International Journal of Clinical Practice最新文献

{"title":"Development and Psychometric Validation of a Questionnaire to Assess Attitudes Toward Medical Law Reasoning (MLRAQ)","authors":"Mohammad Abdi,&nbsp;Ali Norouzi,&nbsp;Mahboobeh Khabaz Mafinejad","doi":"10.1155/ijcp/5167920","DOIUrl":"https://doi.org/10.1155/ijcp/5167920","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Attitude toward medical law reasoning is the first step in improving medical law reasoning skills in physicians. Despite its importance, no validated instrument currently exists to assess it. This study aimed to develop and validate a Medical Law Reasoning Attitude Questionnaire (MLRAQ) in medical students.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The MLRAQ was developed based on the seven steps of AMEE Guide No. 87, related to designing questionnaires for educational research. In the first step, relevant articles were extracted through a systematic search. In the second step, medical law micro-skills were explored through a qualitative study by conducting 20 interviews. In the third and fourth steps, the identified medical law micro-skills were compared conceptually with previous studies, and the MLRAQ items were developed. Finally, content validity, cognitive interview, exploratory factor analysis, confirmatory factor analysis, and reliability analysis were performed in the fifth to seventh steps.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MLRAQ consists of five factors and 24 items. The validation results showed that the content validity index (CVI) and content validity ratio (CVR) were greater than 0.90. Five subscales (prerequisites, problem identification, application of rule, analysis, and conclusion) explained 67.26% of the variance in exploratory factor analysis. Cronbach’s alpha = 0.894, indicating high internal consistency. ICC = 0.771–0.942, demonstrating strong reliability across measurements. In confirmatory factor analysis, SRMR and RMSEA were 0.078 and 0.058, respectively. GFI was 0.880, and CFI was 0.901, indicating acceptable fit indices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The MLRAQ demonstrated valid and reliable evidence. Therefore, this instrument can assess attitudes toward medical law reasoning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5167920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Duloxetine for the Treatment of Osteoarthritis: Systematic Review and Meta-Analysis","authors":"Betânia Ferreira Leite,&nbsp;Dalila Fernandes Gomes,&nbsp;Gustavo Laine Araújo de Oliveira,&nbsp;Roberta Borges Silva,&nbsp;Cecília Menezes Farinasso,&nbsp;Tania Sales de Alencar Fidelix,&nbsp;Virgínia Fernandes Moça Trevisani","doi":"10.1155/ijcp/4976407","DOIUrl":"https://doi.org/10.1155/ijcp/4976407","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Osteoarthritis (OA) is a common illness that is widespread globally, especially among individuals aged 65 and older. Since 2019/2020, the OARSI and ACR recommendations have included the use of medicines such duloxetine, which function as analgesics for pain patients including central sensitization. Recent studies have assessed duloxetine as an adjunctive treatment in decreasing OA pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Assess the effectiveness and safety of duloxetine in treating OA pain in adults aged 40 and above.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review and meta-analysis of randomized clinical trials. The scientific evidence search was conducted in the following databases: MEDLINE via PubMed, Cochrane Library, Embase, LILACS, Web of Science, Scopus, CINAHL, ProQuest, SciELO, and Google Scholar.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>The systematic review comprised nine randomized controlled trials (RCTs). The studies showed that using duloxetine for OA treatment was more effective than a placebo in achieving a 50% pain reduction (RR = 1.57, 95% CI = 1.31; 1.89) and a 30% pain reduction (RR = 1.41; 95% CI = 1.29; 1.55). This improvement was observed in pain, physical function, and stiffness as measured by the WOMAC subscales, as well as in the CGI-SEVERITY scale and the AUSCAN functional index. Duloxetine was found to be more effective than gabapentin and acetaminophen in treating moderate to severe knee OA, as it decreased ratings on the whole WOMAC scale and its subscales for pain, physical function, and stiffness. There was no statistically significant difference in adverse events between duloxetine and gabapentin, both of which were more effective than acetaminophen, which did not cause any adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This systematic review indicates that duloxetine is an effective treatment for pain in OA in adult patients over 40 years old, with a reasonable level of safety when compared to other centrally acting medications and placebo.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4976407","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on the Therapeutic Effects of Salvia hispanica L. (Chia) on Metabolic Dysfunction–Associated Fatty Liver Disease: Special Focus on Pathogenesis","authors":"Maryam Parimi,&nbsp;Sara Arefhosseini,&nbsp;Helda Tutunchi,&nbsp;Seyed Rafie Arefhosseini,&nbsp;Mehrangiz Ebrahimi-Mameghani","doi":"10.1155/ijcp/8660821","DOIUrl":"https://doi.org/10.1155/ijcp/8660821","url":null,"abstract":"<p>Metabolic dysfunction–associated fatty liver disease (MAFLD) is the most common chronic liver condition with a bidirectional relation with multimetabolic disorders. By considering lifestyle interventions as the approved treatment strategy, several herbal products have been examined as conjugated therapy in the prevention/treatment of the disease. The annual herbaceous plant known as <i>Salvia hispanica</i> L. (chia) is an ancient grain trending in modern diets. Chia seeds are not only an excellent source of nutrients and bioactive compounds but also have shown effectiveness in the management of a number of metabolic disorders. However, studies on MAFLD are limited and mainly include animal models. Moreover, the exact molecular mechanisms by which chia influences MAFLD-related outcomes remain inadequately investigated. Hence, the aim of the present comprehensive review is to explore the effectiveness of chia supplementation in MAFLD by various forms (seeds, oil, and flour) with a view point on molecular pathways, metabolic regulation, and clinical outcomes.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8660821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145366398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Stroke Care Delivery: 12-Month Experience of a Tertiary Stroke Center in Central Asia","authors":"Marina Grigolashvili,&nbsp;Dmitriy Klyuyev,&nbsp;Dmitry Kasatkin,&nbsp;Sharbanu Battakova,&nbsp;Yelena Shayakhmetova,&nbsp;Mira Beisembayeva,&nbsp;Shynar Muratbekova,&nbsp;Alina Koshelyuk,&nbsp;Yessenbay Baituyak,&nbsp;Ivan Turkevich,&nbsp;Alexey Dey","doi":"10.1155/ijcp/8109173","DOIUrl":"https://doi.org/10.1155/ijcp/8109173","url":null,"abstract":"<p>The present study is a retrospective analysis of the activities of a tertiary stroke center (SC) operating on the basis of Akzhan Clinic in Karaganda Region during the year 2024. The primary objective of this study was to examine the epidemiological features, the structure of stroke morbidity, and the efficacy of thrombolytic therapy (TLT) in patients with ischemic stroke (IS). The study included data from a total of 585 patients, out of which 437 had been hospitalized with acute cerebrovascular disorders, and 104 of these patients had received TLT for IS. The analysis revealed a high level of utilization of TLT (23.8%), which was significantly higher than the average regional and national figures, owing to the efficient organization of prehospital and in-hospital stages, availability of skilled personnel, and a state-of-the-art technical infrastructure. Additionally, mechanical thrombectomy (MT) was performed in 100 instances, further confirming the high level of adoption of advanced treatment modalities. The proportion of hemorrhagic transformations (7.69%) and mortality (6.7%) was comparable to or lower than international benchmarks. The results demonstrate the high effectiveness of the performance of the SC “Akzhan” and the need for the further expansion of similar facilities in order to improve the accessibility and quality of stroke treatment in Kazakhstan.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8109173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodegenerative Effects of Monopolar Electrocautery on Myenteric Ganglia During Penile Surgery: A Preliminary Experimental Rabbit Study","authors":"Binali Firinci,&nbsp;Cetin Aydin,&nbsp;Dilek Yunluel,&nbsp;Ozgur Caglar,&nbsp;Mehmet Dumlu Aydin,&nbsp;Ali Ahiskalioglu","doi":"10.1155/ijcp/8849240","DOIUrl":"https://doi.org/10.1155/ijcp/8849240","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Circumcision has been used for thousands of years with the belief that it is beneficial for sexual health and on religious grounds. The histopathological results regarding the neurobiological damage of this procedure have been rarely investigated. This study aimed to examine the potential adverse effects of circumcision, particularly the use of monopolar electrocautery, on pudendal nerve ganglia, Onuf’s nucleus, and the myenteric plexus (Auerbach’s ganglia) of the colon in rabbits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighteen male rabbits were allocated to a control group (Group I, <i>n</i> = 5), and groups where circumcisions were performed without (Group II, <i>n</i> = 5) and with (Group III, <i>n</i> = 8) using monopolar electrocautery. The rabbits were followed up for 3 weeks and then sacrificed under general anesthesia. Penile tissues, Onuf’s nucleus and pudendal fiber origin complexes, dorsal root ganglion at sacral 3 level, and <i>neurons</i> in the myenteric plexus of <i>Auerbach</i> in rectum were examined using stereological methods. Degenerated neuron densities (n/mm³) of S3 ganglia, ganglia of Auerbach’s plexus, and Onuf’s nuclei of male rabbits were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Degenerated neuron intensities (n/mm³) in pudendal ganglia, Onuf’s nucleus, and myenteric ganglia were 9 ± 3, 3 ± 1, and 7 ± 2 in GI; 17 ± 5, 7 ± 2, and 11 ± 3 in GII; and 89 ± 13, 24 ± 5, and 45 ± 8 in GIII. There were no statistically significant differences between the control group (GI) and the sham surgical circumcision group (GII) (<i>p</i> &gt; 0.05). However, both GI and GII showed significantly lower levels of neuronal degeneration when compared to the electrocautery group (GIII) (<i>p</i> &lt; 0.005 for GII vs. GIII; <i>p</i> &lt; 0.00001 for GI vs. GIII).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Denervation of the pudendal nerve ganglia and Onuf’s nucleus caused by surgical removal of the foreskin may also lead to neurodegeneration in the ganglia of Auerbach’s plexus in the rectum innervated by this denervated network.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8849240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dark Chocolate as a Preprocedure Intervention for Anxiety and Pain Reduction in Thyroid FNAB: A Prospective Randomized Controlled Study","authors":"Servan Yaşar","doi":"10.1155/ijcp/5687455","DOIUrl":"https://doi.org/10.1155/ijcp/5687455","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the effects of dark chocolate consumption on anxiety and pain levels in patients undergoing thyroid fine needle aspiration biopsy (FNAB).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This was a single-center, randomized controlled study conducted between June 2024 and October 2024; local ethical approval was obtained. Patients who met the inclusion criteria were randomly divided into two groups: Group 1 received two squares of dark chocolate around 30 min before the procedure, while Group 2 did not. Anxiety levels were assessed using the State-Trait Anxiety Inventory (STAI), and pain levels were measured using the Visual Analog Scale (VAS) method. Anxiety levels were assessed before and after the procedure using the STAI, while pain levels were measured only after the procedure using the VAS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 99 patients included, 82 (82.8%) were female, with a mean age of 47.61 ± 11.32 years. There were no demographic differences between Groups 1 and 2. Significant differences were found between the groups, with Group 1 reporting lower scores for both postprocedural anxiety adjusted for baseline Group STAI score and VAS scores (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dark chocolate consumption prior to thyroid FNAB may be an effective intervention for reducing both anxiety and pain in patients. Further studies with larger samples are recommended to confirm these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5687455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and In-Hospital Prognosis of Patients With First-Ever Acute Myocardial Infarction With a History of Cerebrovascular Disease","authors":"Yue Hu,&nbsp;Jinhuan Gao,&nbsp;Yayun Liu,&nbsp;Yumin Luo,&nbsp;Jinggang Xia","doi":"10.1155/ijcp/7908155","DOIUrl":"https://doi.org/10.1155/ijcp/7908155","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Increasing evidence has demonstrated a causal relationship between cerebrovascular disease (CVD) and cardiovascular events. This study investigated the effects of previous CVD on the in-hospital characteristics and prognosis of patients with first-ever acute myocardial infarction (AMI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study recruited 2993 consecutive patients diagnosed with AMI between January 2017 and December 2022. Baseline characteristics, general evaluations, and cardiac tests were compared between patients with AMI with and without a history of CVD (CVD group and nCVD group, respectively). The primary outcome was major adverse cardiovascular events (MACEs). The secondary outcome was extended length of stay (LOSE). Baseline characteristics were balanced using 1:1 propensity score matching (PSM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study enrolled 536 patients with first-ever AMI after PAM. Compared with patients in the nCVD group, those in the CVD group had higher high-sensitivity C-reactive protein (<i>p</i> = 0.04) and N-terminal pro-B-type natriuretic peptide (<i>p</i> = 0.002) levels, as well as a lower left ventricular ejection fraction (<i>p</i> = 0.004). The CVD group also showed a lower percentage of moderate risk (<i>p</i> = 0.03) and a higher percentage of high risk (<i>p</i> = 0.03) GRACE scores on admission, in addition to a higher overall GRACE score before discharge (<i>p</i> = 0.04) compared with patients in the nCVD group. However, the risk of MACE or LOSE did not differ significantly between patients in the CVD and nCVD groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with AMI and a history of CVD may experience severe damage to cardiac structure and function. However, a history of CVD was not associated with in-hospital outcomes in patients with AMI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7908155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Infarction With No Obstructive Coronary Artery Disease and the 2023 Turkiye Earthquakes","authors":"Abdullah Orhan Demirtas,&nbsp;Abdullah Yildirim,&nbsp;Samet Ayna,&nbsp;Halil Coskun,&nbsp;Hazar Harbalioglu,&nbsp;Mukremin Coskun,&nbsp;Sheldon M. Singh","doi":"10.1155/ijcp/5969719","DOIUrl":"https://doi.org/10.1155/ijcp/5969719","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Increased rates of cardiac events at the time of natural disasters have been reported. However, the relationship between myocardial infarctions and earthquakes is less clear. We report on the rate of myocardial infarction with no obstructive coronary artery (MINOCA) disease during the 2023 Turkiye earthquakes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All patients with a positive troponin undergoing a coronary angiogram at the Adana City Training and Research Hospital 2 months prior and 2 months subsequent to the February 6^th, 2023, Turkiye earthquakes were included. Patients with MINOCA were identified. Multivariate logistic regression analysis was performed to determine variables associated with a diagnosis of MINOCA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>619 patients underwent angiography during the study period—479 prior and 140 subsequent to the earthquake. The median age was 61 years and 73% male. MINOCA was diagnosed in 7.8% of the cohort. MINOCA was higher in the postearthquake period (pre: 3.8% vs. post: 21.4%; <i>p</i> &lt; 0.001). The time period after the earthquake had the highest odds of a diagnosis of MINOCA (odds ratio: 5.76; 95% confidence interval: 2.90–11.44). Survival to hospital discharge was higher in the postearthquake period (pre: 89.4% vs. post: 97.9%; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The rate of MINOCA increased after the Turkiye earthquakes on February 6^th, 2023. This knowledge provides new insight into the spectrum of myocardial infarction after natural disasters. Our work also highlights a potential survivorship bias, which may confound studies reporting on cardiac events after natural disasters. Future work to assess the potential long-term adverse consequences of MINOCA in this population is suggested.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5969719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of the “3L Training + Experiential” Teaching Model in Developing Urinary Surgery Research Nurse Teams","authors":"Jie’an Ding,&nbsp;Xiaofeng Wu,&nbsp;Liru Chen,&nbsp;Xin Cheng,&nbsp;Jie Cao,&nbsp;Jianping Xiu,&nbsp;Shouyan Tang","doi":"10.1155/ijcp/2871990","DOIUrl":"https://doi.org/10.1155/ijcp/2871990","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effectiveness of the “3L Training + Experiential” teaching model in developing clinical research nurse teams in cases of urinary surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The “3L Training + Experiential” teaching model was constructed, and teaching plans and training content were developed. The practical training for the clinical research nurse team employed the 3L approach (hospital–professional group–project simulation) combined with precepting and experiential learning. Thirty clinical research nurses from the urinary surgery unit were selected as the intervention group, and 30 clinical research nurses working at the hospital in 2022 were randomly selected as the control group. The intervention group received training under the “3L Training + Experiential” teaching model, while the control group underwent traditional clinical research nurse training within the hospital. Training assessment results were statistically analyzed using SPSS software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to the control group, clinical research nurses who underwent “3L Training + Experiential” training achieved higher scores in both theoretical and practical assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>After validating the teaching effectiveness through the overall research quality of the projects, the “3L Training + Experiential” teaching model was ultimately constructed and applied to the training of urinary surgery clinical research nurse teams, improving the professionalism and motivation of researchers and achieving positive outcomes in team building for the professional group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2871990","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Analysis of Bidirectional Causality and Immune-Inflammatory Mechanism Between Atrial Fibrillation and Major Depression","authors":"Yan Du,&nbsp;Kaisen Huang,&nbsp;Jingjia Yang,&nbsp;Guojun Xiong,&nbsp;Xiaojian Deng,&nbsp;Yu Lei,&nbsp;Qing Peng","doi":"10.1155/ijcp/3653798","DOIUrl":"https://doi.org/10.1155/ijcp/3653798","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atrial fibrillation (AF) and major depressive disorder (MDD) are prevalent chronic diseases with unclear bidirectional causal relationships and shared mechanisms. This study aimed to explore their associations and underlying pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used two-sample Mendelian randomization (MR) with Genomewide Association Studies (GWAS) data to assess causal links between AF and MDD. Transcriptomic analyses identified differentially expressed genes (DEGs) and hub genes in AF (GSE41177) and MDD (GSE38206) datasets, followed by functional enrichment (GO/KEGG), immune cell infiltration analysis, and gene set enrichment analysis (GSEA) for the key gene HCK. A competing endogenous RNA (ceRNA) network was predicted for upstream/downstream gene regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MR revealed a bidirectional causal relationship: AF increased MDD risk (OR = 1.002, <i>p</i> = 0.019) and MDD elevated AF risk (OR = 4.547, <i>p</i> = 0.035). Through transcriptome gene analysis of AF and MDD, 17 key overlapping genes with dual diseases were identified. Functional enrichment and immune cell infiltration analyses both demonstrated that the key overlapping genes were correlated with immune regulation and inflammatory responses in two diseases. Eight hub genes were identified by Cytoscape software, with HCK as the central gene, upregulated in both diseases and correlated with immune cell infiltration (e.g., monocytes, M1 macrophages in MDD; negative correlation with Tregs in AF). GSEA highlighted toll-like receptor and cytokine–cytokine receptor pathways. The predicted HCK-centered ceRNA network (1 mRNA, 1 miRNA, and 7 lncRNAs) suggested joint regulation of disease pathogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We demonstrated that AF and MDD exhibit a bidirectional causal association and identified 17 key overlapping genes that may be involved in the shared immune-inflammatory mechanisms between AF and MDD. HCK emerges as a potential biomarker, linking immune cell dynamics and inflammation. These findings offer novel targets for integrated management of AF and MDD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3653798","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}