Pub Date : 2018-09-20DOI: 10.15321/GENELTIPDER.2018343485
Kürşat Kargün
Objective: Coronary artery disease is one of the most commonly seen heart diseases worldwide. Given high prevalence in developing countries, it is considered as most frequent causes of death worldwide. Disorders of calcium homeostasis such as primary hyperparathyroidism can increase mortality risk due to cardiovascular causes. In this study, we aimed to investigate role of rs1048213 and rs9883099 polymorphisms in CaSR gene in the pathogenesis of coronary artery disease and to determine whether they are associated to all-causes death and mortality. Material and Method: Data from patients with 135 coronary artery disease and 139 healthy volunteer without heart disease were compared in this study. rs1048213 and rs9883099 polymorphisms were screened by using real-time PCR in blood samples obtained from patients. Results: Significant differences were detected in biochemical parameters, BMI, hypertension, diabetes mellitus, smoking, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol when compared to controls (p<0.05). No significant difference was detected in rs1048312 polymorphism between patients with coronary artery disease and healthy controls while significant differences were detected in rs0993099 polymorphism and A allele (p<0.05). Conclusion: This study showed that there is a significant relationship between rs9883099 polymorphism, A allele and coronary artery disease.
{"title":"CaSR Gen Polimorfizmin Kroner Arter Hastaların Patogenezinde Rolünün Araştırılması","authors":"Kürşat Kargün","doi":"10.15321/GENELTIPDER.2018343485","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018343485","url":null,"abstract":"Objective: Coronary artery disease is one of the most commonly seen heart diseases worldwide. Given high prevalence in developing countries, it is considered as most frequent causes of death worldwide. Disorders of calcium homeostasis such as primary hyperparathyroidism can increase mortality risk due to cardiovascular causes. In this study, we aimed to investigate role of rs1048213 and rs9883099 polymorphisms in CaSR gene in the pathogenesis of coronary artery disease and to determine whether they are associated to all-causes death and mortality. Material and Method: Data from patients with 135 coronary artery disease and 139 healthy volunteer without heart disease were compared in this study. rs1048213 and rs9883099 polymorphisms were screened by using real-time PCR in blood samples obtained from patients. Results: Significant differences were detected in biochemical parameters, BMI, hypertension, diabetes mellitus, smoking, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol when compared to controls (p<0.05). No significant difference was detected in rs1048312 polymorphism between patients with coronary artery disease and healthy controls while significant differences were detected in rs0993099 polymorphism and A allele (p<0.05). Conclusion: This study showed that there is a significant relationship between rs9883099 polymorphism, A allele and coronary artery disease.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126268947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-06DOI: 10.15321/geneltipder.2018241191
Servet Kolgelier, Nazlım Aktuğ Demir, Şua Sümer, L. Demir, Abdullah Arpacı
Objective: Inthisstudy, it was aimed to determine the prevalence of Transfusion Transmitted Virus (TTV) virus in inactivated hepatitis B carriers with and without hemodialysis treatment. Materials and Methods: This study was conducted on 50 inactive hepatitis B patients treated with hemodialysis and 40 inactive hepatitis B patients with normal renal function. Anti-TTV IGG was studied with ELISA kit from serum samples taken from patients. Data were evaluated by Chi-square test. Results: Anti-TTV IGG positivity was detected in 39 (78%) of 50 hemodialysis patients while Anti-TTV IGG positivity was detected in 8 (20%) of 40 inactivated hepatitis B patients without hemodialysis. This difference was statistically significant (p=0.001). Conclusion: We think that standard measures for cleaning, disinfection and infection control should be applied more carefully in these units in order to prevent transmission of hepatitis viruses because of the high TTV seropositivity in hemodialysis patients.
{"title":"Transfusion Transmitted Virüs (TTV) Prevalansı İnaktif Hepatit B Taşıyıcılarında Hemodiyalizden Etkileniyor Mu","authors":"Servet Kolgelier, Nazlım Aktuğ Demir, Şua Sümer, L. Demir, Abdullah Arpacı","doi":"10.15321/geneltipder.2018241191","DOIUrl":"https://doi.org/10.15321/geneltipder.2018241191","url":null,"abstract":"Objective: Inthisstudy, it was aimed to determine the prevalence of Transfusion Transmitted Virus (TTV) virus in inactivated hepatitis B carriers with and without hemodialysis treatment. Materials and Methods: This study was conducted on 50 inactive hepatitis B patients treated with hemodialysis and 40 inactive hepatitis B patients with normal renal function. Anti-TTV IGG was studied with ELISA kit from serum samples taken from patients. Data were evaluated by Chi-square test. Results: Anti-TTV IGG positivity was detected in 39 (78%) of 50 hemodialysis patients while Anti-TTV IGG positivity was detected in 8 (20%) of 40 inactivated hepatitis B patients without hemodialysis. This difference was statistically significant (p=0.001). Conclusion: We think that standard measures for cleaning, disinfection and infection control should be applied more carefully in these units in order to prevent transmission of hepatitis viruses because of the high TTV seropositivity in hemodialysis patients.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"146 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114131921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-06DOI: 10.15321/GENELTIPDER.2018241192
Hüseyin Demir
{"title":"Sağlık çalışanlarının cam tavan algısı","authors":"Hüseyin Demir","doi":"10.15321/GENELTIPDER.2018241192","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241192","url":null,"abstract":"","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133688242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-06DOI: 10.15321/GENELTIPDER.2018241195
B. Tan, E. Babur, Hikmet Fırat Örnek, Cem Süer, Nurcan Dursun
Objective: In thyroid hormone level disorders such as hypothyroidism and hyperthyroidism in developmental period, experimental studies have shown that structural and functional changes in the brain. These changes are known to cause neurological disorders and impairments in cognitive processes, such as learning and memory, in which the hippocampus plays an important role. For this purpose, it is aimed to investigate spatial learning performance between hyperthyroidized male and female rats. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: When repeated ANOVA tests were performed, the gender factor significantly affected the mean distance to the platform (p <0.001). In the following days and trials, the average distance of female rats to the platform is greater than male rats. This data suggest that female rats were swum longer distance to the platform and found the platform later. This effect of the gender factor was not affected by hyperthyroidism. In terms of memory performance, hyperthyroid group rats showed a significant decrease compared to the control group (p=0,023). It was also observed that gender difference increased this decrease in hyperthyroid state (p=0,020). It was observed that the ratio in the target quadrant of female hyperthyroid rats was lesser. Conclusion: As a result, spatial learning and memory performance in hyperthyroid rats varies according to sex.
目的:在甲状腺激素水平紊乱如甲状腺功能减退和甲状腺功能亢进的发育时期，实验研究表明，大脑结构和功能的变化。已知这些变化会导致神经系统疾病和认知过程的损伤，如学习和记忆，海马体在其中起着重要作用。为此，研究了雄性和雌性甲状腺功能亢进大鼠的空间学习表现。材料与方法:雄性和雌性大鼠分别腹腔注射l -甲状腺素0.2 mg/kg，连续21 d诱导甲状腺功能亢进。Morris水迷宫(Morris water maze, MWM)评估大鼠的学习和记忆能力。结果:当进行重复方差分析检验时，性别因素显著影响到平台的平均距离(p <0.001)。在随后的天数和试验中，雌性大鼠到平台的平均距离大于雄性大鼠。这一数据表明，雌性大鼠游到平台的距离更远，找到平台的时间也更晚。性别因素的影响不受甲亢的影响。在记忆表现方面，甲状腺功能亢进组大鼠与对照组相比有显著下降(p= 0.023)。还观察到性别差异增加了甲状腺功能亢进状态的减少(p=0,020)。观察到雌性甲状腺功能亢进大鼠靶象限的比例较小。结论:甲状腺功能亢进大鼠空间学习记忆表现存在性别差异。
{"title":"Hipertiroidili sıçanlarda uzamsal öğrenme performansına cinsiyetin etkisi","authors":"B. Tan, E. Babur, Hikmet Fırat Örnek, Cem Süer, Nurcan Dursun","doi":"10.15321/GENELTIPDER.2018241195","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241195","url":null,"abstract":"Objective: In thyroid hormone level disorders such as hypothyroidism and hyperthyroidism in developmental period, experimental studies have shown that structural and functional changes in the brain. These changes are known to cause neurological disorders and impairments in cognitive processes, such as learning and memory, in which the hippocampus plays an important role. For this purpose, it is aimed to investigate spatial learning performance between hyperthyroidized male and female rats. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: When repeated ANOVA tests were performed, the gender factor significantly affected the mean distance to the platform (p <0.001). In the following days and trials, the average distance of female rats to the platform is greater than male rats. This data suggest that female rats were swum longer distance to the platform and found the platform later. This effect of the gender factor was not affected by hyperthyroidism. In terms of memory performance, hyperthyroid group rats showed a significant decrease compared to the control group (p=0,023). It was also observed that gender difference increased this decrease in hyperthyroid state (p=0,020). It was observed that the ratio in the target quadrant of female hyperthyroid rats was lesser. Conclusion: As a result, spatial learning and memory performance in hyperthyroid rats varies according to sex.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129764665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-06DOI: 10.15321/GENELTIPDER.2018241196
Gökhan Polat
Objective: Intravenous pyelography (IVP) is a method of showing renal functions and anatomical features. However, it is not appropriate to use it in the pediatric age group because of ionizing radiation. For this reason, we are trying to evaluate urinary pathologies with magnetic resonance urography (MRU), which has become popular in recent years. In our study, we aimed to investigate the differences between MRU and IVU, showing dilution of urinary system. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: There was no significant difference in the detection of pelvicalyceal dilatation between MRU and IVP (P <0.0001). MRU was found to be effective in evaluating parenchymal pathologies and in determining the underlying pathologies in patients with no nephrogram phase in IVP. Conclusion: There was no significant difference in the detection of pelvicalyceal dilatation between MRU and IVP (P <0.0001). MRU was found to be effective in evaluating parenchymal pathologies and in determining the underlying pathologies in patients with no nephrogram phase in IVP.
目的:静脉肾盂造影(IVP)是一种显示肾脏功能和解剖特征的方法。然而，由于电离辐射，不宜在儿科年龄组使用。因此，我们正尝试用近年来流行的磁共振尿路造影(MRU)来评估泌尿系统的病理。在我们的研究中，我们旨在探讨MRU和IVU之间的差异，显示泌尿系统的稀释。材料与方法:雄性和雌性大鼠分别腹腔注射l -甲状腺素0.2 mg/kg，连续21 d诱导甲状腺功能亢进。Morris水迷宫(Morris water maze, MWM)评估大鼠的学习和记忆能力。结果:MRU与IVP对盆腔扩张的检测差异无统计学意义(P <0.0001)。发现MRU在评估实质病理和确定IVP无肾图期患者的潜在病理方面是有效的。结论:MRU与IVP对盆腔扩张的检测差异无统计学意义(P <0.0001)。发现MRU在评估实质病理和确定IVP无肾图期患者的潜在病理方面是有效的。
{"title":"Pediatrik Hastalarda Manyetik Rezonans Ürografi İle İntravenöz Piyelografinin Etkinliğinin Karşılaştırılması","authors":"Gökhan Polat","doi":"10.15321/GENELTIPDER.2018241196","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241196","url":null,"abstract":"Objective: Intravenous pyelography (IVP) is a method of showing renal functions and anatomical features. However, it is not appropriate to use it in the pediatric age group because of ionizing radiation. For this reason, we are trying to evaluate urinary pathologies with magnetic resonance urography (MRU), which has become popular in recent years. In our study, we aimed to investigate the differences between MRU and IVU, showing dilution of urinary system. Materials and Methods: Male and female rats were administered with L-thyroxine intraperitoneally at a dose of 0.2 mg/kg for 21 days to induce hyperthyroidism. Morris water maze (MWM) was used to assess learning and memory performance. Results: There was no significant difference in the detection of pelvicalyceal dilatation between MRU and IVP (P <0.0001). MRU was found to be effective in evaluating parenchymal pathologies and in determining the underlying pathologies in patients with no nephrogram phase in IVP. Conclusion: There was no significant difference in the detection of pelvicalyceal dilatation between MRU and IVP (P <0.0001). MRU was found to be effective in evaluating parenchymal pathologies and in determining the underlying pathologies in patients with no nephrogram phase in IVP.","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116386951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-06DOI: 10.15321/GENELTIPDER.2018241194
Z. E. Çelik, Güler Yavaş, Bursu Sanal Yılmaz, Tolga Tuyan Ilhan, Çağdaş Yavaş, Ozlem Ata
{"title":"Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi","authors":"Z. E. Çelik, Güler Yavaş, Bursu Sanal Yılmaz, Tolga Tuyan Ilhan, Çağdaş Yavaş, Ozlem Ata","doi":"10.15321/GENELTIPDER.2018241194","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241194","url":null,"abstract":"","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124395307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-06DOI: 10.15321/GENELTIPDER.2018241193
Çağrı Özdenk
{"title":"Artan Yüke Karşı Egzersiz Testi Sırasında Solunum Etkinliğinin Antrenmanlı ve Sedanter Erkek Deneklerde Karşılaştırılmalı İncelenmesi","authors":"Çağrı Özdenk","doi":"10.15321/GENELTIPDER.2018241193","DOIUrl":"https://doi.org/10.15321/GENELTIPDER.2018241193","url":null,"abstract":"","PeriodicalId":139503,"journal":{"name":"Genel Tip Dergisi","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123426066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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