Pub Date : 2026-01-13DOI: 10.1186/s40942-025-00794-y
Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita
{"title":"Systemic-retinal inflammatory crosstalk in diabetic macular edema: correlation between hematologic indices and macular OCT-features.","authors":"Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita","doi":"10.1186/s40942-025-00794-y","DOIUrl":"https://doi.org/10.1186/s40942-025-00794-y","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-12DOI: 10.1186/s40942-025-00791-1
Denise Pardini, Carolina Hilgert, Olívia Pereira Kiappe, Talita Virgínia Fernandes de Oliveira, Jorge Henrique Cavalcante Tavares, Marina Roizenblatt, Michel Eid Farah, Maurício Maia, André Maia
{"title":"Outcomes of intraocular lens exchange with combined pars plana vitrectomy and retropupillary iris-claw lens fixation.","authors":"Denise Pardini, Carolina Hilgert, Olívia Pereira Kiappe, Talita Virgínia Fernandes de Oliveira, Jorge Henrique Cavalcante Tavares, Marina Roizenblatt, Michel Eid Farah, Maurício Maia, André Maia","doi":"10.1186/s40942-025-00791-1","DOIUrl":"https://doi.org/10.1186/s40942-025-00791-1","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-10DOI: 10.1186/s40942-025-00796-w
Xueyong Zhang, Yao Xu, Wenji Xu, Tianxu Feng, Zhenyu Li, Yiming Zhu, Yao Chen, Siqi Xiong
{"title":"Modified cyclodialysis suturing with sodium hyaluronate for traumatic choroidal avulsion and cyclodialysis: a retrospective study.","authors":"Xueyong Zhang, Yao Xu, Wenji Xu, Tianxu Feng, Zhenyu Li, Yiming Zhu, Yao Chen, Siqi Xiong","doi":"10.1186/s40942-025-00796-w","DOIUrl":"https://doi.org/10.1186/s40942-025-00796-w","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1186/s40942-025-00790-2
Valdez Melo Dos Anjos Filho, Natalia Garcia Gaban, Sara Hira, Maria Antônia Torres Arteche, Mateus Pimenta Arruda, Bernardo Bolzani Bach
{"title":"Comparative outcomes of focal laser versus 360-degree laser in vitrectomy for retinal detachment: a systematic review and meta-analysis.","authors":"Valdez Melo Dos Anjos Filho, Natalia Garcia Gaban, Sara Hira, Maria Antônia Torres Arteche, Mateus Pimenta Arruda, Bernardo Bolzani Bach","doi":"10.1186/s40942-025-00790-2","DOIUrl":"https://doi.org/10.1186/s40942-025-00790-2","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1186/s40942-025-00793-z
Thiago Meister, Helena Gschwendtner, Eric Koji Azuma Watanabe, Amanda Granero de Castro, Ana Beatriz Ferreira do Amaral Antunes, Luís Expedito Sabage, Carlos Augusto Moreira-Neto
{"title":"Incidence and risk factors for retinal detachment after cataract surgery: a comparison between trainee and experienced surgeons.","authors":"Thiago Meister, Helena Gschwendtner, Eric Koji Azuma Watanabe, Amanda Granero de Castro, Ana Beatriz Ferreira do Amaral Antunes, Luís Expedito Sabage, Carlos Augusto Moreira-Neto","doi":"10.1186/s40942-025-00793-z","DOIUrl":"https://doi.org/10.1186/s40942-025-00793-z","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: To identify baseline predictors of anatomical response after intravitreal bevacizumab in polypoidal choroidal vasculopathy (PCV) and to evaluate anatomical and visual outcomes over 12 months.
Methods: This retrospective study included 81 eyes with PCV treated with three consecutive monthly intravitreal bevacizumab injections. Patients were classified as good or poor responders based on optical coherence tomography (OCT) findings at month 3. Baseline demographic, clinical, and imaging parameters were compared between groups, and predictors of poor response were identified using multivariable regression. Visual acuity (VA), central retinal thickness (CRT), subretinal fluid (SRF), and pigment epithelial detachment (PED) height were analyzed within and between groups through month 12.
Results: Forty eyes (49.4%) were poor responders and 41 (50.6%) were good responders. Greater baseline SRF height and thinner SFCT were independent predictors of poor response (RR per 100 μm: 1.27 and 0.71 respectively; AUC = 0.74). Good responders showed significant VA improvement (0.64 ± 0.08 vs. 0.48 ± 0.06 logMAR, p < 0.001) and CRT reduction (419.5 ± 24.3 vs. 285.5 ± 14.1 μm, p < 0.001) at month 3, and these were maintained at month 12. Among good responders, 75% continued bevacizumab injections (non-switch group) and sustained favorable outcomes. In contrast, 86% of poor responders switched to other medications (switch group), achieving significant VA gain, CRT reduction, and further SRF with PED reduction by month 12. The non-switch group required fewer injections (5.8 ± 2.5 vs. 7.8 ± 3.0 injections; p < 0.001) and achieved longer treatment intervals (11.7 ± 9.0 vs. 7.8 ± 3.0 weeks; p = 0.046) than the switch group.
Conclusions: Approximately half of PCV eyes demonstrated a favorable response to bevacizumab monotherapy. Baseline SRF height and SFCT were significant predictors of treatment response. Early assessment after three monthly bevacizumab injections allowed for the differentiation between relatively mild and a more severe disease requiring more frequent and sustained anti-VEGF injections. Switching of anti-VEGFs was associated with improved outcomes in poor responders.
背景：确定贝伐单抗玻璃体内治疗息肉样脉络膜血管病变（PCV）后解剖反应的基线预测因素，并评估12个月内解剖和视觉结果。方法：本回顾性研究纳入81只连续3个月玻璃体内注射贝伐单抗治疗的PCV眼。根据第3个月的光学相干断层扫描（OCT）结果，将患者分为良好或不良反应。比较各组之间的基线人口学、临床和影像学参数，并使用多变量回归确定不良反应的预测因素。随访12个月，观察两组患者的视力（VA）、视网膜中央厚度（CRT）、视网膜下液（SRF）、色素上皮脱离（PED）高度。结果：不良反应40只（49.4%），良好反应41只（50.6%）。较高的基线SRF高度和较薄的SFCT是不良反应的独立预测因子（每100 μm的RR分别为1.27和0.71;AUC = 0.74）。良好应答者表现出显著的VA改善（0.64±0.08 vs 0.48±0.06 logMAR, p）。结论：大约一半的PCV眼对贝伐单抗单药治疗表现出良好的反应。基线SRF高度和SFCT是治疗反应的重要预测因子。三个月注射贝伐单抗后的早期评估可以区分相对轻微和更严重的疾病，需要更频繁和持续的抗vegf注射。在不良应答者中，切换抗vegf与改善预后相关。
{"title":"Predictors of response to bevacizumab monotherapy in polypoidal choroidal vasculopathy: a 12-month retrospective study.","authors":"Chinnapat Montrisuksirikun, Supredee Pongrujikorn, Nuttawut Rodanant, Somanus Thoongsuwan, Supalert Prakhunhungsit, Nida Wongchaisuwat, Nopasak Phasukkijwatana","doi":"10.1186/s40942-025-00795-x","DOIUrl":"https://doi.org/10.1186/s40942-025-00795-x","url":null,"abstract":"<p><strong>Background: </strong>To identify baseline predictors of anatomical response after intravitreal bevacizumab in polypoidal choroidal vasculopathy (PCV) and to evaluate anatomical and visual outcomes over 12 months.</p><p><strong>Methods: </strong>This retrospective study included 81 eyes with PCV treated with three consecutive monthly intravitreal bevacizumab injections. Patients were classified as good or poor responders based on optical coherence tomography (OCT) findings at month 3. Baseline demographic, clinical, and imaging parameters were compared between groups, and predictors of poor response were identified using multivariable regression. Visual acuity (VA), central retinal thickness (CRT), subretinal fluid (SRF), and pigment epithelial detachment (PED) height were analyzed within and between groups through month 12.</p><p><strong>Results: </strong>Forty eyes (49.4%) were poor responders and 41 (50.6%) were good responders. Greater baseline SRF height and thinner SFCT were independent predictors of poor response (RR per 100 μm: 1.27 and 0.71 respectively; AUC = 0.74). Good responders showed significant VA improvement (0.64 ± 0.08 vs. 0.48 ± 0.06 logMAR, p < 0.001) and CRT reduction (419.5 ± 24.3 vs. 285.5 ± 14.1 μm, p < 0.001) at month 3, and these were maintained at month 12. Among good responders, 75% continued bevacizumab injections (non-switch group) and sustained favorable outcomes. In contrast, 86% of poor responders switched to other medications (switch group), achieving significant VA gain, CRT reduction, and further SRF with PED reduction by month 12. The non-switch group required fewer injections (5.8 ± 2.5 vs. 7.8 ± 3.0 injections; p < 0.001) and achieved longer treatment intervals (11.7 ± 9.0 vs. 7.8 ± 3.0 weeks; p = 0.046) than the switch group.</p><p><strong>Conclusions: </strong>Approximately half of PCV eyes demonstrated a favorable response to bevacizumab monotherapy. Baseline SRF height and SFCT were significant predictors of treatment response. Early assessment after three monthly bevacizumab injections allowed for the differentiation between relatively mild and a more severe disease requiring more frequent and sustained anti-VEGF injections. Switching of anti-VEGFs was associated with improved outcomes in poor responders.</p>","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scleral buckling as a standalone surgery in the era of pars plana vitrectomy: a 10-year retrospective cohort study.","authors":"Yosra Er-Reguyeg, Moncef Berkache, Mélanie Hébert, Georges Hallak, Sihame Doukkali, Eunice Linh You, Serge Bourgault, Mathieu Caissie, Éric Tourville, Ali Dirani","doi":"10.1186/s40942-025-00785-z","DOIUrl":"https://doi.org/10.1186/s40942-025-00785-z","url":null,"abstract":"","PeriodicalId":14289,"journal":{"name":"International Journal of Retina and Vitreous","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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