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ROLE OF ULTRASOUND-GUIDED HYDROSTATIC REDUCTION OF INTUSSUSCEPTION IN CHILDREN WITH EARLY PRESENTATION 超声引导下流体静压复位术治疗早期患儿肠套叠的作用
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V3I2.23914
S. Hossain, A. Huq, J. Hannan, K. Hasina, Rn Sarker
General objective: To study the efficacy of Ultrasoundguided hydrostatic reduction of intussusception in children with early presentation. Methods: The study group included children aged 03 months to 02 years with early case of intussusception confirmed on ultrasonography. One litre of normal saline bag was suspended at 100 cm height from the patient’s level. After connecting the saline bag with Foley’s catheter introduced in the rectum, gradual distension of colon and retrograde movement of intussusceptum towards the caecum monitored by real time ultrasound.Successful reduction was assumed once mass was disappeared and passage of saline into the small intestine. If 1 st attempt failed but there is some movement of the mass was present and child had no abdominal signs, 2 nd and 3 rd attempts were taken at least 30 min interval. Result: The overall success rate of US-guided hydrostatic reduction of intussusception in children with early presentation was about 90%, with no immediate recurrence and no perforation. Conclusion: Ultrasound guided hydrostatic reduction should be the first line of the treatment in patients with early presentation of intussusceptions aged between 3 months and 2 years old. In cases with failed initial reduction, a second or even third attempt may provide successful reduction. J. Paediatr. Surg. Bangladesh 3 (2): 61-64, 2012 (July)
总目的:探讨超声引导下液体静压复位术治疗早期患儿肠套叠的疗效。方法:研究对象为年龄为03月龄~ 02岁,超声检查证实有早期肠套叠的患儿。将1升生理盐水袋悬浮在离患者水平100厘米的高度。将生理盐水袋与置入直肠的Foley导管连接后,实时超声监测结肠逐渐膨胀,肠套向盲肠逆行运动。一旦肿块消失,生理盐水进入小肠,就假定成功复位。如果第一次尝试失败,但肿块有一些移动,孩子没有腹部征象,第二次和第三次尝试至少间隔30分钟。结果:早期表现的患儿采用us引导下静水复位肠套叠的总成功率约为90%,无立即复发,无穿孔。结论:对于3个月~ 2岁早期出现肠套叠的患者,超声引导下静水复位应作为首选治疗方法。在初次复位失败的情况下,第二次甚至第三次尝试可以提供成功的复位。j . Paediatr。孟加拉外科3 (2):61-64,2012 (7)
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引用次数: 4
Diabetes Mellitus and Gestational Diabetes Mellitus 糖尿病和妊娠期糖尿病
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V5I1.23887
S. Begum, Romena Afroz, Q. Khanam, A. Khanom, T. Choudhury
Diabetes mellitus (DM), also known as simply diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Worldwide in 2012 and 2013 diabetes resulted in 1.5 to 5.1 million deaths per year, making it the 8th leading cause of death. Diabetes overall at least doubles the risk of death. This high blood sugar produces the symptoms of frequent urination, increased thirst, and increased hunger. Untreated, diabetes can cause many complications. Acute complications include diabetic ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include heart disease, stroke, kidney failure, foot ulcers and damage to the eyes. The number of people with diabetes is expected to rise to 592 million by 2035. The economic costs of diabetes globally were estimated in 2013 at $548 billion and in the United States in 2012 $245 billion. [3]Globally, as of 2013, an estimated 382 million people have diabetes worldwide, with type 2 diabetes making up about 90% of the cases. This is equal to 8.3% of the adults’ population, with equal rates in both women and men. There are three main types of diabetes mellitus: In case of type 1 Diabetes mellitus, results from the body’s failure to produce enough insulin. This form was previously referred to as “insulin-dependent diabetes mellitus” (IDDM) or “juvenile diabetes”. The cause is unknown. Another type is type 2 diabetes mellitus begins with insulin resistance, a condition in which cells fail to respond to insulin properly. As the disease progresses a lack of insulin may also develop. This form was previously referred to as “non insulin-dependent diabetes mellitus” (NIDDM) or “adult-onset diabetes”. The primary cause is excessive body weight and not enough exercise. Gestational diabetes is the third main form and occurs when pregnant women without a previous history of diabetes develop a high blood glucose level. Gestational diabetes usually resolves after the birth of the baby. It occurs in about 2–10% of all pregnancies and may improve or disappear after delivery. However, after pregnancy approximately 5–10% of women with gestational diabetes are found to have diabetes mellitus, most commonly type 2. Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy. J. Paediatr. Surg. Bangladesh 5 (1): 30-35, 2014 (January)
糖尿病(DM),也被称为简单的糖尿病,是一组代谢疾病,其中有长期高血糖水平。2012年和2013年,全世界每年有150万至510万人死于糖尿病,使其成为第八大死因。总体而言,糖尿病使死亡风险至少增加一倍。这种高血糖会产生尿频、口渴和饥饿的症状。如果不治疗,糖尿病会引起许多并发症。急性并发症包括糖尿病酮症酸中毒和非酮症高渗性昏迷。严重的长期并发症包括心脏病、中风、肾衰竭、足部溃疡和眼睛损伤。到2035年,糖尿病患者人数预计将增加到5.92亿。据估计,2013年全球糖尿病的经济成本为5480亿美元,2012年美国为2450亿美元。[3]在全球范围内,截至2013年,全球估计有3.82亿人患有糖尿病,其中2型糖尿病约占90%。这相当于成年人口的8.3%,男女比例相等。糖尿病主要有三种类型:1型糖尿病是由身体不能产生足够的胰岛素引起的。这种形式以前被称为“胰岛素依赖性糖尿病”(IDDM)或“青少年糖尿病”。事故原因尚不清楚。另一种类型是2型糖尿病,始于胰岛素抵抗,这是一种细胞不能对胰岛素做出正确反应的情况。随着病情的发展,还可能出现胰岛素缺乏。这种形式以前被称为“非胰岛素依赖型糖尿病”(NIDDM)或“成人发病糖尿病”。主要原因是体重过重和缺乏锻炼。妊娠期糖尿病是第三种主要形式,发生在没有糖尿病病史的孕妇出现高血糖水平时。妊娠期糖尿病通常在婴儿出生后消退。约2-10%的妊娠发生此病,分娩后可能改善或消失。然而,怀孕后,大约5-10%的妊娠糖尿病妇女被发现患有糖尿病,最常见的是2型糖尿病。妊娠期糖尿病是完全可以治疗的,但在整个妊娠期间需要仔细的医疗监督。j . Paediatr。孟加拉外科5 (1):30-35,2014 (1)
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引用次数: 12
DIAGNOSIS OF CONGENITAL ANOMALIES OF KIDNEY AND URETER BY ULTRASONOGRAPHY 先天性肾、输尿管异常的超声诊断
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V5I1.23882
Fathima Nusrath Halim, M. A. Sarker, Farah Nazlee, N. Islam
Present study was conducted to investigate the diagnostic accuracy of transabdominal ultrasonography in correlation with IVU in suspected patients of Congenital anomalies of kidney and Ureter. In study, ultrasonography and IVU was done in 50 clinically suspected patients of congenital anomalies of kidney that was admitted in BSMMU, BIRDEM & DMCH during the period of July 2008 to May 2009. Patients of all ages and both sexes were included. Findings of USG and IVU were correlated. Sonographically abnormalities were diagnosed in 46 (92%) cases, out of which 45 (95.7%) also diagnosed by IVU and 1 (33.3) was normal in IVU. Out of 4 (8%) Sonographically demonstrated normal cases, 2 (4.3%) were proved normal by IVU and 2 (66.7%) cases which missed by sonography were diagnosed by IVU. Sensitivity of ultrasonography in diagnosing congenital kidney disease was 95.7% and specificity was 66.7%, positive predictive value was 97.8%, negative predictive value was 50.0% and accuracy was 94.0%. So, we conclude that ultrasonography has significant sensitivity, specificity, positive predictive value, and accuracy in diagnosis of congenital kidney anomalies correlating with IVU. As such, USG can be considered as an appropriate imaging tool for diagnosis of congenital anomalies of kidney. J. Paediatr. Surg. Bangladesh 5 (1): 8-11, 2014 (January)
探讨经腹超声与IVU对疑似先天性肾、输尿管异常患者的诊断准确性。本研究对2008年7月至2009年5月在BSMMU、BIRDEM和DMCH住院的50例临床疑似先天性肾脏异常患者进行超声和IVU检查。包括所有年龄和性别的患者。USG与IVU结果有相关性。超声异常46例(92%),IVU诊断45例(95.7%),IVU正常1例(33.3%)。4例(8%)超声显示正常,2例(4.3%)超声诊断正常,2例(66.7%)超声诊断漏诊。超声诊断先天性肾脏疾病的敏感性为95.7%,特异性为66.7%,阳性预测值为97.8%,阴性预测值为50.0%,准确率为94.0%。因此,我们认为超声诊断与IVU相关的先天性肾脏异常具有显著的敏感性、特异性、阳性预测值和准确性。因此,超声心动图可作为诊断先天性肾脏异常的合适影像工具。j . Paediatr。孟加拉外科5 (1):8-11,2014 (1)
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引用次数: 1
Comparative study between intralesional Dexamethasone and oral Prednisolone in the treatment of Infantile Hemangioma 地塞米松与泼尼松隆治疗婴幼儿血管瘤的比较研究
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V5I1.23884
T. A. Chowdhury, A. Bhuiyan, Mohammed Hakim
Background : Infantile Hemangioma (IH) is one of the most common childhood neoplasm. Current treatments for children with endangering Infantile Hemangioma are limited, and include primarily oral corticosteroid which has many systemic adverse effects. Furthermore, approximately one third of IH does not respond to oral steroids, prompting active investigations for new treatments. Objective: To compare the efficacy, side effects, and influencing factors of oral Prednisolone and intralesional Dexamethasone (IL) in treatment of IH and thus to find out an effective, cheap and safe modality of treatment for this anomaly. Materials and Methods : This study was carried out on 48 patients of IH with the age range from 1 day to 12 years. Group A (n 1 =26) patients were treated by oral Prednisolone and group B (n 2 =22) patients were treated by IL Dexamethasone .Periorbital Hemangioma and IH >54 cubic centimeter were excluded. Therapeutic response of Prednisolone and Dexamethasone was graded as excellent, good, poor and no response. We monitored volume of the lesion and its color change to evaluate the response to treatment. Results: Overall therapeutic responses were 69.2% in Group A and 68.2% in group B. Side effects were noted in 65.4% patient of group A and 36.4% patient of group B. In group A, the commonest (38.5%) side effect was excessive weight gain with cushingoid facies and in group B, commonest (27.3%) side effect was ulceration at injection site. Side effects were more in children of group A. Range of treatment was 4-20 weeks in group A and in group B, it was 4-24 weeks. Conclusion : IL Dexamethasone is effective as oral Prednisolone for treatment of IH .Unlike Prednisolone, IL Dexamethasone is devoid of systemic side effects. J. Paediatr. Surg. Bangladesh 5 (1): 12-19, 2014 (January)
背景:婴幼儿血管瘤是儿童最常见的肿瘤之一。目前对儿童危险血管瘤的治疗是有限的,主要包括口服皮质类固醇,这有许多全身不良反应。此外,大约三分之一的IH对口服类固醇没有反应,促使积极研究新的治疗方法。目的:比较口服强的松龙与局部地塞米松治疗IH的疗效、毒副作用及影响因素,探索有效、廉价、安全的治疗IH的方法。材料与方法:本研究纳入48例IH患者,年龄从1天到12岁不等。A组(n 1 =26)口服强的松龙治疗,B组(n 2 =22)口服地塞米松治疗,排除眼眶周围血管瘤和ihbb0 54立方厘米。强的松和地塞米松的疗效分为优、良、差和无疗效。我们监测病变的体积和颜色变化来评估对治疗的反应。结果:A组和B组的总有效率分别为69.2%和68.2%。A组和B组的副作用发生率分别为65.4%和36.4%。A组中最常见的副作用为库欣样相体重过度增加(38.5%),B组中最常见的副作用为注射部位溃疡(27.3%)。A组患儿副反应较多,治疗时间A组为4 ~ 20周,B组为4 ~ 24周。结论:地塞米松可作为口服强的松龙治疗IH,与强的松龙不同,地塞米松无全身副作用。j . Paediatr。孟加拉外科5 (1):12-19,2014 (1)
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引用次数: 1
Pediatric Laparoscopic Surgery: Four Years Experience in Dhaka Medical College Hospital 儿童腹腔镜手术:在达卡医学院医院四年的经验
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V4I1.23929
Tahmina Hossain, A. Huq
Purpose: Laparoscopy is gaining popularity over laparotomy in various surgical conditions. Now a day, an increasing number of diagnostic and therapeutic surgical procedures are being done laparoscopically. The aim of this study was to assess the safety and feasibility of laparoscopy in children. Materials and Methods : This retrospective study was carried out in the Department of Pediatric Surgery of Dhaka Medical College Hospital over a period of 52 (Fifty two) months from June 2009 to August 2013. A total of 123 patients were operated laparoscopically up to 12 years of age for different surgical conditions. Data was collected from the hospital records and analyzed retrospectively. Results: Out of these 123 laparoscopically performed cases, Appendectomy was performed in 39 cases, closure of internal inguinal ring for Inguinal Hernia was done in 36 patients, 20 patients underwent Cholecystctomy, 16 patients had laparoscopic procedures for impalpable Undescended Testis (UDT), 5 patients were operated for Adnexal Mass of which one case was converted into open procedure due to technical difficulties and 1 for Pancreatic Pseudo cyst. Diagnostic Laparoscopy was performed for 2 patients with Biliary Atresia and 4 patients for Ambiguous Genitalia. Median age of the patients was 6.08 years (ranging from 2 months to 12 years of age). The length of post operative hospital stay was 2-3 days. All the laparoscopic procedures for Inguinal Hernia and impalpable UDT were performed as day care surgery. Operative and post operative complications were minimal. Other advantages of the laparoscopic procedures were smaller incisions, incidental diagnosis of other associated pathology, lesser post operative pain, earlier oral feeding, quicker mobilization and a better cosmetic result. Conclusion: With the recent development of laparoscopic surgical techniques and equipments, laparoscopic surgical procedures are becoming popular day by day and can be performed safely for both diagnostic and therapeutic purposes in pediatric surgical patients. J. Paediatr. Surg. Bangladesh 4 (1): 11-18, 2013 (January)
目的:在各种手术条件下,腹腔镜手术比剖腹手术越来越受欢迎。现在,越来越多的诊断和治疗外科手术正在腹腔镜下进行。本研究的目的是评估儿童腹腔镜手术的安全性和可行性。材料与方法:本回顾性研究于2009年6月至2013年8月在达卡医学院附属医院儿科外科进行,为期52(52)个月。在不同的手术条件下,共有123例12岁以下的患者接受腹腔镜手术。从医院记录中收集数据并进行回顾性分析。结果:123例腹腔镜下行阑尾切除术39例,腹股沟疝行腹股沟内环闭合术36例,胆囊切除术20例,腹腔镜下行不可触及性隐睾(UDT)手术16例,行附件肿块手术5例,其中1例因技术困难转开腹手术,1例胰假性囊肿手术。诊断性腹腔镜治疗胆道闭锁2例,阴部不清4例。患者中位年龄为6.08岁(2个月~ 12岁)。术后住院时间2 ~ 3天。所有腹股沟疝的腹腔镜手术和不可触及的UDT均作为日间护理手术进行。手术及术后并发症极少。腹腔镜手术的其他优点是切口较小,其他相关病理的偶然诊断,术后疼痛较小,早期口服喂养,更快的活动和更好的美容效果。结论:随着腹腔镜手术技术和设备的发展,腹腔镜手术日益普及,在儿科外科患者的诊断和治疗中均可安全进行。j . Paediatr。孟加拉外科4 (1):11-18,2013 (1)
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引用次数: 0
Immediate Outcome of Neonate With Pneumothorax 新生儿气胸的直接预后
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V5I1.23880
M. Begum, Z. Haque, Mahmuda Hassan, A. Mannan, N. Jahan
Objectives : To determine the outcome of pneumothorax in term and post term neonates. Study Design : Neonates presented with respiratory distress and diagnosed pneumothorax by X-ray at the time of admission or during the course of hospital stay were included in this study. Results: Total 49 cases were included for the study, among them 29(59.18%)were male and 20(40.82%) female, 42(85%)babies cured and 7(15%)expired. Thirty-five (71.46%) delivered by LUCS, 14(28.57%) by NVD. Pneumothorax associated with maternal risk factors like UTI 10(21.2%), PROM 5(10.2%), GDM 2(4.2%)cases, PIH 1(2.0%), PET 1(2%), were observed. No maternal risk factor has been identified in 25(51%)cases and 4(8.1%)cases due to other reason. Nineteen neonates (38.77%) with meconium aspiration syndrome, 14(28.57%) required PPV, 10(20.40%) with pneumonia 2(4.08%) with congenital heart disease, 2(4.08%) with TTN, pneumothorax 2(4.02%). Total 40(81.63%) cases were in patient, only 3(7.5%) of them died, 9(18.36%) babies were out patient among them 4(8.16%) died, (P value Â0.001). Significant death were seen among those who admitted after 24 hours of age, 3 out of 6 cases). Four (8.16) out of 36(73.4%)expired who admitted before 24 hours of age, (P value  0.001.) Pneumothorax were managed by nitrogen wash out 29(59.18%), 5(10.20%) needle aspiration with high flow oxygen, 5(10.20%)needed needle aspiration, chest tube with high flow oxygen. Ten (20.40%)babies needed needling, chest tube drainage with ventilator, among them 6(12.24%)expired and 4 survived. No death were observed among the neonates who were managed with high flow oxygen. Conclusions: High index of suspicion, prompt diagnosis by cold light and urgent portable X-ray and immediate intervention is needed for life saving and better outcome J. Paediatr. Surg. Bangladesh 5 (1): 3-7, 2014 (January)
目的:探讨足月及足月后新生儿气胸的预后。研究设计:在入院时或住院期间以呼吸窘迫和x线诊断为气胸的新生儿纳入本研究。结果:共纳入49例患儿,其中男29例(59.18%),女20例(40.82%),患儿治愈42例(85%),死亡7例(15%)。LUCS交付35例(71.46%),NVD交付14例(28.57%)。气胸与产妇危险因素如UTI 10(21.2%)、PROM 5(10.2%)、GDM 2(4.2%)、PIH 1(2.0%)、PET 1(2%)相关。25例(51%)未发现产妇危险因素,4例(8.1%)为其他原因所致。胎粪吸入综合征19例(38.77%),PPV 14例(28.57%),肺炎10例(20.40%),合并先天性心脏病2例(4.08%),TTN 2例(4.08%),气胸2例(4.02%)。住院40例(81.63%),死亡3例(7.5%),门诊9例(18.36%),死亡4例(8.16%)(P值Â0.001)。在24小时后入院的患者(6例中有3例)中出现明显死亡。未满24小时入院的患者中,有4人(8.16人)(73.4%)死亡(P值Â 0.001)。气胸采用氮气洗出29例(59.18%),高流量吸氧针吸5例(10.20%),需要吸氧针吸5例(10.20%),胸管高流量吸氧。10例(20.40%)患儿需要穿刺、胸管引流并使用呼吸机,其中死亡6例(12.24%),存活4例。使用高流量氧气治疗的新生儿无死亡。结论:疑点高,应及时冷光及紧急便携式x线检查诊断,及时干预,挽救生命,改善预后。孟加拉外科5(1):2014年1月3-7日
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引用次数: 2
Collaboration in Pediatric Surgical Training & Education among Asian Countries & Beyond Bangladesh perspective 亚洲国家和孟加拉国以外地区的儿科外科培训与教育合作
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V3I2.23912
Abdul Hanif Tablu
Bangladesh is one of the most densely populated countries & while still a developing economy, has significant improvements in health and social development. Per capita income was only US $ 78 in 1972-just after independence which is now reached US$ 1044 and Bangladesh is now going to enter into middle income country! Though agriculture, garments industry & remittance have played a major role in economy it has been at the forefront of several advances in development and health. Oral Rehydration Solution (ORS) was developed and popularized in Bangladesh. It has been credited with saving 40 million lives worldwide. Bangladesh is on the right track in achieving millennium development goals & due to reduction of under five mortality rate Hon’ble Prime Minister Sheikh Hasina has received MDG 4 award from the United Nations in 2010. The micro-credit movement pioneered by Grameen Bank and Nobel laureate Professor Yunus is now a global phenomenon and also directly resulted in improvement of health care at the grass-root level.
孟加拉国是人口最密集的国家之一,虽然仍是一个发展中经济体,但在卫生和社会发展方面取得了重大进展。1972年人均收入只有78美元,刚刚独立,现在达到1044美元,孟加拉国现在即将进入中等收入国家!虽然农业、服装业和汇款在经济中发挥了重要作用,但它在发展和卫生方面一直处于若干进步的前沿。口服补液(ORS)在孟加拉国得到开发和推广。它被认为在全世界挽救了4000万人的生命。孟加拉国在实现千年发展目标方面走在正确的轨道上,由于降低了五岁以下儿童死亡率,谢赫·哈西娜总理于2010年获得联合国千年发展目标4奖。由格莱珉银行和诺贝尔奖得主尤努斯教授开创的小额信贷运动现已成为一种全球现象,并直接导致了基层医疗保健的改善。
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引用次数: 0
Effects of multiple micronutrients (MMN) on ovulation inductionin subfertile women with PCOS 多种微量营养素(MMN)对多囊卵巢综合征低生育能力妇女促排卵的影响
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V4I2.23938
J. Banu, F. Deeba, P. Sultana, A. Chowdhury, A. Khan
Introduction: PCOS is a very common disorder of reproductive women characterized by hyperandrogenism and chronic auovulation. The beneficial effects on micronutrients supplements may have been mediated not only through the presence of multiple vitamin & minerals and multiple antioxidant such as vitamin C and vitamin E. It also mediated insulin sensitization with inositol and improvement of the blood flow in the pelvic organ with the presence of L-arginine. Multiple micronutrients supplementation is a cost effective remedy that is well tolerated with no adverse effects. Its use as an adjuvant in fertility treatment may benefit women pre conceptionaly. Objective: The aims of this study was to investigate the effects of MMN in subfertile women with PCOS.And also to demonstrate that MMN is act as adjuvant therapy to a standard ovulation induction regimen. And to identify ovulation rate and pregnancy rate. Materials and methods: This is a prospective randomized control trial. In this study total 100 patients between the age of 20-40 years were taken from infertility OPD, BSMMU and in private sector, Baridhara, Dhaka, during the period from July 2011 to June 2012.Among 100 patients 50 infertile patients undergoing ovulation induction for 3 months were allocated to receive adjuvant MMN treated as group A. 50 infertile patient undergoing ovulation induction were not allocated to receive adjuvant treated as group B. Results : Clinical pregnancy rate are assessed after third cycle or as soon as the women achieved pregnancy. There was no significant differences in age, menstrual history, BMI (kg/m2) in both groups. This difference was statistically significant p 9mm in 31 patients and less than 9mm in 11 patients with case group compared with the control group >9mm 11 patient and <9mm in 17 patients which is statistically significant p value <0.05. There was no significant difference in progesterone in both groups. There were 22 of 50 patient conceived during the study 2 miscarriage in first trimester in group A and 6 of 50 are conceived in group B and 2 miscarriage in 1 st trimester. There was significant difference pregnancy rate p <0.001. Discussion: Our study is to demonstrate that multiple micronutrients supplementation is adjuvant therapy to a standard ovulation induction regimen in women undergoing treatment for anovulatory PCOS patients. The effect of this adjuvant therapy is improved the ovulation and pregnancy rate. Women who take adjuvant micronutrients supplementation during ovulation induction have a higher chance of pregnancy compared with women without micronutrients supplementation. Conclusions: Women who take adjuvant micronutrients supplementation during ovulation induction have a higher chance of pregnancy compared with women without micronutrients supplementation. J. Paediatr. Surg. Bangladesh 4 (2): 50-53, 2013 (July)
简介:多囊卵巢综合征是一种非常常见的生殖女性疾病,其特征是雄激素分泌过多和慢性排卵。微量营养素补充剂的有益作用可能不仅是通过多种维生素和矿物质以及多种抗氧化剂如维生素C和维生素e介导的,还通过肌醇介导胰岛素增敏,并通过l -精氨酸改善盆腔器官的血流量。多种微量营养素补充是一种成本有效的补救措施,耐受性好,无不良反应。它作为辅助治疗生育可能有利于妇女孕前。目的:本研究的目的是探讨MMN对多囊卵巢综合征不孕妇女的影响。同时也证明MMN可以作为标准促排卵疗法的辅助疗法。确定排卵率和怀孕率。材料和方法:这是一项前瞻性随机对照试验。在这项研究中,从2011年7月至2012年6月期间,共有100名年龄在20-40岁之间的患者从不孕不育OPD, BSMMU和私营部门,Baridhara, Dhaka。在100例患者中,50例诱导排卵3个月的不孕患者被分配接受辅助MMN治疗,作为a组。50例诱导排卵的不孕患者未被分配接受辅助MMN治疗,作为b组。结果:在第三周期后或刚怀孕时评估临床妊娠率。两组患者的年龄、月经史、体重指数(kg/m2)差异无统计学意义。差异有统计学意义p <9mm 31例,小于9mm 11例,病例组与对照组>9mm 11例,<9mm 17例,p <0.05。两组患者孕酮水平无显著差异。50例妊娠患者中,A组有22例妊娠早期流产2例,B组有6例妊娠早期流产2例。妊娠率差异有统计学意义p <0.001。讨论:我们的研究是为了证明补充多种微量营养素对于接受无排卵性PCOS治疗的女性来说是标准促排卵方案的辅助治疗。这种辅助治疗的效果是提高排卵和妊娠率。在促排卵期间补充辅助微量营养素的妇女与没有补充微量营养素的妇女相比,怀孕的机会更高。结论:与未补充微量营养素的妇女相比,在促排卵期间补充辅助微量营养素的妇女怀孕的机会更高。j . Paediatr。孟加拉外科4 (2):50-53,2013 (7)
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引用次数: 1
Effect of Preoperative Chemotherapy in the Treatment of Advanced Wilms’ Tumor 术前化疗在晚期肾母细胞瘤治疗中的作用
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V3I2.23913
K. Hasina, K. Hassan, A. Hanif, A. Khan, Muh. Syaiful Islam
Introduction: The management of Wilms’ tumor still remains a matter of great challenge to pediatric surgeons and also to pediatric oncologists. The tumor continues to be the subject of intensive investigations that with the aid of co-operative protocols by the National Wilms’ Tumor Study (NWTS) have resulted in marked improvement in survival. Surgical excision remains the cornerstone of treatment of Wilms’ tumor; however the dramatic improvement in overall survival is the result of coordinated use of surgery, chemotherapy and radiation therapy. Materials and methods: This was a prospective study, started in September, 1999 and completed in November, 2000 in Pediatric Surgery department of Dhaka Shishu (Children) Hospital and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Preoperative chemotherapy was given to all the patients of advanced Wilms’ tumor for four weeks with vincristine and actinomycin D according to the Societe Internationale d’ Oncologie Pediatrique (SIOP) protocol (Herdrich K, 1982). The patients were followed up every 2 weekly by ultrasonography, LFT, Hb% and chest X-ray for one month. The size of the tumor as well as the metastatic lesions in the prechemotherapeutic and postchemotherapeutic ultrasonographic findings was compared after one month. Results: After giving neoadjuvant chemotherapy, the size of the tumor was reduced in 08 patients and it was measured by USG after one month. The change in the metastatic lesions was also compared by USG at the same time. Two patients died during the course of neoadjuvant chemotherapy and nephroureterectomy was done in 08 patients. All the resected specimens were sent for histopathology. The reports revealed features of Wilms’ tumor with favorable histology (FH) in 07 cases and unfavorable histology (UH) in 01 case. Conclusion: It is evident from this study that advanced stage of Wilms’ tumor, where operative treatment was not primarily possible, preoperative chemotherapy downsized the tumor significantly. It is then possible to perform nephroureterectomy. J. Paediatr. Surg. Bangladesh 3 (2): 56-60, 2012 (July)
对小儿外科医生和儿科肿瘤学家来说,Wilms肿瘤的治疗仍然是一个巨大的挑战。在国家威尔姆斯肿瘤研究(NWTS)的合作方案的帮助下,该肿瘤继续成为深入研究的主题,其生存率显著提高。手术切除仍然是治疗Wilms肿瘤的基石;然而,总体生存率的显著提高是手术、化疗和放疗协调使用的结果。材料和方法:这是一项前瞻性研究,于1999年9月开始,2000年11月在达卡Shishu(儿童)医院和Bangabandhu Sheikh Mujib医科大学(BSMMU)儿科外科完成。所有晚期Wilms肿瘤患者术前根据国际儿科肿瘤学协会(SIOP)方案(Herdrich K, 1982)给予长春新碱和放线菌素D化疗4周。每2周对患者进行超声、LFT、Hb%、胸片随访1个月。一个月后比较化疗前和化疗后超声检查肿瘤大小及转移灶情况。结果:08例患者接受新辅助化疗后,肿瘤体积减小,1个月后用USG测量。同时用USG比较转移灶的变化。2例患者在新辅助化疗过程中死亡,08例患者行肾输尿管切除术。所有切除标本送组织病理学检查。本组报告的Wilms肿瘤表现为组织学有利(FH)者07例,组织学不利(UH)者01例。结论:从本研究中可以明显看出,在手术治疗不可能的晚期Wilms肿瘤中,术前化疗可以显著缩小肿瘤。然后可以进行肾输尿管切除术。j . Paediatr。孟加拉外科3 (2):56-60,2012 (7)
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引用次数: 0
Birth Defect: An Over view 出生缺陷:概观
Pub Date : 2015-06-30 DOI: 10.3329/JPSB.V4I2.23940
N. Begum, S. Mahmood, P. S. Nahar, S. Islam, B. S. Naher, A. Huq
Birth defects are a leading cause of infant death, accounting for more than 1 of every 5 infant deaths. Every year more than 8.14 million children are born with a serious birth defect, due to genetic or environmental causes. In the low and middle income countries the burden of birth defects is much higher than in highincome countries. Birth defects may be due to chromosomal, single-gene or multifactorial causes. Environmental factors are responsible for 5–10% of total birth defects, and include nutritional deficiencies, infectious diseases, maternal medical conditions, teratogenic medications, alcohol, recreational drugs, and teratogenic pollutants. Birth defects can be diagnosed during pregnancy or after the baby is born, depending on the specific type of birth defect. Of course, many birth defects cannot be prevented; this is especially true of defects that have a genetic component. However, ultrasonography and maternal serum screening can be used to detect serious foetal anomalies, including neural tube defects and chromosomal disorders. Early detection and treatment of birth defects can help prevent stillbirth or physical and intellectual disabilities. J. Paediatr. Surg. Bangladesh 4 (2): 58-66, 2013 (July)
出生缺陷是婴儿死亡的主要原因,占婴儿死亡人数的五分之一以上。由于遗传或环境原因,每年有超过814万儿童出生时患有严重的先天缺陷。在低收入和中等收入国家,出生缺陷的负担远高于高收入国家。出生缺陷可能是由染色体、单基因或多因素引起的。环境因素占出生缺陷总数的5-10%,包括营养缺乏、传染病、产妇医疗条件、致畸药物、酒精、娱乐性药物和致畸污染物。根据出生缺陷的具体类型,可以在怀孕期间或婴儿出生后诊断出出生缺陷。当然,许多先天缺陷是无法预防的;对于有遗传成分的缺陷尤其如此。然而,超声检查和母体血清筛查可用于检测严重的胎儿异常,包括神经管缺陷和染色体疾病。早期发现和治疗出生缺陷有助于预防死产或身体和智力残疾。j . Paediatr。孟加拉外科4 (2):58-66,2013 (7)
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引用次数: 0
期刊
Journal of Paediatric Surgeons of Bangladesh
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