首页 > 最新文献

International Journal of General Medicine最新文献

英文 中文
Predictive Value of NLR, PLR, RDW and PDW in the Adverse Prognosis of Neonatal Pneumonia. NLR、PLR、RDW、PDW对新生儿肺炎不良预后的预测价值。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S549124
Xin Liu, Ying Shen, Yuqiao Diao, Tao Fan, Hongrui Zhang

Objective: Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Red-cell-distribution width (RDW) and Platelet-distribution width(PDW) have been proved to be related to the severity of a variety of diseases and poor prognosis. But their predictive value in neonatal pneumonia is still unknown. Therefore, this study explored the predictive value of NLR, PLR, RDW and PDW in the adverse prognosis of neonatal pneumonia.

Methods: We retrospectively analyzed 132 neonates with pneumonia treated in our hospital from April 2022 to October 2024. At the same time, 50 healthy newborns delivered in our hospital during the same period were selected as the control group. The levels of NLR, PLR, RDW and PDW in children with different disease severity and prognosis were analyzed; The correlation between NLR, PLR, RDW, PDW levels and disease severity was analyzed, and the predictive value for the adverse prognosis of neonatal pneumonia.

Results: Among 132 children, 65 were mild, 44 moderate and 23 severe; 26 cases had poor prognosis. The levels of NLR, PLR, RDW and PDW in children with different disease severity were significantly different (P<0.05). Spearman test showed that NLR, PLR, RDW, PDW were significantly positively correlated with the severity of neonatal pneumonia (P<0.05). Multivariate logistic regression analysis showed that NLR, PLR, RDW and PDW were the related factors influencing the poor prognosis of neonatal pneumonia (p<0.05). ROC curve analysis showed that the value of combined prediction of four indicators for poor prognosis of neonatal pneumonia was higher than that of single indicators, and the sensitivity of combined prediction was 100%, and the specificity was 94.9%.

Conclusion: NLR, PLR, RDW, PDW were positively correlated with the severity of neonatal pneumonia, and the value of combined prediction of poor prognosis was higher.

目的:中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、红细胞分布宽度(RDW)和血小板分布宽度(PDW)已被证实与多种疾病的严重程度和不良预后有关。但其对新生儿肺炎的预测价值尚不清楚。因此,本研究探讨NLR、PLR、RDW、PDW对新生儿肺炎不良预后的预测价值。方法:回顾性分析2022年4月至2024年10月我院收治的132例新生儿肺炎。同时选取同期在我院出生的健康新生儿50例作为对照组。分析不同疾病严重程度及预后患儿NLR、PLR、RDW、PDW水平;分析NLR、PLR、RDW、PDW水平与疾病严重程度的相关性,以及对新生儿肺炎不良预后的预测价值。结果:132例患儿中,轻度65例,中度44例,重度23例;预后不良26例。不同疾病严重程度患儿NLR、PLR、RDW、PDW水平差异有统计学意义(p)结论:NLR、PLR、RDW、PDW与新生儿肺炎严重程度呈正相关,联合预测不良预后价值较高。
{"title":"Predictive Value of NLR, PLR, RDW and PDW in the Adverse Prognosis of Neonatal Pneumonia.","authors":"Xin Liu, Ying Shen, Yuqiao Diao, Tao Fan, Hongrui Zhang","doi":"10.2147/IJGM.S549124","DOIUrl":"https://doi.org/10.2147/IJGM.S549124","url":null,"abstract":"<p><strong>Objective: </strong>Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR), Red-cell-distribution width (RDW) and Platelet-distribution width(PDW) have been proved to be related to the severity of a variety of diseases and poor prognosis. But their predictive value in neonatal pneumonia is still unknown. Therefore, this study explored the predictive value of NLR, PLR, RDW and PDW in the adverse prognosis of neonatal pneumonia.</p><p><strong>Methods: </strong>We retrospectively analyzed 132 neonates with pneumonia treated in our hospital from April 2022 to October 2024. At the same time, 50 healthy newborns delivered in our hospital during the same period were selected as the control group. The levels of NLR, PLR, RDW and PDW in children with different disease severity and prognosis were analyzed; The correlation between NLR, PLR, RDW, PDW levels and disease severity was analyzed, and the predictive value for the adverse prognosis of neonatal pneumonia.</p><p><strong>Results: </strong>Among 132 children, 65 were mild, 44 moderate and 23 severe; 26 cases had poor prognosis. The levels of NLR, PLR, RDW and PDW in children with different disease severity were significantly different (P<0.05). Spearman test showed that NLR, PLR, RDW, PDW were significantly positively correlated with the severity of neonatal pneumonia (P<0.05). Multivariate logistic regression analysis showed that NLR, PLR, RDW and PDW were the related factors influencing the poor prognosis of neonatal pneumonia (p<0.05). ROC curve analysis showed that the value of combined prediction of four indicators for poor prognosis of neonatal pneumonia was higher than that of single indicators, and the sensitivity of combined prediction was 100%, and the specificity was 94.9%.</p><p><strong>Conclusion: </strong>NLR, PLR, RDW, PDW were positively correlated with the severity of neonatal pneumonia, and the value of combined prediction of poor prognosis was higher.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"549124"},"PeriodicalIF":2.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Age of Molecular Biomarkers: Cancer in the Era of Personalized Medicine. What Do Pathologists in Developing Countries Need to Know and Understand? 分子生物标志物时代:个体化医疗时代的癌症。发展中国家的病理学家需要知道和理解什么?
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S590285
Zubair Ahmad, Shabina Rahim, Maha Zubair, Jamshid Abdul-Ghafar

The complexity of cancer care is continuously increasing in the era of personalized medicine and there is a paradigm shift in the diagnosis and management of cancer. This is the era of precision oncology whose main objective is to identify cancer patients who are candidates for specific targeted therapies. This advanced approach to cancer care formulates treatment strategies for cancer patients based on the specific molecular characteristics of a malignant tumor which are identified through advanced molecular testing. This is the age of advanced prognostic and predictive biomarkers. Targeted therapies represent a groundbreaking shift in cancer therapy and are the cornerstone of precision oncology. Termed "tumor agnostic therapy", these drugs can treat different cancer types across multiple organs which demonstrate the same molecular alterations. A targeted drug in a specific cancer may be effective in another non-related cancer if the same genomic alteration is present. Pathologists need to appreciate these radical and exciting changes and adapt their practices as they will be required to be collaborative clinicians in the new era with a role in diagnosis, prognostication, and treatment of cancer. Pathologists need to become familiar with the ever-expanding number of new biomarkers and their crucial role in cancer care. They need to understand and adapt to new technologies such as Next Generation Sequencing and Comprehensive Genomic Profiling, liquid biopsies, DNA and transcriptome studies etc. They also need to familiarize themselves with tumor agnostic therapies, and concepts such as tumor heterogeneity and resistance to therapy. They can no longer be just morphologists but assume a central role in cancer care. Pathologists in developing countries and resource limited settings who may not currently have access to advanced molecular techniques need to be aware of and understand these fundamental shifts in cancer care and especially their role in the new era. The major changes in cancer care in the era of personalized medicine are discussed in this review mainly for the benefit of pathologists working in LMICs.

在个性化医疗时代,癌症治疗的复杂性不断增加,癌症的诊断和管理也发生了范式转变。这是精确肿瘤学的时代,其主要目标是确定癌症患者谁是特定靶向治疗的候选人。这种先进的癌症护理方法根据恶性肿瘤的特定分子特征制定癌症患者的治疗策略,这些特征是通过先进的分子检测确定的。这是一个先进的预后和预测性生物标志物的时代。靶向治疗代表了癌症治疗的突破性转变,是精确肿瘤学的基石。这些药物被称为“肿瘤不可知论疗法”,可以治疗表现出相同分子改变的多个器官的不同类型的癌症。如果存在相同的基因组改变,针对特定癌症的靶向药物可能对另一种不相关的癌症有效。病理学家需要认识到这些激进和令人兴奋的变化,并调整他们的实践,因为他们将被要求成为新时代的合作临床医生,在癌症的诊断、预测和治疗中发挥作用。病理学家需要熟悉数量不断增加的新生物标志物及其在癌症治疗中的关键作用。他们需要了解和适应新技术,如下一代测序和综合基因组分析,液体活检,DNA和转录组研究等。他们还需要熟悉肿瘤不可知论疗法,以及肿瘤异质性和治疗耐药性等概念。它们不再仅仅是形态学家,而是在癌症治疗中扮演着核心角色。在发展中国家和资源有限的环境中,病理学家目前可能无法获得先进的分子技术,他们需要意识到并理解癌症治疗的这些基本转变,特别是它们在新时代的作用。本文主要讨论了个体化医疗时代癌症治疗的主要变化,以供低收入国家的病理学家参考。
{"title":"The Age of Molecular Biomarkers: Cancer in the Era of Personalized Medicine. What Do Pathologists in Developing Countries Need to Know and Understand?","authors":"Zubair Ahmad, Shabina Rahim, Maha Zubair, Jamshid Abdul-Ghafar","doi":"10.2147/IJGM.S590285","DOIUrl":"https://doi.org/10.2147/IJGM.S590285","url":null,"abstract":"<p><p>The complexity of cancer care is continuously increasing in the era of personalized medicine and there is a paradigm shift in the diagnosis and management of cancer. This is the era of precision oncology whose main objective is to identify cancer patients who are candidates for specific targeted therapies. This advanced approach to cancer care formulates treatment strategies for cancer patients based on the specific molecular characteristics of a malignant tumor which are identified through advanced molecular testing. This is the age of advanced prognostic and predictive biomarkers. Targeted therapies represent a groundbreaking shift in cancer therapy and are the cornerstone of precision oncology. Termed \"tumor agnostic therapy\", these drugs can treat different cancer types across multiple organs which demonstrate the same molecular alterations. A targeted drug in a specific cancer may be effective in another non-related cancer if the same genomic alteration is present. Pathologists need to appreciate these radical and exciting changes and adapt their practices as they will be required to be collaborative clinicians in the new era with a role in diagnosis, prognostication, and treatment of cancer. Pathologists need to become familiar with the ever-expanding number of new biomarkers and their crucial role in cancer care. They need to understand and adapt to new technologies such as Next Generation Sequencing and Comprehensive Genomic Profiling, liquid biopsies, DNA and transcriptome studies etc. They also need to familiarize themselves with tumor agnostic therapies, and concepts such as tumor heterogeneity and resistance to therapy. They can no longer be just morphologists but assume a central role in cancer care. Pathologists in developing countries and resource limited settings who may not currently have access to advanced molecular techniques need to be aware of and understand these fundamental shifts in cancer care and especially their role in the new era. The major changes in cancer care in the era of personalized medicine are discussed in this review mainly for the benefit of pathologists working in LMICs.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"590285"},"PeriodicalIF":2.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Methods for Activated Partial Thromboplastin Time -Based Clot Waveform Analysis: Normalization and Multi-Parameter Combination. 基于活化部分凝血活素时间的血块波形分析新方法:归一化和多参数组合。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S579403
Hongmei Dong, Qi Hu, Huan Wang, Cong Li, Hong Chen

Background: The evaluation of a prolonged activated partial thromboplastin time (APTT) traditionally relies on a diagnostic cascade, including mixing studies to screen for inhibitors, specific factor activity assays, and specialized tests like lupus anticoagulant detection. Activated partial thromboplastin time-based clot waveform analysis (CWA-APTT) has emerged as an optical technique that captures the entire kinetic profile of clot formation, offering potential for enhanced diagnostic triage and monitoring. However, conventional analysis of CWA-APTT parameters, particularly peak-related metrics, is confounded by variables like fibrinogen concentration, limiting their specificity for accurately quantifying coagulation factor activity. Furthermore, the diagnostic utility of time-distribution parameters remains underexplored, especially for distinguishing between factor deficiencies and phospholipid-dependent inhibitors. This study aims to improve the correlation between peak-related parameters in APTT-based clotting curves and coagulation factor activity through novel data analysis methods and to investigate the potential clinical utility of time-distribution parameters in distinguishing sample types.

Methods: A total of 263 blood samples collected from patients with hemophilia A, hemophilia B, or lupus anticoagulant positivity were used to perform CWA-APTT. Normalization methods were applied to process the characteristic parameters in CWA-APTT. Then, the correlation between the processed peak-related parameters and coagulation factor activity was analyzed, and the ability of time-distribution parameters to distinguish different sample types was investigated.

Results: Following normalization, peak-related parameters more accurately reflect coagulation factor activity. Time-distribution parameters can also monitor coagulation factor activity and exhibit a certain degree of sample specificity. Combined analysis of time-distribution parameters enhances the ability to distinguish sample types, achieving a higher concordance rate in curve feature recognition compared to APTT correction tests.

Conclusion: This study innovatively explored new applications of CWA-APTT characteristic parameters. It was found that normalization enables peak-related parameters to more accurately reflect coagulation factor activity, and multi-parameter combined analysis can significantly enhance the ability of CWA-APTT to distinguish clinical samples.

背景:延长活化部分凝血活素时间(APTT)的评估传统上依赖于诊断级联,包括混合研究筛选抑制剂,特定因子活性测定和狼疮抗凝血检测等专门试验。活化的部分凝血活素基于时间的血块波形分析(CWA-APTT)已经成为一种光学技术,可以捕获血块形成的整个动力学剖面,为增强诊断分类和监测提供潜力。然而,常规的CWA-APTT参数分析,尤其是与峰相关的指标,容易受到纤维蛋白原浓度等变量的干扰,限制了其准确量化凝血因子活性的特异性。此外,时间分布参数的诊断效用仍未得到充分探索,特别是在区分因子缺乏和磷脂依赖抑制剂方面。本研究旨在通过新颖的数据分析方法,改善基于aptt的凝血曲线中峰相关参数与凝血因子活性之间的相关性,并探讨时间分布参数在区分样品类型方面的潜在临床应用价值。方法:采集血友病A、血友病B、狼疮抗凝阳性患者263份血样,进行CWA-APTT检测。采用归一化方法对CWA-APTT的特征参数进行处理。然后,分析了处理后的峰相关参数与凝血因子活性的相关性,并考察了时间分布参数对不同样品类型的区分能力。结果:归一化后,峰相关参数更准确地反映凝血因子活性。时间分布参数也可以监测凝血因子活性,并表现出一定的样品特异性。时间分布参数的联合分析增强了样本类型的区分能力,与APTT校正测试相比,曲线特征识别的一致性更高。结论:本研究创新性地探索了CWA-APTT特征参数的新应用。我们发现归一化可以使峰相关参数更准确地反映凝血因子活性,多参数联合分析可以显著增强CWA-APTT对临床样本的区分能力。
{"title":"New Methods for Activated Partial Thromboplastin Time -Based Clot Waveform Analysis: Normalization and Multi-Parameter Combination.","authors":"Hongmei Dong, Qi Hu, Huan Wang, Cong Li, Hong Chen","doi":"10.2147/IJGM.S579403","DOIUrl":"https://doi.org/10.2147/IJGM.S579403","url":null,"abstract":"<p><strong>Background: </strong>The evaluation of a prolonged activated partial thromboplastin time (APTT) traditionally relies on a diagnostic cascade, including mixing studies to screen for inhibitors, specific factor activity assays, and specialized tests like lupus anticoagulant detection. Activated partial thromboplastin time-based clot waveform analysis (CWA-APTT) has emerged as an optical technique that captures the entire kinetic profile of clot formation, offering potential for enhanced diagnostic triage and monitoring. However, conventional analysis of CWA-APTT parameters, particularly peak-related metrics, is confounded by variables like fibrinogen concentration, limiting their specificity for accurately quantifying coagulation factor activity. Furthermore, the diagnostic utility of time-distribution parameters remains underexplored, especially for distinguishing between factor deficiencies and phospholipid-dependent inhibitors. This study aims to improve the correlation between peak-related parameters in APTT-based clotting curves and coagulation factor activity through novel data analysis methods and to investigate the potential clinical utility of time-distribution parameters in distinguishing sample types.</p><p><strong>Methods: </strong>A total of 263 blood samples collected from patients with hemophilia A, hemophilia B, or lupus anticoagulant positivity were used to perform CWA-APTT. Normalization methods were applied to process the characteristic parameters in CWA-APTT. Then, the correlation between the processed peak-related parameters and coagulation factor activity was analyzed, and the ability of time-distribution parameters to distinguish different sample types was investigated.</p><p><strong>Results: </strong>Following normalization, peak-related parameters more accurately reflect coagulation factor activity. Time-distribution parameters can also monitor coagulation factor activity and exhibit a certain degree of sample specificity. Combined analysis of time-distribution parameters enhances the ability to distinguish sample types, achieving a higher concordance rate in curve feature recognition compared to APTT correction tests.</p><p><strong>Conclusion: </strong>This study innovatively explored new applications of CWA-APTT characteristic parameters. It was found that normalization enables peak-related parameters to more accurately reflect coagulation factor activity, and multi-parameter combined analysis can significantly enhance the ability of CWA-APTT to distinguish clinical samples.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"579403"},"PeriodicalIF":2.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Tumor Location Within the Prostate on Prognostic Outcomes Following Radical Prostatectomy. 前列腺肿瘤位置对根治性前列腺切除术后预后的影响。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S577000
Natália D Avilez, Ricardo A F Ferro, Matheus B Santos, Gabriela Barbosa, Fernandes Denardi, Athanase Billis, Leonardo O Reis

Purpose: To evaluate whether tumor zonal origin is associated with clinical, pathological, and prognostic outcomes in patients with prostate cancer (PC) treated with radical prostatectomy (RP).

Patients and methods: This retrospective cohort study analyzed 488 patients who underwent RP at UNICAMP between 1997 and 2017. Tumor zonal origin was defined by the dominant (index) lesion, identified through standardized whole-mount pathological analysis based on the highest ISUP grade and largest tumor volume. The primary endpoint was a composite of biochemical recurrence and/or metastasis, selected to capture clinically significant disease relapse and ensure statistical robustness in a long-term cohort. Associations were assessed using the Mann-Whitney U-test and the Chi-square test. Multivariate logistic regression was performed to identify independent predictors of progression (p < 0.05).

Results: The index tumor originated in the peripheral zone (PZ) in 79.9% of cases and in the transition zone (TZ) in 6.5%. During follow-up, 38.3% of patients experienced biochemical recurrence or metastasis. Tumor location was not significantly associated with biochemical recurrence or metastasis (p = 0.428). Independent predictors included clinical stage (risk classification), pathological ISUP grade, positive surgical margins, and extra prostatic extension. Notably, biopsy ISUP grade and lymph node status were not independently predictive. The limited representation of TZ tumors may have constrained the statistical power to detect subtle prognostic differences.

Conclusion: Within the limitations of this cohort, tumor zonal origin was not independently associated with biochemical recurrence or metastasis following RP. Established pathological factors remain the primary determinants of disease progression.

目的:评估前列腺癌(PC)根治性前列腺切除术(RP)患者的肿瘤区生性是否与临床、病理和预后相关。患者和方法:这项回顾性队列研究分析了1997年至2017年在UNICAMP接受RP的488例患者。肿瘤的区域起源由显性(指数)病变定义,通过标准化的全载病理分析确定,基于最高的ISUP分级和最大的肿瘤体积。主要终点是生化复发和/或转移的组合,选择以捕获临床显著的疾病复发并确保长期队列中的统计稳健性。使用Mann-Whitney u检验和卡方检验评估相关性。采用多因素logistic回归来确定病情进展的独立预测因素(p < 0.05)。结果:指标肿瘤起源于外周区(PZ)占79.9%,转移区(TZ)占6.5%。随访期间,38.3%的患者出现生化复发或转移。肿瘤部位与生化复发、转移无显著相关性(p = 0.428)。独立预测因素包括临床分期(风险分类)、病理ISUP分级、阳性手术切缘和前列腺外展。值得注意的是,活检ISUP分级和淋巴结状态不能独立预测。TZ肿瘤的有限代表性可能限制了检测细微预后差异的统计能力。结论:在本研究的范围内,肿瘤的区域性起源与RP术后的生化复发或转移没有独立的相关性。已确定的病理因素仍然是疾病进展的主要决定因素。
{"title":"Impact of Tumor Location Within the Prostate on Prognostic Outcomes Following Radical Prostatectomy.","authors":"Natália D Avilez, Ricardo A F Ferro, Matheus B Santos, Gabriela Barbosa, Fernandes Denardi, Athanase Billis, Leonardo O Reis","doi":"10.2147/IJGM.S577000","DOIUrl":"https://doi.org/10.2147/IJGM.S577000","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether tumor zonal origin is associated with clinical, pathological, and prognostic outcomes in patients with prostate cancer (PC) treated with radical prostatectomy (RP).</p><p><strong>Patients and methods: </strong>This retrospective cohort study analyzed 488 patients who underwent RP at UNICAMP between 1997 and 2017. Tumor zonal origin was defined by the dominant (index) lesion, identified through standardized whole-mount pathological analysis based on the highest ISUP grade and largest tumor volume. The primary endpoint was a composite of biochemical recurrence and/or metastasis, selected to capture clinically significant disease relapse and ensure statistical robustness in a long-term cohort. Associations were assessed using the Mann-Whitney <i>U</i>-test and the Chi-square test. Multivariate logistic regression was performed to identify independent predictors of progression (p < 0.05).</p><p><strong>Results: </strong>The index tumor originated in the peripheral zone (PZ) in 79.9% of cases and in the transition zone (TZ) in 6.5%. During follow-up, 38.3% of patients experienced biochemical recurrence or metastasis. Tumor location was not significantly associated with biochemical recurrence or metastasis (p = 0.428). Independent predictors included clinical stage (risk classification), pathological ISUP grade, positive surgical margins, and extra prostatic extension. Notably, biopsy ISUP grade and lymph node status were not independently predictive. The limited representation of TZ tumors may have constrained the statistical power to detect subtle prognostic differences.</p><p><strong>Conclusion: </strong>Within the limitations of this cohort, tumor zonal origin was not independently associated with biochemical recurrence or metastasis following RP. Established pathological factors remain the primary determinants of disease progression.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"577000"},"PeriodicalIF":2.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in Dementia Awareness, Contact and Stigma Attitudes Across Generations: A Community-Based Cross-Sectional Study in Shanghai, China. 痴呆认知、接触和污名化态度的代际差异:中国上海基于社区的横断面研究
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S577884
Wenjia Li, Han Gao, Xinni Zhang, Qinghe Tang
<p><strong>Background: </strong>Against the backdrop of population aging and the accelerated development of dementia-friendly communities, public stigmatizing attitudes toward dementia have emerged as a critical barrier to the social integration of affected individuals. To date, limited empirical research in China has examined the mechanisms linking dementia knowledge, contact, and stigmatizing attitudes (perceived stigma) across different age groups within indigenous community settings. This study, conducted as part of a pilot dementia-friendly community initiative in Shanghai, seeks to investigate intergenerational differences in dementia knowledge, contact experiences, and stigmatizing attitudes, and to examine the mediating role of contact in the relationship between knowledge and stigma, thereby contributing locally grounded empirical evidence to the field.</p><p><strong>Methods: </strong>A cross-sectional survey design was employed. A total of 397 community-dwelling residents aged 18 years and older in Shanghai participated in the study. Data were collected on sociodemographic characteristics, dementia knowledge, contact experiences with individuals living with dementia, and stigmatizing attitudes. Descriptive statistics and between-group analyses were used to compare age-group differences, and a mediation model was constructed to test the associations among dementia knowledge, contact, and stigma.</p><p><strong>Results: </strong>Significant intergenerational differences were observed in dementia knowledge, contact experiences, and stigmatizing attitudes. Middle-aged adults demonstrated higher levels of knowledge and more positive contact intentions; older adults reported the highest frequency of contact and the lowest levels of stigma; and younger adults exhibited the most pronounced stigmatizing attitudes. Mediation analysis further revealed that contact experience partially mediated the relationship between dementia knowledge and stigmatizing attitudes, suggesting that higher levels of dementia knowledge may be associated with reduced stigma through the facilitation of positive contact.</p><p><strong>Conclusion: </strong>Enhancing public knowledge of dementia and promoting positive contact with affected individuals may contribute to reducing social stigma and supporting the social inclusion of people living with dementia. This study further elucidates the pathway linking dementia knowledge and stigmatizing attitudes, identifying contact behavior as a significant mediator. The findings lend support to intervention strategies that integrate cognitive enhancement with structured contact initiatives, and provide preliminary evidence for age-specific community-based anti-stigma practices. It should be noted that the mediation pathway identified in this study is correlational rather than causal; moreover, as the sample was drawn from pilot dementia-friendly communities in Shanghai, the generalizability of the findings to other communities or r
背景:在人口老龄化和痴呆症友好社区加速发展的背景下,公众对痴呆症的污名化态度已经成为痴呆症患者融入社会的关键障碍。迄今为止,中国有限的实证研究已经考察了土著社区环境中不同年龄组的痴呆症知识、接触和污名化态度(感知污名化)之间的联系机制。本研究是上海痴呆症友好社区试点项目的一部分,旨在调查痴呆知识、接触经历和污名化态度的代际差异,并研究接触在知识和污名化关系中的中介作用,从而为该领域提供立足当地的经验证据。方法:采用横断面调查设计。上海市共有397名18岁及以上的社区居民参与了这项研究。收集的数据包括社会人口学特征、痴呆症知识、与痴呆症患者的接触经历以及污名化态度。使用描述性统计和组间分析来比较年龄组差异,并构建中介模型来检验痴呆知识、接触和耻辱之间的关联。结果:在痴呆知识、接触经历和污名化态度方面观察到显著的代际差异。中年人表现出更高的知识水平和更积极的接触意向;老年人报告的接触频率最高,病耻感最低;年轻人表现出最明显的污名化态度。中介分析进一步发现,接触经验部分中介了痴呆症知识与污名化态度之间的关系,表明通过促进积极接触,更高水平的痴呆症知识可能与污名化减少相关。结论:提高公众对痴呆症的认识,促进与痴呆症患者的积极接触,可能有助于减少社会耻辱感,支持痴呆症患者融入社会。本研究进一步阐明了痴呆症知识和污名化态度之间的联系途径,确定了接触行为是一个重要的中介。研究结果支持了将认知增强与结构化接触倡议相结合的干预策略,并为针对特定年龄的社区反污名做法提供了初步证据。值得注意的是,本研究确定的中介途径是相关的,而不是因果关系;此外,由于样本来自上海的痴呆症友好试点社区,因此研究结果在其他社区或地区的推广可能受到当地支持系统、公众意识和老龄化概况的差异的限制。未来的研究应采用纵向或介入性设计,在更广泛的人群中验证这些发现。
{"title":"Variations in Dementia Awareness, Contact and Stigma Attitudes Across Generations: A Community-Based Cross-Sectional Study in Shanghai, China.","authors":"Wenjia Li, Han Gao, Xinni Zhang, Qinghe Tang","doi":"10.2147/IJGM.S577884","DOIUrl":"https://doi.org/10.2147/IJGM.S577884","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Against the backdrop of population aging and the accelerated development of dementia-friendly communities, public stigmatizing attitudes toward dementia have emerged as a critical barrier to the social integration of affected individuals. To date, limited empirical research in China has examined the mechanisms linking dementia knowledge, contact, and stigmatizing attitudes (perceived stigma) across different age groups within indigenous community settings. This study, conducted as part of a pilot dementia-friendly community initiative in Shanghai, seeks to investigate intergenerational differences in dementia knowledge, contact experiences, and stigmatizing attitudes, and to examine the mediating role of contact in the relationship between knowledge and stigma, thereby contributing locally grounded empirical evidence to the field.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A cross-sectional survey design was employed. A total of 397 community-dwelling residents aged 18 years and older in Shanghai participated in the study. Data were collected on sociodemographic characteristics, dementia knowledge, contact experiences with individuals living with dementia, and stigmatizing attitudes. Descriptive statistics and between-group analyses were used to compare age-group differences, and a mediation model was constructed to test the associations among dementia knowledge, contact, and stigma.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Significant intergenerational differences were observed in dementia knowledge, contact experiences, and stigmatizing attitudes. Middle-aged adults demonstrated higher levels of knowledge and more positive contact intentions; older adults reported the highest frequency of contact and the lowest levels of stigma; and younger adults exhibited the most pronounced stigmatizing attitudes. Mediation analysis further revealed that contact experience partially mediated the relationship between dementia knowledge and stigmatizing attitudes, suggesting that higher levels of dementia knowledge may be associated with reduced stigma through the facilitation of positive contact.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Enhancing public knowledge of dementia and promoting positive contact with affected individuals may contribute to reducing social stigma and supporting the social inclusion of people living with dementia. This study further elucidates the pathway linking dementia knowledge and stigmatizing attitudes, identifying contact behavior as a significant mediator. The findings lend support to intervention strategies that integrate cognitive enhancement with structured contact initiatives, and provide preliminary evidence for age-specific community-based anti-stigma practices. It should be noted that the mediation pathway identified in this study is correlational rather than causal; moreover, as the sample was drawn from pilot dementia-friendly communities in Shanghai, the generalizability of the findings to other communities or r","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"577884"},"PeriodicalIF":2.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, Practice and Barriers to Exercise Rehabilitation Among Chinese Patients with Acute Musculoskeletal Injury: A Mixed-Methods Study [Letter]. 中国急性肌肉骨骼损伤患者运动康复的知识、实践和障碍:一项混合方法研究[字母]。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-07 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S605356
Soner Kocak
{"title":"Knowledge, Practice and Barriers to Exercise Rehabilitation Among Chinese Patients with Acute Musculoskeletal Injury: A Mixed-Methods Study [Letter].","authors":"Soner Kocak","doi":"10.2147/IJGM.S605356","DOIUrl":"https://doi.org/10.2147/IJGM.S605356","url":null,"abstract":"","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"605356"},"PeriodicalIF":2.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Five-Gene PANoptosis Signature Correlates with Immune Infiltration and Secondary Brain Injury in Intracerebral Hemorrhage. 五基因PANoptosis特征与脑出血患者的免疫浸润和继发性脑损伤相关。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-06 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S581629
Zhaohui Chen, Xueyuan Zhang, Zhicheng Deng, Jiali Luo, Chunyang Han, Yinlun Weng

Objective: Primary intracerebral hemorrhage (ICH) is a severe stroke subtype characterized by high mortality and disability rates, largely attributable to secondary brain injury (SBI). While programmed cell death (PCD) pathways contribute to SBI, their mechanisms remain incompletely understood. This research investigated PANoptosis, a newly defined integrated PCD pathway, and its interactions with immune responses in ICH.

Methods: The transcriptomic dataset GSE24265 was analyzed to identify differentially expressed genes (DEGs), which were intersected with a PANoptosis-related gene set. PANoptosis-related DEGs were analyzed through protein-protein interaction (PPI) networks, functional enrichment, and machine learning (LASSO and Random Forest) to identify signature genes. The diagnostic utility was evaluated using nomograms and receiver operating characteristic (ROC) curves. Immune interactions were assessed using CIBERSORT. Key findings were validated in clinical specimens using qRT-PCR and Western blot.

Results: We identified 50 PANoptosis-related DEGs in ICH and derived five signature genes (AKR1C2, SLC2A14, FTL, TNFRSF12A, and SLC2A3) that were significantly upregulated and had high diagnostic accuracy. These genes were implicated in an inflammatory cell death hub, as their expression correlated with altered proportions of T follicular helper and T gamma delta cells, linking PANoptosis to immune dysregulation. Experimental validation confirmed the upregulation of mRNA levels of SLC2A3, SLC2A14, and TNFRSF12A in perihematomal tissues, along with increased protein levels of SLC2A3 and SLC2A14. Functional enrichment analysis linked these genes to HIF-1, NF-κB, and TNF signaling pathways in ICH PANoptosis.

Conclusion: Our study identifies PANoptosis as a pathological hub connecting SBI and neuroinflammation in ICH, with five signature genes serving as key diagnostic biomarkers. Notably, SLC2A3 was significantly elevated in peripheral blood, highlighting its potential as a non-invasive plasma biomarker for ICH. These genes likely contribute to neuroinflammation through immune crosstalk and metabolic reprogramming, offering novel mechanistic insights and potential therapeutic targets for SBI post-ICH.

目的:原发性脑出血(ICH)是一种死亡率和致残率高的严重脑卒中亚型,主要归因于继发性脑损伤(SBI)。虽然程序性细胞死亡(PCD)途径与SBI有关,但其机制尚不完全清楚。本研究探讨了PANoptosis(一种新定义的综合PCD途径)及其与ICH免疫应答的相互作用。方法:分析转录组数据集GSE24265,以鉴定与panoptosis相关基因集相交的差异表达基因(deg)。通过蛋白质-蛋白质相互作用(PPI)网络、功能富集和机器学习(LASSO和Random Forest)分析panoptosis相关的deg,以识别特征基因。诊断效用评估采用诺线图和受试者工作特征(ROC)曲线。使用CIBERSORT评估免疫相互作用。使用qRT-PCR和Western blot在临床标本中验证了关键发现。结果:我们在ICH中鉴定了50个panoptoss相关的deg,并获得了5个显著上调的特征基因(AKR1C2, SLC2A14, FTL, TNFRSF12A和SLC2A3),具有较高的诊断准确性。这些基因与炎症细胞死亡中心有关,因为它们的表达与T滤泡辅助细胞和T γ δ细胞的比例改变有关,将PANoptosis与免疫失调联系起来。实验证实,SLC2A3、SLC2A14和TNFRSF12A在血肿周围组织中mRNA水平上调,SLC2A3和SLC2A14蛋白水平升高。功能富集分析将这些基因与ICH PANoptosis中HIF-1、NF-κB和TNF信号通路联系起来。结论:我们的研究确定PANoptosis是ICH中连接SBI和神经炎症的病理枢纽,其中五个特征基因可作为关键的诊断生物标志物。值得注意的是,SLC2A3在外周血中显著升高,突出了其作为脑出血非侵入性血浆生物标志物的潜力。这些基因可能通过免疫串扰和代谢重编程参与神经炎症,为脑出血后SBI提供了新的机制见解和潜在的治疗靶点。
{"title":"A Five-Gene PANoptosis Signature Correlates with Immune Infiltration and Secondary Brain Injury in Intracerebral Hemorrhage.","authors":"Zhaohui Chen, Xueyuan Zhang, Zhicheng Deng, Jiali Luo, Chunyang Han, Yinlun Weng","doi":"10.2147/IJGM.S581629","DOIUrl":"https://doi.org/10.2147/IJGM.S581629","url":null,"abstract":"<p><strong>Objective: </strong>Primary intracerebral hemorrhage (ICH) is a severe stroke subtype characterized by high mortality and disability rates, largely attributable to secondary brain injury (SBI). While programmed cell death (PCD) pathways contribute to SBI, their mechanisms remain incompletely understood. This research investigated PANoptosis, a newly defined integrated PCD pathway, and its interactions with immune responses in ICH.</p><p><strong>Methods: </strong>The transcriptomic dataset GSE24265 was analyzed to identify differentially expressed genes (DEGs), which were intersected with a PANoptosis-related gene set. PANoptosis-related DEGs were analyzed through protein-protein interaction (PPI) networks, functional enrichment, and machine learning (LASSO and Random Forest) to identify signature genes. The diagnostic utility was evaluated using nomograms and receiver operating characteristic (ROC) curves. Immune interactions were assessed using CIBERSORT. Key findings were validated in clinical specimens using qRT-PCR and Western blot.</p><p><strong>Results: </strong>We identified 50 PANoptosis-related DEGs in ICH and derived five signature genes (AKR1C2, SLC2A14, FTL, TNFRSF12A, and SLC2A3) that were significantly upregulated and had high diagnostic accuracy. These genes were implicated in an inflammatory cell death hub, as their expression correlated with altered proportions of T follicular helper and T gamma delta cells, linking PANoptosis to immune dysregulation. Experimental validation confirmed the upregulation of mRNA levels of SLC2A3, SLC2A14, and TNFRSF12A in perihematomal tissues, along with increased protein levels of SLC2A3 and SLC2A14. Functional enrichment analysis linked these genes to HIF-1, NF-κB, and TNF signaling pathways in ICH PANoptosis.</p><p><strong>Conclusion: </strong>Our study identifies PANoptosis as a pathological hub connecting SBI and neuroinflammation in ICH, with five signature genes serving as key diagnostic biomarkers. Notably, SLC2A3 was significantly elevated in peripheral blood, highlighting its potential as a non-invasive plasma biomarker for ICH. These genes likely contribute to neuroinflammation through immune crosstalk and metabolic reprogramming, offering novel mechanistic insights and potential therapeutic targets for SBI post-ICH.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"581629"},"PeriodicalIF":2.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophilic Heart Disease: Pathophysiology, Diagnosis, and Management - A Narrative Review. 嗜酸性心脏疾病:病理生理学,诊断和管理-叙述性回顾。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-05 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S586348
Jing Dong, Haoran Fu, Na Wu, Liting Hu, Yinuo Du, Huhu Li, Li Liu

Eosinophilic heart disease (EHD) is an inflammatory cardiac disorder characterized by the infiltration and subsequent heart tissue damage mediated by eosinophils. The clinical manifestations of EHD vary widely, ranging from asymptomatic to severe, life-threatening conditions. Diagnosis relies on a multimodal approach, incorporating clinical presentations, laboratory findings (e.g. hypereosinophilia), and advanced imaging studies such as cardiac magnetic resonance imaging (MRI) and echocardiography. However, the gold standard for definitive diagnosis remains endomyocardial biopsy, which demonstrates eosinophilic infiltration and associated myocardial injury. Currently, there is no established consensus on specific therapeutic protocols for EHD. Management primarily targets the underlying etiology and mitigates eosinophil-induced cardiac damage. Prognosis is highly variable and largely dependent on the causative pathology, with outcomes spanning from rapidly progressive and fatal courses to indolent, chronic disease progression. Given the heterogeneity in clinical presentation and treatment responses, there is an urgent need for evidence-based clinical guidelines to standardize the management of EHD.

嗜酸性心脏病(EHD)是一种炎症性心脏疾病,其特征是由嗜酸性粒细胞介导的浸润和随后的心脏组织损伤。EHD的临床表现差异很大,从无症状到严重的危及生命的疾病。诊断依赖于多模式方法,包括临床表现、实验室结果(如嗜酸性粒细胞增多)和先进的成像研究,如心脏磁共振成像(MRI)和超声心动图。然而,最终诊断的金标准仍然是心内膜活检,它显示嗜酸性粒细胞浸润和相关的心肌损伤。目前,对于EHD的具体治疗方案还没有达成共识。治疗主要针对潜在的病因,减轻嗜酸性粒细胞引起的心脏损伤。预后是高度可变的,很大程度上取决于病因病理学,其结果从快速进展和致命的过程到惰性,慢性疾病进展。鉴于临床表现和治疗反应的异质性,迫切需要循证临床指南来规范EHD的管理。
{"title":"Eosinophilic Heart Disease: Pathophysiology, Diagnosis, and Management - A Narrative Review.","authors":"Jing Dong, Haoran Fu, Na Wu, Liting Hu, Yinuo Du, Huhu Li, Li Liu","doi":"10.2147/IJGM.S586348","DOIUrl":"https://doi.org/10.2147/IJGM.S586348","url":null,"abstract":"<p><p>Eosinophilic heart disease (EHD) is an inflammatory cardiac disorder characterized by the infiltration and subsequent heart tissue damage mediated by eosinophils. The clinical manifestations of EHD vary widely, ranging from asymptomatic to severe, life-threatening conditions. Diagnosis relies on a multimodal approach, incorporating clinical presentations, laboratory findings (e.g. hypereosinophilia), and advanced imaging studies such as cardiac magnetic resonance imaging (MRI) and echocardiography. However, the gold standard for definitive diagnosis remains endomyocardial biopsy, which demonstrates eosinophilic infiltration and associated myocardial injury. Currently, there is no established consensus on specific therapeutic protocols for EHD. Management primarily targets the underlying etiology and mitigates eosinophil-induced cardiac damage. Prognosis is highly variable and largely dependent on the causative pathology, with outcomes spanning from rapidly progressive and fatal courses to indolent, chronic disease progression. Given the heterogeneity in clinical presentation and treatment responses, there is an urgent need for evidence-based clinical guidelines to standardize the management of EHD.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"586348"},"PeriodicalIF":2.0,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal Variation in the Onset of Acute Cerebral Infarction and Its Association with Clinical Severity and Risk Factors: A Five-Year Single-Center Retrospective Study. 急性脑梗死发病的季节变化及其与临床严重程度和危险因素的关系:一项为期五年的单中心回顾性研究
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-05 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S582545
Jia Chen, Zhiqian Han, Saisai Xue, Chunmei You, Xiaoqun Huang

Objective: Winter low temperatures may affect the occurrence of acute cerebral infarction by affecting blood pressure, but little is known about the association between seasonal variation and the clinical severity of acute cerebral infarction. This study aims to explore the seasonal variation of acute cerebral infarction and its relationship with stroke severity and vascular risk factors.

Methods: A five-year retrospective study was conducted including 692 patients with acute cerebral infarction admitted to a second class A hospital. Patients were stratified by season of onset. Stroke severity was assessed using NIHSS, and multivariable logistic regression was applied to analyze associations and interactions.

Results: While incidence did not differ significantly by season, stroke severity was highest in winter. Spring onset might be independently associated with lower odds of severe stroke (OR = 0.38, 95% CI: 0.14-0.94, p = 0.05). Significant interactions were observed for alcohol use in summer (OR = 10.69, 95% CI: 1.42-222.84) and atrial fibrillation in spring (OR = 7.30, 95% CI: 1.13-66.12). Sex-stratified analysis revealed that spring onset was associated with lower incidence of moderate-to-severe stroke (NIHSS ≥ 8) among females, while atrial fibrillation and hypertension were risk factors for moderate-to-severe cerebral infarction in males.

Conclusion: A seasonal variation was found in the clinical severity of acute cerebral infarction and was highest in winter. Due to the lack of direct environmental exposure data collection (such as environmental temperature, humidity, air pollution), the specific mechanism still needs further exploration.

目的:冬季低温可能通过影响血压影响急性脑梗死的发生,但季节变化与急性脑梗死临床严重程度的关系尚不清楚。本研究旨在探讨急性脑梗死的季节变化及其与脑卒中严重程度和血管危险因素的关系。方法:对某二甲医院收治的急性脑梗死患者692例进行为期5年的回顾性研究。患者按发病季节分层。采用NIHSS评估脑卒中严重程度,并应用多变量逻辑回归分析相关性和相互作用。结果:各季节卒中发生率无显著差异,但冬季卒中严重程度最高。春季发病可能与较低的严重卒中发生率独立相关(OR = 0.38, 95% CI: 0.14-0.94, p = 0.05)。在夏季饮酒(OR = 10.69, 95% CI: 1.42-222.84)和春季房颤(OR = 7.30, 95% CI: 1.13-66.12)之间观察到显著的相互作用。性别分层分析显示,春季发病与女性中重度脑梗死(NIHSS≥8)发生率较低相关,而房颤和高血压是男性中重度脑梗死的危险因素。结论:急性脑梗死的临床严重程度有季节变化,以冬季最高。由于缺乏直接的环境暴露数据采集(如环境温度、湿度、空气污染),具体机制仍需进一步探索。
{"title":"Seasonal Variation in the Onset of Acute Cerebral Infarction and Its Association with Clinical Severity and Risk Factors: A Five-Year Single-Center Retrospective Study.","authors":"Jia Chen, Zhiqian Han, Saisai Xue, Chunmei You, Xiaoqun Huang","doi":"10.2147/IJGM.S582545","DOIUrl":"https://doi.org/10.2147/IJGM.S582545","url":null,"abstract":"<p><strong>Objective: </strong>Winter low temperatures may affect the occurrence of acute cerebral infarction by affecting blood pressure, but little is known about the association between seasonal variation and the clinical severity of acute cerebral infarction. This study aims to explore the seasonal variation of acute cerebral infarction and its relationship with stroke severity and vascular risk factors.</p><p><strong>Methods: </strong>A five-year retrospective study was conducted including 692 patients with acute cerebral infarction admitted to a second class A hospital. Patients were stratified by season of onset. Stroke severity was assessed using NIHSS, and multivariable logistic regression was applied to analyze associations and interactions.</p><p><strong>Results: </strong>While incidence did not differ significantly by season, stroke severity was highest in winter. Spring onset might be independently associated with lower odds of severe stroke (OR = 0.38, 95% CI: 0.14-0.94, p = 0.05). Significant interactions were observed for alcohol use in summer (OR = 10.69, 95% CI: 1.42-222.84) and atrial fibrillation in spring (OR = 7.30, 95% CI: 1.13-66.12). Sex-stratified analysis revealed that spring onset was associated with lower incidence of moderate-to-severe stroke (NIHSS ≥ 8) among females, while atrial fibrillation and hypertension were risk factors for moderate-to-severe cerebral infarction in males.</p><p><strong>Conclusion: </strong>A seasonal variation was found in the clinical severity of acute cerebral infarction and was highest in winter. Due to the lack of direct environmental exposure data collection (such as environmental temperature, humidity, air pollution), the specific mechanism still needs further exploration.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"582545"},"PeriodicalIF":2.0,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Value of MicroRNA Profiles in Septic Patients with Rare Hereditary Anemias: Insights from a Longitudinal Cohort Study. MicroRNA谱在脓毒症罕见遗传性贫血患者中的预后价值:来自纵向队列研究的见解。
IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-04 eCollection Date: 2026-01-01 DOI: 10.2147/IJGM.S556083
May AlMoshary, Nahid Abdulhamid Qushmaq, Abba Elgujja, Abdullah Mikki Alamoudi, Maha Abuhatlah AlQahtani, Hind Bugshan, Marytonia Valiyaveettil Antony, Fatimah Alshahrani

Background: MicroRNAs (miRNAs) are small molecules that regulate gene expression and may influence the severity and progression of rare hereditary anemias. Understanding their role can support the development of targeted treatments. To our knowledge, this multicenter longitudinal cohort is among the first to characterize miRNA profiles-particularly miR-155-in pediatric patients with rare hereditary anemias presenting with sepsis, and to report exploratory translational observations relevant to gene-based modulation frameworks.

Objective: This study aimed to profile miRNA expression in septic patients with rare hereditary anemias and evaluate associations with disease severity, progression, and response to gene therapy.

Methods: This prospective cohort study was conducted at five medical centers in the United States and Saudi Arabia, enrolling 400 participants-200 patients with rare hereditary anemias and 200 healthy controls. Blood samples were analyzed using high-throughput sequencing and advanced bioinformatics. Randomization and blinding procedures were applied to ensure data integrity and minimize bias.

Results: At baseline enrollment during septic presentation, patients exhibited significantly lower mean hemoglobin levels compared to controls (9.2 g/dL vs 12.5 g/dL, p < 0.001). Patients with hereditary anemia had significantly lower average hemoglobin levels (9.2 g/dL) compared to controls (12.5 g/dL, p < 0.001) and higher reticulocyte counts. miR-155 was upregulated 2.5-fold in affected patients (p < 0.01). These patients required an average of six transfusions annually, compared to none in the control group (p < 0.001). Thirty-five percent of patients experienced worsening anemia over time. ROC curve analysis demonstrated miR-155 as a strong diagnostic biomarker, with 85% sensitivity, 90% specificity, and an AUC of 0.97.

Conclusion: miR-155 plays a key role in the progression of rare hereditary anemias in septic patients and shows potential as both a diagnostic and therapeutic target. These findings highlight opportunities for personalized, miRNA-based therapies to improve disease management and patient outcomes. No clinically evident severe vector-related adverse events were observed during follow-up.

Clinical trial number: ECRIN-EU-TRIAL-2025-002739.

背景:MicroRNAs (miRNAs)是调节基因表达的小分子,可能影响罕见遗传性贫血的严重程度和进展。了解它们的作用有助于开发靶向治疗方法。据我们所知,这个多中心纵向队列是第一个在以脓毒症为表现的罕见遗传性贫血的儿科患者中表征miRNA谱(特别是mir -155)的研究,并报告了与基于基因的调节框架相关的探索性转化观察。目的:本研究旨在分析罕见遗传性贫血脓毒症患者的miRNA表达,并评估其与疾病严重程度、进展和基因治疗反应的关系。方法:这项前瞻性队列研究在美国和沙特阿拉伯的五个医疗中心进行,招募了400名参与者——200名罕见遗传性贫血患者和200名健康对照者。血液样本分析使用高通量测序和先进的生物信息学。采用随机化和盲法程序,以确保数据的完整性和最小化偏差。结果:在脓毒症出现期间的基线入组时,患者的平均血红蛋白水平明显低于对照组(9.2 g/dL vs 12.5 g/dL, p < 0.001)。遗传性贫血患者的平均血红蛋白水平(9.2 g/dL)明显低于对照组(12.5 g/dL, p < 0.001),网状红细胞计数较高。miR-155在患者中上调2.5倍(p < 0.01)。这些患者平均每年需要6次输血,而对照组则没有(p < 0.001)。35%的患者随着时间的推移出现了贫血恶化。ROC曲线分析显示miR-155是一种很强的诊断性生物标志物,灵敏度为85%,特异性为90%,AUC为0.97。结论:miR-155在脓毒症患者罕见遗传性贫血的进展中发挥关键作用,具有作为诊断和治疗靶点的潜力。这些发现突出了个性化、基于mirna的治疗方法改善疾病管理和患者预后的机会。随访期间未见明显的严重病媒相关不良事件。临床试验编号:ECRIN-EU-TRIAL-2025-002739。
{"title":"Prognostic Value of MicroRNA Profiles in Septic Patients with Rare Hereditary Anemias: Insights from a Longitudinal Cohort Study.","authors":"May AlMoshary, Nahid Abdulhamid Qushmaq, Abba Elgujja, Abdullah Mikki Alamoudi, Maha Abuhatlah AlQahtani, Hind Bugshan, Marytonia Valiyaveettil Antony, Fatimah Alshahrani","doi":"10.2147/IJGM.S556083","DOIUrl":"https://doi.org/10.2147/IJGM.S556083","url":null,"abstract":"<p><strong>Background: </strong>MicroRNAs (miRNAs) are small molecules that regulate gene expression and may influence the severity and progression of rare hereditary anemias. Understanding their role can support the development of targeted treatments. To our knowledge, this multicenter longitudinal cohort is among the first to characterize miRNA profiles-particularly miR-155-in pediatric patients with rare hereditary anemias presenting with sepsis, and to report exploratory translational observations relevant to gene-based modulation frameworks.</p><p><strong>Objective: </strong>This study aimed to profile miRNA expression in septic patients with rare hereditary anemias and evaluate associations with disease severity, progression, and response to gene therapy.</p><p><strong>Methods: </strong>This prospective cohort study was conducted at five medical centers in the United States and Saudi Arabia, enrolling 400 participants-200 patients with rare hereditary anemias and 200 healthy controls. Blood samples were analyzed using high-throughput sequencing and advanced bioinformatics. Randomization and blinding procedures were applied to ensure data integrity and minimize bias.</p><p><strong>Results: </strong>At baseline enrollment during septic presentation, patients exhibited significantly lower mean hemoglobin levels compared to controls (9.2 g/dL vs 12.5 g/dL, p < 0.001). Patients with hereditary anemia had significantly lower average hemoglobin levels (9.2 g/dL) compared to controls (12.5 g/dL, p < 0.001) and higher reticulocyte counts. miR-155 was upregulated 2.5-fold in affected patients (p < 0.01). These patients required an average of six transfusions annually, compared to none in the control group (p < 0.001). Thirty-five percent of patients experienced worsening anemia over time. ROC curve analysis demonstrated miR-155 as a strong diagnostic biomarker, with 85% sensitivity, 90% specificity, and an AUC of 0.97.</p><p><strong>Conclusion: </strong>miR-155 plays a key role in the progression of rare hereditary anemias in septic patients and shows potential as both a diagnostic and therapeutic target. These findings highlight opportunities for personalized, miRNA-based therapies to improve disease management and patient outcomes. No clinically evident severe vector-related adverse events were observed during follow-up.</p><p><strong>Clinical trial number: </strong>ECRIN-EU-TRIAL-2025-002739.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"19 ","pages":"556083"},"PeriodicalIF":2.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of General Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1