Background: Psychological distress has become an epidemic among cancer patients. Less is known about the pattern of anxiety and depression in cancer patients with minor children. Gender issue is also important in this regard. Psychological distress is an important predictor of quality of life in cancer patients. A majority of these disorders are eminently treatable. Materials and methods: A cross-sectional comparative study was done to compare anxiety and depression status between cancer patients having and not having minor children, attending at National Institute of Cancer Research Hospital, Oncology department in Dhaka Medical College Hospital and in Uttara Adhunik Medical College Hospital. The study was conducted for the time period from September, 2012 to June, 2013. In study group, having underage children, 123 cancer patients were included. Whereas in comparison group without having underage children, 116 patients were selected. Purposive sampling was applied. Cancer patients in both groups were selected randomly, each between the age from 20 to 60 years, corresponding to Karnofsky Performance Scale Score > 79. All The included cancer patients were married and did not have history of substance use or any prior psychiatric illness or co morbidities related to development of secondary psychiatric disorders. Distress among the patients were measured with the Hospital Anxiety and Depression Scale (Two sub scales – A – Anxiety subscale and D – Depression subscale). Result: In the study group, 60.2% respondents was male and 39.8% was female. And in comparison group male and female ratio was 42.2% and 57.8%. Mean age of the participants in study group was 36.97±4.37 and in comparison group was 42.98±11.74 years respectively. The mean duration since diagnosis was 12.85±13.11 months in study group and 11.53±6.72 months in comparison group. Majority of the respondents in study group were suffering from guynaecological cancer (25.2%) and gastro intestinal cancer (25.2%). Whereas majority cancer patients in comparison group were guynaecological cancer (31%) and haematolymphoid cancer (20.7) as well. Metastasis was present in 42.3% patients in study sample and 64.7% patients in comparison group. It was noticed that, both male and female in study group were found significantly more distressed than the comparison group (p < 0.001). In study group mean anxiety score in male (n=74) was 15.72±2.314 and in female (n=49) was 12.06±2.802, i.e. father with minor children were suffering from more anxiety than the mother (t = 7.878, p < 0.001). Mean depression score in male (study group) was 11.91±2.489, whereas in female it was 17.55±2.542, i.e. female cancer patients with minor children were found more depressed than male (t = 12.211; and p < 0.001). In comparison group, mean anxiety score among male (n=49) was 7.27±1.630 and in female (n=67) mean anxiety score was 8.84±1.592. Female were more anxious than male in comparison group (t = 5.196; p < 0.001). In thi
{"title":"Gender Specific Psychological Distress in Cancer Patients with Underage Children","authors":"J. Akter, M. H. Khan, Jaglul Gaffer Khan","doi":"10.3329/JPSB.V6I1.27741","DOIUrl":"https://doi.org/10.3329/JPSB.V6I1.27741","url":null,"abstract":"Background: Psychological distress has become an epidemic among cancer patients. Less is known about the pattern of anxiety and depression in cancer patients with minor children. Gender issue is also important in this regard. Psychological distress is an important predictor of quality of life in cancer patients. A majority of these disorders are eminently treatable. Materials and methods: A cross-sectional comparative study was done to compare anxiety and depression status between cancer patients having and not having minor children, attending at National Institute of Cancer Research Hospital, Oncology department in Dhaka Medical College Hospital and in Uttara Adhunik Medical College Hospital. The study was conducted for the time period from September, 2012 to June, 2013. In study group, having underage children, 123 cancer patients were included. Whereas in comparison group without having underage children, 116 patients were selected. Purposive sampling was applied. Cancer patients in both groups were selected randomly, each between the age from 20 to 60 years, corresponding to Karnofsky Performance Scale Score > 79. All The included cancer patients were married and did not have history of substance use or any prior psychiatric illness or co morbidities related to development of secondary psychiatric disorders. Distress among the patients were measured with the Hospital Anxiety and Depression Scale (Two sub scales – A – Anxiety subscale and D – Depression subscale). Result: In the study group, 60.2% respondents was male and 39.8% was female. And in comparison group male and female ratio was 42.2% and 57.8%. Mean age of the participants in study group was 36.97±4.37 and in comparison group was 42.98±11.74 years respectively. The mean duration since diagnosis was 12.85±13.11 months in study group and 11.53±6.72 months in comparison group. Majority of the respondents in study group were suffering from guynaecological cancer (25.2%) and gastro intestinal cancer (25.2%). Whereas majority cancer patients in comparison group were guynaecological cancer (31%) and haematolymphoid cancer (20.7) as well. Metastasis was present in 42.3% patients in study sample and 64.7% patients in comparison group. It was noticed that, both male and female in study group were found significantly more distressed than the comparison group (p < 0.001). In study group mean anxiety score in male (n=74) was 15.72±2.314 and in female (n=49) was 12.06±2.802, i.e. father with minor children were suffering from more anxiety than the mother (t = 7.878, p < 0.001). Mean depression score in male (study group) was 11.91±2.489, whereas in female it was 17.55±2.542, i.e. female cancer patients with minor children were found more depressed than male (t = 12.211; and p < 0.001). In comparison group, mean anxiety score among male (n=49) was 7.27±1.630 and in female (n=67) mean anxiety score was 8.84±1.592. Female were more anxious than male in comparison group (t = 5.196; p < 0.001). In thi","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"214 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114426894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hemophilia is the most common serious congenital coagulation factor deficiencies. The prevalence of hemophilia is estimated to be about 1:10,000 birth and that of the severe form of the disease to be about 6% per 1,00,000 population. The most pathetic part of this disease is that even medical personnel are sometimes not familiar with its diagnosis and management. There is obviously a need to establish facilities and treatment options that will help the patient with hemophilia to manage their life with ease. As this is a genetic disorder no complete cure is possible as of now. The only available treatment option is the infusion of factors and some adjuvant therapies depending upon the bleeding conditions .Hemophilia, if not properly managed, can lead to chronic disease and lifelong disabilities. The challenges and issues in infants/young children are different from those in older children and adults although episodes of bleeding still predominate as the diagnostic trigger. Currently, inhibitor development is a challenging complication of pediatric hemophilia and prophylaxis is emerging as the optimal preventive care strategy. In this section we will review some important aspects of hemophilia in children including early prophylaxis, current evidence relating to inhibitor development. J. Paediatr. Surg. Bangladesh 6 (2): 54-63, 2015 (July)
{"title":"Hemophilia in Children","authors":"S. Islam, A. Morshed, Z. J. Khan","doi":"10.3329/JPSB.V6I2.27750","DOIUrl":"https://doi.org/10.3329/JPSB.V6I2.27750","url":null,"abstract":"Hemophilia is the most common serious congenital coagulation factor deficiencies. The prevalence of hemophilia is estimated to be about 1:10,000 birth and that of the severe form of the disease to be about 6% per 1,00,000 population. The most pathetic part of this disease is that even medical personnel are sometimes not familiar with its diagnosis and management. There is obviously a need to establish facilities and treatment options that will help the patient with hemophilia to manage their life with ease. As this is a genetic disorder no complete cure is possible as of now. The only available treatment option is the infusion of factors and some adjuvant therapies depending upon the bleeding conditions .Hemophilia, if not properly managed, can lead to chronic disease and lifelong disabilities. The challenges and issues in infants/young children are different from those in older children and adults although episodes of bleeding still predominate as the diagnostic trigger. Currently, inhibitor development is a challenging complication of pediatric hemophilia and prophylaxis is emerging as the optimal preventive care strategy. In this section we will review some important aspects of hemophilia in children including early prophylaxis, current evidence relating to inhibitor development. J. Paediatr. Surg. Bangladesh 6 (2): 54-63, 2015 (July)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133271956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Siddiqui, Mohammad Mahabubul Alam, Am Shahinur, A. Z. Hossain, G. Z. Hasan
Gastric bezoar in neonate is a rare presentation. Because of rarity of phytobezoar and lactobezoar are not considered as the differential diagnosis of a lump and vomiting commonly. A 7 month female presented with left upper abdominal undifferentiated hard mobile lump and post prandial occasional vomiting. Diagnosis was non-conclusive with USG, contrast medium study of stomach and duodenum and contrast enhanced CT scan. After laparotomy and gastrostomy mass was removed and diagnosed as phytolactobezoar on macroscopic appearance. J. Paediatr. Surg. Bangladesh 6 (1): 24-27, 2015 (Jan)
{"title":"Gastric Bezoar - A Rare Presentation in Infant","authors":"M. Siddiqui, Mohammad Mahabubul Alam, Am Shahinur, A. Z. Hossain, G. Z. Hasan","doi":"10.3329/JPSB.V6I1.27744","DOIUrl":"https://doi.org/10.3329/JPSB.V6I1.27744","url":null,"abstract":"Gastric bezoar in neonate is a rare presentation. Because of rarity of phytobezoar and lactobezoar are not considered as the differential diagnosis of a lump and vomiting commonly. A 7 month female presented with left upper abdominal undifferentiated hard mobile lump and post prandial occasional vomiting. Diagnosis was non-conclusive with USG, contrast medium study of stomach and duodenum and contrast enhanced CT scan. After laparotomy and gastrostomy mass was removed and diagnosed as phytolactobezoar on macroscopic appearance. J. Paediatr. Surg. Bangladesh 6 (1): 24-27, 2015 (Jan)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133507673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Tuyà, Ch Battulga, Ts Tsogtsolmaa, M. Tumennasan, N. Davaatseren, K. Hasina
Introduction : Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality. To explore whether abdominal ultrasound (AUS) provide additional information over plain radiography in cases of necrotizing enterocolitis (NEC). Materials & Methods : This study is a prospective study of 30 premature neonates with NEC in our neonatal intensive care unit between September 2013 and November 2014. Fifteen premature control neonates were also included in the study. Results: Patients were classified into two groups: the first group with suspected NEC (stage I) (n = 14) and the second with definite NEC (stage II or III) (n = 16). In group I abdominal ultrasound (AUS) revealed intramural air (n = 9) and portal venous gas (PVG) (n = 1) while plain radiography showed only gaseous distension. In group II, intramural air (n = 10), PVG (n = 2), free fluid (n = 6) focal fluid (n = 1) and free air (n = 6) detected by AUS compared to pneumatosis intestinalis (PI) (n = 2) PVG (n = 1) and free air (n = 5) by plain radiography. Additionally bowel wall thinning was detected in 2 neonates of group I and 3 of group II. Conclusion: Our results suggest AUS to be superior to plain radiography in early detection of complication as intestinal perforation by eliciting PVG and fluid collection and so early surgical management. Therefore this may decrease morbidity and mortality rates. J. Paediatr. Surg. Bangladesh 6 (2): 47-53, 2015 (July)
{"title":"Abdominal Ultrasonography and Radiography Diagnosis in Preterm Necrotizing Enterocolitis","authors":"S. Tuyà, Ch Battulga, Ts Tsogtsolmaa, M. Tumennasan, N. Davaatseren, K. Hasina","doi":"10.3329/JPSB.V6I2.27749","DOIUrl":"https://doi.org/10.3329/JPSB.V6I2.27749","url":null,"abstract":"Introduction : Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality. To explore whether abdominal ultrasound (AUS) provide additional information over plain radiography in cases of necrotizing enterocolitis (NEC). Materials & Methods : This study is a prospective study of 30 premature neonates with NEC in our neonatal intensive care unit between September 2013 and November 2014. Fifteen premature control neonates were also included in the study. Results: Patients were classified into two groups: the first group with suspected NEC (stage I) (n = 14) and the second with definite NEC (stage II or III) (n = 16). In group I abdominal ultrasound (AUS) revealed intramural air (n = 9) and portal venous gas (PVG) (n = 1) while plain radiography showed only gaseous distension. In group II, intramural air (n = 10), PVG (n = 2), free fluid (n = 6) focal fluid (n = 1) and free air (n = 6) detected by AUS compared to pneumatosis intestinalis (PI) (n = 2) PVG (n = 1) and free air (n = 5) by plain radiography. Additionally bowel wall thinning was detected in 2 neonates of group I and 3 of group II. Conclusion: Our results suggest AUS to be superior to plain radiography in early detection of complication as intestinal perforation by eliciting PVG and fluid collection and so early surgical management. Therefore this may decrease morbidity and mortality rates. J. Paediatr. Surg. Bangladesh 6 (2): 47-53, 2015 (July)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128836857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical education is the science behind teaching and learning in medicine has been firmly established as a separate discipline. It has gained tremendous progress as a discipline parallel to medical science. It achieved a phase where it is not limited to the understanding of fault but know how to correct these fault. So medical education has converted itself from the role of problem identifier to that of solution provider.
{"title":"Residency Program A new era in postgraduate medical education in Bangladesh","authors":"T. Siddiqui","doi":"10.3329/JPSB.V6I1.27738","DOIUrl":"https://doi.org/10.3329/JPSB.V6I1.27738","url":null,"abstract":"Medical education is the science behind teaching and learning in medicine has been firmly established as a separate discipline. It has gained tremendous progress as a discipline parallel to medical science. It achieved a phase where it is not limited to the understanding of fault but know how to correct these fault. So medical education has converted itself from the role of problem identifier to that of solution provider.","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117217836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mizanur Rahman, S. Mondal, A. L. Kabir, R. Amin, Matiur Rahman
Background: Total splenectomy, exposes children to the high risk of overwhelming postsplenectomy infections (OPSI). To avoid these adverse consequences, partial splenectomy has long been practiced for thalasseemia in children. It has been reported that the partial splenectomy keeps the child immunologically competent, hematologically stable with minimum blood transfusion and makes their life more comfortable in comparison to total splenectomy. Objectives: To compare the results of partial and total splenectomy. Methodology: This prospective interventional comperative study was done in the department of Pediatric Surgery, BSMMU from 2010 to 2012. Children who underwent partial splenectomy were considered as the case and who underwent total splenectomy as the control. Number of blood (RCC) transfusions (ml/ kg/year), Peripheral blood film (Hb%, WBC count, platelet count, Howell-Jolly body, serum bilirubin), volume of liver (ml), volume of spleen (ml), number of OPSI case, were compared between the case and control groups both pre and postoperatively. Results: Postsplenectomy blood transfusion requirement is comparatively more decreased in control group than case group. The inter group difference at 6 month is significant (p= 0.004). Peripheral blood pictures are improved in both groups. Post splenectomy hemoglobin level was increased in both groups but it was maintained at a more static fashion in control group than case group (P = 0.114). Howell-jolly body in the partial splenectomy group disappeared almost completely at month 6, while the same inclusion body in the total splenectomy group appeared in all the children (p= 0.001). There was no postsplenectomy infection in case group while two found in control group. After partial splenectomy the residual volume of the spleen was gradually increasing. The increase in volume of the liver was notably greater in the total splenectomy group than that in the partial splenectomy group (p< 0.05). Conclusion: Partial splenectomy in patients with ²-thalassemia is effective in controlling hemolysis, improving peripheral blood picture while preserving the residual splenic phagocytic and immune function. J. Paediatr. Surg. Bangladesh 6 (2): 39-46, 2015 (July)
{"title":"Outcome of Partial Splenectomy for Hypersplenism in Children with Thalassemia","authors":"Mizanur Rahman, S. Mondal, A. L. Kabir, R. Amin, Matiur Rahman","doi":"10.3329/JPSB.V6I2.27748","DOIUrl":"https://doi.org/10.3329/JPSB.V6I2.27748","url":null,"abstract":"Background: Total splenectomy, exposes children to the high risk of overwhelming postsplenectomy infections (OPSI). To avoid these adverse consequences, partial splenectomy has long been practiced for thalasseemia in children. It has been reported that the partial splenectomy keeps the child immunologically competent, hematologically stable with minimum blood transfusion and makes their life more comfortable in comparison to total splenectomy. Objectives: To compare the results of partial and total splenectomy. Methodology: This prospective interventional comperative study was done in the department of Pediatric Surgery, BSMMU from 2010 to 2012. Children who underwent partial splenectomy were considered as the case and who underwent total splenectomy as the control. Number of blood (RCC) transfusions (ml/ kg/year), Peripheral blood film (Hb%, WBC count, platelet count, Howell-Jolly body, serum bilirubin), volume of liver (ml), volume of spleen (ml), number of OPSI case, were compared between the case and control groups both pre and postoperatively. Results: Postsplenectomy blood transfusion requirement is comparatively more decreased in control group than case group. The inter group difference at 6 month is significant (p= 0.004). Peripheral blood pictures are improved in both groups. Post splenectomy hemoglobin level was increased in both groups but it was maintained at a more static fashion in control group than case group (P = 0.114). Howell-jolly body in the partial splenectomy group disappeared almost completely at month 6, while the same inclusion body in the total splenectomy group appeared in all the children (p= 0.001). There was no postsplenectomy infection in case group while two found in control group. After partial splenectomy the residual volume of the spleen was gradually increasing. The increase in volume of the liver was notably greater in the total splenectomy group than that in the partial splenectomy group (p< 0.05). Conclusion: Partial splenectomy in patients with ²-thalassemia is effective in controlling hemolysis, improving peripheral blood picture while preserving the residual splenic phagocytic and immune function. J. Paediatr. Surg. Bangladesh 6 (2): 39-46, 2015 (July)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115206331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Islam, R. Amin, Abu Saleh Md Oliullah, A. Basher, A. Biswas, N. Islam
Intractable fecal and urinary incontinence, often associated with myelomeningocele (MMC), usually prevents children from achieving physical and social independence. The Malone Antegrade Continence Enema (MACE) procedure, often performed in conjunction with a Mitrofanoff procedure to gain fecal & urinary continence, can help these patients to attain a better quality of life. In patients, who underwent the combined Mitrofanoff and MACE procedures simultaneously, the success rate is- 83% satisfactory for both bowel & urinary continence. With this procedure we report here, for the first time in Bangladesh, to the best of our knowledge, an association between two previously described techniques (the Mitrofanoff principle and MACE), that can solve the problem of dual incontinence in children with MMC. The case involved a 14 years old boy with total neurogenic feco-urinary incontinence following excision & repair of MMC at the age of 4 months. After the surgery, the boy is continent with normal renalfunction. J. Paediatr. Surg. Bangladesh 6 (1): 28-31, 2015 (Jan)
{"title":"Combined MACE & Mitrofanoff Procedure for Total Neurogenic Feco-urinary Incontinence A Case Report","authors":"K. Islam, R. Amin, Abu Saleh Md Oliullah, A. Basher, A. Biswas, N. Islam","doi":"10.3329/JPSB.V6I1.27745","DOIUrl":"https://doi.org/10.3329/JPSB.V6I1.27745","url":null,"abstract":"Intractable fecal and urinary incontinence, often associated with myelomeningocele (MMC), usually prevents children from achieving physical and social independence. The Malone Antegrade Continence Enema (MACE) procedure, often performed in conjunction with a Mitrofanoff procedure to gain fecal & urinary continence, can help these patients to attain a better quality of life. In patients, who underwent the combined Mitrofanoff and MACE procedures simultaneously, the success rate is- 83% satisfactory for both bowel & urinary continence. With this procedure we report here, for the first time in Bangladesh, to the best of our knowledge, an association between two previously described techniques (the Mitrofanoff principle and MACE), that can solve the problem of dual incontinence in children with MMC. The case involved a 14 years old boy with total neurogenic feco-urinary incontinence following excision & repair of MMC at the age of 4 months. After the surgery, the boy is continent with normal renalfunction. J. Paediatr. Surg. Bangladesh 6 (1): 28-31, 2015 (Jan)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123170140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primitive neuroectodectodermal tumor is a rare tumor in childhood. It is aggressive childhood malignancies and offer a significant challenge to treatment. An eleven year old female baby presented with fever, pain and neurologic manifestation. Initialy it was diagnose as TB vertebrae and treated accordingly but no improvment rather new metastatic swelling appear after few days. Diagnosis was made by MRI and local tissue biopsy and immunohistohistochemistry. As it is rare and highly invasssive malignancy with poor out come the case was presented along with literature review. J. Paediatr. Surg. Bangladesh 6 (2): 64-67, 2015 (July)
{"title":"SPINAL PRIMITIVE NEUROECTODERMAL TUMOR IN CHILDREN-A RARE CASE REPORT AND LITERATURE REVIEW","authors":"A. Morshed, S. Islam, S. Anwar","doi":"10.3329/JPSB.V6I2.27751","DOIUrl":"https://doi.org/10.3329/JPSB.V6I2.27751","url":null,"abstract":"Primitive neuroectodectodermal tumor is a rare tumor in childhood. It is aggressive childhood malignancies and offer a significant challenge to treatment. An eleven year old female baby presented with fever, pain and neurologic manifestation. Initialy it was diagnose as TB vertebrae and treated accordingly but no improvment rather new metastatic swelling appear after few days. Diagnosis was made by MRI and local tissue biopsy and immunohistohistochemistry. As it is rare and highly invasssive malignancy with poor out come the case was presented along with literature review. J. Paediatr. Surg. Bangladesh 6 (2): 64-67, 2015 (July)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127700173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tofazzal Hossain, M. Mannan, S. Nahar, A. Morshed, S. Islam, L. Helaly
Background: Corticosteroids are an essential component of treatment for acute lymphoblastic leukemia (ALL). Prednisolone is the most commonly used steroid. There is increasing evidence that, even in equipotent dosage for glucocorticoid effect, dexamethasone has enhanced lymphoblast cytotoxicity and penetration of central nervous system compared with prednisolone. Objectives: To determine the effect of dexamethasone and prednisolone and to compare them in induction therapy of ALL in Children. Material & Methods: A total of 60 newly diagnosed cases of ALL confirmed by bone marrow study, children of either sex with age >1 year were included in this study. Variables studied were age, sex, presenting features, neutrophil count, blast cell count, platelet count, bone marrow status at diagnosis, on D15 & D29 of induction and side effects. Results: Mean age of the patients of group A was 6.28 years & that of group B was 7.2 years. Out of all patients of group A 19 (63.3%) were male and 11 (36.7%) were female. In group B 21 (70.0%) patients were male and rests 9 (30.3%) were female. No statistically significant difference was observed in both groups in terms of age, sex & presenting features. After induction significant difference was observed in liver & spleen size at day 7 and day 15. All patients of both groups had M3 marrow status at diagnosis. Overall, in group A 93.3% patients achieved M1 marrow status (fewer than 5% blasts) and 6.7% had M2 marrow status (5-25% blasts) at day 15 of induction. On the other side 66.7% patients of group B achieved M1 status and 33.3% M2 status at day 15. Statistically significant difference was observed between groups on day 15 in term of achieved marrow status (p<0.05). No statistically significant difference was observed between groups in term of infection in difference days of induction. On day 16 of induction maximum incidence of infection was observed in both groups. Conclusion: Dexamethasone may be an effective alternative option to prednisolone for the treatment of acute lymphoblastic leukemia in children. J. Paediatr. Surg. Bangladesh 6 (1): 3-9, 2015 (Jan)
{"title":"Effectiveness of Dexamethasone compared with Prednisolone in Induction Therapy of Childhood Acute Lymphoblastic Leukemia","authors":"Tofazzal Hossain, M. Mannan, S. Nahar, A. Morshed, S. Islam, L. Helaly","doi":"10.3329/JPSB.V6I1.27740","DOIUrl":"https://doi.org/10.3329/JPSB.V6I1.27740","url":null,"abstract":"Background: Corticosteroids are an essential component of treatment for acute lymphoblastic leukemia (ALL). Prednisolone is the most commonly used steroid. There is increasing evidence that, even in equipotent dosage for glucocorticoid effect, dexamethasone has enhanced lymphoblast cytotoxicity and penetration of central nervous system compared with prednisolone. Objectives: To determine the effect of dexamethasone and prednisolone and to compare them in induction therapy of ALL in Children. Material & Methods: A total of 60 newly diagnosed cases of ALL confirmed by bone marrow study, children of either sex with age >1 year were included in this study. Variables studied were age, sex, presenting features, neutrophil count, blast cell count, platelet count, bone marrow status at diagnosis, on D15 & D29 of induction and side effects. Results: Mean age of the patients of group A was 6.28 years & that of group B was 7.2 years. Out of all patients of group A 19 (63.3%) were male and 11 (36.7%) were female. In group B 21 (70.0%) patients were male and rests 9 (30.3%) were female. No statistically significant difference was observed in both groups in terms of age, sex & presenting features. After induction significant difference was observed in liver & spleen size at day 7 and day 15. All patients of both groups had M3 marrow status at diagnosis. Overall, in group A 93.3% patients achieved M1 marrow status (fewer than 5% blasts) and 6.7% had M2 marrow status (5-25% blasts) at day 15 of induction. On the other side 66.7% patients of group B achieved M1 status and 33.3% M2 status at day 15. Statistically significant difference was observed between groups on day 15 in term of achieved marrow status (p<0.05). No statistically significant difference was observed between groups in term of infection in difference days of induction. On day 16 of induction maximum incidence of infection was observed in both groups. Conclusion: Dexamethasone may be an effective alternative option to prednisolone for the treatment of acute lymphoblastic leukemia in children. J. Paediatr. Surg. Bangladesh 6 (1): 3-9, 2015 (Jan)","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130467901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We the Paediatic Surgeons are to deal Paediatic patients of different ages with different types of problems. Majority of the problems are congenital in origin, may need multistaged operation, Post operative complications are more than adults. Childrens can not say about their problems upto a certain age. We are to remain more alert to detect problem & progresses of their illness status. Due to natural affection Parents/ attendants remain anxious and tense. So we are to deal & manage not only the Paediatic Surgical patients but also to manage their patients/attendants. We need to explain about the cause, nature and consequences of the illness the parents.
{"title":"Counselling of Parents, attendants, guardians in dealing of Paediatic Surgical Patients","authors":"K. Rahman","doi":"10.3329/JPSB.V6I2.27746","DOIUrl":"https://doi.org/10.3329/JPSB.V6I2.27746","url":null,"abstract":"We the Paediatic Surgeons are to deal Paediatic patients of different ages with different types of problems. Majority of the problems are congenital in origin, may need multistaged operation, Post operative complications are more than adults. Childrens can not say about their problems upto a certain age. We are to remain more alert to detect problem & progresses of their illness status. Due to natural affection Parents/ attendants remain anxious and tense. So we are to deal & manage not only the Paediatic Surgical patients but also to manage their patients/attendants. We need to explain about the cause, nature and consequences of the illness the parents.","PeriodicalId":137868,"journal":{"name":"Journal of Paediatric Surgeons of Bangladesh","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127578992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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