Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa2810
J. Sumner, E. Robinson, R. Wiggans, C. Barber, D. Fishwick
{"title":"Assessing the impact of workers’ prior experience of lung function testing and potential effects on future testing","authors":"J. Sumner, E. Robinson, R. Wiggans, C. Barber, D. Fishwick","doi":"10.1183/13993003.congress-2019.pa2810","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa2810","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89835514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa1986
D. Norbäck, Xin Zhang, Tian Li, Chenghuan Li, X. Bai, Zhuohui Zao
{"title":"Two-year onset of respiratory symptoms among Chinese school children: the role of dampness, ETS and redecoration at home and PM10, NO2, SO2 and inadequate ventilation flow in the classroom","authors":"D. Norbäck, Xin Zhang, Tian Li, Chenghuan Li, X. Bai, Zhuohui Zao","doi":"10.1183/13993003.congress-2019.pa1986","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1986","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79497386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa2841
M. Gangadi, G. Dounias, P. Bakakos, Vasilios Panagoulias, E. Zervas, Nikoleta Rovina, P. Katsaounou
{"title":"Air Pollution and Hospital Admission for Respiratory Diseases in Athens, Greece","authors":"M. Gangadi, G. Dounias, P. Bakakos, Vasilios Panagoulias, E. Zervas, Nikoleta Rovina, P. Katsaounou","doi":"10.1183/13993003.congress-2019.pa2841","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa2841","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"13 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78402684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa1982
D. Vinnikov, Z. Tulekov, A. Raushanova
{"title":"‘Clean’ outdoor jobs are not clean because of very high levels of PM exposure in polluted cities","authors":"D. Vinnikov, Z. Tulekov, A. Raushanova","doi":"10.1183/13993003.congress-2019.pa1982","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1982","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75607015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa3280
A. Niranjala, V. Moore, G. Walters, A. Robertson, S. Burge
{"title":"Why are specific inhalation challenges (SIC) negative in workers with suspected occupational asthma?","authors":"A. Niranjala, V. Moore, G. Walters, A. Robertson, S. Burge","doi":"10.1183/13993003.congress-2019.oa3280","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa3280","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79960331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa2836
M. Klarić, Daniela Jakšić, S. Kocsubé
{"title":"Biodiversity and inflammatory properties of Aspergillus section Versicolores - what flood has to do with it?","authors":"M. Klarić, Daniela Jakšić, S. Kocsubé","doi":"10.1183/13993003.congress-2019.pa2836","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa2836","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83480724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa2830
J. Bassein, S. Ganesh, Myra G. dela Pena-Ponce, J. Backer, M. Lanclus, D. Belmans, C. V. Holsbeke, L. Miller
Rationale: Wildfires are predicted to increase in frequency as a result of climate change. The impact of acute wildfire smoke inhalation on development of chronic disease is unknown. Previously, we have reported lung function decrements in a cohort of adolescent rhesus macaque monkeys that were exposed as infants to the Northern California wildfires (Black, et. al. 2017). For this current study, we hypothesized that pulmonary changes due to early life wildfire smoke exposure would persist into adulthood and lead to transmission of maternal phenotype into offspring. Methods: Adult female rhesus monkeys were born and reared in an outdoor environment within three months prior to the Trinity and Humboldt County summer wildfires in 2008, which produced significant episodes of PM2.5 exposures within one mile of the primate colony. High resolution computerized tomography (CT) imaging of the thoracic cavity was conducted on adult animals only. CT scans were analyzed using Functional Respiratory Imaging to quantify structural changes and functional deficits. A second cohort born in the spring of 2009 served as a control group; biospecimen collection and imaging were conducted in subsequent years to normalize age. Results: CT scans from wildfire smoke-exposed adult monkeys showed significant reductions in lung volume, inspiratory capacity, and ventilation perfusion relative to controls. A significant increase in specific airway radius and blood vessel density was also detected in wildfire smoke-exposed adult monkeys. Conclusions: Our findings demonstrate that early life ambient wildfire smoke exposure results in pulmonary responses that persist into adulthood. Funding: California Air Resources Board and NIEHS T32 ES007059
理由:据预测，由于气候变化，野火发生的频率会增加。急性野火烟雾吸入对慢性疾病发展的影响尚不清楚。此前，我们曾报道过一组青少年恒河猴的肺功能下降，这些恒河猴在婴儿时期暴露于北加州的野火中(Black, et al. 2017)。在目前的研究中，我们假设由于早期暴露于野火烟雾导致的肺部变化将持续到成年，并导致母体表型遗传给后代。方法:在2008年三一县和洪堡县夏季野火发生前的三个月内，成年雌性恒河猴出生并在室外环境中饲养，这些野火在灵长类动物聚居区一英里内产生了严重的PM2.5暴露事件。高分辨率计算机断层扫描(CT)仅对成年动物进行了胸腔成像。CT扫描分析使用功能呼吸成像量化结构变化和功能缺陷。2009年春天出生的第二组人作为对照组;在随后的几年中进行生物标本收集和成像以使年龄正常化。结果:野火烟雾暴露的成年猴子的CT扫描显示，与对照组相比，肺容量、吸气量和通气灌注显著减少。在野火烟雾暴露的成年猴子中，也发现了比气道半径和血管密度的显著增加。结论:我们的研究结果表明，早期生活环境野火烟雾暴露导致肺部反应持续到成年期。资助:加州空气资源委员会和NIEHS T32 ES007059
{"title":"Wildfire Smoke Exposure During Infancy Results in Impaired Lung Function","authors":"J. Bassein, S. Ganesh, Myra G. dela Pena-Ponce, J. Backer, M. Lanclus, D. Belmans, C. V. Holsbeke, L. Miller","doi":"10.1183/13993003.congress-2019.pa2830","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa2830","url":null,"abstract":"Rationale: Wildfires are predicted to increase in frequency as a result of climate change. The impact of acute wildfire smoke inhalation on development of chronic disease is unknown. Previously, we have reported lung function decrements in a cohort of adolescent rhesus macaque monkeys that were exposed as infants to the Northern California wildfires (Black, et. al. 2017). For this current study, we hypothesized that pulmonary changes due to early life wildfire smoke exposure would persist into adulthood and lead to transmission of maternal phenotype into offspring. Methods: Adult female rhesus monkeys were born and reared in an outdoor environment within three months prior to the Trinity and Humboldt County summer wildfires in 2008, which produced significant episodes of PM2.5 exposures within one mile of the primate colony. High resolution computerized tomography (CT) imaging of the thoracic cavity was conducted on adult animals only. CT scans were analyzed using Functional Respiratory Imaging to quantify structural changes and functional deficits. A second cohort born in the spring of 2009 served as a control group; biospecimen collection and imaging were conducted in subsequent years to normalize age. Results: CT scans from wildfire smoke-exposed adult monkeys showed significant reductions in lung volume, inspiratory capacity, and ventilation perfusion relative to controls. A significant increase in specific airway radius and blood vessel density was also detected in wildfire smoke-exposed adult monkeys. Conclusions: Our findings demonstrate that early life ambient wildfire smoke exposure results in pulmonary responses that persist into adulthood. Funding: California Air Resources Board and NIEHS T32 ES007059","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83212865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.oa483
Norrice M. Liu, J. Grigg
{"title":"The potential for air purification to reduce children’s overall pollution exposure","authors":"Norrice M. Liu, J. Grigg","doi":"10.1183/13993003.congress-2019.oa483","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa483","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77763302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa2818
S. Sánchez-Díez, M. Cruz, Miquel de Homdedeu, I. Ojanguren, C. Romero-Mesones, A. Villar, X. Muñoz
{"title":"YKL-40 and KL-6 in serum and sputum samples of patients diagnosed with hypersensitivity pneumonitis","authors":"S. Sánchez-Díez, M. Cruz, Miquel de Homdedeu, I. Ojanguren, C. Romero-Mesones, A. Villar, X. Muñoz","doi":"10.1183/13993003.congress-2019.pa2818","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa2818","url":null,"abstract":"","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83688523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.1183/13993003.congress-2019.pa5252
R. Wiggans, J. Sumner, E. Robinson, A. Codling, L. Bradshaw, L. Lewis, J. Feary, C. Barber
Background: Fractional exhaled nitric oxide (FENO) is increasingly used in asthma, but its role in occupational asthma (OA) is not established. Aim: To explore relationships between FENO and symptoms, asthma, and lung function in wood, foundry, and laboratory animal workers. Method: Workers underwent validated questionnaire, FENO, and spirometry measured to ATS/ERS standards. Associations were examined between FENO >40ppb and work-related respiratory symptoms (WRRS); and between current asthma symptoms (CAS) and either FENO >40ppb, or CAS and FEV1 below the lower limit of normal (LLN). Degree of overlap between workers with FENO >40ppb, FEV1 Results: In total 655 workers took part. Mean age was 39 (SD 12.5) years, 86% were male and 25% current smokers. Overall 40% of workers reported CAS and 20% had elevated FENO. FENO >40ppb was associated with asthma (OR for FENO >40 ppb 2.12, 95% CI 1.19 – 3.78). Nine per cent of workers had both CAS and high FENO: the risk of WRRS was elevated in this group (OR 3.75, 2.01 – 7.00). No increased risk of WRRS was seen in workers with CAS and obstructive spirometry. Among workers with CAS, little overlap existed between those with high FENO and those with low FEV1. Over half those with CAS and high FENO had no previous asthma diagnosis. Conclusion: CAS were common among workers exposed to a range of known occupational allergens. Measurement of FENO in the workplace can be used to help identify symptomatic workers with eosinophilic airway inflammation. A significant proportion of these workers have never been diagnosed with asthma, suggesting there may be a role for FENO in health surveillance for OA.
{"title":"Respiratory symptoms, airway inflammation and lung function in workers at risk of occupational asthma","authors":"R. Wiggans, J. Sumner, E. Robinson, A. Codling, L. Bradshaw, L. Lewis, J. Feary, C. Barber","doi":"10.1183/13993003.congress-2019.pa5252","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa5252","url":null,"abstract":"Background: Fractional exhaled nitric oxide (FENO) is increasingly used in asthma, but its role in occupational asthma (OA) is not established. Aim: To explore relationships between FENO and symptoms, asthma, and lung function in wood, foundry, and laboratory animal workers. Method: Workers underwent validated questionnaire, FENO, and spirometry measured to ATS/ERS standards. Associations were examined between FENO >40ppb and work-related respiratory symptoms (WRRS); and between current asthma symptoms (CAS) and either FENO >40ppb, or CAS and FEV1 below the lower limit of normal (LLN). Degree of overlap between workers with FENO >40ppb, FEV1 Results: In total 655 workers took part. Mean age was 39 (SD 12.5) years, 86% were male and 25% current smokers. Overall 40% of workers reported CAS and 20% had elevated FENO. FENO >40ppb was associated with asthma (OR for FENO >40 ppb 2.12, 95% CI 1.19 – 3.78). Nine per cent of workers had both CAS and high FENO: the risk of WRRS was elevated in this group (OR 3.75, 2.01 – 7.00). No increased risk of WRRS was seen in workers with CAS and obstructive spirometry. Among workers with CAS, little overlap existed between those with high FENO and those with low FEV1. Over half those with CAS and high FENO had no previous asthma diagnosis. Conclusion: CAS were common among workers exposed to a range of known occupational allergens. Measurement of FENO in the workplace can be used to help identify symptomatic workers with eosinophilic airway inflammation. A significant proportion of these workers have never been diagnosed with asthma, suggesting there may be a role for FENO in health surveillance for OA.","PeriodicalId":14308,"journal":{"name":"International Journal of Occupational and Environmental Health","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84532073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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