Pub Date : 2023-11-09DOI: 10.1007/s10989-023-10579-2
Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren
{"title":"Correction: Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NFκB and MAPK Activation","authors":"Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren","doi":"10.1007/s10989-023-10579-2","DOIUrl":"https://doi.org/10.1007/s10989-023-10579-2","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-09DOI: 10.1007/s10989-023-10576-5
Niloufar Shakibapour, Ahmad Asoodeh, Yasamin Yousefi, Jamshidkhan Chamani
{"title":"Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells","authors":"Niloufar Shakibapour, Ahmad Asoodeh, Yasamin Yousefi, Jamshidkhan Chamani","doi":"10.1007/s10989-023-10576-5","DOIUrl":"https://doi.org/10.1007/s10989-023-10576-5","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135242633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.1007/s10989-023-10577-4
Sima Sadat Seyedjavadi, Mehdi Razzaghi-Abyaneh, Parmida Bagheri, Mehdi Goudarzi
{"title":"Antibacterial Mechanism of a Novel Peptide Dendrocin‑ZM1 Against Staphylococcus aureus by Increasing Membrane Permeability","authors":"Sima Sadat Seyedjavadi, Mehdi Razzaghi-Abyaneh, Parmida Bagheri, Mehdi Goudarzi","doi":"10.1007/s10989-023-10577-4","DOIUrl":"https://doi.org/10.1007/s10989-023-10577-4","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-06DOI: 10.1007/s10989-023-10575-6
Lei Zhao, Zhaoyang Liu, Mingyang Ji
{"title":"Improving the Antibacterial Activity of Tryptophan-Containing Peptide Nanostructures Through Self-Assembly","authors":"Lei Zhao, Zhaoyang Liu, Mingyang Ji","doi":"10.1007/s10989-023-10575-6","DOIUrl":"https://doi.org/10.1007/s10989-023-10575-6","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-19DOI: 10.1007/s10989-023-10572-9
Alakesh Das, Dikshita Deka, Nabajyoti Baildya, Antara Banerjee, Atil Bisgin, Suman Adhikari, Asim K. Duttaroy, Surajit Pathak
Abstract BMAP-27 peptide is reported to possess apoptotic and anti-proliferative effects against cancer cells but the actual mechanism of action is yet to be investigated. In the current investigation, we aimed to study the role of the BMAP-27 peptide in reducing proliferation and increasing apoptosis in colon cancer cell lines. In this study, we used primary and metastatic colon cancer cell lines SW480 and SW620. Cell proliferation was measured using MTT and CCK-8 assays, and cellular damage was analyzed by lactate dehydrogenase assay. Apoptosis, cell cycle, and proliferation potentials were measured by the expression of CASPASE3, BAX, BCL-2, TP53, CDK-6, PCNA, WNT11, AXIN1 , and CTNNB1 genes. Additionally, in-silico studies were conducted to determine the binding affinities of BMAP-27 with adenomatous polyposis coli (APC) and β-catenin proteins, one of the primary regulators of colon cancer. BMAP-27 peptide reduced colon cancer cell proliferation, upregulated tumor suppressor genes CASPASE3, BAX, TP53, AXIN1 expression, and downregulated the expression of oncogenes BCL-2, CDK-6, PCNA, WNT11, CTNNB1 in both the cell lines, however, in the primary colon cancer cell line the changes are found to be more significant. The molecular dynamic simulation analysis revealed substantial binding affinity of the peptide to APC and β-catenin proteins. BMAP-27 peptide significantly inhibited the proliferation and induced apoptosis in the primary colon cancer cell line than in the metastatic colon cancer cell line. In-silico results suggest that BMAP-27 shows a strong binding affinity with APC and β-catenin proteins, highlighting its role in inhibiting colon cancer cell proliferation.
{"title":"BMAP-27 Peptide Reduces Proliferation and Increases Apoptosis in Primary and Metastatic Colon Cancer Cell Lines","authors":"Alakesh Das, Dikshita Deka, Nabajyoti Baildya, Antara Banerjee, Atil Bisgin, Suman Adhikari, Asim K. Duttaroy, Surajit Pathak","doi":"10.1007/s10989-023-10572-9","DOIUrl":"https://doi.org/10.1007/s10989-023-10572-9","url":null,"abstract":"Abstract BMAP-27 peptide is reported to possess apoptotic and anti-proliferative effects against cancer cells but the actual mechanism of action is yet to be investigated. In the current investigation, we aimed to study the role of the BMAP-27 peptide in reducing proliferation and increasing apoptosis in colon cancer cell lines. In this study, we used primary and metastatic colon cancer cell lines SW480 and SW620. Cell proliferation was measured using MTT and CCK-8 assays, and cellular damage was analyzed by lactate dehydrogenase assay. Apoptosis, cell cycle, and proliferation potentials were measured by the expression of CASPASE3, BAX, BCL-2, TP53, CDK-6, PCNA, WNT11, AXIN1 , and CTNNB1 genes. Additionally, in-silico studies were conducted to determine the binding affinities of BMAP-27 with adenomatous polyposis coli (APC) and β-catenin proteins, one of the primary regulators of colon cancer. BMAP-27 peptide reduced colon cancer cell proliferation, upregulated tumor suppressor genes CASPASE3, BAX, TP53, AXIN1 expression, and downregulated the expression of oncogenes BCL-2, CDK-6, PCNA, WNT11, CTNNB1 in both the cell lines, however, in the primary colon cancer cell line the changes are found to be more significant. The molecular dynamic simulation analysis revealed substantial binding affinity of the peptide to APC and β-catenin proteins. BMAP-27 peptide significantly inhibited the proliferation and induced apoptosis in the primary colon cancer cell line than in the metastatic colon cancer cell line. In-silico results suggest that BMAP-27 shows a strong binding affinity with APC and β-catenin proteins, highlighting its role in inhibiting colon cancer cell proliferation.","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135732571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1007/s10989-023-10571-w
Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren
{"title":"Anti-Inflammatory Mechanism of Walnut Meal Peptide/ Ellagic Acid Nanoparticles on LPS-Stimulated RAW264.7 Cells by Inhibition of NF-κB and MAPK Activation","authors":"Yuxi Ling, Yanxia Feng, Ziqi Li, Le Cheng, Xuan Zhang, Difeng Ren","doi":"10.1007/s10989-023-10571-w","DOIUrl":"https://doi.org/10.1007/s10989-023-10571-w","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dried Blood Spot Sampling in Protein and Peptide Bioanalysis: Optimism, Experience, and the Path Forward","authors":"Sneha Kaareddy, Pooja Dhakne, Megha Pillai, Niraj Rajput, Tarang Jadav, Rakesh K. Tekade, Pinaki Sengupta","doi":"10.1007/s10989-023-10570-x","DOIUrl":"https://doi.org/10.1007/s10989-023-10570-x","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.1007/s10989-023-10566-7
Lalita Sharma, Gopal Singh Bisht
{"title":"In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12","authors":"Lalita Sharma, Gopal Singh Bisht","doi":"10.1007/s10989-023-10566-7","DOIUrl":"https://doi.org/10.1007/s10989-023-10566-7","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.1007/s10989-023-10564-9
Chaman Ara, Memoona Arshad, Shaukat Ali, Hafiz Abdullah Shakir, Muhammad Summer, Muhammad Khan, Iram Liaqat, Madeeha Arshad
{"title":"Aspartame, a Synthetic Dipeptide Mediated Biochemical and Histopathological Alterations in Hepato-nephric Tissues of Mice and Pharmaceutical Intervention by Sesame Oil","authors":"Chaman Ara, Memoona Arshad, Shaukat Ali, Hafiz Abdullah Shakir, Muhammad Summer, Muhammad Khan, Iram Liaqat, Madeeha Arshad","doi":"10.1007/s10989-023-10564-9","DOIUrl":"https://doi.org/10.1007/s10989-023-10564-9","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135696550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.1007/s10989-023-10569-4
Tamil Selvi Alagumuthu, Sugapriya Samidurai, Yasmin Khambhaty, Kanagaraj James
{"title":"Evaluation of Antimicrobial Property of Bacteriocin Capped Silver Nanoparticles Prepared from Cell Free Supernatant of Lactobacillus brevis Isolated from Marine Fishes","authors":"Tamil Selvi Alagumuthu, Sugapriya Samidurai, Yasmin Khambhaty, Kanagaraj James","doi":"10.1007/s10989-023-10569-4","DOIUrl":"https://doi.org/10.1007/s10989-023-10569-4","url":null,"abstract":"","PeriodicalId":14217,"journal":{"name":"International Journal of Peptide Research and Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135344107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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