Seanna Yang, Olivia Burke, Jacob Beer, Kyaw Zin Htet, Nicole A Negbenebor
{"title":"Immune-Related Dermatological Conditions Among Refugee and Migrant Populations.","authors":"Seanna Yang, Olivia Burke, Jacob Beer, Kyaw Zin Htet, Nicole A Negbenebor","doi":"10.1111/ijd.70273","DOIUrl":"https://doi.org/10.1111/ijd.70273","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angad S Sidhu, Daniel J Konig, Beverly X Yu-Corpuz, George S Corpuz
{"title":"Unregulated Melanotan Use Promoted via Social Media: Emerging Dermatologic and Public Health Risks.","authors":"Angad S Sidhu, Daniel J Konig, Beverly X Yu-Corpuz, George S Corpuz","doi":"10.1111/ijd.70286","DOIUrl":"https://doi.org/10.1111/ijd.70286","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing Quality of Life in Pediatric Alopecia Areata.","authors":"Samuel Tringali","doi":"10.1111/ijd.70272","DOIUrl":"https://doi.org/10.1111/ijd.70272","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily E Limmer, Jorge Roman, Stanislav N Tolkachjov
{"title":"Argyria: A Case of Blue Lunulae.","authors":"Emily E Limmer, Jorge Roman, Stanislav N Tolkachjov","doi":"10.1111/ijd.70293","DOIUrl":"https://doi.org/10.1111/ijd.70293","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristina Nazzicone, Erin Dahlke, Linden Head, Thomas Herzinger, Lourdes Ramírez Hobak, Yuanshen Huang, Menelaos Konstantinidis, Glykeria Martou, Sonja Molin, Douglas R McKay, Yuka Asai
{"title":"Exploring What Constitutes a Good-Quality Referral for a Potentially Malignant Skin Lesion: A Modified Delphi Consensus.","authors":"Kristina Nazzicone, Erin Dahlke, Linden Head, Thomas Herzinger, Lourdes Ramírez Hobak, Yuanshen Huang, Menelaos Konstantinidis, Glykeria Martou, Sonja Molin, Douglas R McKay, Yuka Asai","doi":"10.1111/ijd.70300","DOIUrl":"https://doi.org/10.1111/ijd.70300","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yannick Foerster, Julia Palaras, Kristine Mayer, Tilo Biedermann, Oana-Diana Persa
Kidney transplant recipients (KTRs) are at increased risk of developing cutaneous squamous cell carcinoma (cSCC), particularly when treated with calcineurin inhibitors (CNI), which are strongly associated with tumorigenesis. In contrast, mTOR inhibitors such as sirolimus have demonstrated antitumor activity, but their role in secondary prevention of cSCC remains unclear. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of switching from a CNI-based to an mTOR inhibitor-based immunosuppressive regimen on the incidence of cSCC in KTRs with prior cSCC. MEDLINE, EMBASE, CENTRAL, and trial registries were searched through June 2025. Incidence rate ratios (IRRs) for cSCC and risk ratios (RRs) for adverse events (AEs) were pooled using a random-effects model. Risk of bias was assessed with Cochrane RoB2. The study was registered in PROSPERO prior to data extraction (CRD42024583966). The study was unfunded. Four RCTs (393 patients) were included. Sirolimus significantly reduced 2-year cSCC incidence (IRR 0.51, 95% CI 0.39-0.67). However, discontinuation was more frequent (RR 8.60, 95% CI 1.95-37.93) due to AEs. No significant differences in mortality or graft rejection were found. Certainty of evidence was high for cSCC incidence and low for adverse events due to heterogeneity and selective reporting. In conclusion, sirolimus reduces secondary cSCC risk but increases AEs; patient selection and monitoring are essential. Trial Registration: PROSPERO number: CRD42024583966.
肾移植受者（KTRs）发生皮肤鳞状细胞癌（cSCC）的风险增加，特别是当使用钙调磷酸酶抑制剂（CNI）治疗时，这与肿瘤发生密切相关。相比之下，mTOR抑制剂如西罗莫司已显示出抗肿瘤活性，但其在cSCC二级预防中的作用尚不清楚。我们对随机对照试验（RCTs）进行了系统回顾和荟萃分析，以评估从基于cni的免疫抑制方案切换到基于mTOR抑制剂的免疫抑制方案对既往有cSCC的ktr患者cSCC发病率的影响。MEDLINE、EMBASE、CENTRAL和试验注册中心被检索到2025年6月。采用随机效应模型汇总cSCC的发病率比（IRRs）和不良事件的风险比（rr）。采用Cochrane RoB2评估偏倚风险。该研究在数据提取前已在PROSPERO注册（CRD42024583966）。这项研究没有得到资助。纳入4项随机对照试验（rct），共393例患者。西罗莫司显著降低2年cSCC发病率（IRR 0.51, 95% CI 0.39-0.67）。然而，由于不良反应而停药的发生率更高（RR 8.60, 95% CI 1.95-37.93）。死亡率和移植排斥反应无显著差异。由于异质性和选择性报道，cSCC发病率的证据确定性高，不良事件的证据确定性低。总之，西罗莫司降低继发性cSCC风险，但增加ae；病人的选择和监测是必不可少的。试验注册：PROSPERO号：CRD42024583966。
{"title":"Sirolimus for Secondary Prevention of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Yannick Foerster, Julia Palaras, Kristine Mayer, Tilo Biedermann, Oana-Diana Persa","doi":"10.1111/ijd.70285","DOIUrl":"https://doi.org/10.1111/ijd.70285","url":null,"abstract":"<p><p>Kidney transplant recipients (KTRs) are at increased risk of developing cutaneous squamous cell carcinoma (cSCC), particularly when treated with calcineurin inhibitors (CNI), which are strongly associated with tumorigenesis. In contrast, mTOR inhibitors such as sirolimus have demonstrated antitumor activity, but their role in secondary prevention of cSCC remains unclear. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of switching from a CNI-based to an mTOR inhibitor-based immunosuppressive regimen on the incidence of cSCC in KTRs with prior cSCC. MEDLINE, EMBASE, CENTRAL, and trial registries were searched through June 2025. Incidence rate ratios (IRRs) for cSCC and risk ratios (RRs) for adverse events (AEs) were pooled using a random-effects model. Risk of bias was assessed with Cochrane RoB2. The study was registered in PROSPERO prior to data extraction (CRD42024583966). The study was unfunded. Four RCTs (393 patients) were included. Sirolimus significantly reduced 2-year cSCC incidence (IRR 0.51, 95% CI 0.39-0.67). However, discontinuation was more frequent (RR 8.60, 95% CI 1.95-37.93) due to AEs. No significant differences in mortality or graft rejection were found. Certainty of evidence was high for cSCC incidence and low for adverse events due to heterogeneity and selective reporting. In conclusion, sirolimus reduces secondary cSCC risk but increases AEs; patient selection and monitoring are essential. Trial Registration: PROSPERO number: CRD42024583966.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Chrispim Gimenez, Alicia Mizes, Francisco Tausk, Margaret R Puelle
{"title":"Pruritus of Unknown Origin Treated With Aripiprazole.","authors":"Mariana Chrispim Gimenez, Alicia Mizes, Francisco Tausk, Margaret R Puelle","doi":"10.1111/ijd.70296","DOIUrl":"https://doi.org/10.1111/ijd.70296","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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