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Impacto de un Programa de Recuperación Funcional en Músculos Ventilatorios y Apendiculares en Pacientes Post-ventilación Mecánica por COVID-19 COVID-19机械通气后患者通气和阑尾肌肉功能恢复方案的影响
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501485
María Fernanda del-Valle-Valdés, Constanza Díaz-Canales, Mariano del Sol, Máximo Escobar-Cabello, Jorge Valenzuela-Vásquez, Rodrigo Muñoz-Cofré
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引用次数: 0
Radiologıcal Evaluation of Volar Cortical Angle in the Anatolian Population 安那托利亚人群掌侧皮质角的影像学评价
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501508
Asrın Nalbant, Eren Ismailoglu, Ebru Turhan, Özden Bedre Duygu
Distal radius fractures are the most common fractures of the upper limb. The most commonly used method in the repair of these fractures is volar locking plates. Recently, the frequency of removal of volar locking plates after surgery has increased. There are many factors in its reduction. Anatomically, incompatibility of the distal end of the radius with volar locking plates is one of them. In previous studies, different volar cortical angle (VCA) values were found in other races. For this reason, this study aimed to determine the mean values by making VCA measurements of the Anatolian population. The study was designed retrospectively. In the study, measurements were made on computed tomography (CT) images of the distal end of the radius of 53 men and 28 women. Radial width, intermediate volar angle, and radial volar angle were measured in the images. On average, the radius width was 23.35±1.96 mm, and the intermediate volar angle was 26.02±.3.83°, radial volar angle was 24±3.07°. Radial width, intermediate volar angle, and radial volar angle differed significantly by gender (p<0.001). A significant correlation was found between radius width, intermediate volar angle, and radial volar angle values (p<0.001). It has been determined that the Anatolian population has a different VCA value than the European, Asian, and other populations. When using volar locking plates in distal radius fracture surgery, volar locking plates should be selected by considering the average values of the races.
桡骨远端骨折是上肢最常见的骨折。这类骨折最常用的治疗方法是掌侧锁定钢板。最近,手术后掌侧锁定钢板取出的频率有所增加。它的减少有很多因素。解剖上,桡骨远端与掌侧锁定钢板不相容是其中之一。在以往的研究中,其他种族的掌侧皮质角(VCA)值不同。因此,本研究旨在通过对安纳托利亚人口进行VCA测量来确定平均值。本研究采用回顾性设计。在这项研究中,对53名男性和28名女性的桡骨远端进行了计算机断层扫描(CT)成像。测量图像的径向宽度、中间掌角和径向掌角。平均半径宽度23.35±1.96 mm,中间掌侧角26.02±.3.83°,桡骨掌侧角24±3.07°。径向宽度、中间掌角和径向掌角在性别上差异显著(p<0.001)。桡骨宽度、中间掌角和桡骨掌角值之间存在显著相关性(p<0.001)。已经确定安纳托利亚人口的VCA值与欧洲、亚洲和其他人口不同。在桡骨远端骨折手术中使用掌侧锁定钢板时,应考虑椎体的平均值来选择掌侧锁定钢板。
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引用次数: 0
Analysis of Wrist Morphology Through Hamate and Lunate Bone Variations in Anatolian Population Using Plain Radiography 利用x线平片分析安纳托利亚人群钩骨和月骨的腕部形态变化
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501343
Ahmet Savran
The present study aimed to evaluate wrist (lunate) anatomy in terms of the incidence of lunatum morphology on plain-radiographs among the Anatolian (Turkey) population, accompanied by demographic analysis. We obtained all the patients’ data regarding demographical features, diagnosis, and posteroanterior (PA) X-ray imaging. Two radiograph-reviewers repeated the analysis twice, one month later, blinded to their findings before the previous review. The lunatum structure was determined as Type-1 (n:293) and Type-2 (n:207) for each radiograph. Most of the 500 wrists' radiographs [n:293 (58.6 %)] were type-I lunate. The mean age was 36.7±13.3 (range:18-90) years. Sex distribution was as follows: 185 (63.1 %) males to 108 (36.9 %) females. Type-2 lunate was seen in 207 participants (41.4 %). The mean age for type-2 was 41.6±15.2 (18-88) years. 142 (68.6 %) participants were male sex, while 65 (31.4 %) were females. The mean age of subjects with type-I showed a difference with type-II (p=0.007). There was no relationship in terms of sex (p=0.206) between the groups. In the Anatolian region, type-1 lunate was dominant compared to type-2. The incidence rate of lunate type in Anatolian population was similar to the Arab population.
本研究旨在评估腕部(月骨)解剖在安那托利亚(土耳其)人口中月骨形态的平片发生率,并伴有人口统计学分析。我们获得了所有患者的人口学特征、诊断和后前路(PA) x射线成像的数据。一个月后,两名放射线检查人员重复了两次分析,在前一次检查之前对他们的发现不知情。每张x线片均确定月状体结构为1型(n:293)和2型(n:207)。500张腕关节x线片[n:293(58.6%)]多为i型月骨。平均年龄36.7±13.3岁(18 ~ 90岁)。性别分布:男性185人(63.1%),女性108人(36.9%)。207名参与者(41.4%)出现2型月骨。2型患者平均年龄为41.6±15.2(18-88)岁。142名(68.6%)参与者为男性,65名(31.4%)参与者为女性。ⅰ型与ⅱ型患者的平均年龄差异有统计学意义(p=0.007)。各组之间在性别方面没有关系(p=0.206)。在安纳托利亚地区,与2型相比,1型月牙占主导地位。月型在安纳托利亚人群中的发病率与阿拉伯人群相似。
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引用次数: 0
Methodological Proposal for the Adequate Use of the Osteotechnics Technique 充分使用骨技术的方法学建议
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501281
J. Stephan Sánchez-Torrijos, G. L Serrano-González, L. A San-Martín-Martínez, G Mejía-Medina, L Valencia-Caballero
Osteotechnics is one of the different anatomical preservation techniques and can be defined as the technique designed to prepare, clean, obtain and preserve bone structures that can be used in the teaching, museographic or research field. The osteotechnical technique procedure consists of the following phases: debulk and disjoint, maceration, cooking, cleaning, degreasing, bleaching, and labeling to obtain bone material. Seven phases will be explained in detail, as well as the materials, instruments, quantities of the substances used, and the time required to obtain human bone material. We consider that this article can serve as a guide, given that all the experimentation was carried out with human biological material. This methodological proposal could be consolidated and established based on the experience acquired during the creation of the contemporary skeletal collection of the department of innovation in human biological material (DIMBIH). Therefore, the purpose of our proposal is to provide tools that facilitate the work of those who carry out this work and fundamentally to avoid irreversible or irreparable damage to the osteological material, since it is of great value and difficult to acquire for disciplines as anatomy, veterinary, physical and forensic anthropology, medicine, dentistry and biology.
骨技术是一种不同的解剖保存技术,可以定义为用于教学、博物馆或研究领域的骨结构的制备、清洁、获取和保存技术。骨技术程序包括以下几个阶段:剥离和分离、浸渍、烹饪、清洁、脱脂、漂白和标记以获得骨材料。将详细解释七个阶段,以及材料,仪器,所用物质的数量,以及获得人骨材料所需的时间。我们认为这篇文章可以作为一个指南,因为所有的实验都是用人体生物材料进行的。这一方法建议可以根据人类生物材料创新部(DIMBIH)在创建当代骨骼收藏期间获得的经验加以巩固和确立。因此,我们提议的目的是提供工具,以方便那些开展这项工作的人的工作,并从根本上避免对骨材料的不可逆转或不可修复的损害,因为它对解剖学,兽医学,物理和法医人类学,医学,牙科和生物学等学科具有重要价值且难以获得。
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引用次数: 0
Anthropometric Similarities and Differences in Children of Aymara and Non-Aymara Descent in Northern Chile: Implications for Health and Development 智利北部艾马拉和非艾马拉后裔儿童的人体测量相似性和差异性:对健康和发展的影响
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501411
Luis A Barrio-Mateu, Dayneri León-Valladares, Josivaldo de-Souza-Lima, Rodrigo Yáñez-Sepúlveda, Yaiza Cordero-Rodríguez, Fernanda Borges-Silva, Ernesto Ponce, Daniel Ponce, Muriel Ponce
This study aims to assess the nutritional status of Aymara and non-Aymara children in Arica, comparing anthropometric measurements of boys and girls aged 4-10 to inform interventions for child health and development. We conducted a non-experimental, quantitative, cross-sectional study in Arica, Chile. The sample included 458 children, with equal representation of Aymara and non-Aymara children from diverse socioeconomic backgrounds. Trained research assistants collected anthropometric data using standardized techniques. IBM SPSS statistical software was used for data analysis, including Student's t-test and the Levene test. Both Aymara and non-Aymara children showed high prevalence of overweight and obesity. Boys had a meso-endomorph somatotype, while girls had an endomorph somatotype. Among 8-year-olds, non-Aymara children had a slightly higher mean body weight (35.87, SD 4.50) compared to Aymara children (32.27, SD 4.31), but the difference was not statistically significant (p>0.05). However, 10-year-old Aymara girls had a significantly higher mean body mass index (22.34, SD 4.21) than non-Aymara girls (20.10, SD 3.58) (p=0.05). Regarding body fat percentage, 10-year- old non-Aymara girls had a slightly higher mean (31.01, SD 5.64) than Aymara girls (26.12, SD 5.63), but the difference was not statistically significant (p>0.05). The study found high levels of overweight and obesity in children from northern Chile, increasing with age for both Aymara and non-Aymara groups. The somatotype patterns were consistent across both groups. Although the differences between Aymara and non-Aymara children were not statistically significant, the Aymara group showed slightly higher levels of overweight and obesity. Further research with a larger sample size is needed to confirm these results and identify potential trends. Efforts should focus on promoting healthy nutrition and physical activity to address the growing problem of overweight and obesity in this region.
这项研究旨在评估非洲艾马拉和非艾马拉儿童的营养状况,比较4-10岁男孩和女孩的人体测量值,为儿童健康和发展的干预措施提供信息。我们在智利的阿利卡进行了一项非实验性、定量的横断面研究。样本包括458名儿童,来自不同社会经济背景的艾马拉和非艾马拉儿童的比例相等。训练有素的研究助理使用标准化技术收集人体测量数据。采用IBM SPSS统计软件进行数据分析,包括Student’st检验和Levene检验。艾马拉儿童和非艾马拉儿童超重和肥胖的发生率都很高。男孩是中内型,而女孩是内型。8岁儿童中,非艾马拉族儿童的平均体重(35.87,SD 4.50)略高于艾马拉族儿童(32.27,SD 4.31),但差异无统计学意义(p>0.05)。然而,10岁艾马拉女孩的平均体重指数(22.34,SD 4.21)显著高于非艾马拉女孩(20.10,SD 3.58) (p=0.05)。10岁非艾马拉族女孩体脂率平均值(31.01,SD 5.64)略高于艾马拉族女孩(26.12,SD 5.63),但差异无统计学意义(p>0.05)。研究发现,智利北部的儿童超重和肥胖程度很高,随着年龄的增长,艾马拉族和非艾马拉族的儿童超重和肥胖程度都在增加。两组的体型模式是一致的。尽管艾马拉儿童和非艾马拉儿童之间的差异在统计上并不显著,但艾马拉儿童的超重和肥胖程度略高。需要进行更大样本量的进一步研究来证实这些结果并确定潜在趋势。应着重促进健康营养和体育活动,以解决本区域日益严重的超重和肥胖问题。
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引用次数: 0
Histomorphological, Histochemical and Ultrastructural Studies on the Healthy Liver of Yemen Veiled Chameleon (Chamaeleo calyptratus) in Southern Saudi Arabia 沙特阿拉伯南部也门面纱变色龙健康肝脏的组织形态学、组织化学和超微结构研究
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501513
Amin A Al-Doaiss, Mohammed A Alshehri, Ali A Shati, Mohammad Y Alfaifi, Mohammed A Al-Kahtani, Ahmed Ezzat Ahmed, Refaat A Eid, Laila A Al-Shuraym, Fahd A Al-Mekhlafi, Mohammed Al-Zahrani, Mohammed Mubarak
The livers of reptiles are being studied as a model for the link between the environment and hepatic tissue. There have been few investigations on the histology of reptile livers, and very few or no studies have examined the histology of liver of veiled chameleon (Chamaeleo calyptratus). This paper describes the histomorphological, histochemical and ultrastructural characterization of the liver of veiled chameleons in southern Saudi Arabia. Seven Chamaeleo calyptratus were captured in the summer season in Abha City, Aseer region, southern Saudi Arabia. Chamaeleon liver samples were processed for histomorphology, histochemistry and ultrastructure analyses. Morphologically liver of Chamaeleo calyptratus was observed as a large dark brown organ with lighter speckles, which represent melanin deposits. It located at the ventral part of abdominal cavity forward of the stomach. Its dimensions approximately were 3.7 x 2 cm. The liver was a bilobed organ divided into two lobes, right and left lobes. The right one was bigger than the others. The gallbladder was well developed and had an elongated shape, situated between the two lobes and contained the bile for the digestion. Microscopically, the liver was found to be covered by a thick layer of connective tissue, which formed the hepatic capsule. Hepatic parenchyma probably appeared in cross sections as hepatic glandular-like alveoli “acini” or follicular structures with various diameters, each acinus contains approximately four to six hepatocytes, surrounded by sinusoidal capillaries filled with abundant melanomacrophages, which are absent in birds and mammals. Melanomacrophages are common in the hepatic parenchyma's perisinusoidal areas, particularly near portal spaces. Hepatocytes are polyhedral or pyramidal with and mostly contained large, rounded nuclei mostly peripherally located, with prominent dark oval nucleoli. Some of nuclei are eccentric or central position. The cytoplasm appeared spongy or vacuolated and more eosinophilic when stained by hematoxylin-eosin and strongly reactive to PAS staining technique, indicating abundant glycogen content. The reticular fibers that surround hepatocytes, blood arteries, and sinusoids supported the hepatic parenchyma. The blood sinusoids are seen interspersed among hepatocytes of varying sizes. The sinusoidal lumen was bordered by flattened endothelial cells and includes elliptical nucleated erythrocytes and liver macrophages as phagocytes, which are also known as Kupffer cells. Branches of the portal vein, hepatic artery, small bile duct, and lymph vessels were detected in the hepatic portal area “tract” or triad which made up of connective. Hematopoietic tissue was observed in subcapsular region and portal triads. Ultrastructurally, the hepatocyte appeared polyhedric containing a single large rounded basal or eccentric vesicular nucleus with prominent nucleolus. Extensive network of rough endoplasmic reticulum (RER) often arranged in an array parallel
爬行动物的肝脏正在被研究作为环境和肝组织之间联系的模型。关于爬行动物肝脏的组织学研究很少,而关于面纱变色龙(Chamaeleo calyptratus)肝脏组织学的研究很少或没有。本文描述了沙特阿拉伯南部面纱变色龙肝脏的组织形态学、组织化学和超微结构特征。夏季在沙特阿拉伯南部阿泽尔地区阿布哈市捕获了7只变色龙。对变色龙肝脏标本进行组织形态学、组织化学和超微结构分析。形态学上,卡利特龙的肝脏是一个大的深棕色器官,有较浅的斑点,代表黑色素沉积。它位于胃前方的腹腔腹侧。它的尺寸约为3.7 x 2厘米。肝脏是一个分两叶的器官,分为左右两叶。右边的那个比其他的都大。胆囊发育良好,形状细长,位于两叶之间,容纳胆汁供消化。显微镜下,肝脏被一层厚厚的结缔组织覆盖,形成肝囊。肝实质可能在横切面上表现为肝腺样肺泡或不同直径的滤泡结构,每个腺泡含有大约4 - 6个肝细胞,周围是充满丰富的黑素巨噬细胞的正弦毛细血管,这在鸟类和哺乳动物中是不存在的。黑素巨噬细胞常见于肝实质的窦周区,尤其是门静脉间隙附近。肝细胞呈多面体或锥体,多数含有大而圆的细胞核,多数位于周围,核仁呈明显的暗色卵形。部分核偏心或居中。苏木精-伊红染色细胞质呈海绵状或空泡状,嗜酸性增强,PAS染色反应强烈,提示糖原含量丰富。环绕肝细胞、血动脉和窦的网状纤维支撑着肝实质。血窦分布在大小不等的肝细胞中。窦状管腔被扁平的内皮细胞包围,包括椭圆形有核红细胞和肝巨噬细胞,它们也被称为库普弗细胞。在肝门静脉区(由结缔组织组成的)内可见门静脉分支、肝动脉分支、小胆管分支和淋巴管分支。在囊下区和门静脉三联区可见造血组织。在超微结构上,肝细胞呈多面体,含有单个大的圆形基核或偏心泡状核,核仁突出。广泛的粗内质网(RER)通常排列在平行于核膜的阵列上,有许多线粒体和高尔基体。细胞质中含有糖原颗粒、囊泡或液泡,分布在细胞质中,特别是在顶端区域。还讨论了胆管和肝“库普弗”细胞。这是沙特阿拉伯南部也门面纱变色龙健康肝脏组织学特征的首次研究。本研究结果可作为参考,与该动物肝脏病理异常进行比较。
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引用次数: 0
Dissectional Orientation: Morphological Variations of Teres Minor Muscle and its Nerve Supply 解剖取向:小圆肌形态变化及其神经供应
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501445
Chutikan Kaensa, Sirinush Sricharoenvej, Passara Lanlua, Sani Baimai
.
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引用次数: 0
Comparative Assessment of Contact Osteogenesis at the Titanium Implant-Bone Junction in Male Rabbits with Dissimilar Femoral Defects 不同股骨缺损雄性兔钛植入骨接口处接触成骨的比较评价
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501317
V. Duma, A. F Gal, V Rus, Maria-Catalina Matei-Latiu, C Ratiu, B. C Alexandru, C Latiu, C Martonos, L. I Oana
Traumatized bone tissue has the capacity to repair itself so that it eventually regains its almost original form, even in the case of artificially inserted implants. The process that stays at the base of the regeneration is represented by osteogenesis or remote osteogenesis. The major difference between the two types of bone formation is the location of the cement line, which is located on the surface of the implant for contact osteogenesis and on the surface of the bone defect for remote osteogenesis. The aim of the present study was to assess the contact osteogenesis in the case of inserted titanium screws in holes with diameters of 1.8 mm and 1 mm respectively. The obtained results show, in the case of the groove with 1.8 mm that the newly proliferated bone represents 73.85 % of the total area, while in the case of the groove with 1 mm in diameter the value of the newly proliferated bone is 26.15 %. In conclusion, the insertion of titanium screws by self-tapping into the hole smaller than the core of the screw is accompanied by bone proliferation by contact osteogenesis much more modest than in the case of insertion into the hole larger than the core of the screw.
受创伤的骨组织有自我修复的能力,即使在人工植入的情况下,它最终也能恢复到几乎原始的形态。停留在再生底部的过程被称为成骨或远端成骨。这两种类型的骨形成的主要区别在于水泥线的位置,它位于种植体的表面,用于接触成骨,而位于骨缺损的表面,用于远程成骨。本研究的目的是评估在直径分别为1.8 mm和1mm的孔内插入钛螺钉的情况下接触成骨。结果表明,直径为1.8 mm的凹槽中,新增殖骨占总面积的73.85%,而直径为1 mm的凹槽中,新增殖骨占总面积的26.15%。综上所述,自攻入小于螺钉核心孔的钛螺钉与大于螺钉核心孔的钛螺钉相比,通过接触成骨实现的骨增殖要温和得多。
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引用次数: 0
The Digastric Muscle: Its Anatomy and Functions Revisited 二腹肌:解剖与功能重访
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501501
Jae-Heon Kim, Hye-Jung Yoon, Soyeon Kim, Wanki Lee, Young-Seok Park
As one of the suprahyoid muscles, the digastric muscle is characterized by two separate bellies of different embryologic origins. The origin of the anterior belly is the digastric fossa, while the origin of the posterior belly is the mastoid notch. They share a common insertion: the intermediate tendon. When the digastric muscle contracts, the hyoid bone is raised. Opening of the jaw and swallowing of food boli are associated with digastric muscle activity. This review discusses the general anatomic features of the digastric muscle and its variation, primary functions, and clinical implications focused on surgical reconstruction and rejuvenation.
作为舌骨上肌之一,二腹肌的特点是有两个不同胚胎起源的独立腹部。前腹的起源是二腹肌窝,后腹的起源是乳突切迹。它们有一个共同的止点:中间肌腱。当二腹肌收缩时,舌骨凸起。张开下颚和吞咽食物颗粒与二腹肌活动有关。这篇综述讨论了二腹肌的一般解剖特征及其变异,主要功能,以及手术重建和恢复的临床意义。
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引用次数: 0
Protective Effects and Mechanisms of Huangqi Decoction Against Radiation-Induced Bystander Effects 黄芪汤对辐射诱导的旁观者效应的保护作用及其机制
4区 医学 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-10-01 DOI: 10.4067/s0717-95022023000501527
Fangyu An, Chunlu Yan, Jiajin Li, Xueying Lv, Caixia Wang, Jie Deng, Biao Shi, Jinlong Zhang, Wenxuan Che, Wenrui Zheng
The 12C6+ heavy ion beam irradiation can cause bystander effects. The inflammatory cytokines, endocrine hormones and apoptotic proteins may be involved in 12C6+ irradiation-induced bystander effects. This study characterized the protective effects and mechanisms of Huangqi decoction (HQD) against 12C6+ radiation induced bystander effects. Wistar rats were randomly divided into control, 12C6+ heavy ion irradiation model, and high-dose/medium-dose/low-dose HQD groups. HE staining assessed the pathological changes of brain and kidney. Peripheral blood chemical indicators as well as inflammatory factors and endocrine hormones were detected. Apoptosis was measured with TUNEL. Proliferating cell nuclear antigen (PCNA) expression was determined with real-time PCR and Western blot.Irradiation induced pathological damage to the brain and kidney tissues. After irradiation, the numbers of white blood cells (WBC) and monocyte, and the expression of interleukin (IL)-2, corticotropin-releasing hormone (CRH) and PCNA decreased. The damage was accompanied by increased expression of IL-1β, IL-6, corticosterone (CORT) and adrenocorticotropic hormone (ACTH) as well as increased neuronal apoptosis. These effects were indicative of radiation-induced bystander effects. Administration of HQD attenuated the pathological damage to brain and kidney tissues, and increased the numbers of WBC, neutrophils, lymphocyte and monocytes, as well as the expression of IL-2, CRH and PCNA. It also decreased the expression of IL-1β, IL-6, CORT and ACTH as well as neuronal apoptosis. HQD exhibits protective effects against 12C6+ radiation-induced bystander effects. The underlying mechanism may involve the promotion of the production of peripheral blood cells, inhibition of inflammatory factors and apoptosis, and regulation of endocrine hormones.
12C6+重离子束辐照可引起旁观者效应。炎症因子、内分泌激素和凋亡蛋白可能参与12C6+照射诱导的旁观者效应。本研究探讨了黄芪汤对12C6+辐射诱导的旁观者效应的保护作用及其机制。Wistar大鼠随机分为对照组、12C6+重离子辐照模型和HQD高/中/低剂量组。HE染色观察脑、肾的病理变化。检测外周血化学指标、炎症因子及内分泌激素。TUNEL法检测细胞凋亡。采用实时荧光定量PCR和Western blot检测增殖细胞核抗原(PCNA)的表达。辐照对脑组织和肾组织造成病理性损伤。照射后,白细胞(WBC)和单核细胞数量以及白细胞介素(IL)-2、促肾上腺皮质激素释放激素(CRH)和PCNA的表达均下降。损伤伴IL-1β、IL-6、皮质酮(CORT)、促肾上腺皮质激素(ACTH)表达增加,神经元凋亡增加。这些影响表明辐射引起的旁观者效应。HQD可减轻脑、肾组织的病理损伤,提高WBC、中性粒细胞、淋巴细胞和单核细胞的数量以及IL-2、CRH和PCNA的表达。同时降低IL-1β、IL-6、CORT、ACTH的表达及神经元凋亡。HQD对12C6+辐射诱导的旁观者效应具有保护作用。其潜在机制可能涉及促进外周血细胞的产生,抑制炎症因子和细胞凋亡,调节内分泌激素。
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引用次数: 0
期刊
International Journal of Morphology
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