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Prevalence of Subclinical Hypothyroidism in Chronic Kidney Disease in a Population-based Study: Tehran Thyroid Study. 一项基于人群的慢性肾病亚临床甲状腺功能减退患病率研究:德黑兰甲状腺研究
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-03-17 eCollection Date: 2021-04-01 DOI: 10.5812/ijem.103750
Sara Kazempour-Ardebili, Atefeh Amouzegar, Maryam Tohidi, Atieh Amouzegar, Fereidoun Azizi

Background: Chronic kidney disease (CKD) is a rising public health concern that has detrimental effects on cardiovascular health and overall survival. Subclinical hypothyroidism (SCH) has been associated with poor outcomes in the general population. It is thought to be more prevalent in CKD subjects, and their coexistence may contribute to poor outcomes in these patients. We aimed to determine the prevalence of SCH in CKD.

Methods: Using data from the Tehran thyroid study, which is a prospective population-based cohort study, adult subjects with an estimated Glomerular Filtration Rate (eGFR) of 60 mL/min/1.73 m2 or less were selected for studying the prevalence of thyroid abnormalities, as well as other known cardiovascular risk factors.

Results: Of 5,626 subjects recruited, 823 (14.6%) individuals had CKD. Individuals with CKD were older, heavier, had a higher prevalence of diabetes, higher serum thyrotropin, and thyroid peroxidase anti-body levels, but lower free thyroxine levels. The prevalence of SCH was 7.3% and 5.2% (P < 0.001) in kidney disease and non-kidney disease subjects, respectively. However, there was no difference in the risk of SCH between CKD and non-CKD subjects after adjustment for age, sex, BMI, smoking, and TPOAb (OR: 1.28; 95%CI, 0.89 - 1.83). None of the metabolic markers compared between the CKD subgroups of those with and without SCH remained statistically significantly different after adjusting for age and gender.

Conclusions: The prevalence of SCH was not higher in CKD after controlling for confounding factors. Besides, CKD subjects with and without SCH had no different metabolic parameters.

背景:慢性肾脏疾病(CKD)是一个日益严重的公共卫生问题,对心血管健康和总体生存有不利影响。在一般人群中,亚临床甲状腺功能减退症(SCH)与不良预后相关。它被认为在CKD患者中更为普遍,它们的共存可能导致这些患者预后不良。我们的目的是确定慢性肾病中SCH的患病率。方法:使用来自德黑兰甲状腺研究的数据,这是一项前瞻性人群队列研究,选择肾小球滤过率(eGFR)估计为60 mL/min/1.73 m2或以下的成人受试者,研究甲状腺异常的患病率,以及其他已知的心血管危险因素。结果:在招募的5626名受试者中,823人(14.6%)患有CKD。CKD患者年龄较大,体重较重,糖尿病患病率较高,血清促甲状腺素和甲状腺过氧化物酶抗体水平较高,但游离甲状腺素水平较低。肾脏疾病和非肾脏疾病患者的SCH患病率分别为7.3%和5.2% (P < 0.001)。然而,在调整年龄、性别、BMI、吸烟和TPOAb后,CKD和非CKD受试者之间发生SCH的风险没有差异(OR: 1.28;95%ci, 0.89 - 1.83)。在调整年龄和性别后,有和没有SCH的CKD亚组之间的代谢标志物比较没有统计学意义上的显著差异。结论:在控制了混杂因素后,慢性阻塞性肺病的SCH患病率并不高。此外,有无SCH的CKD受试者的代谢参数没有差异。
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引用次数: 1
Clinical and Laboratory Characteristics of a Large Iranian Kindred Afflicted with Von Hippel Lindau Disease. 一个伊朗大亲属患Von Hippel Lindau病的临床和实验室特征
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-03-16 eCollection Date: 2021-04-01 DOI: 10.5812/ijem.105189
Ali Asghar Mir Saeid Ghazi, Atieh Amouzegar, Azita Zadeh-Vakili, Abdolreza Sheikh Rezaei, Alireza Amirbaigloo, Marjan Zarif Yeganeh, Hasan Hashemi, Fereidoun Azizi

Background: Von Hippel Lindau (VHL) disease is a hereditary disorder characterized by the development of benign or malignant tumors in the brain, spinal cord, eyes, adrenal medulla, kidney, pancreas, and many other organs. Advances in molecular diagnosis have led to the identification of the affected members of families at earlier stages. We present the clinical, laboratory, and genetic characteristics of five generations of a large Iranian kindred with VHL.

Methods: The proband, a 52-year-old Iranian man, was recognized with VHL. All family members underwent clinical, laboratory, imaging, and genetic evaluation. Medical files and histopathology reports of patients who had been operated on before were also reviewed. Diagnosis of the disease was based on clinical findings, positive family history of VHL, and development of a central nervous system or retinal hemangioblastoma or pheochromocytoma.

Results: Based on diagnostic criteria, our initial evaluations revealed that 10 members of the family had already been affected by the disease. Among them, nine had pheochromocytoma, and one had retinal hemangioblastoma. There was no case of kidney tumors among the kindred.

Conclusions: Study results show the high penetrance of the disease and focus on the large burden imposed by the disease on the health and quality of life of patients afflicted with the disease, emphasizing the importance of surveillance from early childhood for detection and management of the disease as early as possible.

背景:Von Hippel - Lindau (VHL)病是一种遗传性疾病,其特征是在脑、脊髓、眼睛、肾上腺髓质、肾脏、胰腺和许多其他器官中发生良性或恶性肿瘤。分子诊断的进步使我们能够在早期阶段识别出受影响的家庭成员。我们提出临床,实验室和遗传特征的五代大伊朗亲属与VHL。方法:先证者为52岁伊朗男性,确诊为VHL。所有家庭成员都接受了临床、实验室、影像学和遗传评估。对既往手术患者的医疗档案和组织病理学报告也进行了回顾。该疾病的诊断基于临床表现、VHL阳性家族史、中枢神经系统或视网膜血管母细胞瘤或嗜铬细胞瘤的发展。结果:根据诊断标准,我们的初步评估显示,该家庭已有10名成员受到该病的影响。其中嗜铬细胞瘤9例,视网膜血管母细胞瘤1例。本组亲属无肾肿瘤病例。结论:研究结果显示该病的高外显率,并关注该病对患者健康和生活质量造成的巨大负担,强调儿童早期监测对尽早发现和管理该病的重要性。
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引用次数: 1
Clinical and Biochemical Characteristics and Treatment Outcomes of Ketosis-Prone Diabetes: The Remission Prone Diabetes. 酮症易发糖尿病的临床生化特征及治疗结果:缓解易发糖尿病。
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-03-07 eCollection Date: 2021-04-01 DOI: 10.5812/ijem.106799
Swaraj Shrikant Waddankeri, Meenakshi Swaraj Waddankeri, Basavraj Gurushantappa Mangshetty

Background: Diabetic ketoacidosis (DKA) is one of the severe acute complications of diabetes. It has long been considered a key clinical characteristic of type 1 diabetes mellitus (T1DM) with severe and irreversible deficient insulin levels. Ketosis-prone diabetes (KPD) has pathophysiology close to T2DM but shows signs and symptoms associated with T1DM. In general, patients with ketosis-prone diabetes display elevated glucose and ketone levels; also, a higher hemoglobin A1C than conventional T2DM.

Objectives: The current research aimed to elucidate the clinical presentation and outline a management plan for KPD in the Indian population.

Methods: The present case series is a descriptive, prospective, and observational case series on six unprovoked cases of KPD. They were managed using the standard protocol of DKA management.

Results: The recruited cases followed a set pattern of very high insulin requirement at diagnosis. On follow-up, the insulin requirement progressively declined, and all of the cases were able to stop insulin therapy after a mean period of four weeks. None of the cases presented any organ damage at diagnosis. There was no recurrence of DKA during the two-year follow-up. All of the cases had normal liver and renal functions. Autoantibodies were negative in all of the cases.

Conclusions: Ketosis-prone diabetes is the most under-recognized and under-diagnosed among all types of diabetes. Its recognition is of utmost importance as the approach of its treatment varies widely from that of the conventional type of diabetes. Proper follow-up, especially in unprovoked cases of DKA with obese phenotype, could help elucidate this rare entity of KPD where insulin can be stopped and maintain normoglycemia for a substantial period without insulin.

背景:糖尿病酮症酸中毒(DKA)是糖尿病严重急性并发症之一。长期以来,它一直被认为是1型糖尿病(T1DM)严重且不可逆的胰岛素水平不足的关键临床特征。酮症易发糖尿病(KPD)的病理生理与T2DM相似,但其体征和症状与T1DM相关。一般来说,易患酮症的糖尿病患者表现为葡萄糖和酮水平升高;同时,糖化血红蛋白也高于常规T2DM。目的:目前的研究旨在阐明临床表现和概述了印度人口的KPD的管理计划。方法:目前的病例系列是一个描述性、前瞻性和观察性的病例系列,对6例无因性KPD进行了研究。它们使用DKA管理的标准协议进行管理。结果:所招募的病例在诊断时具有很高的胰岛素需要量。在随访中,胰岛素需求逐渐下降,所有病例在平均4周后都能够停止胰岛素治疗。所有病例在诊断时均未出现任何器官损害。2年随访期间无DKA复发。所有病例肝肾功能正常。所有病例自身抗体均为阴性。结论:酮症易感性糖尿病是所有类型糖尿病中最不被认识和诊断的。它的认识是至关重要的,因为它的治疗方法与传统类型的糖尿病有很大不同。适当的随访,特别是在无诱因的肥胖型DKA病例中,可以帮助阐明这种罕见的KPD,在没有胰岛素的情况下可以停止胰岛素并维持正常血糖。
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引用次数: 2
Comparing Oxidative Stress Status Among Iranian Males and Females with Malignant and Non-malignant Thyroid Nodules. 比较伊朗男性和女性恶性和非恶性甲状腺结节的氧化应激状态。
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-01-26 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.105669
Bita Faam, Ata A Ghadiri, Mohammad Ali Ghaffari, Mehdi Totonchi, Layasadat Khorsandi

Background: Oxidative stress is commonly accrued in thyroid tissue during hormone synthesis.

Objectives: We aimed to examine oxidative stress in patients with thyroid cancer, benign thyroid nodules, and healthy individuals.

Methods: In this study, 138 individuals were involved. Among the selected participants, 108 had thyroid nodules, including 30 papillary thyroid cancer (PTC), 30 follicular thyroid cancer (FTC), six anaplastic thyroid cancer (ATC), 12 medullary thyroid cancer (MTC), and 30 benign nodules. In addition, 30 individuals were selected as a healthy control group. The levels of total antioxidant capacity (TAC) and total oxidant status (TOS) of thyroid tissue were measured using the ELISA method, and the oxidative stress index (OSI) was calculated.

Results: The TAC level was significantly lower in MTC and FTC subtypes than in controls. The TOS level was considerably higher in the MTC group than in the control and benign nodule groups. The TOS level was not changed in other groups. The OSI was considerably higher in MTC and FTC subtypes. The TAC and OSI in benign nodules were significantly lower and higher than those of controls, respectively. The OSI was higher in female patients than in males.

Conclusions: The OSI can not be considered a diagnostic biomarker for benign nodules and MTC. The diverse oxidative stress status between genders may be related to the elevated cancer incidence in females.

背景:在激素合成过程中,氧化应激通常在甲状腺组织中积累。目的:研究甲状腺癌、良性甲状腺结节和健康人的氧化应激。方法:本研究共涉及138例个体。在入选的参与者中,有108例甲状腺结节,包括30例乳头状甲状腺癌(PTC), 30例滤泡性甲状腺癌(FTC), 6例间变性甲状腺癌(ATC), 12例甲状腺髓样癌(MTC)和30例良性结节。另外,选取30人作为健康对照组。采用ELISA法测定大鼠甲状腺组织总抗氧化能力(TAC)和总氧化状态(TOS)水平,计算氧化应激指数(OSI)。结果:MTC和FTC亚型患者TAC水平明显低于对照组。MTC组的TOS水平明显高于对照组和良性结节组。其他组的TOS水平无变化。在MTC和FTC亚型中,OSI相当高。良性结节的TAC和OSI分别显著低于对照组和高于对照组。女性患者的OSI高于男性。结论:OSI不能被认为是良性结节和MTC的诊断性生物标志物。性别间氧化应激状态的差异可能与女性癌症发病率升高有关。
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引用次数: 4
A Pediatric Parathyroid Carcinoma: An Unusual Clinical Presentation and Mini-review. 小儿甲状旁腺癌:一个不寻常的临床表现和小型回顾。
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-01-25 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.110234
Abbas Rahimi, Roghayeh Shahbazi, Pooneh Nikuei, Sanaz Soleimani, Azadeh Moradkhani, Ali Atashabparvar, Farnaz Khajehrahimi, Ghazal Zoghi, Masoumeh Kheirandish

Introduction: Primary hyperparathyroidism (PHPT) is a rare condition in the pediatric population. Parathyroid carcinoma (PC) is a very uncommon cause of PHPT, accounting for < 1% of pediatric PHPT cases. It is challenging to distinguish between parathyroid adenoma (PA), the most common cause of PHPT, and PC. In this report, we described a young female who presented with a history of progressive limping and was finally diagnosed with PC.

Case presentation: A 15-year-old girl presented with progressive limping and bone pain for 8 years. She was referred by an orthopedic surgeon because of elevated intact parathyroid hormone (iPTH) for further evaluation. Physical examination revealed a large, firm, and non-tender neck mass, left hip tenderness, and limited range of motion. The initial biochemistry tests showed a borderline high calcium level of 10.8 mg/dl, an elevated iPTH level of 2876 pg/mL, and a decreased phosphorus level of 2.4 mg/dL. The 99mTechnetium (Tc) sestamibi scan displayed early intense activity in the right thyroid lobe persisting in the three-hour repeat scan, compatible with a parathyroid lesion. The patient underwent right-sided neck exploration and parathyroidectomy. Intraoperative and pathology findings confirmed the diagnosis of PC. Immunohistochemistry (IHC) staining revealed creatine kinase (CK) and CD31 in endothelial cells of the tumor. Ki67 staining was also positive in 2% - 3% of tumor cells. The whole exome sequencing (WES) study was negative for cell division cycle 73 (CDC73) and multiple endocrine neoplasia 1 (MEN1) genes.

Conclusions: PC should be considered as a differential diagnosis of PHPT in the pediatric population, even in the presence of mild hypercalcemia.

简介:原发性甲状旁腺功能亢进(PHPT)是一种罕见的儿童疾病。甲状旁腺癌(PC)是一种非常罕见的病因,占儿童PHPT病例的不到1%。区分PHPT最常见的原因甲状旁腺瘤(PA)和PC是很有挑战性的。在本报告中,我们描述了一位年轻女性,她表现为进行性跛行,最终被诊断为PC。病例介绍:一名15岁女孩,表现为进行性跛行和骨痛8年。由于完整甲状旁腺激素(iPTH)升高,她被骨科医生转介进一步评估。体格检查显示颈部肿块大,结实,无压痛,左髋关节压痛,活动范围有限。最初的生化检查显示钙水平为10.8 mg/dl, iPTH水平升高至2876 pg/mL,磷水平下降至2.4 mg/dl。99mTechnetium (Tc) sestamibi扫描显示右侧甲状腺叶早期强烈活动,持续3小时重复扫描,与甲状旁腺病变相符。患者行右侧颈部探查及甲状旁腺切除术。术中及病理结果证实了PC的诊断。免疫组化(IHC)染色显示肿瘤内皮细胞中存在肌酸激酶(CK)和CD31。Ki67染色在2% ~ 3%的肿瘤细胞中呈阳性。全外显子组测序(WES)检测细胞分裂周期73 (CDC73)和多发性内分泌肿瘤1 (MEN1)基因均为阴性。结论:在儿童人群中,即使存在轻度高钙血症,PC也应被视为PHPT的鉴别诊断。
{"title":"A Pediatric Parathyroid Carcinoma: An Unusual Clinical Presentation and Mini-review.","authors":"Abbas Rahimi,&nbsp;Roghayeh Shahbazi,&nbsp;Pooneh Nikuei,&nbsp;Sanaz Soleimani,&nbsp;Azadeh Moradkhani,&nbsp;Ali Atashabparvar,&nbsp;Farnaz Khajehrahimi,&nbsp;Ghazal Zoghi,&nbsp;Masoumeh Kheirandish","doi":"10.5812/ijem.110234","DOIUrl":"https://doi.org/10.5812/ijem.110234","url":null,"abstract":"<p><strong>Introduction: </strong>Primary hyperparathyroidism (PHPT) is a rare condition in the pediatric population. Parathyroid carcinoma (PC) is a very uncommon cause of PHPT, accounting for < 1% of pediatric PHPT cases. It is challenging to distinguish between parathyroid adenoma (PA), the most common cause of PHPT, and PC. In this report, we described a young female who presented with a history of progressive limping and was finally diagnosed with PC.</p><p><strong>Case presentation: </strong>A 15-year-old girl presented with progressive limping and bone pain for 8 years. She was referred by an orthopedic surgeon because of elevated intact parathyroid hormone (iPTH) for further evaluation. Physical examination revealed a large, firm, and non-tender neck mass, left hip tenderness, and limited range of motion. The initial biochemistry tests showed a borderline high calcium level of 10.8 mg/dl, an elevated iPTH level of 2876 pg/mL, and a decreased phosphorus level of 2.4 mg/dL. The <sup>99m</sup>Technetium (Tc) sestamibi scan displayed early intense activity in the right thyroid lobe persisting in the three-hour repeat scan, compatible with a parathyroid lesion. The patient underwent right-sided neck exploration and parathyroidectomy. Intraoperative and pathology findings confirmed the diagnosis of PC. Immunohistochemistry (IHC) staining revealed creatine kinase (CK) and CD31 in endothelial cells of the tumor. Ki67 staining was also positive in 2% - 3% of tumor cells. The whole exome sequencing (WES) study was negative for cell division cycle 73 (CDC73) and multiple endocrine neoplasia 1 (MEN1) genes.</p><p><strong>Conclusions: </strong>PC should be considered as a differential diagnosis of PHPT in the pediatric population, even in the presence of mild hypercalcemia.</p>","PeriodicalId":13969,"journal":{"name":"International Journal of Endocrinology and Metabolism","volume":"19 1","pages":"e110234"},"PeriodicalIF":2.1,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/9d/ijem-19-1-110234.PMC8010565.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25574091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study. 伊朗新生儿先天性甲状腺功能减退的家族相关风险:一项基于人群的病例对照研究
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-01-20 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.104889
Shahin Yarahmadi, Nasrin Azhang, Mahmood Salesi, Khaled Rahmani

Background: Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation.

Objective: This study aimed to identify familial-related risk factors for CH in Iranian newborns.

Methods: A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor.

Results: Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother's hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%).

Conclusions: This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone.

背景:先天性甲状腺功能减退症(CH)是一种最常见的内分泌疾病,是一种可预防的智力低下原因。目的:本研究旨在确定伊朗新生儿CH的家族相关危险因素。方法:在伊朗CH患者的国家登记系统中进行了一项基于人群的病例对照研究。在这项研究中,906名对照组和454名病例进行了为期一年的研究。采用logistic回归模型调查家族相关因素。还计算了每个重要危险因素的人口归因分数(PAF)。结果:通过多因素分析,观察到先天性异常(优势比(OR): 5.77, 95%可信区间(CI): 2.37 - 14.01)、家族精神发育迟滞史(OR:2.10, 95% CI: 1.15-3.83)、孕期母亲甲状腺功能减退(OR: 2.01, 95% CI: 1.33 - 3.03)、家族内婚姻(OR:1.49, 95% CI: 1.18 - 1.89)、妊娠期糖尿病(OR: 1.69, 95% CI: 1.09 - 2.63)、家族中有甲状腺功能减退的孩子(OR: 2.48, 95% CI: 2.48)的患者发生CH的风险增加。1.39 - 4.42),双胞胎或更多(or: 2.61, 95% CI: 1.31 - 5.21)。家庭相关危险因素中PAF最高的是家庭内婚姻(14.9%)。结论:本研究揭示家族相关危险因素和近亲婚姻在伊朗CH高发中起重要作用。在伊朗,大约15%的CH可以仅仅归因于家庭内部婚姻。
{"title":"Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study.","authors":"Shahin Yarahmadi,&nbsp;Nasrin Azhang,&nbsp;Mahmood Salesi,&nbsp;Khaled Rahmani","doi":"10.5812/ijem.104889","DOIUrl":"https://doi.org/10.5812/ijem.104889","url":null,"abstract":"<p><strong>Background: </strong>Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation.</p><p><strong>Objective: </strong>This study aimed to identify familial-related risk factors for CH in Iranian newborns.</p><p><strong>Methods: </strong>A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor.</p><p><strong>Results: </strong>Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother's hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%).</p><p><strong>Conclusions: </strong>This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone.</p>","PeriodicalId":13969,"journal":{"name":"International Journal of Endocrinology and Metabolism","volume":"19 1","pages":"e104889"},"PeriodicalIF":2.1,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/17/ijem-19-1-104889.PMC8010566.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25574086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Correction of Hyperthyroidism with Anti-thyroid Drugs on the Glycated Hemoglobin in Non-diabetic Patients with Primary Hyperthyroidism. 抗甲状腺药物矫正甲亢对非糖尿病原发性甲亢患者糖化血红蛋白的影响。
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-01-19 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.105751
Dasari Mani Deepthi, Suresh Vaikkakara, Avinash Patil, Sandeep Ganta, Alok Sachan, Katakam Raghavendra, Vinapamula S Kiranmayi, Amit Kumar Chowhan

Background: Glycated hemoglobin (HbA1c) levels are dependent not only on the average blood glucose levels over the preceding 2 - 3 months but also on the turnover of erythrocytes. Hyperthyroidism is known to be associated with an increase in erythrocyte turnover that may falsely lower the HbA1c in relation to the level of glycemia.

Objectives: To assess the impact of medical correction of hyperthyroidism on HbA1c, independent of changes in the fasting plasma glucose and 2-hour post-oral glucose tolerance test plasma glucose.

Methods: Adult patients with overt hyperthyroidism (n = 36) were tested for their hemoglobin, reticulocyte percentage, HbA1c and fasting and post-oral glucose tolerance test (OGTT) 2-hour plasma glucose, both at baseline and following at least three months of near normalization of serum thyroxin on Carbimazole treatment.

Results: Correction of hyperthyroidism in 36 patients was associated with an increase in the hemoglobin (P = 0.004) and a rise in HbA1c (P = 0.025), even though no significant change was observed in both the fasting (P = 0.28) and post OGTT two-hour plasma glucose (P = 0.54). Also, the proportion of patients with HbA1c ≥ 5.7% rose from 3/36 to 10/36; P = 0.016, while the proportion of patients with either abnormal fasting or abnormal post OGTT 2-hour plasma glucose or both did not show any significant change (P = 0.5). The sensitivity of HbA1c to diagnose prediabetes increased from 20% to 50% post- treatment.

Conclusions: Glycated hemoglobin is falsely low in relation to glycemia in patients with untreated hyperthyroidism.

背景:糖化血红蛋白(HbA1c)水平不仅取决于前2 - 3个月的平均血糖水平,还取决于红细胞的周转。众所周知,甲状腺机能亢进与红细胞周转增加有关,这可能会错误地降低与血糖水平相关的HbA1c。目的:评估甲状腺机能亢进医学矫正对HbA1c的影响,不依赖于空腹血糖和口服糖耐量试验后2小时血糖的变化。方法:对36例明显甲状腺功能亢进的成年患者进行血红蛋白、网状红细胞百分比、糖化血红蛋白(HbA1c)、空腹和口服后糖耐量试验(OGTT) 2小时血糖检测,包括基线时和至少3个月卡咪唑治疗后血清甲状腺素接近正常化后。结果:36例甲状腺功能亢进患者的纠正与血红蛋白升高(P = 0.004)和HbA1c升高(P = 0.025)相关,尽管空腹(P = 0.28)和OGTT后两小时血浆葡萄糖(P = 0.54)均未观察到显著变化。HbA1c≥5.7%的患者比例从3/36上升到10/36;P = 0.016,而空腹或OGTT后2小时血糖异常或两者均异常的患者比例无显著变化(P = 0.5)。治疗后,HbA1c诊断前驱糖尿病的敏感性从20%提高到50%。结论:在未经治疗的甲亢患者中,糖化血红蛋白与血糖的关系是错误的低。
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引用次数: 2
COVID-19-Related Weight Gain in School-Aged Children. 与covid -19相关的学龄儿童体重增加。
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-12-29 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.110634
Mohammadreza Rezaeipour
Dear Editor, This letter describes a proposed method to prevent children from gaining weight during not attending school due to COVID-19. The pandemic of Coronavirus Disease 2019 (COVID-19) is making considerable mortality and morbidity, putting pressure on health care systems, winding down the economy, and increasing school absenteeism. While lowering its immediate impact is a priority, I want to focus on a long-term impact on the health of children. By not attending school and staying at home, COVID-19 may lead to a stepped-up children’s obesity epidemic and increases obesity disorders. The COVID-19 pandemic has prevented students from attending school, forcing them to stay at home in many parts of Iran. The school system is not expected to return to normal this school year. Experiences gained in the Middle East countries such as Iran indicate that the observance of social distancing if canceled after a short time, must be periodically re-established its orders to control the prevalence of COVID-19 (1, 2). In summary, the COVID-19 pandemic in Iran is expected to intensify dramatically this year and increase school absenteeism, which will make worse the risk factors for weight gain related to summer vacations. Although a lot of literature is available about poor eating habits and body exercises in schools, according to research, children experience an increase in unhealthy weight not within the school year but generally in the summer months when they do not attend school (3-5). A study during school years has shown that the outbreak of overweight/obesity in students occurred only within the summer vacations (3). Research and follow-up studies show that an abnormal increase in weight is evident at school summer vacation, especially for some breeds, as well as children who were already extra weight (3, 5). It is worth noting that the data obtained indicate that the weight increased during the summer months remains throughout the school year and accumulates from summer to summer (5). Abnormal weight gain in childhood is a long-standing problem, as another study showed that childhood obesity is related to adulthood weight gain (6). For example, an abnormal increase in weight at the age of five was significantly linked to an increase in body mass index and fat mass in middle age (6). I argue that with raising out-of-school time, the pandemic of COVID-19 aggravates all risk factors for abnormal weight gain due to summer vacations (7). Not attending school, staying at home, and on-place shelter orders challenge children in the field of nutrition and physical exercise. On the one hand, physical activity and doing it in groups are limited for children, and on the other hand, they are provided with a variety of food resources in terms of entertainment. Predictions consistent with the culture and home facilities of Iranians demonstrate that not attending school can lead to more eating foods (8), junk foods, and/or miss meals (8) among children of school ag
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引用次数: 5
Iranian Endocrine Society Guidelines for Screening, Diagnosis, and Management of Gestational Diabetes Mellitus. 伊朗内分泌学会妊娠期糖尿病筛查、诊断和管理指南。
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-12-23 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.107906
Majid Valizadeh, Farhad Hosseinpanah, Fahimeh Ramezani Tehrani, Hengameh Abdi, Ladan Mehran, Farzad Hadaegh, Atieh Amouzegar, Farzaneh Sarvghadi, Fereidoun Azizi

Context: Gestational diabetes mellitus (GDM) is an important endocrine disorder in perinatology, associated with several maternal and neonatal complications. Development of national guidelines can inform clinicians, health policymakers, and researchers about the most recent evidence and practical issues of diagnosis and management of GDM.

Objectives: We aimed to develop clinical practice guidelines for the diagnosis and management of GDM in Iranian pregnant women.

Evidence acquisition: The Iranian Endocrine Society constituted a task force, consisting of obstetrician-gynecologists, endocrinologists, a clinical nutritionist, a clinical epidemiologist, and a librarian, to review the published literature and propose national guidelines for the diagnosis and management of GDM. The consensus was reached on all recommendations in several group meetings with a majority decision. The evidence and recommendations were graded according to the American College of Physicians' Guideline Grading System.

Results: The proposed guidelines included recommendations for screening, diagnosis, and management of GDM in Iran.

Conclusions: By using an evidence-based approach, these national GDM guidelines can address important clinical issues in the diagnosis and management of Iranian women with GDM.

背景:妊娠期糖尿病(GDM)是围产儿中一种重要的内分泌疾病,与多种孕产妇和新生儿并发症相关。国家指南的制定可以使临床医生、卫生政策制定者和研究人员了解GDM诊断和管理的最新证据和实际问题。目的:我们旨在为伊朗孕妇GDM的诊断和管理制定临床实践指南。证据获取:伊朗内分泌学会成立了一个工作组,由妇产科医生、内分泌学家、临床营养师、临床流行病学家和图书管理员组成,负责审查已发表的文献,并为GDM的诊断和管理提出国家指南。在几次小组会议上以多数决定就所有建议达成了协商一致意见。证据和建议根据美国医师学会指南分级系统进行分级。结果:建议的指南包括对伊朗GDM的筛查、诊断和管理的建议。结论:通过采用循证方法,这些国家GDM指南可以解决伊朗女性GDM诊断和管理中的重要临床问题。
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引用次数: 4
Scientific Publishing in Biomedicine: How to Choose a Journal? 生物医学科学出版:如何选择期刊?
IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-11-25 eCollection Date: 2021-01-01 DOI: 10.5812/ijem.108417
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi

Publishing in peer-reviewed high-quality journals is a gold standard method for disseminating scientific work. Choosing the right journal is one of the most important and difficult aspects of publishing research results. Submitting to an inappropriate journal is one of the most common reasons for fast rejection of manuscripts, resulting in time wasted by the authors and journals' editors. Here, we discuss important factors that should be considered for choosing the right journal to get your work published successfully and effectively. The most important factors for journal targeting are: (1) The journal's characteristics, including its scientific prestige, performance, publishing model, acceptance possibility, and specialty; (2) the manuscript's characteristics, including its relevance to the journal's aim and scope, its intrinsic value, meaning the novelty of the research, soundness of the methodology, potential impact in the field, and its implication; and (3) authors' priorities and limitations.

在同行评议的高质量期刊上发表文章是传播科学工作的黄金标准方法。选择合适的期刊是发表科研成果最重要也是最困难的方面之一。投稿到不合适的期刊是快速退稿最常见的原因之一,导致作者和期刊编辑浪费时间。在这里,我们讨论了选择合适的期刊以使你的工作成功有效地发表时应该考虑的重要因素。期刊定位最重要的因素有:(1)期刊的特点,包括期刊的科学声望、学术表现、出版模式、被接受的可能性和专业性;(2)稿件的特征,包括其与期刊目标和范围的相关性、内在价值、研究的新颖性、方法的合理性、在该领域的潜在影响及其含义;(3)作者的工作重点和局限性。
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引用次数: 5
期刊
International Journal of Endocrinology and Metabolism
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