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Association of Helicobacter pylori Infection with Depression and Anxiety: A Systematic Review and Meta-Analysis 幽门螺杆菌感染与抑郁和焦虑的关系:系统回顾与元分析
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-10 DOI: 10.1155/2024/9247586
Lu Li, Yadi Ren, Zeyu Wang, Yanqing Niu, Ying Zhao, Xiaherezhati Aihaiti, Yinglan Ji, Man Li

Introduction. The association between Helicobacter pylori (H. pylori) infection and depression and anxiety has been reported in the literature. The aim of this meta-analysis is to investigate the association of H. pylori infection with depression and anxiety. Methods. A systematic search was conducted in PubMed, Web of Science, Embase, and Chinese databases for observational studies that reported the incidence or prevalence of depression and anxiety in patients with H. pylori infection. We conducted meta-analysis with a random-effects model. Results. A total of twelve studies were included in this meta-analysis. Significant and positive association was found for H. pylori infection with anxiety (OR 2.49, 95% CI 1.83–3.39), but not depression (OR 1.40, 95% CI 0.75–2.58). Subgroup analysis from study design noted a significant positive association between H. pylori infection and anxiety (case-control and cross-sectional study, OR 2.36, 95% CI 1.65–3.38; cohort study, RR 1.72, 95% CI 1.28–2.32). The similar trend among studies used the Self-Rating Anxiety Scale (OR 2.43, 95% CI 1.78–3.32) and other questionnaires (OR 2.41, 95% CI 1.50–3.87) have been observed. However, subgroup analysis of the association between H. pylori infection and depression yields different results. Subgroup analysis from cohort studies noted a significant association between H. pylori infection and depression (RR 1.99, 95% CI 1.33–2.99), but not case-control and cross-sectional studies (OR 1.20, 95% CI 0.59–2.46). A significant positive association has been observed among studies used the Self-Rating Depression Scale (OR 2.03, 95% CI 1.11–3.70), as opposed to studies using other questionnaires (OR 1.03, 95% CI 0.31–3.44). Conclusion. This meta-analysis provide the support that a significant positive association between H. pylori infection and anxiety disorders. However, the association between H. pylori infection and depression appears to be insignificant.

简介幽门螺杆菌(H. pylori)感染与抑郁和焦虑之间的关系已有文献报道。本荟萃分析旨在研究幽门螺杆菌感染与抑郁和焦虑之间的关系。研究方法我们在 PubMed、Web of Science、Embase 和中文数据库中对报道幽门螺杆菌感染患者抑郁和焦虑发生率或流行率的观察性研究进行了系统检索。我们采用随机效应模型进行了荟萃分析。结果本次荟萃分析共纳入了 12 项研究。研究发现,幽门螺杆菌感染与焦虑(OR 2.49,95% CI 1.83-3.39)有显著的正相关,但与抑郁(OR 1.40,95% CI 0.75-2.58)无显著相关。根据研究设计进行的分组分析表明,幽门螺杆菌感染与焦虑之间存在显著的正相关关系(病例对照和横断面研究,OR 2.36,95% CI 1.65-3.38;队列研究,RR 1.72,95% CI 1.28-2.32)。使用焦虑自评量表(OR 2.43,95% CI 1.78-3.32)和其他问卷(OR 2.41,95% CI 1.50-3.87)进行的研究也观察到类似的趋势。然而,对幽门螺杆菌感染与抑郁之间的关系进行的亚组分析却得出了不同的结果。对队列研究进行的亚组分析表明,幽门螺杆菌感染与抑郁之间存在显著关联(RR 1.99,95% CI 1.33-2.99),但病例对照和横断面研究(OR 1.20,95% CI 0.59-2.46)则未发现这种关联。使用抑郁自评量表的研究(OR 2.03,95% CI 1.11-3.70)与使用其他问卷的研究(OR 1.03,95% CI 0.31-3.44)相比,观察到了明显的正相关。结论这项荟萃分析支持幽门螺杆菌感染与焦虑症之间存在显著的正相关。然而,幽门螺杆菌感染与抑郁症之间的关系似乎并不显著。
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引用次数: 0
Noninvasive Tests to Assess Liver Stiffness in Patients with Chronic Hepatitis B: APRI, FIB-4, and FIB-5 Scores 评估慢性乙型肝炎患者肝脏硬度的无创检验:APRI、FIB-4 和 FIB-5 评分
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-09 DOI: 10.1155/2024/5540648
Aysun Yakut, Murat Aladag

Background. Invasive percutaneous liver parenchymal biopsy is the best test used to evaluate liver stiffness and fibrosis in the follow-up and treatment of chronic hepatitis B (CHB) patients. In this study, we aimed to indirectly evaluate the severity of liver parenchymal fibrosis with tests used in the laboratory. Methods. This retrospective study was conducted with 201 patients diagnosed with CHB who underwent liver biopsy between 2021 and 2022. Preprocedural examination information, laboratory tests, and histopathological data of the patients were taken from the hospital database and examined. “Aspartate aminotransferase (AST)-platelet ratio index” (APRI), “4 factor-based fibrosis index” (FIB-4) score, and “5 factor-based fibrosis index” (FIB-5) score were calculated and compared with liver histopathological features. Results. Of the 201 CHB patients, 76 were females and 125 were males. The average age of the patients was 38.05 ± 12.63 years. A weak, statistically significant correlation was observed between FIB-4 and APRI scores. The patients’ significant fibrosis scores were 31.3% and 33.8%, respectively (r = 0.313; r = 0.338; p = 0.001; p < 0.01). The very weak negative correlation of 17.4% between the patients’ FIB-5 score and fibrosis score was statistically significant (r = −0.174; p = 0.014; p < 0.05). Conclusions. According to the data we obtained in our study, while the APRI score and FIB-4 score can be used safely, more comprehensive studies are needed for the reliability of the FIB-5 score.

背景。在慢性乙型肝炎(CHB)患者的随访和治疗中,有创经皮肝实质活检是用于评估肝脏硬度和纤维化的最佳检测方法。在本研究中,我们的目的是通过实验室使用的检测方法间接评估肝实质纤维化的严重程度。研究方法这项回顾性研究的对象是 2021 年至 2022 年期间接受肝活检的 201 例确诊为慢性乙型肝炎的患者。患者的术前检查信息、实验室检测和组织病理学数据均来自医院数据库,并对其进行了检查。计算 "天冬氨酸氨基转移酶(AST)-血小板比值指数"(APRI)、"基于4因子的纤维化指数"(FIB-4)评分和 "基于5因子的纤维化指数"(FIB-5)评分,并与肝组织病理学特征进行比较。结果在 201 名慢性阻塞性肺病患者中,女性 76 人,男性 125 人。患者的平均年龄为(38.05 ± 12.63)岁。FIB-4 和 APRI 评分之间存在微弱的统计学相关性。患者的明显纤维化评分分别为 31.3% 和 33.8%(r = 0.313; r = 0.338; p = 0.001; p <0.01)。患者的 FIB-5 评分与纤维化评分之间存在极弱的负相关,为 17.4%,具有统计学意义(r = -0.174; p = 0.014; p <0.05)。结论根据我们的研究数据,虽然 APRI 评分和 FIB-4 评分可以安全使用,但 FIB-5 评分的可靠性还需要更全面的研究。
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引用次数: 0
Evaluating Acute Ischemic Strokes despite Regular Anticoagulation: A Comparative Analysis of Direct Oral Anticoagulants and Warfarin in Treatment Outcomes 评估常规抗凝治疗后的急性缺血性脑卒中:直接口服抗凝剂与华法林治疗效果比较分析
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-04 DOI: 10.1155/2024/7676634
Sumeyye Cakmak, Ruken Simsekoglu

Objective. We aim to compare the outcomes between acute ischemic stroke (AIS) patients under vitamin K antagonist with those under direct oral anticoagulants (DOACs). Methods. This prospective, cross-sectional study was conducted for one year in a tertiary hospital operating as a stroke center. A total of 135 patients receiving oral anticoagulants (DOACs: 98 and VKA: 37) with AIS were included in the study. The patients’ vital parameters, examination and laboratory findings, acute stroke severity scores, stroke localizations, and 3-month clinical outcomes were recorded. Results. Of the 135 patients, 98 (mean age: 76.2, 52 women) were on DOACs while 37 (mean age: 69.7, 26 women) were on VKA. The average age was significantly higher in the group of patients receiving DOACs (p = 0.005). Although the mean age of the patient group using DOACs was higher, they did not score worse than patients using VKAs in terms of stroke severity and 3-month outcomes were equal in both groups. The rates of receiving iv-tPA (8.2% and 2.7%, respectively) and thrombectomy rates (23.5% and 29.7%, respectively) were low in the DOACs and VKA groups. Conclusion. The equality in stroke severity and 3-month outcome scores between the DOACs group, characterized by higher average age, and the VKA group is indicative of the comparable efficacy of DOACs in stroke management.

目的我们旨在比较服用维生素 K 拮抗剂和直接口服抗凝剂(DOACs)的急性缺血性脑卒中(AIS)患者的预后。研究方法这项前瞻性横断面研究在一家作为卒中中心的三级甲等医院进行,为期一年。研究共纳入 135 名接受口服抗凝药物治疗的 AIS 患者(DOACs:98 人,VKA:37 人)。记录了患者的生命参数、检查和实验室结果、急性卒中严重程度评分、卒中定位以及 3 个月的临床结果。研究结果135 名患者中,98 人(平均年龄 76.2 岁,女性 52 人)使用 DOACs,37 人(平均年龄 69.7 岁,女性 26 人)使用 VKA。接受 DOACs 治疗的患者组平均年龄明显更高(p = 0.005)。虽然使用 DOACs 的患者组平均年龄更高,但就中风严重程度而言,他们的评分并不比使用 VKAs 的患者差,两组患者 3 个月的预后相同。DOACs 组和 VKA 组患者接受 iv-tPA 的比例(分别为 8.2% 和 2.7%)和血栓切除术的比例(分别为 23.5% 和 29.7%)均较低。结论平均年龄较高的 DOACs 组和 VKA 组的卒中严重程度和 3 个月结果评分相同,这表明 DOACs 在卒中治疗中的疗效相当。
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引用次数: 0
A New Nomogram to Predict the Success of Shock Wave Lithotripsy in Ureteral Stones 预测输尿管结石冲击波碎石术成功率的新标准图
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-03 DOI: 10.1155/2024/6872476
Muhammed Fatih Simsekoglu, Engin Derekoylu, Mustafa Ozkaya, Muhammet Demirbilek, Ugur Aferin, Berin Selcuk, Ahmet Erozenci, Bulent Onal

Purpose. To design a new nomogram predicting the probability of stone-free status of shock wave lithotripsy (SWL) in patients with ureteral stones. Materials and Methods. We retrospectively enrolled 2,144 patients with ureteral stones who underwent SWL between January 1993 and April 2020. The demographic and clinical parameters were assessed. The predictors of stone-free status following SWL were identified. A logistic regression-based nomogram was created by including the significant predictors in the multivariate analysis. Results. The mean age was 42.93 ± 13.85 in the stone-free group (Group 1) and 46.51 ± 13.66 in the treatment-failure group (Group 2) (p = 0.001). The cutoff value of the age was 45.5 years. The mean stone load was 0.71 ± 0.36 cm2 in Group 1 and 0.96 ± 0.51 cm2 in Group 2 (p = 0.001). Of the 2,144 patients, 1,708 (79.6%) were stone-free within the first three SWL sessions. According to the multiple logistic regression analysis, older age, a stone load larger than 1 cm2, the presence of multiple stones, third-generation lithotripter use, and pre-SWL catheterization were statistically associated with low stone-free rates. The C-index was determined to be 0.75 in the bootstrapping method. Conclusion. A stone load larger than 1 cm2, age older than 45.5 years, the presence of multiple stones, new- (third-) generation lithotripter use, and pre-SWL catheterization had statistically significant effects on lower stone-free rates in patients who underwent SWL due to ureteral stones. A nomogram was developed to predict the success of SWL. As a result of the internal validation of the nomogram, it was concluded to be suitable for clinical use.

目的设计一种预测输尿管结石患者冲击波碎石术(SWL)无石概率的新提名图。材料和方法。我们回顾性地纳入了 1993 年 1 月至 2020 年 4 月间接受过冲击波碎石术的 2,144 名输尿管结石患者。对人口统计学和临床参数进行了评估。确定了 SWL 术后无结石状态的预测因素。通过将重要的预测因素纳入多变量分析,建立了基于逻辑回归的提名图。结果。无结石组(第 1 组)的平均年龄为 42.93 ± 13.85 岁,治疗失败组(第 2 组)的平均年龄为 46.51 ± 13.66 岁(P = 0.001)。年龄的临界值为 45.5 岁。第 1 组的平均结石量为 0.71 ± 0.36 平方厘米,第 2 组为 0.96 ± 0.51 平方厘米(P = 0.001)。在 2,144 名患者中,1,708 人(79.6%)在前三次 SWL 治疗中无结石。根据多元逻辑回归分析,年龄较大、结石量大于 1 平方厘米、存在多发性结石、使用第三代碎石机以及在 SWL 前接受导管插入术与低无结石率存在统计学关联。在引导法中,C指数被确定为0.75。结论结石体积大于1平方厘米、年龄大于45.5岁、存在多发性结石、使用新一代(第三代)碎石机以及接受SWL导管术前检查对因输尿管结石而接受SWL手术的患者无石率较低有显著的统计学影响。为预测 SWL 的成功率,我们开发了一个提名图。经过内部验证,该提名图被认为适合临床使用。
{"title":"A New Nomogram to Predict the Success of Shock Wave Lithotripsy in Ureteral Stones","authors":"Muhammed Fatih Simsekoglu,&nbsp;Engin Derekoylu,&nbsp;Mustafa Ozkaya,&nbsp;Muhammet Demirbilek,&nbsp;Ugur Aferin,&nbsp;Berin Selcuk,&nbsp;Ahmet Erozenci,&nbsp;Bulent Onal","doi":"10.1155/2024/6872476","DOIUrl":"https://doi.org/10.1155/2024/6872476","url":null,"abstract":"<div>\u0000 <p><i>Purpose</i>. To design a new nomogram predicting the probability of stone-free status of shock wave lithotripsy (SWL) in patients with ureteral stones. <i>Materials and Methods</i>. We retrospectively enrolled 2,144 patients with ureteral stones who underwent SWL between January 1993 and April 2020. The demographic and clinical parameters were assessed. The predictors of stone-free status following SWL were identified. A logistic regression-based nomogram was created by including the significant predictors in the multivariate analysis. <i>Results</i>. The mean age was 42.93 ± 13.85 in the stone-free group (Group 1) and 46.51 ± 13.66 in the treatment-failure group (Group 2) (<i>p</i> = 0.001). The cutoff value of the age was 45.5 years. The mean stone load was 0.71 ± 0.36 cm<sup>2</sup> in Group 1 and 0.96 ± 0.51 cm<sup>2</sup> in Group 2 (<i>p</i> = 0.001). Of the 2,144 patients, 1,708 (79.6%) were stone-free within the first three SWL sessions. According to the multiple logistic regression analysis, older age, a stone load larger than 1 cm<sup>2</sup>, the presence of multiple stones, third-generation lithotripter use, and pre-SWL catheterization were statistically associated with low stone-free rates. The C-index was determined to be 0.75 in the bootstrapping method. <i>Conclusion</i>. A stone load larger than 1 cm<sup>2</sup>, age older than 45.5 years, the presence of multiple stones, new- (third-) generation lithotripter use, and pre-SWL catheterization had statistically significant effects on lower stone-free rates in patients who underwent SWL due to ureteral stones. A nomogram was developed to predict the success of SWL. As a result of the internal validation of the nomogram, it was concluded to be suitable for clinical use.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6872476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Anxiety Scales and Serum Copeptin Levels in Determining the Preprocedure Anxiety Status of Patients Who Undergo Fiberoptic Bronchoscopy and Endobronchial Ultrasonography 焦虑量表和血清 Copeptin 水平在确定纤维支气管镜检查和支气管内超声检查患者术前焦虑状态中的作用
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-07-01 DOI: 10.1155/2024/5524757
Sümeyye Kodalak Cengiz, Canan Yılmaz, Ahmet Selim Yurdakul

Introduction. Fiberoptic bronchoscopy (FOB) and endobronchial ultrasonography (EBUS) are safe and frequently used minimally invasive procedures. However, the decision to undergo an interventional procedure causes anxiety development and negative consequences in the individual. Objective. To determine the role of the State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), visual analog scale (VAS), and serum copeptin levels, their sensitivity, specificity, and the correlation between them in the anxiety levels of patients before undergoing FOB and EBUS. Method. A total of 219 patients who were scheduled to undergo FOB/EBUS were included in this prospective observational study. Demographic data were recorded. Patients’ anxiety levels before the procedure were evaluated using STAI-SA, STAI-TA, BAI, and VAS. Copeptin levels were measured before and after the procedure. Results. Patients were moderately anxious according to STAI-SA, STAI-TA, and VAS and were mildly anxious according to the BAI. Women and patients aged under 65 years were significantly more anxious. All scales were positively correlated. Serum copeptin levels before the procedure were 5.8 ± 4.8 and 4.3 ± 3.9 ng/mL afterwards, with a significant difference between them. The specificity and sensitivity of VAS were found to be the highest. Conclusion. All anxiety scales are correlated with each other, and we recommend VAS as a powerful alternative for determining anxiety levels in terms of easier understanding and implementation. Serum copeptin levels before the procedure were significantly higher than afterwards and may be used as a potential biomarker for preprocedural anxiety.

导言。纤维支气管镜(FOB)和支气管内超声波检查(EBUS)是安全且常用的微创手术。然而,接受介入手术的决定会使患者产生焦虑和负面影响。研究目的确定状态-特质焦虑量表(STAI)、贝克焦虑量表(BAI)、视觉模拟量表(VAS)和血清 copeptin 水平在接受 FOB 和 EBUS 检查前患者焦虑水平中的作用、敏感性、特异性以及它们之间的相关性。研究方法本前瞻性观察研究共纳入 219 名计划接受 FOB/EBUS 手术的患者。研究记录了患者的人口统计学数据。使用 STAI-SA、STAI-TA、BAI 和 VAS 评估患者术前的焦虑水平。在手术前后测量了谷丙肽水平。结果根据 STAI-SA、STAI-TA 和 VAS,患者焦虑程度为中度,根据 BAI,患者焦虑程度为轻度。女性和 65 岁以下的患者焦虑程度明显更高。所有量表均呈正相关。手术前和手术后的血清 copeptin 水平分别为 5.8 ± 4.8 和 4.3 ± 3.9 ng/mL,两者之间存在显著差异。VAS 的特异性和敏感性最高。结论所有焦虑量表之间都存在相关性,我们推荐使用 VAS,因为它更易于理解和实施,是确定焦虑水平的有力替代方法。手术前的血清 copeptin 水平明显高于手术后,可作为手术前焦虑的潜在生物标记物。
{"title":"The Role of Anxiety Scales and Serum Copeptin Levels in Determining the Preprocedure Anxiety Status of Patients Who Undergo Fiberoptic Bronchoscopy and Endobronchial Ultrasonography","authors":"Sümeyye Kodalak Cengiz,&nbsp;Canan Yılmaz,&nbsp;Ahmet Selim Yurdakul","doi":"10.1155/2024/5524757","DOIUrl":"https://doi.org/10.1155/2024/5524757","url":null,"abstract":"<div>\u0000 <p><i>Introduction</i>. Fiberoptic bronchoscopy (FOB) and endobronchial ultrasonography (EBUS) are safe and frequently used minimally invasive procedures. However, the decision to undergo an interventional procedure causes anxiety development and negative consequences in the individual. <i>Objective</i>. To determine the role of the State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), visual analog scale (VAS), and serum copeptin levels, their sensitivity, specificity, and the correlation between them in the anxiety levels of patients before undergoing FOB and EBUS. <i>Method</i>. A total of 219 patients who were scheduled to undergo FOB/EBUS were included in this prospective observational study. Demographic data were recorded. Patients’ anxiety levels before the procedure were evaluated using STAI-SA, STAI-TA, BAI, and VAS. Copeptin levels were measured before and after the procedure. <i>Results</i>. Patients were moderately anxious according to STAI-SA, STAI-TA, and VAS and were mildly anxious according to the BAI. Women and patients aged under 65 years were significantly more anxious. All scales were positively correlated. Serum copeptin levels before the procedure were 5.8 ± 4.8 and 4.3 ± 3.9 ng/mL afterwards, with a significant difference between them. The specificity and sensitivity of VAS were found to be the highest. <i>Conclusion</i>. All anxiety scales are correlated with each other, and we recommend VAS as a powerful alternative for determining anxiety levels in terms of easier understanding and implementation. Serum copeptin levels before the procedure were significantly higher than afterwards and may be used as a potential biomarker for preprocedural anxiety.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5524757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141488032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopy and Laparotomy for Endometrioid Adenocarcinoma: Short- and Long-Term Outcomes’ Comparison 腹腔镜和开腹手术治疗子宫内膜样腺癌:短期和长期疗效比较
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-30 DOI: 10.1155/2024/9013582
Lan Hong, Xiuzhen Wang, Shengtan Wang, Wei Li, Lang Zheng, Jun Liu, Haocheng Gao, Xiaohang Liu, Guifei Li, Lifan Shen, Hengzhi Zhuang, Genhai Zhu

Aims. To analyze the short-term and long-term outcomes of laparoscopy versus laparotomy in treatment of endometrioid adenocarcinoma and examine the benefits of laparoscopy. Methods. From January 2012 to July 2020, 693 endometrioid adenocarcinoma patients undergoing laparoscopy versus laparotomy were retrospectively identified and enrolled in this study. Basic information for the patients, their perioperative indexes, and recurrence rates were reviewed to assess the therapeutic effect of these two approaches for endometrioid adenocarcinoma. Results. A total of 365 endometrioid adenocarcinoma patients underwent laparoscopy, and 328 patients underwent laparotomy. When compared with the laparotomic group, the laparoscopic group had longer operative times, lower intraoperative bleeding volumes, and shorter postoperative hospital stays. The rate of less-radical hysterectomy and radical hysterectomy performed in the laparoscopic group (59/365, 16.16%) was significantly lower than that in the laparotomic group (162/328, 49.39%). There was no statistically significant difference in the local recurrence rate between the two groups; however, the remote recurrence rate in the laparotomic group (15/308, 4.87%) was significantly higher than that in the laparoscopic group (3/351, 0.85%). A further subgroup analysis revealed a higher survival benefit both in I/II patients (314/314, 100%, vs. 7/242, 28.93%) and III/IV patients (35/37, 94.59%, vs. 51/66, 77.27%) in the laparoscopic group, when compared with the laparotomic group. Conclusion. Patients who received laparoscopic surgery had a faster surgical recovery and a lower postoperative recurrence rate in the short term than patients who received laparotomic surgery. Laparoscopic surgery is a safe and effective treatment for endometrioid adenocarcinoma.

目的分析腹腔镜手术与开腹手术治疗子宫内膜样腺癌的短期和长期疗效,并研究腹腔镜手术的益处。方法。从2012年1月至2020年7月,回顾性地确定了693名接受腹腔镜手术与开腹手术的子宫内膜样腺癌患者,并将其纳入本研究。研究人员回顾了患者的基本信息、围手术期指标和复发率,以评估这两种方法对子宫内膜样腺癌的治疗效果。结果共有 365 名子宫内膜样腺癌患者接受了腹腔镜手术,328 名患者接受了开腹手术。与开腹组相比,腹腔镜组的手术时间更长,术中出血量更少,术后住院时间更短。腹腔镜组进行的次根治性子宫切除术和根治性子宫切除术的比例(59/365,16.16%)明显低于开腹组(162/328,49.39%)。两组患者的局部复发率没有明显的统计学差异,但腹腔镜组的远处复发率(15/308,4.87%)明显高于腹腔镜组(3/351,0.85%)。进一步的亚组分析显示,与腹腔镜组相比,腹腔镜组 I/II 期患者(314/314,100%;7/242,28.93%)和 III/IV 期患者(35/37,94.59%;51/66,77.27%)的生存率更高。结论与接受开腹手术的患者相比,接受腹腔镜手术的患者手术恢复更快,术后短期复发率更低。腹腔镜手术是治疗子宫内膜样腺癌的一种安全有效的方法。
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引用次数: 0
Considering the Attitudes toward the COVID-19 Vaccine, the Levels of Vaccine Hesitancy among Family Healthcare Center (FHC) Employees: A Cross-Sectional Study 考虑到对 COVID-19 疫苗的态度,家庭保健中心 (FHC) 员工的疫苗犹豫程度:横断面研究
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-29 DOI: 10.1155/2024/2698910
Vasfiye Bayram Değer, Gülhan Yiğitalp

Aim. The primary objective of this study was to investigate the attitudes towards the COVID-19 vaccine, the extent of vaccine hesitancy, and the factors influencing the Family Healthcare Center staff who are responsible for delivering primary healthcare services. Methods. The research, which employed a cross-sectional design, was carried out with a sample of 102 healthcare professionals employed at family healthcare centers located in the city center. The study data were collected using three instruments: the “Personal Information Form,” the “Vaccination Hesitancy in Pandemic Scale,” and the “Attitudes towards COVID-19 Vaccine Scale.” Results. A total of 13.7% of the participants said that they were hesitant about having themselves vaccinated. The mean total score of vaccine hesitancy in the pandemic was found to be 22.760 ± 8.323, and the attitude towards the COVID-19 vaccine was 3.640 ± 0.831. A negative and weak relation was detected between the total score of vaccine hesitancy and the total score of attitude towards the COVID-19 vaccine in the pandemic. It was also found that the situation of considering the vaccine as partially necessary increases the vaccine hesitancy in the pandemic and the decrease in the degree of considering the childhood vaccines as necessary decreases the attitude towards the COVID-19 vaccine. Discussion. Despite the relatively low prevalence of vaccination hesitancy among healthcare workers, it remains a noteworthy concern. It is imperative to conduct a thorough investigation into the various factors that contribute to vaccine hesitancy and the attitudes held by healthcare professionals, with a particular focus on those factors having a negative impact.

研究目的本研究的主要目的是调查负责提供初级医疗保健服务的家庭保健中心工作人员对 COVID-19 疫苗的态度、对疫苗犹豫不决的程度以及影响因素。研究方法研究采用横断面设计,以位于市中心的家庭保健中心的 102 名医护人员为样本。研究数据通过三种工具收集:"个人信息表"、"大流行病疫苗接种意愿量表 "和 "对 COVID-19 疫苗的态度量表"。结果共有 13.7% 的参与者表示对接种疫苗犹豫不决。大流行病疫苗犹豫总分的平均值为 22.760 ± 8.323,对 COVID-19 疫苗的态度为 3.640 ± 0.831。在大流行病中,疫苗犹豫不决的总分与对 COVID-19 疫苗的态度总分之间发现了微弱的负相关。研究还发现,认为疫苗部分必要的情况会增加大流行病中的疫苗犹豫度,而认为儿童疫苗必要的程度降低则会降低对 COVID-19 疫苗的态度。讨论。尽管医护人员中疫苗接种犹豫的发生率相对较低,但它仍然是一个值得关注的问题。当务之急是对导致疫苗接种犹豫的各种因素以及医护人员所持的态度进行深入调查,尤其要关注那些具有负面影响的因素。
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引用次数: 0
Identification and Validation of TEAD Family’s Prognostic Effects and Immune Microenvironment Regulations in Glioma 胶质瘤中 TEAD 家族预后效应和免疫微环境调控的鉴定与验证
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-25 DOI: 10.1155/2024/7113457
Zhengyuan Huo, Shaorui Gu, Zheng Bian, Wenli Wang, Zhifeng Jiang

Background. Gliomas are primary malignant tumors of the central nervous system. The TEA domain transcription factor (TEAD) family proteins are the ultimate effector molecules of the Hippo pathway. However, their expression and function in gliomas have not been further studied. Methods. This study employed R software as the primary analysis tool. Public databases were used to analyze the expression and prognostic significance of TEADs. Functional enrichment analyses were conducted to determine the functions of the TEADs. We then explored their interaction with tumor-infiltrating immune cells and immune checkpoint proteins (ICPs). A Cox regression model was used to estimate the prognostic value of the TEADs. Finally, we conducted experiments to confirm TEAD3’s function in vitro. Results. TEAD expression was frequently increased in glioma and other malignant tumors. High TEAD expression was found to be substantially linked with isocitrate dehydrogenase (IDH) wild type, noncodeletion of 1p/19q, high WHO grade, and poor prognosis in glioma patients. Functional analyses revealed TEAD involvement in cancer cell transcription. The high expression of TEADs was greatly related to the myeloid-derived suppressor cells (MDSCs) and regulatory T-cells (Tregs) infiltration. TEADs also showed significant correlations with ICP expression in glioma tissues. The Cox regression model demonstrated significant diagnostic and prognostic efficacy in glioma patients. The reduction in TEAD3 affects tumor cell proliferation, migration, invasion, and immune regulation. RNA sequencing disclosed that TEAD3 regulates immune-related pathways, including negative regulation of the CTLA4 inhibitory pathway. Higher TEAD3 expression portended shorter overall survival (OS) and disease-free survival (DFS) in patients with gliomas based on clinical samples. Conclusions. TEADs are overexpressed in gliomas and are associated with a poor prognosis. Importantly, this study discovered that TEADs influence the immunological milieu of glioma by modulating genes associated with immune infiltration.

背景。胶质瘤是中枢神经系统的原发性恶性肿瘤。TEA结构域转录因子(TEAD)家族蛋白是Hippo通路的最终效应分子。然而,它们在胶质瘤中的表达和功能尚未得到进一步研究。研究方法本研究采用 R 软件作为主要分析工具。使用公共数据库分析 TEADs 的表达和预后意义。进行功能富集分析以确定 TEADs 的功能。然后,我们探讨了它们与肿瘤浸润免疫细胞和免疫检查点蛋白(ICPs)之间的相互作用。我们使用 Cox 回归模型来估计 TEADs 的预后价值。最后,我们进行了实验来确认 TEAD3 在体外的功能。结果发现在胶质瘤和其他恶性肿瘤中,TEAD的表达经常增加。研究发现,TEAD的高表达与异柠檬酸脱氢酶(IDH)野生型、1p/19q非编码缺失、WHO分级高以及胶质瘤患者预后不良密切相关。功能分析显示 TEAD 参与了癌细胞的转录。TEADs 的高表达与髓源性抑制细胞(MDSCs)和调节性 T 细胞(Tregs)的浸润有很大关系。TEADs与脑胶质瘤组织中ICP的表达也有明显的相关性。Cox 回归模型显示了神经胶质瘤患者的诊断和预后疗效。TEAD3 的减少会影响肿瘤细胞的增殖、迁移、侵袭和免疫调节。RNA测序显示,TEAD3调节免疫相关通路,包括负向调节CTLA4抑制通路。根据临床样本,TEAD3表达越高,胶质瘤患者的总生存期(OS)和无病生存期(DFS)越短。结论TEADs在胶质瘤中过度表达,与不良预后有关。重要的是,本研究发现 TEADs 通过调节与免疫浸润相关的基因影响胶质瘤的免疫环境。
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引用次数: 0
Deciphering Parkinson’s Disease through Eye Movements: A Promising Tool for Early Diagnosis in the Face of Cognitive Impairment 通过眼动解密帕金森病:认知障碍早期诊断的有效工具
IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-21 DOI: 10.1155/2024/5579238
Xianglian Liao, Jian Yao, Hongyin Tang, Yilan Xing, Xin Zhao, Daao Nie, Ping Luan, Guihua Li

Cognitive dysfunction is the most common and important nonmotor symptom in Parkinson’s disease (PD) and can occur at any stage. However, there is still a lack of effective biomarkers to evaluate the decline in cognitive function and predict the progression of the disease, especially in the early stage. At present, the cognitive scale is widely used to evaluate the cognitive function of patients with PD, but its sensitivity and accuracy are relatively limited, especially in the early identification of mild cognitive impairment. Eye movement tracking is an advanced neurophysiological measurement method that serves as a powerful means to study the relationship between behavior and neural mechanisms. In recent years, eye movement tracking has been found to provide a nonverbal and less cognitive method to measure the disease progress of patients with cognitive impairment. Moreover, there is a good correlation between eye movement tracking and the traditional cognitive assessment scale, indicating that eye movement tracking can be used to evaluate and monitor the cognitive status, disease severity, and disease progression of patients with PD. Compared to the traditional cognitive scale, the eye movement detected by the instrument has better objectivity and repeatability. Existing studies have found that executive dysfunction is one of the most important manifestations of cognitive dysfunction in patients with PD and is related to an increase in the error rate of the saccade, an increase in the disinhibition of the delayed saccade task, and a prolongation of the saccade reaction time. This suggests that eye movement measurement plays an important role in the early diagnosis, progression, and differential diagnosis of PD and may even help to predict the disease progression of patients with PD and cognitive impairment. In this article, we review the correlation between cognitive impairment and eye movement disorder in patients with PD.

认知功能障碍是帕金森病(PD)最常见、最重要的非运动症状,可发生在任何阶段。然而,目前仍缺乏有效的生物标志物来评估认知功能的下降并预测疾病的进展,尤其是在早期阶段。目前,认知量表被广泛用于评估帕金森病患者的认知功能,但其灵敏度和准确性相对有限,尤其是在早期识别轻度认知障碍方面。眼动跟踪是一种先进的神经生理学测量方法,是研究行为与神经机制关系的有力手段。近年来,人们发现眼动跟踪是一种非语言且认知程度较低的测量认知障碍患者疾病进展的方法。此外,眼动追踪与传统认知评估量表之间存在良好的相关性,表明眼动追踪可用于评估和监测帕金森病患者的认知状态、疾病严重程度和疾病进展。与传统认知量表相比,该仪器检测到的眼动具有更好的客观性和可重复性。现有研究发现,执行功能障碍是帕金森病患者认知功能障碍的重要表现之一,与囊回错误率增加、延迟囊回任务抑制增加和囊回反应时间延长有关。这表明眼动测量在帕金森病的早期诊断、进展和鉴别诊断中起着重要作用,甚至有助于预测帕金森病和认知障碍患者的疾病进展。本文回顾了认知障碍与帕金森病患者眼球运动障碍之间的相关性。
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引用次数: 0
Effect of Oligopin Administration on Ovarian Morphology in Women with Polycystic Ovarian Syndrome (PCOS) 服用奥利戈平对多囊卵巢综合征(PCOS)女性卵巢形态的影响
IF 2.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-06-12 DOI: 10.1155/2024/6479885
Sayed Mahmoud Sajjadi-Jazi, Milad Sanginabadi, Behnaz Moradi, Amir Pejman Hashemi Taheri, Mehrnam Amouei, Mostafa Qorbani, Saeed Hosseini, Masoumeh Gity, Mohammad Reza Mohajeri-Tehrani, Seyed Vahid Taheri, Asieh Mansour

Background. The effects of oligopin as an antioxidant on polycystic ovarian morphology (PCOM) have not yet been examined. Therefore, the objective of this study was to evaluate the oligopin supplementation on PCOM among patients with polycystic ovarian syndrome (PCOS). Methods. This randomized, placebo-controlled trial was carried out at Shariati Hospital, Arash Hospital, and Yas Hospital, Tehran, Iran, to determine the effect of oligopin (50 mg/d) or placebo in PCOS patients. The ultrasonographic ovarian morphology was assessed in women aged 18–40 years, before and after 3 months of intervention. Results. Among 45 randomized participants, 32 participants, of whom 17 were in the oligopin group and 15 were in the placebo group completed the trial. There was only one adverse event in the oligopin group. The mean (standard deviation) age of the patients was 30.47 (6.30) years and the median (interquartile range) BMI was 27.50 (23.42–33.55). Three months of oligopin therapy significantly decreased ovarian stromal area (p = 0.01) and stromal/total area (p = 0.003). However, no significant differences were observed in the ovarian volume, ovarian area, 2–9 mm antral follicle counts, or peripheral follicle distribution pattern at 3 months. Conclusion. Among participants with PCOS, the use of oligopin (50 mg) daily, as compared with a placebo, resulted in improvement of the stromal area and stromal/total area at the end of the 3 months of treatment. Further studies are, however, needed to evaluate the longer-term efficacy and safety. This trial is registered with IRCT20140406017139N3.

背景。低聚果糖作为一种抗氧化剂对多囊卵巢形态(PCOM)的影响尚未得到研究。因此,本研究旨在评估多囊卵巢综合征(PCOS)患者补充低聚果糖对 PCOM 的影响。研究方法这项随机安慰剂对照试验在伊朗德黑兰的沙里亚提医院、阿拉什医院和亚斯医院进行,以确定低聚果糖(50 毫克/天)或安慰剂对多囊卵巢综合征患者的影响。在干预 3 个月前后,对 18-40 岁女性的卵巢超声形态进行了评估。结果显示在45名随机参与者中,有32人完成了试验,其中寡肽组17人,安慰剂组15人。寡肽组仅发生了一起不良事件。患者的平均年龄(标准差)为30.47(6.30)岁,体重指数中位数(四分位数间距)为27.50(23.42-33.55)。寡肽治疗三个月后,卵巢基质面积(p = 0.01)和基质/总面积(p = 0.003)明显减少。然而,3个月后,卵巢体积、卵巢面积、2-9毫米前卵泡计数或外周卵泡分布模式均无明显差异。结论在患有多囊卵巢综合症的参与者中,与安慰剂相比,每天服用寡肽(50 毫克)可在 3 个月治疗结束时改善基质面积和基质/总面积。不过,还需要进一步的研究来评估其长期疗效和安全性。该试验已注册为 IRCT20140406017139N3。
{"title":"Effect of Oligopin Administration on Ovarian Morphology in Women with Polycystic Ovarian Syndrome (PCOS)","authors":"Sayed Mahmoud Sajjadi-Jazi,&nbsp;Milad Sanginabadi,&nbsp;Behnaz Moradi,&nbsp;Amir Pejman Hashemi Taheri,&nbsp;Mehrnam Amouei,&nbsp;Mostafa Qorbani,&nbsp;Saeed Hosseini,&nbsp;Masoumeh Gity,&nbsp;Mohammad Reza Mohajeri-Tehrani,&nbsp;Seyed Vahid Taheri,&nbsp;Asieh Mansour","doi":"10.1155/2024/6479885","DOIUrl":"https://doi.org/10.1155/2024/6479885","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. The effects of oligopin as an antioxidant on polycystic ovarian morphology (PCOM) have not yet been examined. Therefore, the objective of this study was to evaluate the oligopin supplementation on PCOM among patients with polycystic ovarian syndrome (PCOS). <i>Methods</i>. This randomized, placebo-controlled trial was carried out at Shariati Hospital, Arash Hospital, and Yas Hospital, Tehran, Iran, to determine the effect of oligopin (50 mg/d) or placebo in PCOS patients. The ultrasonographic ovarian morphology was assessed in women aged 18–40 years, before and after 3 months of intervention. <i>Results</i>. Among 45 randomized participants, 32 participants, of whom 17 were in the oligopin group and 15 were in the placebo group completed the trial. There was only one adverse event in the oligopin group. The mean (standard deviation) age of the patients was 30.47 (6.30) years and the median (interquartile range) BMI was 27.50 (23.42–33.55). Three months of oligopin therapy significantly decreased ovarian stromal area (<i>p</i> = 0.01) and stromal/total area (<i>p</i> = 0.003). However, no significant differences were observed in the ovarian volume, ovarian area, 2–9 mm antral follicle counts, or peripheral follicle distribution pattern at 3 months. <i>Conclusion</i>. Among participants with PCOS, the use of oligopin (50 mg) daily, as compared with a placebo, resulted in improvement of the stromal area and stromal/total area at the end of the 3 months of treatment. Further studies are, however, needed to evaluate the longer-term efficacy and safety. This trial is registered with IRCT20140406017139N3.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6479885","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International Journal of Clinical Practice
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