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Traditional food security and food sovereignty in the coastal region of South-Central Alaska. 阿拉斯加中南部沿海地区的传统粮食安全和粮食主权。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-05-24 DOI: 10.1080/22423982.2024.2359161
Joseph Nyholm, Amanda Walch, Leslie Redmond

A food assessment questionnaire was completed by Alutiiq and Eyak peoples of the Chugach Region of Alaska in 2016-2017. This questionnaire, conducted by the Chugach Regional Resource Commission, gathered 87 responses from adults residing in seven communities. The questions related to traditional food systems, food security, and food sovereignty and were organised into six sections: Community Food Resources, Diet and Health, Culture, Organisation and Governance, Food Resources, and Natural Resources and Environment. Nine questions directly addressed food sovereignty. Results revealed the importance of traditional food sources in the communities, foods that are not readily available or are difficult to access, resources that are useful to improve traditional food security, health problems that are perceived to be caused or exacerbated by the lack of traditional foods in the area, traditional foods commonly consumed, and barriers from accessing traditional foods. Additionally, recommendations for improving food systems and addressing barriers are provided.

2016-2017 年,阿拉斯加楚加奇地区的阿鲁蒂克人和埃雅克人完成了一份食物评估问卷。该问卷由楚加奇地区资源委员会进行,收集了居住在七个社区的成年人的 87 份答复。问题涉及传统粮食系统、粮食安全和粮食主权,分为六个部分:社区食物资源、饮食与健康、文化、组织与管理、食物资源以及自然资源与环境。九个问题直接涉及粮食主权。结果显示了传统食物来源在社区中的重要性、不容易获得或难以获得的食物、有助于改善传统食物安全的资源、认为因该地区缺乏传统食物而导致或加剧的健康问题、通常食用的传统食物以及获得传统食物的障碍。此外,还提供了改善食物系统和消除障碍的建议。
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引用次数: 0
Updated review on contaminant communication experiences in the circumpolar Arctic. 北极圈污染物传播经验的最新回顾。
IF 1.3 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-12-01 Epub Date: 2024-07-10 DOI: 10.1080/22423982.2024.2371623
Eva M Krümmel, Amanda D Boyd, Danielle Brandow, Michael Brubaker, Chris M Furgal, Robert Gerlach, Brian D Laird, Mélanie Lemire, Lisa L Loseto, Gert Mulvad, Shannon P O'Hara, Kristin Olafsdottir, Jennifer F Provencher, Mylène Ratelle, Arja Rautio, Kelly Skinner, Pál Weihe, Maria Wennberg

Arctic populations are amongst the highest exposed populations to long-range transported contaminants globally, with the main exposure pathway being through the diet. Dietary advice is an important immediate means to address potential exposure and help minimize adverse health effects. The objective of this work is to enable easier access to dietary advice and communication guidance on contaminants with a focus on the Arctic. This manuscript is part of a special issue summarizing the Arctic Monitoring and Assessment Programme's Assessment 2021: Human Health in the Arctic. The information was derived with internet searches, and by contacting relevant experts directly. Results include risk communication efforts in European Arctic countries, effectiveness evaluation studies for several Arctic countries, experience of social media use, and the advantages and challenges of using social media in risk communication. We found that current risk communication activities in most Arctic countries emphasize the importance of a nutritious diet. Contaminant-related restrictions are mostly based on mercury; a limited amount of dietary advice is based on other contaminants. While more information on effectiveness evaluation was available, specific information, particularly from Arctic countries other than Canada, is still very limited.

北极居民是全球接触远距离迁移污染物最多的人群之一,主要接触途径是饮食。膳食建议是解决潜在暴露问题的重要直接手段,有助于最大限度地减少对健康的不利影响。这项工作的目的是使人们更容易获得有关污染物的膳食建议和交流指导,重点关注北极地区。本手稿是北极监测与评估计划《2021 年评估:北极地区的人类健康》特刊的一部分。信息来源于互联网搜索和直接联系相关专家。结果包括欧洲北极国家的风险交流工作、几个北极国家的效果评估研究、社交媒体的使用经验以及在风险交流中使用社交媒体的优势和挑战。我们发现,大多数北极国家目前的风险交流活动都强调营养饮食的重要性。与污染物相关的限制大多以汞为基础;而针对其他污染物的饮食建议数量有限。虽然有更多关于效果评估的信息,但具体信息,尤其是来自加拿大以外的北极国家的信息仍然非常有限。
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引用次数: 0
Living with chronic obstructive pulmonary disease or type 2 diabetes in Greenland - a qualitative interpretive description study. 格陵兰慢性阻塞性肺病或 2 型糖尿病患者的生活--定性解释性描述研究。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2023-12-21 DOI: 10.1080/22423982.2023.2296706
Maja Hykkelbjerg Nielsen, Annesofie Lunde Jensen, Michael Lynge Pedersen, Lene Seibæk

Non-communicable diseases such as chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2D) represent major challenges for health systems all over the world. In an interview study, we explored patient experiences and perspectives of being diagnosed and living with COPD or T2D in Greenland. Participants (n = 24) were selected by purposeful sampling and recruited by phone. We conducted individual semi-structured interviews at the National Hospital in Nuuk and the four regional hospitals. Interviews were audio-recorded, transcribed verbatim, and analysed using interpretive description. Three themes emerged: shock and shame on receiving the diagnosis, coping with a changed life, and varying needs for care and communication. We found that being diagnosed with COPD or T2D required a rapid change in the participants' everyday lives and lifestyle behaviours. Some self-managed their disease well and were able to transfer their knowledge and integrate it into their daily lives, while others struggled to make lifestyle changes. Additionally, living with COPD or T2D could be related to silence and shame. The findings contribute to a better understanding of living with COPD or T2D in the Arctic region and the development of future, culturally-adapted patient education initiatives.

慢性阻塞性肺病(COPD)和 2 型糖尿病(T2D)等非传染性疾病是全世界卫生系统面临的主要挑战。在一项访谈研究中,我们探讨了格陵兰患者被诊断出患有慢性阻塞性肺病或 T2D 并在其中生活的经历和观点。参与者(n = 24)是通过有目的的抽样和电话招募选出的。我们在努克国立医院和四家地区医院进行了个人半结构化访谈。我们对访谈进行了录音、逐字记录,并使用解释性描述法进行了分析。访谈中出现了三个主题:接受诊断时的震惊和羞愧、应对生活的改变以及对护理和沟通的不同需求。我们发现,被诊断出患有慢性阻塞性肺病或肺结核后,参与者的日常生活和生活行为需要迅速改变。有些人能够很好地自我管理疾病,并将所学知识融入日常生活,而有些人则在改变生活方式方面举步维艰。此外,患有慢性阻塞性肺病或肺结核可能与沉默和羞耻感有关。这些研究结果有助于更好地了解北极地区慢性阻塞性肺病或肺结核患者的生活状况,并有助于未来制定适应当地文化的患者教育计划。
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引用次数: 0
Using latent class analysis to operationalize a wholistic assessment of Inuit health and well-being. 利用潜类分析对因纽特人的健康和福祉进行整体评估。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-03-11 DOI: 10.1080/22423982.2024.2322186
Morgen Bertheussen, Mylene Riva, Brittany Wenniserí Iostha Jock, Christopher Fletcher, Pierre Ayotte, Gina Muckle, Natalia Poliakova, Richard Bélanger

Many indigenous cultures conceptualize health wholistically, whereby physical, mental, spiritual and relational dimensions of health are interconnected. Yet, quantitative approaches to studying Indigenous health remain anchored in western perspectives, that separate the dimensions of health. This paper aims to operationalize a wholistic indicator of health based on the IQI model of Inuit health. Variables from the 2017 Nunavik Health Survey (N = 1196) were selected based on their representativeness of IQI model. Exploratory Latent Class Analysis (LCA) was used to identify wholistic health profiles. Once participants assigned to their health profile, sociodemographic characteristics were compared across profiles, and multinomial regression models were used to examine the relationship between community-level social determinants of health and the profiles. The LCA revealed three health profiles, labelled as "excellent", "good" and "fair" based on the distribution of answers to the indicators. Nunavimmiut in "excellent" and "good" health were more likely to: rate their health positively; be over 30 years old; be in a relationship; and have participated or volunteered in community events. Nunavimmiut in "fair" health tended to report lower levels of community cohesion, family relationships, and emotional support. Intergrating culturally relevant models of health can support improved health status assessments and identify opportunities for health promotion.

许多原住民文化对健康的概念是全面的,即身体、心理、精神和关系层面的健康是相互关联的。然而,研究原住民健康的定量方法仍以西方观点为基础,将健康的各个维度分开。本文旨在根据因纽特人健康的 IQI 模型,对整体健康指标进行操作化。根据 IQI 模型的代表性,选择了 2017 年努纳维克健康调查(N = 1196)中的变量。探索性潜类分析(LCA)用于识别整体健康特征。一旦参与者被分配到自己的健康档案,则对不同档案的社会人口特征进行比较,并使用多项式回归模型来研究社区层面的健康社会决定因素与档案之间的关系。生命周期评估显示了三种健康状况,根据指标答案的分布分为 "优秀"、"良好 "和 "一般"。健康状况 "极佳 "和 "良好 "的努纳维米安人更有可能:对自己的健康状况给予积极评价;年龄在 30 岁以上;有伴侣;参加过社区活动或做过志愿者。健康状况 "一般 "的努纳维米人往往在社区凝聚力、家庭关系和情感支持方面表现较差。纳入与文化相关的健康模式可以支持改进健康状况评估,并确定促进健康的机会。
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引用次数: 0
The use of artificial intelligence to assess diabetic eye disease among the Greenlandic population. 利用人工智能评估格陵兰岛居民的糖尿病眼病。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI: 10.1080/22423982.2024.2314802
Trine Jul Larsen, Maria Bråthen Pettersen, Helena Nygaard Jensen, Michael Lynge Pedersen, Henrik Lund-Andersen, Marit Eika Jørgensen, Stine Byberg

Background: Retina fundus images conducted in Greenland are telemedically assessed for diabetic retinopathy by ophthalmological nurses in Denmark. Applying an AI grading solution, in a Greenlandic setting, could potentially improve the efficiency and cost-effectiveness of DR screening.Method: We developed an AI model using retina fundus photos, performed on persons registered with diabetes in Greenland and Denmark, using Optos® ultra wide-field scanning laser ophthalmoscope, graded according to ICDR.Using the ResNet50 network we compared the model's ability to distinguish between different images of ICDR severity levels in a confusion matrix.Results: Comparing images with ICDR level 0 to images of ICDR level 4 resulted in an accuracy of 0.9655, AUC of 0.9905, sensitivity and specificity of 96.6%.Comparing ICDR levels 0,1,2 with ICDR levels 3,4, we achieved a performance with an accuracy of 0.8077, an AUC of 0.8728, a sensitivity of 84.6% and a specificity of 78.8%. For the other comparisons, we achieved a modest performance.Conclusion: We developed an AI model using Greenlandic data, to automatically detect DR on Optos retina fundus images. The sensitivity and specificity were too low for our model to be applied directly in a clinical setting, thus optimising the model should be prioritised.

背景:丹麦的眼科护士在格陵兰岛通过远程医疗方式对视网膜眼底图像进行糖尿病视网膜病变评估。在格陵兰环境中应用人工智能分级解决方案,有可能提高糖尿病视网膜病变筛查的效率和成本效益:我们使用 Optos® 超宽视场扫描激光眼底镜为格陵兰和丹麦的糖尿病登记患者拍摄了视网膜眼底照片,并根据 ICDR 进行了分级,利用 ResNet50 网络开发了一个人工智能模型:将 ICDR 0 级图像与 ICDR 4 级图像进行比较,准确率为 0.9655,AUC 为 0.9905,灵敏度和特异性均为 96.6%。将 ICDR 0、1、2 级与 ICDR 3、4 级进行比较,我们的准确率为 0.8077,AUC 为 0.8728,灵敏度为 84.6%,特异性为 78.8%。在其他比较中,我们的表现一般:我们利用格陵兰岛的数据开发了一个人工智能模型,用于自动检测 Optos 视网膜眼底图像上的 DR。由于灵敏度和特异性太低,我们的模型无法直接应用于临床,因此应优先优化模型。
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引用次数: 0
Repeated freezing to very low temperatures does not impact the amount ejected from EpiPen® and Jext® adrenaline autoinjectors. 反复低温冷冻不会影响 EpiPen® 和 Jext® 肾上腺素自动注射器的喷射量。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-06-14 DOI: 10.1080/22423982.2024.2367273
Felix N R Wood, Rosemary Hartley, Rebecca Boys, Timothy Parham, Jonathon Lowe, Matthew Warner

It has previously been shown that EpiPen® autoinjectors are likely to activate normally following up to five excursions to -25°C but data about the post-freezing performance of other brands of adrenaline autoinjectors has not previously been published. Additionally, conditions experienced by polar medics may be substantially colder than this and the performance of adrenaline autoinjectors following more extreme freeze-thaw cycles remains uncharacterised. Investigators in Antarctica and the United Kingdom performed laboratory testing on two brands of adrenaline autoinjector, EpiPen® and Jext® (12 devices of each type). A single freeze-thaw cycle involved freezing the device to -80°C then allowing it to come to room temperature. Devices were exposed to 0, 1, 5 or 15 freeze-thaw cycles. The mass of liquid ejected from each device, when activated, was then measured. No significant differences in the mass of the liquid ejected was found between the test groups. Multiple freeze-thaw cycles to -80°C are unlikely to significantly impact the amount of adrenaline solution expelled from EpiPen® and EpiPen® autoinjectors. This preliminary finding encourages further work investigating the safety and effectiveness of adrenaline autoinjectors after exposure to very low temperatures. This information would be valuable for future polar medics planning and delivering medical provision in extreme environments.

以前的研究表明,EpiPen® 自动注射器在摄氏零下 25 度的环境中最多可以正常启动五次,但有关其他品牌肾上腺素自动注射器冷冻后性能的数据以前尚未公布。此外,极地医疗人员所经历的条件可能比这还要冷得多,肾上腺素自动注射器在更极端的冻融循环后的性能仍未得到描述。南极洲和英国的研究人员对 EpiPen® 和 Jext® 两种品牌的肾上腺素自动注射器进行了实验室测试(每种设备各 12 支)。单次冻融循环包括将设备冷冻到零下 80 摄氏度,然后让其恢复到室温。装置分别经过 0、1、5 或 15 次冻融循环。然后测量每个装置在激活时喷出的液体质量。测试组之间喷出液体的质量没有明显差异。多次-80°C冻融循环不太可能对 EpiPen® 和 EpiPen® 自动注射器排出的肾上腺素溶液量产生重大影响。这一初步发现有助于进一步研究肾上腺素自动注射器暴露于极低温度后的安全性和有效性。这些信息对于未来极地医疗人员在极端环境中规划和提供医疗服务非常有价值。
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引用次数: 0
Subarachnoid haemorrhage and intracranial aneurysms in Greenland in the period 2018-2021: incidence, outcome and familial disposition. 2018-2021年期间格陵兰岛的蛛网膜下腔出血和颅内动脉瘤:发病率、结果和家族性。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-05-24 DOI: 10.1080/22423982.2024.2356889
Joo Roerholm Svendsen, Michael Lynge Pedersen, John Hauerberg, Ole Gredal

Subarachnoid haemorrhages (SAH) caused by rupture of intracranial aneurysms (IA) are a severe condition. Earlier studies found a higher incidence of SAH in Greenlandic patients compared to Danish patients, with familial aggregation also higher in Greenland. However, updated data is lacking. To investigate the contemporary incidence, outcome, and familial disposition of SAH/IA in Greenlandic patients in 2018-2021. Greenlandic patients diagnosed with ruptured or unruptured IA (UIA) during 2018-2021 were included. Data was obtained from patient files, x-ray department, and discharge registry. Incidence rates were estimated as cases/100,000/year. Direct age-standardised incidence rates were calculated using WHO 2000-2025 as standards. Of 30 SAH patients, 20 (66.7%) were females, 10 (33.3%) males. Of 36 UIA patients, 27 (75.0%) were females, 9 (25.0%) males. For SAH, crude incidence was 13.4/100,000/year, age-standardised incidence was 10.8/100,000/year. Familial history was observed in 30.0% of SAH patients. 5 patients (16.7%) died before treatment, 28-day case-fatality rate (CFR) for all patients was 23.3%. Overall and age-standardised incidence rates were similar to previous studies but higher among females and compared to neighbouring countries. A high occurrence of familial history was reported. SAH remains a serious condition in Greenland, as evidenced by five fatalities before treatment was administered.

颅内动脉瘤(IA)破裂引起的蛛网膜下腔出血(SAH)是一种严重的疾病。早期研究发现,格陵兰患者的蛛网膜下腔出血发病率高于丹麦患者,格陵兰的家族聚集性也更高。然而,目前还缺乏最新数据。目的:调查2018-2021年格陵兰患者SAH/IA的当代发病率、结局和家族性倾向。纳入2018-2021年期间诊断为破裂或未破裂IA(UIA)的格陵兰患者。数据来自患者档案、X光部门和出院登记处。发病率按病例/100,000/年估算。直接年龄标准化发病率以 WHO 2000-2025 年为标准计算。在30例SAH患者中,20例(66.7%)为女性,10例(33.3%)为男性。在 36 名 UIA 患者中,27 名(75.0%)为女性,9 名(25.0%)为男性。SAH的粗发病率为13.4/100,000/年,年龄标准化发病率为10.8/100,000/年。30.0%的 SAH 患者有家族史。5名患者(16.7%)在治疗前死亡,所有患者的28天病死率(CFR)为23.3%。总发病率和年龄标准化发病率与之前的研究相似,但女性发病率高于邻国。据报告,家族病史的发生率很高。在格陵兰,SAH仍然是一种严重的疾病,在治疗前就有5人死亡就是证明。
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引用次数: 0
Hysteroscopy needs of indigenous communities in Northern Quebec: a retrospective cohort study. 魁北克北部原住民社区对宫腔镜检查的需求:一项回顾性队列研究。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1080/22423982.2024.2359162
Andrew Zakhari, Dong Bach Nguyen, Jessica Papillon Smith, Fady W Mansour, Srinivasan Krishnamurthy

We aimed to determine the surgical output for patients from Nunavik undergoing transfer to an urban centre for hysteroscopy, and associated costs. We performed a retrospective chart review of all patients from the 14 villages of Nunavik transferred for hysteroscopic surgery from 2016 to 2021. Diagnoses, surgical intervention, and nature of the procedure were all extracted from the patient charts, and costs/length of stay obtained from logisticians and administrators servicing the Nunavik region. Over a 5-year period, 22 patients were transferred from Nunavik for hysteroscopy, of which all were elective save one. The most common diagnosis was endometrial or cervical polyp and the most common procedure was diagnostic hysteroscopy. The average cost for patient transfer and lodging to undergo hysteroscopy in Montreal ranged from $6,000 to $15,000 CDN. On average, 4-5 patient transfers occur annually for hysteroscopy, most commonly for management of endometrial polyps, at a cost of $6,000 to $15,000 CDN, suggesting the need to investigate local capacity building in Nunavik and assess cost-effectiveness.

我们旨在确定从努纳维克转到城市中心接受宫腔镜手术的患者的手术量和相关费用。我们对2016年至2021年期间努纳维克14个村庄所有转院接受宫腔镜手术的患者进行了回顾性病历审查。诊断、手术干预和手术性质均从患者病历中提取,费用/住院时间则从努纳维克地区的后勤人员和管理人员处获得。5 年间,共有 22 名患者从努纳维克转院接受宫腔镜检查,其中除一名患者外,其余均为择期手术。最常见的诊断是子宫内膜或宫颈息肉,最常见的手术是诊断性宫腔镜检查。在蒙特利尔接受宫腔镜检查的病人转院和住宿的平均费用为 6,000 至 15,000 加元不等。平均而言,每年有 4-5 名患者转院接受宫腔镜检查,最常见的是子宫内膜息肉的治疗,费用为 6,000 至 15,000 加元,这表明有必要调查努纳维克当地的能力建设情况并评估成本效益。
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引用次数: 0
Funding the pandemic response for Indigenous Peoples: an equity-based analysis of COVID-19 using a Health Equity Impact Assessment (HEIA) Indigenous lens tool. 为土著人民的大流行病应对措施提供资金:利用健康公平影响评估(HEIA)土著透镜工具对 COVID-19 进行基于公平的分析。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-06-12 DOI: 10.1080/22423982.2024.2361987
Sean A Hillier, Elias Chaccour, Hamza Al-Shammaa, Bernice Downey, Laura C Senese, Jill Tinmouth, Naana Afua Jumah

This study examines the allocation of COVID-19 funding for Indigenous Peoples in Canada, Australia, New Zealand, and the United States during the pandemic's first wave. Indigenous communities, already facing health disparities, systemic discrimination, and historical forces of colonisation, found themselves further vulnerable to the virus. Analysing the funding policies of these countries, we employed a Health Equity Impact Assessment (HEIA) tool and an Indigenous Lens Tool supplement to evaluate potential impacts. Our results identify three major funding equity issues: unique health and service needs, socioeconomic disparities, and limited access to community and culturally safe health services. Despite efforts for equitable funding, a lack of meaningful consultation led to shortcomings, as seen in Canada's state of emergency declaration and legal disputes in the United States. New Zealand stood out for integrating Māori perspectives, showcasing the importance of consultation. The study calls for a reconciliation-minded path, aligning with Truth and Reconciliation principles, the UN Declaration on the Rights of Indigenous Peoples, and evolving government support. The paper concludes that co-creating equitable funding policies grounded in Indigenous knowledge requires partnership, meaningful consultation, and organisational cultural humility. Even in emergencies, these measures ensure responsiveness and respect for Indigenous self-determination.

本研究探讨了 COVID-19 大流行第一波期间加拿大、澳大利亚、新西兰和美国为土著居民分配资金的情况。原住民社区本已面临着健康差异、系统性歧视和殖民化的历史影响,他们发现自己更容易受到病毒的侵袭。在分析这些国家的资助政策时,我们采用了健康公平影响评估(HEIA)工具和土著透镜工具补充工具来评估潜在的影响。我们的研究结果发现了三个主要的资金公平问题:独特的健康和服务需求、社会经济差异以及社区和文化安全健康服务的有限性。尽管为实现资金公平做出了努力,但缺乏有意义的协商导致了不足之处,加拿大宣布进入紧急状态和美国的法律纠纷就说明了这一点。新西兰在纳入毛利人观点方面表现突出,展示了协商的重要性。研究报告呼吁走和解之路,与真相与和解原则、《联合国土著人民权利宣言》以及不断发展的政府支持保持一致。本文的结论是,共同制定以土著知识为基础的公平资助政策需要伙伴关系、有意义的磋商和组织文化上的谦逊。即使在紧急情况下,这些措施也能确保对土著自决的响应和尊重。
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引用次数: 0
Orientation affects the integrity of glass ampoules of 1 in 1000 adrenaline on exposure to very low temperatures. 在极低的温度下,方向会影响 1:1000 肾上腺素玻璃安瓿的完整性。
IF 1.3 4区 医学 Q2 Social Sciences Pub Date : 2024-12-01 Epub Date: 2024-01-30 DOI: 10.1080/22423982.2024.2309756
Felix N R Wood, Jason Hicks, Rhiannon Wilkinson, Rosemary Hartley, Jonathon Lowe

In very cold environments, it may be burdensome or impossible for the polar medic to prevent medicines from freezing. We sought to investigate whether orientation affected the risk that glass ampoules of 1 in 1000 adrenaline, an important emergency drug, would break during freezing and subsequent thawing. Ampoules of adrenaline were orientated either upright, horizontally or inverted. They were exposed to freezing temperatures (-25°C or -80°C) and then allowed to thaw. A crossover design was used whereby the orientation of unbroken ampoules was changed for the next trial. No ampoules broke when frozen at -25°C and then thawed. When this was repeated at -80°C, ampoules reliably broke unless they were upright with no liquid in the top part of the ampoule. Upright orientation prevents the breakage of glass ampoules of 1 in 1000 adrenaline rapidly frozen at -80°C. The polar medic may consider storing ampoules upright if they are to be exposed to very low temperatures.

在非常寒冷的环境中,极地医疗人员要防止药品结冰可能是一种负担,甚至是不可能的。我们试图研究方向是否会影响装有千分之一肾上腺素(一种重要的急救药物)的玻璃安瓿在冻结和随后解冻过程中破裂的风险。我们将肾上腺素安瓿瓶竖放、横放或倒放。将它们置于冷冻温度(-25°C 或 -80°C)下,然后让其解冻。采用交叉设计,在下一次试验中改变未破损安瓿的方向。在-25°C下冷冻后解冻,没有安瓿破损。在零下 80 摄氏度的条件下再次进行试验时,除非安瓿是直立的,且安瓿上部没有液体,否则安瓿就会可靠地破裂。直立放置可防止在零下 80 摄氏度快速冷冻的千分之一肾上腺素玻璃安瓿破裂。如果安瓿要暴露在极低的温度下,极地医疗人员可考虑将其竖直存放。
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引用次数: 0
期刊
International Journal of Circumpolar Health
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