Milene Vitória Sampaio Sobral, João Lucas de Magalhães Leal Moreira, Livia Kneipp Rodrigues, Paula Rocha, Rafaela da Cunha Pirolla, Victor Gonçalves Soares, Davi Santos Lima, Isac Ribeiro Moulaz, Beatrhiz Costa da Silva, Caroline Baima de Melo
The benefits and potential risks of oral minoxidil therapy versus topical minoxidil therapy in patients with androgenetic alopecia (AGA) are controversial. We systematically searched PubMed, Embase, and Cochrane for randomized clinical trials (RCTs) comparing the use of oral minoxidil and minoxidil topical solution in patients with AGA. Statistical analyses were performed using R Studio 4.3.2. Standard mean difference (SMD) and risk ratio (RR) with 95% confidence intervals (CI) were pooled across trials. This meta-analysis included four RCTs reporting data on 279 patients. Follow-up ranged from 24 to 39 weeks. There were no differences in hair density (SMD 0.02; 95% CI -0.25 to 0.29; P = 0.88; I2 = 0%) or hair diameter (SMD -0.25; 95% CI -0.75 to 0.26; P = 0.34; I2 = 36%). The incidence of hypertrichosis was statistically significantly higher in the oral minoxidil group when compared to the topical minoxidil group (RR 2.01; 95% CI 1.18-3.41; P = 0.01; I2 = 0%). There was no statistically significant difference between groups for the incidence of hypotension (RR 2.42; 95% CI 0.26-22.46; P = 0.44; I2 = 0%). In patients with AGA, oral minoxidil and minoxidil topical solution have similar efficacy and safety, with equivalent improvements in hair density, hair diameter, and incidence of adverse events, such as hypotension.
在雄激素性脱发（AGA）患者中，口服米诺地尔疗法与外用米诺地尔疗法的益处和潜在风险存在争议。我们系统地检索了 PubMed、Embase 和 Cochrane 中比较 AGA 患者使用米诺地尔口服液和米诺地尔外用溶液的随机临床试验 (RCT)。统计分析使用 R Studio 4.3.2 进行。对各试验的标准平均差 (SMD) 和风险比 (RR) 以及 95% 置信区间 (CI) 进行了汇总。这项荟萃分析包括四项 RCT，报告了 279 名患者的数据。随访时间从 24 周到 39 周不等。毛发密度（SMD 0.02；95% CI -0.25至0.29；P = 0.88；I2 = 0%）或毛发直径（SMD -0.25；95% CI -0.75至0.26；P = 0.34；I2 = 36%）无差异。与外用米诺地尔组相比，口服米诺地尔组的多毛症发生率在统计学上明显更高（RR 2.01；95% CI 1.18-3.41；P = 0.01；I2 = 0%）。在低血压发生率方面，组间差异无统计学意义（RR 2.42；95% CI 0.26-22.46；P = 0.44；I2 = 0%）。对于AGA患者，米诺地尔口服液和米诺地尔局部溶液具有相似的疗效和安全性，在头发密度、头发直径和低血压等不良反应发生率方面的改善程度相当。
{"title":"Efficacy and safety of oral minoxidil versus topical solution in androgenetic alopecia: a meta-analysis of randomized clinical trials.","authors":"Milene Vitória Sampaio Sobral, João Lucas de Magalhães Leal Moreira, Livia Kneipp Rodrigues, Paula Rocha, Rafaela da Cunha Pirolla, Victor Gonçalves Soares, Davi Santos Lima, Isac Ribeiro Moulaz, Beatrhiz Costa da Silva, Caroline Baima de Melo","doi":"10.1111/ijd.17524","DOIUrl":"https://doi.org/10.1111/ijd.17524","url":null,"abstract":"<p><p>The benefits and potential risks of oral minoxidil therapy versus topical minoxidil therapy in patients with androgenetic alopecia (AGA) are controversial. We systematically searched PubMed, Embase, and Cochrane for randomized clinical trials (RCTs) comparing the use of oral minoxidil and minoxidil topical solution in patients with AGA. Statistical analyses were performed using R Studio 4.3.2. Standard mean difference (SMD) and risk ratio (RR) with 95% confidence intervals (CI) were pooled across trials. This meta-analysis included four RCTs reporting data on 279 patients. Follow-up ranged from 24 to 39 weeks. There were no differences in hair density (SMD 0.02; 95% CI -0.25 to 0.29; P = 0.88; I<sup>2</sup> = 0%) or hair diameter (SMD -0.25; 95% CI -0.75 to 0.26; P = 0.34; I<sup>2</sup> = 36%). The incidence of hypertrichosis was statistically significantly higher in the oral minoxidil group when compared to the topical minoxidil group (RR 2.01; 95% CI 1.18-3.41; P = 0.01; I<sup>2</sup> = 0%). There was no statistically significant difference between groups for the incidence of hypotension (RR 2.42; 95% CI 0.26-22.46; P = 0.44; I<sup>2</sup> = 0%). In patients with AGA, oral minoxidil and minoxidil topical solution have similar efficacy and safety, with equivalent improvements in hair density, hair diameter, and incidence of adverse events, such as hypotension.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent developments in the understanding of the pathophysiology of inflammatory skin diseases have resulted in the emergence of new treatments. However, new therapies are frequently accompanied by new side effects. In the November issue of the Journal, we explore recent advances on how Cutibacterium acnes phylotypes are involved in biofilm formation and its significance in therapy resistance. The Janus kinase (JAK) inhibitor-induced acneiform eruptions also raise intriguing questions about the complex relationship between JAK inhibition and acne pathophysiology. We also provide real-world data on recent therapies for atopic dermatitis, hyperkeratotic hand and foot dermatitis, and generalized pustular psoriasis.
近年来，人们对炎症性皮肤病的病理生理学有了更深入的了解，因此出现了新的治疗方法。然而，新疗法往往伴随着新的副作用。在11月刊上，我们将探讨痤疮棒状杆菌系统型如何参与生物膜的形成及其在耐药性中的意义。此外，Janus 激酶 (JAK) 抑制剂诱发的痤疮样溃疡也提出了 JAK 抑制与痤疮病理生理学之间复杂关系的有趣问题。我们还提供了有关特应性皮炎、角化过度手足皮炎和泛发性脓疱型银屑病最新疗法的实际数据。
{"title":"Editor's highlights – November, 2024","authors":"Lajos Kemény","doi":"10.1111/ijd.17505","DOIUrl":"https://doi.org/10.1111/ijd.17505","url":null,"abstract":"<p>Recent developments in the understanding of the pathophysiology of inflammatory skin diseases have resulted in the emergence of new treatments. However, new therapies are frequently accompanied by new side effects. In the November issue of the Journal, we explore recent advances on how <i>Cutibacterium acnes</i> phylotypes are involved in biofilm formation and its significance in therapy resistance. The Janus kinase (JAK) inhibitor-induced acneiform eruptions also raise intriguing questions about the complex relationship between JAK inhibition and acne pathophysiology. We also provide real-world data on recent therapies for atopic dermatitis, hyperkeratotic hand and foot dermatitis, and generalized pustular psoriasis.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"63 11","pages":"1471-1472"},"PeriodicalIF":3.5,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ethical considerations regarding patient privacy when employing artificial intelligence in dermatology.","authors":"Mohamad Goldust, Jane M Grant-Kels","doi":"10.1111/ijd.17525","DOIUrl":"https://doi.org/10.1111/ijd.17525","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel P Friedmann, Eshani Mehta, Kritin K Verma, Ryan Harris
{"title":"Treatment-refractory granulomatous reaction to microneedling with transepidermal drug delivery of vitamin C, niacinamide, and botanical extracts.","authors":"Daniel P Friedmann, Eshani Mehta, Kritin K Verma, Ryan Harris","doi":"10.1111/ijd.17542","DOIUrl":"https://doi.org/10.1111/ijd.17542","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerem Balan, Pelin Sagut, Amanda C Ederle, Elisa Glover Bath, Dirk M Elston
{"title":"Cutaneous sarcoidosis treated with intralesional adalimumab.","authors":"Kerem Balan, Pelin Sagut, Amanda C Ederle, Elisa Glover Bath, Dirk M Elston","doi":"10.1111/ijd.17549","DOIUrl":"https://doi.org/10.1111/ijd.17549","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alice J Tan, Yuying Zhang, Karen G Makhoul, Nikki A Levin
{"title":"Lovastatin/cholesterol cream for the treatment of disseminated superficial actinic porokeratosis: a retrospective cohort study.","authors":"Alice J Tan, Yuying Zhang, Karen G Makhoul, Nikki A Levin","doi":"10.1111/ijd.17533","DOIUrl":"https://doi.org/10.1111/ijd.17533","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shivkar Amara, Anusha Pasumarthi, Neil Parikh, Nilesh Kodali, Mark Lebwohl, George Monks
Psoriasis, a common chronic inflammatory skin disorder, encompasses various subtypes, including guttate, pustular, erythrodermic, and the most common type, plaque psoriasis. Irrespective of the subtype, psoriasis can manifest with multisystemic presentations, including psoriatic arthritis, metabolic disorders, cardiovascular disease, malignancies, chronic kidney disease (CKD), psychiatric illness, and inflammatory bowel disease (IBD). Many comorbidities and concomitant conditions must be considered when selecting the most appropriate therapy for a patient (Kaushik et al., 2019 and Monks et al., 2021) . Ongoing clinical trials and the development of new therapeutic targets contribute to the continuous improvement of available treatment options. Given the dynamic landscape of therapies, particularly when managing complex patients with multiple comorbidities, dermatologists are constantly challenged with the task of adeptly tailoring treatments to each psoriasis patient. This article systematically reviews the current evidence, presenting it as an updated Psoriasis Decision Tree to assist physicians in selecting tailored treatment options.
{"title":"Psoriasis management tree based on comorbidity.","authors":"Shivkar Amara, Anusha Pasumarthi, Neil Parikh, Nilesh Kodali, Mark Lebwohl, George Monks","doi":"10.1111/ijd.17497","DOIUrl":"https://doi.org/10.1111/ijd.17497","url":null,"abstract":"<p><p>Psoriasis, a common chronic inflammatory skin disorder, encompasses various subtypes, including guttate, pustular, erythrodermic, and the most common type, plaque psoriasis. Irrespective of the subtype, psoriasis can manifest with multisystemic presentations, including psoriatic arthritis, metabolic disorders, cardiovascular disease, malignancies, chronic kidney disease (CKD), psychiatric illness, and inflammatory bowel disease (IBD). Many comorbidities and concomitant conditions must be considered when selecting the most appropriate therapy for a patient (Kaushik et al., 2019 and Monks et al., 2021) . Ongoing clinical trials and the development of new therapeutic targets contribute to the continuous improvement of available treatment options. Given the dynamic landscape of therapies, particularly when managing complex patients with multiple comorbidities, dermatologists are constantly challenged with the task of adeptly tailoring treatments to each psoriasis patient. This article systematically reviews the current evidence, presenting it as an updated Psoriasis Decision Tree to assist physicians in selecting tailored treatment options.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atypical Spitz tumor: classic methods, new technologies, and the role of line-field confocal optical coherence tomography.","authors":"Simone Viola, Simone Soglia, Marina Venturini, Valeria Boccaletti","doi":"10.1111/ijd.17538","DOIUrl":"https://doi.org/10.1111/ijd.17538","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>In this issue of the Journal, Uzun et al. nicely summarize the current knowledge on the diagnosis and management of scabies infestation.<span><sup>1</sup></span> In their scoping review, the authors describe a health scourge that has plagued humans since antiquity. We can trace records of scabies infestation to biblical times, where the term <i>zaraath</i> (which initially referred to scaling skin but then became the origin of the word leprosy) likely referred to conditions including scabies infestation.<span><sup>2</sup></span> This may explain how some were ‘cured’ of leprosy by bathing in the sulfur-rich Jordan River.</p><p>We can also find records of scabies described as “lice in the flesh” in Aristotle's treatise <i>De historia animalium</i>. Aristotle's description of a contagious and itchy eruption caused by an organism that could be extracted from the skin with needles fits well with scabies and its scientific name, <i>Sarcoptes scabiei var. hominis</i>.<span><sup>2</sup></span> <i>Scabiei</i> is derived from the Latin word s<i>cabere</i>, which means to scratch and s<i>arcoptes</i> is from the Greek words <i>sarx</i> and <i>koptein</i> which mean “flesh cutting.” In 25 AD, the Roman author Aulus Cornelius Celsus was credited with first giving the name “scabies” to the disease and using a sulfur compound as a remedy.</p><p>During the medieval period, poets such as Dante, in his Divine Comedy (circa 1308–1321 AD), described the suffering of alchemists and forgers from scabies. In the 16th century, physician and arthropod enthusiast Dr. Thomas Moffett correctly established the pathogenic role of the scabies mite, which he described and distinguished from the louse. The 17th century produced the first drawings of the scabies mite by August Hauptmann (1607–1674 AD) and Michael Ettmüller (1644–1683 AD), shortly after the pioneering work on the microscope. It was around this time that the parasite was first extracted from the end of a burrow on human skin (Figure 1a) by Giovanni Cosim Bonomo (1663–1696 AD) and documented in his famous letter entitled, “Observations concerning the fleshworms of the human body” in 1687. Using the microscope, he was able to observe a female mite depositing an egg (Figure 1b). Bonomo noted the contagiousness of the disease and found that external remedies could control scabies, while oral treatments at the time were of no use. In 1801, the physician Joseph Adams demonstrated the transmission of disease after affixing an extracted mite to his fingers, successfully infecting himself (and, inadvertently, his family).<span><sup>2</sup></span></p><p>Until recently, diagnosis of scabies infestation was made via skin scraping, a method similar to the procedure in the 16th century where the mite would be removed using a needle from the skin. However, in 2007, dermoscopy was shown to be a very effective tool in diagnosing scabies (Figure 1c). It has high sensitivity, even in inexperienced hands, and the accuracy of diagn
{"title":"Scabies: a historical perspective","authors":"Joseph M. Lam, Wingfield Rehmus","doi":"10.1111/ijd.17536","DOIUrl":"10.1111/ijd.17536","url":null,"abstract":"<p>In this issue of the Journal, Uzun et al. nicely summarize the current knowledge on the diagnosis and management of scabies infestation.<span><sup>1</sup></span> In their scoping review, the authors describe a health scourge that has plagued humans since antiquity. We can trace records of scabies infestation to biblical times, where the term <i>zaraath</i> (which initially referred to scaling skin but then became the origin of the word leprosy) likely referred to conditions including scabies infestation.<span><sup>2</sup></span> This may explain how some were ‘cured’ of leprosy by bathing in the sulfur-rich Jordan River.</p><p>We can also find records of scabies described as “lice in the flesh” in Aristotle's treatise <i>De historia animalium</i>. Aristotle's description of a contagious and itchy eruption caused by an organism that could be extracted from the skin with needles fits well with scabies and its scientific name, <i>Sarcoptes scabiei var. hominis</i>.<span><sup>2</sup></span> <i>Scabiei</i> is derived from the Latin word s<i>cabere</i>, which means to scratch and s<i>arcoptes</i> is from the Greek words <i>sarx</i> and <i>koptein</i> which mean “flesh cutting.” In 25 AD, the Roman author Aulus Cornelius Celsus was credited with first giving the name “scabies” to the disease and using a sulfur compound as a remedy.</p><p>During the medieval period, poets such as Dante, in his Divine Comedy (circa 1308–1321 AD), described the suffering of alchemists and forgers from scabies. In the 16th century, physician and arthropod enthusiast Dr. Thomas Moffett correctly established the pathogenic role of the scabies mite, which he described and distinguished from the louse. The 17th century produced the first drawings of the scabies mite by August Hauptmann (1607–1674 AD) and Michael Ettmüller (1644–1683 AD), shortly after the pioneering work on the microscope. It was around this time that the parasite was first extracted from the end of a burrow on human skin (Figure 1a) by Giovanni Cosim Bonomo (1663–1696 AD) and documented in his famous letter entitled, “Observations concerning the fleshworms of the human body” in 1687. Using the microscope, he was able to observe a female mite depositing an egg (Figure 1b). Bonomo noted the contagiousness of the disease and found that external remedies could control scabies, while oral treatments at the time were of no use. In 1801, the physician Joseph Adams demonstrated the transmission of disease after affixing an extracted mite to his fingers, successfully infecting himself (and, inadvertently, his family).<span><sup>2</sup></span></p><p>Until recently, diagnosis of scabies infestation was made via skin scraping, a method similar to the procedure in the 16th century where the mite would be removed using a needle from the skin. However, in 2007, dermoscopy was shown to be a very effective tool in diagnosing scabies (Figure 1c). It has high sensitivity, even in inexperienced hands, and the accuracy of diagn","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"63 12","pages":"1637-1638"},"PeriodicalIF":3.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijd.17536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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