodes. Increasing the solution-electrode interface area drastically changes the impedance of the sensor-solution resulting in a better sensitivity. Low concentrations of di-ethylhexyl phthalate (DEHP) in deionized water are used as the target chemical to demonstrate the advantage of new design over conventional planar interdigitated sensors. Experimental measurements are carried out to characterize the response of the planar and 3D sensors and their Nyquist plots are compared, displaying significant sensitivity improvement in 3D sensors. An electrical model for the sensors is developed that considers different physical phenomena such as doublelayer capacitance, solution resistance, Warburg effect and parasitic parameters. Nonlinear interpolations of the experimental data show that the equivalent electrical circuit is in good agreement with the Nyquist plots obtained from test data. The curve fitting of the tested data to the equivalent electrical circuit displays good agreement between the model and the tested data.
{"title":"Three-Dimensional Impedance-Based Sensors for Detection of Chemicals in Aqueous Solutions","authors":"E. ToloueiNadia, Mazrouei Roya, S. Mohammad","doi":"10.35840/ijabm/2412","DOIUrl":"https://doi.org/10.35840/ijabm/2412","url":null,"abstract":"In this work, the development of three-dimensional impedance-based biochemical sensors for detection of chemicals and biological agents in aqueous solutions is presented. The sensors are made of a stack of suspended electrodes that allow the solution to occupy the space between them and create a larger interface area between the aqueous solution and the electrodes. Increasing the solution-electrode interface area drastically changes the impedance of the sensor-solution resulting in a better sensitivity. Low concentrations of di-ethylhexyl phthalate (DEHP) in deionized water are used as the target chemical to demonstrate the advantage of new design over conventional planar interdigitated sensors. Experimental measurements are carried out to characterize the response of the planar and 3D sensors and their Nyquist plots are compared, displaying significant sensitivity improvement in 3D sensors. An electrical model for the sensors is developed that considers different physical phenomena such as doublelayer capacitance, solution resistance, Warburg effect and parasitic parameters. Nonlinear interpolations of the experimental data show that the equivalent electrical circuit is in good agreement with the Nyquist plots obtained from test data. The curve fitting of the tested data to the equivalent electrical circuit displays good agreement between the model and the tested data.","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74426756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. SebaiyMahmoud, E. AbdellatefHisham, M. ElhenaweeMagda, A. ElmosallamyMohamed, Alshuwaili Mustafa Kh
{"title":"Review Article: Instrumental Analysis of Olopatadine Hydrochloride, Oxeladine Citrate, Amlodipine Besylate and Xipamide","authors":"M. SebaiyMahmoud, E. AbdellatefHisham, M. ElhenaweeMagda, A. ElmosallamyMohamed, Alshuwaili Mustafa Kh","doi":"10.35840/2633-8912/2410","DOIUrl":"https://doi.org/10.35840/2633-8912/2410","url":null,"abstract":"","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"284 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74379965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gómez-Ruiz Humberto, G. Hernandez, B. Díaz, Ortiz-Pérez María Deogracias
{"title":"Gas Diffusion-Flow Injection System with Preconcentration for the Analysis of Fluoride in Semen","authors":"Gómez-Ruiz Humberto, G. Hernandez, B. Díaz, Ortiz-Pérez María Deogracias","doi":"10.35840/ijabm/2409","DOIUrl":"https://doi.org/10.35840/ijabm/2409","url":null,"abstract":"","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78508494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebaiy Mahmoud M, Abdellatef Hisham E, Elhenawee Magda M, Elmosallamy Mohamed A, Alshuwaili Mustafa Kh
In this literature review, we will introduce all reported methods that have been developed for determination of the antihistaminic drug, olopatadine HCl, the cough suppressant drug oxeladine citrate, and certain antihypertensive drugs such as amlodipine besylate and xipamide in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of allergy and hypertension. Olopatadine Hydrochloride Olopatadine hydrochloride 11-[(Z)-3-(Dimethylamino) propylidene]-6,11-dihydrodibenzo [b,e]oxepin-2-acetic acid hydrochloride (Figure 1) [1].
{"title":"Review Article: Instrumental Analysis of Olopatadine Hydrochloride, Oxeladine Citrate, Amlodipine Besylate and Xipamide","authors":"Sebaiy Mahmoud M, Abdellatef Hisham E, Elhenawee Magda M, Elmosallamy Mohamed A, Alshuwaili Mustafa Kh","doi":"10.35840/ijabm/2410","DOIUrl":"https://doi.org/10.35840/ijabm/2410","url":null,"abstract":"In this literature review, we will introduce all reported methods that have been developed for determination of the antihistaminic drug, olopatadine HCl, the cough suppressant drug oxeladine citrate, and certain antihypertensive drugs such as amlodipine besylate and xipamide in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of allergy and hypertension. Olopatadine Hydrochloride Olopatadine hydrochloride 11-[(Z)-3-(Dimethylamino) propylidene]-6,11-dihydrodibenzo [b,e]oxepin-2-acetic acid hydrochloride (Figure 1) [1].","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88799320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adaptable to any routine laboratory, the study presents the validation results of a simple, accurate and reliable method developed for the analysis of total amino acids (TAAs) in rice using reversed-phase high-performance liquid chromatography-diode array detection (RP-HPLC-DAD). Exhibiting excellent selectivity with resolution (Rs) ≥ 2 for seventeen amino acids, the method was proven accurate against the analysis performed on the certified reference material (CRM): NIST 3233. Percentages of recoveries were in the range 86% - 100% with percentage relative standard deviation (% RSD) ≤ 6% for all amino acids. Limit of detection (LOD) and limit of quantification (LOQ) values were within 0.024-0.069 g/100 g and 0.025-0.078 g/100 g respectively. A wide working range with satisfactory linearity having regression coefficients ≥ 0.999 were reported for all the amino acids. Complying with international guideline requirements, this validated method can be successfully applied for the determination of seventeen TAAs including all essential amino acids in rice.
{"title":"Analysis of Total Amino Acids in Rice Using a Validated Reversed-Phase High Performance Liquid Chromatographic Method with Diode Array Detection (RP-HPLC-DAD)","authors":"Liyanaarachchi Gvv, Mahanama Krr, Somasiri Hpps, Punyasiri Pan, Kottawa-Arachchi Jd","doi":"10.35840/ijabm/2408","DOIUrl":"https://doi.org/10.35840/ijabm/2408","url":null,"abstract":"Adaptable to any routine laboratory, the study presents the validation results of a simple, accurate and reliable method developed for the analysis of total amino acids (TAAs) in rice using reversed-phase high-performance liquid chromatography-diode array detection (RP-HPLC-DAD). Exhibiting excellent selectivity with resolution (Rs) ≥ 2 for seventeen amino acids, the method was proven accurate against the analysis performed on the certified reference material (CRM): NIST 3233. Percentages of recoveries were in the range 86% - 100% with percentage relative standard deviation (% RSD) ≤ 6% for all amino acids. Limit of detection (LOD) and limit of quantification (LOQ) values were within 0.024-0.069 g/100 g and 0.025-0.078 g/100 g respectively. A wide working range with satisfactory linearity having regression coefficients ≥ 0.999 were reported for all the amino acids. Complying with international guideline requirements, this validated method can be successfully applied for the determination of seventeen TAAs including all essential amino acids in rice.","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77345686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monosodium Glutamate or (MSG) is used in food to enhance flavor, originally used for meat and savory dishes, however these days it’s used in a wide array of foods or ‘food like’ products. Objective of the study is to determine whether MSG is included in dry and wet products that sold in the market and long-term study, how it affects the people once the MSG was detected in the samples and consumed by them. In this current study only detection of MSG was carried out and reported. The samples and the MSG standards are purchased from several grocery markets in Oman and taken picture of the different dry products and wet products. Samples were analysed using Statistics, Thin Layer Chromatography (TLC) and Liquid ChromatographyMass Spectrometry (LCMS). ANOVA statistical analysis was employed for this study. Statistical analysis was performed by SPSS software (Version16). The samples were weighed (equivalent to 1.0 gram) and diluted to 100 ml with HPLC water. TLC for all the samples were done using the mobile phase Methanol:Chloroform:Formic acid (5:5:1). 10 Microlitre used for spotting the samples and standard in the TLC plate. Samples showing high Rf value in TLC were confirmed by LC/MS. Most of the products showed the presence of MSG in the TLC. This study highlighted the importance of adequate baseline and control data and indicated that such a rigorous protocol for individual assessment is feasible.
{"title":"A Survey on the Monosodium Glutamate Occurrence in Food Products and it's Analysis by Thin Layer Chromatography and Liquid Chromatography-Mass Spectrometry from Sultanate of Oman","authors":"Ambusaidi Mohammed Mubarik Sulaiman Khalaf, Pandian Sathish Babu Soundra, Swaminathan Senthilraj, Sudhakar Magapu Solomon","doi":"10.35840/ijabm/2411","DOIUrl":"https://doi.org/10.35840/ijabm/2411","url":null,"abstract":"Monosodium Glutamate or (MSG) is used in food to enhance flavor, originally used for meat and savory dishes, however these days it’s used in a wide array of foods or ‘food like’ products. Objective of the study is to determine whether MSG is included in dry and wet products that sold in the market and long-term study, how it affects the people once the MSG was detected in the samples and consumed by them. In this current study only detection of MSG was carried out and reported. The samples and the MSG standards are purchased from several grocery markets in Oman and taken picture of the different dry products and wet products. Samples were analysed using Statistics, Thin Layer Chromatography (TLC) and Liquid ChromatographyMass Spectrometry (LCMS). ANOVA statistical analysis was employed for this study. Statistical analysis was performed by SPSS software (Version16). The samples were weighed (equivalent to 1.0 gram) and diluted to 100 ml with HPLC water. TLC for all the samples were done using the mobile phase Methanol:Chloroform:Formic acid (5:5:1). 10 Microlitre used for spotting the samples and standard in the TLC plate. Samples showing high Rf value in TLC were confirmed by LC/MS. Most of the products showed the presence of MSG in the TLC. This study highlighted the importance of adequate baseline and control data and indicated that such a rigorous protocol for individual assessment is feasible.","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77162797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thin layers of Cadmium Oxide (CdO) with various volumes of Cadmium acetate solution (60, 80 and 90 ml) were deposited using spray pyrolysis technique over a glassy substrate. Samples were investigated using FESEM images, XRD and UV-V is spectra as well as I-V characteristic. It was found that all samples were grown up with polycrystalline nanostructures along the preferred direction of (002). In addition, it was found that grew up samples in the volume of 80 (ml) are of optimum anti-cancer properties condition in visible range regarding optimum structural (largest crystallite size and lowest crystallite defect density) and optical (smallest band gap and highest light absorption) conditions.
{"title":"Study of Anti-Cancer Properties of Thin Layers of Cadmium Oxide (CdO) Nanostructure","authors":"H. Alireza, E. Jennifer, Caissutti Angela","doi":"10.35840/2633-8912/2403","DOIUrl":"https://doi.org/10.35840/2633-8912/2403","url":null,"abstract":"Thin layers of Cadmium Oxide (CdO) with various volumes of Cadmium acetate solution (60, 80 and 90 ml) were deposited using spray pyrolysis technique over a glassy substrate. Samples were investigated using FESEM images, XRD and UV-V is spectra as well as I-V characteristic. It was found that all samples were grown up with polycrystalline nanostructures along the preferred direction of (002). In addition, it was found that grew up samples in the volume of 80 (ml) are of optimum anti-cancer properties condition in visible range regarding optimum structural (largest crystallite size and lowest crystallite defect density) and optical (smallest band gap and highest light absorption) conditions.","PeriodicalId":13753,"journal":{"name":"International Journal of Analytical and Bioanalytical Methods","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74199805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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